Author Interviews, BMJ, Heart Disease / 09.07.2014

Philippe Pibarot, DVM, PhD, FAHA, FACC, FESC, FASE Professeur titulaire, Département de Médecine, Université Laval Professor, Department of Medicine, Laval University Directeur,  Chaire de Recherche du Canada sur les Maladies Valvulaires Cardiaques Chair,  Canada Research Chair in Valvular Heart Diseases Institut Universitaire de Cardiologie et de Pneumologie de QuébecQuébec Heart & Lung Institute - Local Y4165MedicalResearch.com Interview with : Philippe Pibarot, DVM, PhD, FAHA, FACC, FESC, FASE Professeur titulaire, Département de Médecine, Université Laval Professor, Department of Medicine, Laval University Directeur,  Chaire de Recherche du Canada sur les Maladies Valvulaires Cardiaques Chair,  Canada Research Chair in Valvular Heart Diseases Institut Universitaire de Cardiologie et de Pneumologie de QuébecQuébec Heart & Lung Institute - Local Y4165 Medical Research: What are the main findings of the study? Dr. Pibarot: The optimal timing of aortic valve replacement (AVR) in asymptomatic patients with severe aortic stenosis (AS) remains a matter of debates. Both the American and European guidelines recommend AVR for patients with severe AS who present with symptoms or left ventricular (LV) systolic dysfunction. However, patients with aortic stenosis are often older, less physically active and have more comorbidities, which make the assessment of AS-related symptoms challenging and unreliable. In this study by Capoulade et al, plasma levels of brain natriuretic peptide (BNP) were obtained in 157 patients with severe asymptomatic aortic stenosis and preserved LV ejection fraction at peak of exercise-stress echocardiography. Patients in the upper (>95 pg/ml) and mid (>45 pg/ml) tertiles of exercise BNP respectively had a 5- and 3- fold increase in the risk of events (i.e. AVR or death) compared to those in the lower tertile. Similar results were obtained in the subset of patients with low resting BNP. (more…)
Antibiotic Resistance, Author Interviews, JAMA, Surgical Research / 09.07.2014

Jean Marc Regimbeau MedicalResearch.com Interview with : Pr. Jean-Marc Regimbeau Service de Chirurgie Digestive Oncologique et Métabolique, CHU d’Amiens   Medical Research : What are the main findings of the study? Answer: In our study we found that the absence of postoperative administration of amoxicillin plus clavulanic acid did not improve the occurrence of postoperative infections in patients with mild or moderate acute calculous cholecystitis. The bile cultures were pathogen free in 60.9% of case. Moreover we show that less than 2 percent of the overall population presented a major complication defined according to the Clavien Dindo Classification (Clavien score ≥3a). After cholecystectomy the readmission rate was 6%. (more…)
Author Interviews, JAMA, Smoking / 09.07.2014

MedicalResearch.com Interview with: Coenie Koegelenberg, MBChB, MMed (Int), FCP (SA), MRCP (UK), Cert Pulm (SA), PhD Associate Professor: Pulmonology Stellenbosch University & Tygerberg Academic Hospital MedicalResearch.com Interview with: Coenie Koegelenberg, MBChB, MMed (Int), FCP (SA), MRCP (UK), Cert Pulm (SA), PhD Associate Professor: Pulmonology Stellenbosch University & Tygerberg Academic Hospital Medical Research: What are the main findings of the study? Dr. Koegelenberg: The aim of this study was to evaluate the efficacy of combining varenicline and a nicotine patch versus varenicline alone as an aid to smoking cessation in a double-blind study design in a larger group and with a longer assessment period than has been studied to date. It was found that the combination treatment was associated with a statistically significant and clinically important higher continuous abstinence rate at 12 weeks (55.4% vs. 40.9%; P=.007) and 24 weeks (49.0% vs. 32.6%; P=.004), and point prevalence abstinence rate at 6 months (65.1% vs. 46.7%; P=.002). The present study was not adequately powered to fully assess safety and tolerability endpoints, but the results suggest that adverse events were balanced across treatment arms, except for mild skin reactions that were more frequently observed in the nicotine patch group (14.4% vs. 7.8%, P=.03). (more…)
Author Interviews, Clots - Coagulation, JAMA, Vaccine Studies / 09.07.2014

MedicalResearch.com Interview with: Nikolai Madrid Scheller Department of Epidemiology Research Statens Serum Institut, Copenhagen Medical Research: What are the main findings of the study? Answer: In a large and comprehensive study of more than 1.5 million women including more than 500,000 HPV vaccinated there was no association between HPV vaccination and blood clots. (more…)
Author Interviews, Psychological Science, Weight Research / 08.07.2014

Mark C. Pachucki, PhD Senior Scientist, Mongan Institute for Health Policy Affiliated Faculty, MGHfC Division of General Academic Pediatrics Instructor in Medicine and Pediatrics, Harvard Medical School Boston, MA 02114MedicalResearch:.com Interview with: Mark C. Pachucki, PhD Senior Scientist, Mongan Institute for Health Policy Affiliated Faculty, MGHfC Division of General Academic Pediatrics Instructor in Medicine and Pediatrics, Harvard Medical School Boston, MA 02114 MedicalResearch: What are the main findings of the study? Dr. Pachucki: We found that in in one-child families, having an obese parent made a child about twice as likely to be obese themselves. However, in two-child families, a child’s obesity status was more strongly related with their sibling than with their parent. Even more interesting, in the case of the younger sibling, the parent’s obesity status was not related with that child’s obesity status at all. These findings matter because family members are primary sources of social influence for children – understanding how health status is correlated within a family gives us a better foothold on possible intervention strategies. (more…)
Author Interviews, Diabetes, Diabetologia / 08.07.2014

MedicalResearch.com Interview with: Professor Daniela Jakubowicz MD Diabetes Unit. E. Wolfson Medical Center Sackler Faculty of Medicine, Tel Aviv University and Tel Aviv Medical  Center, IsraelMedicalResearch.com Interview with: Professor Daniela Jakubowicz MD Diabetes Unit. E. Wolfson Medical Center Sackler Faculty of Medicine, Tel Aviv University and Tel Aviv Medical  Center, Israel Medical Research: What are the main findings of the study? Prof. Jakubowicz: In type 2 diabetes there is a deficit of post-meal insulin secretion (from pancreatic beta-cells) that  contributes to an exaggerated elevation in blood glucose. In this study we  found that consumption of whey protein shortly before breakfast augmented  GLP-1 (a gut hormone that stimulates insulin secretion) enhancing insulin response and lowering glucose excursions after breakfast. (more…)
Author Interviews, JAMA, OBGYNE, Pediatrics / 08.07.2014

MedicalResearch.com Interview with: David Olds, Ph.D. Professor of Pediatrics and Director Prevention Research Center for Family and Child Health University of Colorado Department of Pediatrics Aurora, Colorado   80045MedicalResearch.com Interview with: David Olds, Ph.D. Professor of Pediatrics and Director Prevention Research Center for Family and Child Health University of Colorado Department of Pediatrics Aurora, Colorado   80045 Medical Research: What are the main findings of the study? Dr. Olds: We’ve conducted a randomized controlled trial of a program of nurse home visiting for low-income women with no previous live firths during pregnancy and the first two years of the child’s life, with randomization of participants beginning in 1990. In our most recent follow-up of mothers and children in Memphis, those who received nurse-visitation were less likely to have died over a 2-decade period following the child’s birth than those in the control group.  Death among mothers and children in these age ranges in the US is rare and extraordinarily important for what it tells us about the health of the population studied in this trial. For children, the reduction in death was present for preventable causes, that is, sudden infant death syndrome, injuries, and homicide.  All of the child deaths for preventable causes were in the control group, for whom the rate was 1.6%.  None of the nurse-visited children died of preventable causes. The reductions in maternal mortality were found for two nurse-visited groups combined for this report: one received prenatal and newborn visitation and a second received visitation during pregnancy and through child age two.  Overall, mothers assigned to the control group were nearly 3 times more likely to die than those assigned to the two nurse-visited conditions.  The relative reduction in maternal mortality was particularly pronounced for deaths linked to maternal behaviors -- suicide, drug overdose, injuries, and homicide; for these external causes of death, 1.7% of the mothers in the control group had died, compared to 0.2% of those visited by nurses. (more…)
Author Interviews, Infections, mBio / 08.07.2014

Soo Chan Lee, PhD Senior Research Associate, Center for Microbial Pathogenesis, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, N.C. 27710MedicalResearch.com Interview with: Soo Chan Lee, PhD Senior Research Associate, Center for Microbial Pathogenesis, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, N.C. 27710 Medical Research: What are the main findings of the study? Dr. Soo Chan Lee: Mucor circinelloides strain isolated from recalled Chobani yogurt was found to be the most virulent subspecies M. circinelloides forma circinelloides that is commonly associated with human infections. When mice were infected with this fungus through the tail-vein, 80% mortality was observed 5 days post infection. When mice were fed with spores, the fungus survived passage through the GI tract as many as 10 days, indicating the fungus can colonize to cause infections.  Whole genome sequence analysis revealed the possibility that this fungus could produce harmful secondary metabolites that are unknown in this fungal species. (more…)
Author Interviews, Schizophrenia, Sleep Disorders / 08.07.2014

Prof. Dr. Ulrich Ettinger Departments of Psychology University of Bonn Bonn, GermanyMedicalResearch.com Interview with: Prof. Dr. Ulrich Ettinger Departments of Psychology University of Bonn Bonn, Germany Medical Research: What are the main findings of the study? Prof. Ettinger: We found that 24-hour sleep deprivation induced subjective cognitive, perceptual and emotional alterations resembling the symptoms of schizophrenia. We also observed that sleep deprivation led to a deficit in a sensorimotor filter mechanism called prepulse inhibition (PPI), similar to the disturbance seen in schizophrenia. (more…)
Author Interviews, Blood Pressure - Hypertension, Diabetes, Diabetes Care, Sleep Disorders / 08.07.2014

MedicalResearch.com Interview with:Vincenza Spallone MD PhD Endocrinology and Neurology Department of Systems Medicine Tor Vergata University, Rome, Italy Vincenza Spallone MD PhD Endocrinology and Neurology Department of Systems Medicine Tor Vergata University, Rome, Italy   Medical Research: What are the main findings of the study? Dr. Spallone:To investigate a possible relationship between painful diabetic polyneuropathy (PDPN) and the circadian pattern of blood pressure (BP), we performed ambulatory blood pressure monitoring in 113 diabetic patients with PDPN, with painless diabetic polyneuropathy (DPN) and without DPN. In addition, we evaluated neuropathic pain, sleep, risk for obstructive sleep apnoea (OSA), autonomic function, and in a subgroup of patients, depressive symptoms. The main finding was that patients with painful diabetic polyneuropathy displayed impaired nocturnal fall in BP compared to those without neuropathy, and higher nocturnal systolic blood pressure than the other two groups. Although the day-night change (∆) in blood pressure failed to reach a significant difference between painful diabetic polyneuropathy and DPN groups, nondipping (the loss of nocturnal fall in systolic BP) was more strictly associated with painful diabetic polyneuropathy than DPN and in multivariate analysis, including comorbidities and most potential confounders, neuropathic pain was an independent determinant of ∆ BP and nocturnal systolic blood pressure. In summary, we showed a novel association of peripheral diabetic neuropathic pain with nondipping and higher systolic nocturnal blood pressure, which was not entirely explained through pain dependent sleep problems or other pain- or diabetes-related comorbidities, like CAN, OSA and depression. (more…)
Author Interviews, Diabetes, Diabetes Care / 08.07.2014

MedicalResearch.com: Interview with: Interview with Professor Donald W Bowden and Dr. Amanda J Cox Center for Diabetes Research, Center for Genomics and Personalized Medicine Research Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC Medical Research: What are the main findings of the study? Answer: The study examined modifiable cardiovascular disease (CVD) risk factors and risk for mortality in a subset of individuals from the Diabetes Heart Study who were at high risk based for cardiovascular disease based on burden of subclinical CVD assessed by coronary artery calcified plaque scores greater than 1000. Even among this high risk group, known CVD risk factors were still useful in assessing ongoing risk for mortality.  Use of cholesterol-lowering medication was one factor identified to be protective against mortality. (more…)
Author Interviews, JAMA, Psychological Science / 07.07.2014

W Curt LaFrance Jr MD, MPH Assistant Professor of Psychiatry and Neurology, Alpert Medical School, Brown University Director of Neuropsychiatry and Behavioral Neurology, Rhode Island Hospital Providence RI 02903-4923MedicalResearch.com Interview with: W Curt LaFrance Jr MD, MPH Assistant Professor of Psychiatry and Neurology, Alpert Medical School, Brown University Director of Neuropsychiatry and Behavioral Neurology, Rhode Island Hospital Providence RI 02903-4923 MedicalResearch: What are the main findings of the study? Dr. LaFrance: Patients treated with the 12 session, 1 hour, individual psychotherapy seizure treatment workbook had significant reductions in their seizures and improvement in their comorbid symptoms, quality of life and functioning. In contrast, treatment as usual /standard medical care (TAU/SMC) showed no improvement in seizures, comorbid symptoms or other outcomes. (more…)
Author Interviews, Diabetes, Diabetologia, Exercise - Fitness / 07.07.2014

Lukas Schwingshackl, MSc Department of Nutritional Sciences University of Vienna Vienna, AUSTRIAMedicalResearch.com: Interview with: Lukas Schwingshackl, MSc Department of Nutritional Sciences University of Vienna Vienna, AUSTRIA Medical Research: What are the main findings of the study? Lukas Schwingshackl: The results of the present meta-analyses showed that, in patients with established diabetes, aerobic training might be more effective in reducing glycosylated haemoglobin and fasting glucose when compared with resistance training. Combined aerobic and resistance training was more powerful in reducing glycosylated haemoglobin compared with aerobic training, and more effective in reducing glycosylated haemoglobin, fasting glucose and tricylglycerols when compared with resistance training. However, these results could not be confirmed when only low risk of bias studies were included. (more…)
Author Interviews, BMJ, Heart Disease / 07.07.2014

MedicalResearch.com Interview with: Dr Mohanraj K Karunanithi Research Team Leader | Integrated Mobile Health Systems The Australian e-Health Research Centre Digital Productivity and Services Flagship CSIRO Medical Research: What are the main findings of the study? Dr. Karunanithi:
  • 33% more clients completed the innovative home-based cardiac rehabilitation (CR) delivery using smartphone and the internet (Care Assessment Platform CR program) compared with the traditional centre-based cardiac rehabilitation program.
  • Care Assessment Platform-CR  was as effective as tradition CR program in improving physical activity, diet intake, and lowering depression
  • Care Assessment Platform -CR was also effective in reducing weight, and anxiety levels and more importantly, the overall health related quality of life.
(more…)
AHA Journals, Author Interviews, Exercise - Fitness, Heart Disease / 07.07.2014

Peter Kokkinos PhD Veterans Affairs Medical Center, Cardiology Division Washington, DC 20422MedicalResearch.com Interview with: Peter Kokkinos PhD Veterans Affairs Medical Center, Cardiology Division Washington, DC 20422 Medical Research: What are the main findings of the study? Dr. Kokkinos: The main finding of the study is that we defined an exercise capacity threshold for each age category (<50; 50-59; 60-69; and ≥70 years of age). The mortality risk increases progressively below this threshold and decreases above it. We then calculated the 5 and 10-year mortality risk for each age category. (more…)
Breast Cancer, Lipids / 07.07.2014

Dr. Rahul Potluri Honorary Clinical Lecturer in Cardiology School of Medical Sciences, Aston University Birmingham UK;MedicalResearch.com Interview with: Dr. Rahul Potluri Honorary Clinical Lecturer in Cardiology School of Medical Sciences, Aston University Birmingham UK; Medical Research: What are the main findings of the study? Dr. Potluri: Study was conducted by a retrospective analysis of more than 1 million anonymous patient records across the UK between 2000 and 2013 using the Algorithm for Comorbidities, Associations, Length of stay and Mortality (ACALM) protocol. There were 664,159 women and of these, 22 938 had hyperlipidaemia and 9 312 had breast cancer. Some 530 women with hyperlipidaemia developed breast cancer. A statistical model to study the association between hyperlipidaemia and breast cancer. They found that having hyperlipidaemia increased the risk of breast cancer by 1.64 times (95% confidence interval 1.50-1.79). (more…)
Author Interviews, Cancer, Thromboembolism / 07.07.2014

MedicalResearch.com Interview with: Dr. Liang He Department of Anesthesiology Yan’an Hospital of Kunming City, kunming, 650051, China MedicalResearch: What are the main findings of this study? Dr. He: We evaluated the prognostic value of plasma heart-type fatty acid binding protein (H-FABP) in patients with acute pulmonary embolism (PE) with the guidelines of acute PE of European Society Cardiology (ESC). We found that higher H-FABP level (above 6 or 7 ng/ml) was associated with an increased of 30-d mortality and complicated clinical events, from six studies of 85 articles included. H-FABP has the potential to be a novel prognostic marker that can help optimize patient management strategies and risk-stratification algorithms in the population of patients with acute pulmonary embolism. However, few studies had been specifically designed to answer our research questions. (more…)
Author Interviews, Herpes Viruses, HIV, PLoS / 06.07.2014

Dr. Don C. Des Jarlais PhD Director, International Research Core, Center for Drug Use and HIV Research Research Fellow, NDRI Director of Research, Baron Edmond de Rothschild Chemical Dependency Institute, Beth Israel Medical Center Professor of Epidemiology, Department of Epidemiology and Population Health, Albert Einstein College of MedicineMedicalResearch Interview with: Dr. Don C. Des Jarlais PhD Director, International Research Core, Center for Drug Use and HIV Research Research Fellow, NDRI Director of Research, Baron Edmond de Rothschild Chemical Dependency Institute, Beth Israel Medical Center Professor of Epidemiology, Department of Epidemiology and Population Health, Albert Einstein College of Medicine Medical Research: What are the main findings of the study? Dr. Des Jarlais: HIV infection among non-injecting users of heroin and cocaine doubled doubled over the last several decades, from 7% to 14%. Herpes simplex virus type 2 (HSV-2) increases both susceptibility to and transmissibility of HIV. We examined HSV-2 infection among non-injecting heroin and cocaine user over the same time period using stored serum samples. HSV-2 infection was strongly related to HIV infection, and both increased over time. We calculated population attributable risk percentages (PAR%) to estimate the extent to which HSV-2 was driving increased HIV infection. HSV-2 infection was responsible for approximately half of the increase in HIV infection (more…)
Author Interviews, BMJ, Heart Disease / 04.07.2014

MedicalResearch.com Interview with: Dr. Patrícia Lourenço Serviço de Medicina Interna, Centro Hospitalar São João Faculdade de Medicina da Universidade do Porto, Unidade I&D Cardiovascular do Porto Monteiro, Portugal; Medical Research: What are the main findings of the study? Dr. Lourenço: A low prealbumin at hospital discharge associates with morbidity and mortality in acute heart failure patients. The prognostic value of low prealbumin in heart failure is independent of other nutritional markers and of the inflammatory status. (more…)
AHA Journals, Author Interviews, Electronic Records, Medicare, Stroke / 04.07.2014

MedicalResearch.com Interview with Hiraku Kumamar, MD, MPH Department of Epidemiology Harvard School of Public Health, Boston, MA and Soko Setoguchi-Iwata, M.D. Duke Clinical Research Institute Durham, NC 27715 Medical Research: What are the main findings of the study? Answer: We evaluated the accuracy of discharge diagnosis of stroke in the Medicare claims database by linking it to a nationwide epidemiological study cohort with 30239 participants called REasons for Geographic And Racial Differences in Stroke (REGARDS). We found that among the 282 events captured using a strict claims definition of stroke, 91% were true events.  We also found that 12% of the overall strokes had been identified only by Medicare claims, strongly supporting the use of these readily available data for event follow-up in cohort studies. (more…)
Author Interviews, Sleep Disorders / 04.07.2014

Nathaniel F. Watson, MD, MSc Professor of Neurology, University of Washington Co-director, University of Washington Medicine Sleep Center Director, Harborview Medical Center Sleep Clinic Seattle, WashingtonMedicalResearch.com Interview with: Nathaniel F. Watson, MD, MSc Professor of Neurology, University of Washington Co-director, University of Washington Medicine Sleep Center Director, Harborview Medical Center Sleep Clinic Seattle, Washington MedicalResearch: What are the main findings of the study? Dr. Watson: The Singh Index is a composite measure of socioeconomically deprived neighborhoods. We found that as Singh Index increased, sleep duration reduced. This was true in the total sample of twins, and within twin pairs. The fact that we saw this within twin pairs means the association is present after controlling for genetics and shared environment, which substantially strengthens the association. (more…)
AHA Journals, Author Interviews, Heart Disease / 03.07.2014

Sripal Bangalore, MD, MHA Director of Research, Cardiac Catheterization Laboratory, Director, Cardiovascular Outcomes Group, Associate Professor of Medicine, New York University School of Medicine, New York, NY 10016MedicalResearch.com Interview with: Sripal Bangalore, MD, MHA Director of Research, Cardiac Catheterization Laboratory, Director, Cardiovascular Outcomes Group, Associate Professor of Medicine, New York University School of Medicine, New York, NY 10016 Medical Research: What are the main findings of the study? Dr. Bangalore: We found that while CABG was associated with mortality benefit when compared with bare metal stents or first generation drug eluting stent, the gap between CABG and PCI was smaller and non significant when PCI was with newer generation DES. The same was true for repeat revascularization with the magnitude of benefit with CABG descending considerable from comparison with balloon angioplasty to newer generation DES. (more…)
Author Interviews, Cancer Research, Lancet, Mayo Clinic, Radiation Therapy / 03.07.2014

Dr. Robert Foote MD Chair, Department of Radiation Oncology Mayo Clinic, Rochester, MNMedicalResearch.com Interview with: Dr. Robert Foote MD Chair, Department of Radiation Oncology Mayo Clinic, Rochester, MN MedicalResearch: What are the main findings of the study? Dr. Foote: Charged particle therapy (mainly protons and carbon ions) provide superior overall survival, disease-free survival and tumor control when compared to conventional photon therapy.  In particular, it appears that proton beam therapy provides superior disease-free survival and tumor control when compared to the state of the art intensity modulated radiation therapy using photons. (more…)
Author Interviews, Gastrointestinal Disease, Genetic Research, NEJM, Pediatrics / 03.07.2014

Dr. Daniel AgardhMedicalResearch.com Interview with: Dr. Daniel Agardh M.D., Ph.D Department of Pediatrics Diabetes and Celiac Disease Unit Skåne University Hospital Malmo, Sweden, MedicalResearch: What are the main findings of the study? Dr. Agardh: In this study, we stratify the risk of celiac disease among children according to their HLA genotype and country of residence. We confirm that HLA-DQ2/2 genotype is the major risk factor for early celiac disease, but also show how the risk differs between the participating countries despite of sharing similar HLA risk. This points to the direction of an interaction between HLA and the environment that eventually lead to an autoimmune response in genetic susceptible children. (more…)
AHA Journals, Author Interviews, Chocolate, PAD / 03.07.2014

MedicalResearch.com Interview with: Lorenzo Loffredo, MD and Francesco Violi, MD Department of Internal Medicine and Medical Specialties Sapienza University of Rome, Rome, Italy; MedicalResearch: What are the main findings of the study? Answer: Dark chocolate is rich of polyphenols; these natural substances exert antioxidant properties and, through an increase of nitric oxide, dilate arteries. Our research group applied this effect to enhance blood flow in a very common disease, the peripheral arterial disease. This disease is characterized by reduced blood flow to the limbs. There are not any drugs that improve this blood flow, but dark chocolate could. Our study suggest that dark chocolate, and only dark chocolate, could reduce oxidative stress and improve blood flow and walking autonomy in patients with peripheral arterial disease. We observed no effect on blood flow, oxidative stress and on walking autonomy in PAD patients after milk chocolate assumption. This lack of effect was probably due to the low concentration of polyphenols in milk chocolate. (more…)
Accidents & Violence, Author Interviews, Global Health, Lancet, Pharmacology / 03.07.2014

MedicalResearch.com Interview with: Tamara Haegerich, PhD Deputy Associate Director for Science Division of Unintentional Injury Prevention CDC - National Center for Injury Prevention and ControlMedicalResearch.com Interview with: Tamara Haegerich, PhD Deputy Associate Director for Science Division of Unintentional Injury Prevention CDC - National Center for Injury Prevention and Control MedicalResearch: What are the main findings of the study? Dr. Haegerich: In the first three decades of life, more people in the US die from injuries and violence than from any other cause. Approximately 60% of fatal injuries are unintentional (for example, from motor vehicle crashes, drug overdose, and falls), 20% are due to suicide, and 20% are due to homicide. Injuries and violence have been linked to a wide range of physical, mental health, and reproductive health problems, and chronic diseases. They take an enormous economic toll, including the cost of medical care and lost productivity. Importantly, injuries and violence are preventable through education, behavior change, policy, engineering, and environmental supports. For example, laws that promote the use of seat belts and child safety seats, and prevent drunk driving, can reduce motor-vehicle-related injuries. Early childhood home visitation, school-based programs, and therapeutic foster care are examples of evidence-based approaches to preventing violence. Improving proper prescribing of painkillers and access to treatment for substance misuse could prevent prescription drug overdoses. Improvements are possible by framing injuries and violence as preventable, identifying interventions that are cost-effective and based on research, providing information to decision makers, and strengthening the capacity of the health care system. (more…)
Author Interviews, Hematology, JAMA, Stem Cells, Transplantation / 03.07.2014

John F. Tisdale, MDMedicalResearch.com Interview with: Dr. John Tisdale MD Molecular and Clinical Hematology Branch National Institute of Diabetes and Digestive and Kidney Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland MedicalResearch: What are the main findings of the study? Dr. Tisdale: Using a nonmyeloablative allogeneic HLA-match peripheral blood stem cell transplantation strategy aimed at tolerance induction, we were able to revert the phenotype in 26 of 30 adult patients with severe sickle cell disease ranging in age from 16 to 65 years. In contrast to standard transplantation strategies which rely on high doses of chemo and/or radiotherapy after which the entire bone marrow and blood system is replaced by that of the donor, our patients had a mixture of their own and that of their donor. This procedure was well tolerated, with no non-relapse mortality, and led to complete replacement of red blood cells by that of the donor in successfully engrafted patients. This replacement resulted in decreases in pain, pain medication usage, hospitalizations, and improvements in organ function. (more…)
Author Interviews, Connective Tissue Disease, Transplantation / 03.07.2014

MedicalResearch.com Interview with: ProfProf. Dr. Jacob M. van Laar Professor and Chair Dept of Rheumatology & Clinical Immunology University Medical Center Utrecht . Dr. Jacob M. van Laar Professor and Chair Dept of Rheumatology & Clinical Immunology University Medical Center Utrecht MedicalResearch: What are the main findings of the study? Prof. van Laar: The results of the ASTIS-trial demonstrate that stem cell transplantation in selected patients with early, diffuse cutaneous systemic sclerosis, a rare, autoimmune connective tissue disease, prolongs long-term survival and improves clinical manifestations (skin, lung) and quality of life, when compared to monthly infusions with cyclophosphamide. The benefits must be weighed against the risks which include early  treatment-related mortality (10% in the ASTIS-trial) and viral infections. (more…)