MedicalResearch.com Interview with:
Agnes Dechartres, MD, PhD
Centre de Recherche Epidémiologie et Statistique
Centre d’Épidémiologie Clinique, Hôpital Hôtel Dieu, Assistance Publique des Hôpitaux de Paris
Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Medical Research: What are the main findings of the study?
Dr. Dechartres: In this study, we aimed to compare treatment effect estimates obtained from the meta-analysis including all trials to several alternative strategies for analysis. These alternative strategies are:
- 1) the single most precise trial;
- 2) a meta-analysis including only the largest trials;
- 3) a “limit meta-analysis” that is a type of meta-analysis model recently developed to take into account small-study-effect and
- 4) a meta-analysis restricted to trials at low risk of biases.