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12 Jun Platinum-Sensitive, Recurrent Ovarian Cancer: Trial of Surgery + Chemo With and Without Bevacizumab
These highly effective options combined with the negative impact on overall survival in women undergoing sub-optimal surgery, place a premium on patient selection if it is to be undertaken.
11 Jun Lupus: Highly Targeted Antibody Anifrolumab Reduced Flares in Phase 3 Trials
We observed a reduction in lupus flare rates in those who received anifrolumab during the studies. This is important because each time a flare occurs, the well-being of the patient is compromised.
04 Jun ASCO: Antibody-Drug Conjugate Shows Promise in HER2 Positive Advanced Colorectal Cancer
T-DXd has now been shown to be a powerful therapy for HER2+ advanced CRC after failure of standard therapies and its role in the strategy of treatment of colorectal cancer should be further investigated in earlier lines of therapy.
30 May ASCO20: Prognostic Impact of ESR1 mutations in ER+ HER2- Metastatic Breast Cancer
The key question is how and when to use fulvestrant or the many Selective Estrogen Receptor Degraders (SERDs) currently in development.
19 May CARTITUDE-1 Study Shows Promise in Patients With Refractory Myeloma
These longer-term results from the CARTITTUDE-1 study show the continued treatment benefit of JNJ-4528 in heavily pretreated myeloma patients who have few or no remaining treatment options.
14 May Coronary Calcium Score Can Lead to Cost-Effective Statin Treatment in African Americans
Posted at 15:14h
in Author Interviews, Brigham & Women's - Harvard, Cost of Health Care, Heart Disease, Race/Ethnic Diversity, Statins
It is important for African American patients at intermediate risk to discuss their treatment preferences with their physicians when making statin treatment decisions.
13 May KRAS Mutant Cancers: Phase I study RAF-MEK inhibitor and FAK inhibitor defactinib in an intermittent dosing schedule
The Phase 1 regimen with the combination of the two therapies may also have wider implications for other cancers.
11 May Personalized Medicine: Caris Life Sciences Offers DNA and RNA Cancer Profiling
Posted at 19:57h
in Author Interviews
There are essentially no other labs in the world that offer both whole exome (DNA) and whole transcriptome (RNA) testing for every patient and that have the same clinical reach as Caris.
09 May VITRAKVI® (larotrectinib): Outcomes by Prior Treatment & Performance Status in TRK Fusion Cancer Patients
Posted at 11:01h
in AACR, Author Interviews, Biomarkers, Cancer Research, MD Anderson, Pharmaceutical Companies
These data overall demonstrate the importance of testing our patients to identify if they have NTRK gene fusions and may benefit from treatment with larotrectinib.
05 May RNA Profiling Identifies Distinct Classes of White Fat Cells
These differences in gene expression are separate from the process of fat cell browning and beiging
02 Apr Texas Biomed Launches Multi-Species Study to Accelerate COVID-19 Drug Testing
Texas Biomed has unique capabilities in vaccine and drug development, as well as the development of animal models.
01 Apr Monoclonal Antibody Evinacumab is a Major Benefit to Patients with Homozygous Familial Hypercholesterolemia
With the addition of evinacumab to the other lipid lowering therapies available (statins, ezetimibe plus PCSK9 inhibitors) we will change the natural history of homozygous familial hypercholesterolemia.
28 Mar NEJM: Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 Infection
In order to confirm the actual efficacy of lopinavir–ritonavir in severe COVID-19 infections, further trials with larger sample size, milder patients, earlier drug administration and extended treatment course are helpful for finding patients who may benefit from the treatment.
23 Mar Strong Placebo Effects in ED Drug Trials
An important finding that there was no difference between placebo and active drug with daily treatment of PDE5Is for long term recovery of erectile function after prostate cancer treatment
23 Mar Cognitive Outcomes of Prenatal Exposure to Opioid Use Disorder Medications
Our study was interested in the cognitive outcomes (learning, memory, verbal skills, etc) of young children born after medication for opioid use disorder exposure controlled for comparability
20 Mar Maintenance of HIV-1 Suppression Using Long-Acting Cabotegravir and Rilpivirine
Readers should take away the message that these studies pave the way to an exciting new alternative method of receiving antiretroviral therapy. Lifelong, daily oral therapy can be challenging for some patients, and they may welcome an alternative.
17 Mar Increased Distribution, but Pronounced Regional Variation, in US Buprenorphine Use
Federal legislation has increased buprenorphine distribution. However, there continues to be pronounced regional disparities in buprenorphine assess
11 Mar Success of Alcoholics Anonymous and Twelve Step Programs Documented
When treating alcohol use disorder, facilitating some kind of well-articulated Twelve-Step Facilitation intervention such as those included in the randomized controlled trials in this review is likely to produce higher rates of continuous abstinence and remission
27 Feb Rebalancing Immune System May Help Bring Atopic Dermatitis – Eczema – Under Control
We found that NK cell numbers are low in the blood in many patients with eczema and they, in part, appear to be dying off due to stress from chronic inflammation.
25 Feb Radiation Kills Cancer Cells, But May Also Protect Some Tumor Stem Cells That Can Spread
Although radiation kills tumor cells, it can also activate inflammatory responses that may protect some tumor cells.
25 Feb After Age 75 Mammograms May Not Decrease Chance of Dying of Breast Cancer
Posted at 11:52h
in Annals Internal Medicine, Author Interviews, Breast Cancer, Brigham & Women's - Harvard, Cancer Research, Mammograms
MedicalResearch.com Interview with: Xabier Garcia-De-Albeniz MD PhD Research Associate Department of Epidemiology Harvard T.H. Chan School of Public Health Mongan Institute for Health Policy Massachusetts General Hospital MedicalResearch.com: What is the background for this study? Response: The goal of breast cancer screening is to reduce deaths from breast cancer by...
21 Feb ESCAPE-NA1 Trial Offers New Hope for Patients With Devastating Stroke
In Acute Ischemic Stroke subjects that did not receive alteplase, treatment with nerinetide increased the proportion of patients who had a good functional outcome by 9.5% (a relative improvement of 19% over the placebo group), reduced mortality by about 40%, and reduced the volume of the strokes by about 22%.
11 Feb STIVARGA (Regorafenib) For Patients with Unresectable Hepatocellular Carcinoma
This is a real-life observational study of patients with unresectable hepatocellular carcinoma for whom physicians decided to treat with regorafenib.
15 Jan Newer Heart Pumps Help Patients Even If They Are Not Eligible for Heart Transplant
MedicalResearch.com Interview with: Mandeep R. Mehra, MD, MSc, FRCP The William Harvey Distinguished Chair in Advanced Cardiovascular Medicine Medical Director, Heart and Vascular Center Brigham and Women’s Hospital Executive Director Center for Advanced Heart Disease Brigham and Women’s Hospital Professor of Medicine, Harvard Medical School MedicalResearch.com: What is the...
14 Jan Melanoma Cells Change Their Cytoskeleton to Evade Treatment
We find that cancer cells stop responding to both immunotherapies and drugs directed to the tumour’s faulty genes (mutations in the MAPK pathway) by increasing the activity of two cytoskeletal proteins : ROCK and Myosin II.
21 Dec Karius Test Can Detect Blood Stream Infections Before Symptoms in High Risk Patients
Patients treated with chemotherapy for cancer are at a high risk of life-threatening infection; some children with leukemia have a higher chance of dying from infection than from their cancer.
20 Dec Atopic Dermatitis : Positive Phase 3 Studies for Tralokinumab in Moderate to Severe Disease
We can confirm that tralokinumab met all primary and secondary endpoints in its three pivotal Phase 3 studies (ECZTRA 1-3) for the treatment of moderate-to-severe atopic dermatitis (atopic dermatitis) in adults.
19 Dec Neoantigens Can Stimulate Immunity in Relapsed Multiple Myeloma
This is the first study to experimentally validate the immunogenicity of predicted neoantigens from next generation sequencing in relapsed multiple myeloma patients.