MedicalResearch.com Interview with:
Morton Leibowitz, M.D., FACC, Senior Physician
Clalit Research Institute
Clinical Associate Professor of Medicine/Cardiology
NYU School of Medicine
MedicalResearch.com: What is the background for this study? What is known (and not known) about this subject?
Dr. Leibowitz: Statins are upheld as effective treatments in LDL-C lowering and secondary prevention of major cardiovascular events.
Results from recent clinical trials of statins in combination with adjunctive medications for secondary prevention have led to renewed emphasis on a concept that "lower is better" for targeting LDL-C in high-risk patients. Recent meta-analyses have suggested and guidelines have incorporated that intensive statin treatment is recommended for secondary prevention of future cardiac events.
However, on the question “how low is low enough?” for LDL levels in the management of Ischemic Heart Disease patient - the jury is still out.
Past studies do suggest that there is a lower threshold to the beneficial impact of lowering LDL-C, however there still remains uncertainty about what the optimal target is. Some guidelines have suggested a target of LDL below 70 for the group at high-risk for cardiac events, while other guidelines maintain the previously target value of below 100 for these patients. This decision whether indeed "lower is better" has considerable impact on physicians prescription decision-making, and is thus of timely importance.
To address this question, one whould need a very large longitudinal dataset of real-world data on actual prescription, dispensing, laboratory and clinical outcomes data, on tens of thousands of patients for over 5 years. Such databases are available at Clalit Health Services, Israel’s largest healthcare payer/provider, that has 100% Electronic Medical Records for well over a decade. The Clalit Research Institute has created such a retrospective cohort to address this policy question.
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