Author Interviews, Colon Cancer, Gastrointestinal Disease, Immunotherapy / 04.06.2024
Icahn Mt Sinai Study Finds Immunosuppressives Not Likely To Increase Cancer Risk in Inflammatory Bowel Disease Patients
MedicalResearch.com Interview with:
Steven H. Itzkowitz, MD, FACP, FACG, AGAF
Professor of Medicine and Oncological Sciences
Director of the GI Fellowship Program
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This study looked at patients with inflammatory bowel disease (IBD) who had a history of cancer in the past 5 years and asked whether the medications they received for their IBD might have affected their rates of getting future cancer (new or recurrent cancers). Because many of the medicines that are used to treat IBD can affect the immune system in various ways, there has been concern that the medicines might predispose to subsequent cancers.
We found that patients who received immunosuppressive medications had a numerically increased risk of subsequent cancer, this was not statistically higher than those who had not been exposed to these medications. While previous studies have looked at this question retrospectively, this is the first report that analyzed this issue prospectively using individuals from the United States. Moreover, this study represents a multi-institutional collaboration among gastroenterologists at most of the major NYC healthcare systems.
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