Author Interviews, Colon Cancer / 10.09.2013

Dr. Bettina Scholtka Universität Potsdam Institut für Ernährungswissenschaft Abt. Ernährungstoxikologie Arthur-Scheunert-Allee 114-116 14558 Nuthetal, Germany.Dr. Bettina Scholtka Universität Potsdam Institut für Ernährungswissenschaft Abt. Ernährungstoxikologie Arthur-Scheunert-Allee 114-116 14558 Nuthetal, Germany. MedicalResearch.com: What are the main findings of the study? Answer: The extremely high sensitivity of the WTB-HRM technique allows to find very low amounts of different types of colon cancer initiating gene mutations even in stool samples of patients. The method is able to find the expected mutations as well as unknown mutations. So, by applying WTB-HRM to a panel of especially selected marker genes, it is possible to detect cancer precursors in feces before they progress into a malignant stage. (more…)
Author Interviews, Weight Research / 10.09.2013

Lu Qi, MD, PhD, FAHA Assistant Professor of Medicine Harvard Medical School Assistant Professor of Nutrition Harvard School of Public HealthMedicalResearch.com Interview with: Lu Qi, MD, PhD, FAHA Assistant Professor of Medicine Harvard Medical School Assistant Professor of Nutrition Harvard School of Public Health MedicalResearch.com: What are the main findings of the study? Answer: It has been known that weight loss diets may improve metabolic status, in parallel with reduction of body weight. We found that the beneficial of various weight loss diets, such as high-fat and low-fat diets, may be different for people carrying different genotype. (more…)
Author Interviews, JAMA / 10.09.2013

Dr. Amy Sanderson MD Department of Anesthesiology Perioperative & Pain Medicine Boston Children’s Hospital Boston, MassachusettsMedicalResearch.com Interview with: Dr. Amy Sanderson MD Department of Anesthesiology Perioperative & Pain Medicine Boston Children’s Hospital Boston, Massachusetts MedicalResearch.com: What are the main findings of the study? Dr. Sanderson: There is substantial variability in the interpretation of a DNR order. 66.9% of clinicians believed that a DNR order indicates limitation of resuscitative measures only on cardiopulmonary arrest, whereas 33.1% considered a DNR order to be the threshold for the limitation of treatments not specifically related to resuscitation. 68.7% of clinicians reported that the care of a patient changes once a DNR order is written. Of those reporting changes in care, 11.2% reported that this happens only if a cardiopulmonary arrest occurs, while 36.7% believed that there is an increased attention to comfort. Finally, 52.1% reported that care changes beyond both resuscitative measures and focusing on comfort, including limitation or withdrawal of diagnostic and therapeutic interventions. Most clinicians reported that resuscitation status discussions happen later in the illness course than is ideal. (more…)
Author Interviews, Diabetes, Kidney Disease, Stroke / 10.09.2013

MedicalResearch.com Interview with: Yongjun Wang, MD Department of Neurology, Beijing Tiantan Hospital Capital Medical University, Beijing, China MedicalResearch.com: What are the main findings of the study? Answer: Our study demonstrated that reduced eGFR was independently associated with all-cause mortality and other post-stroke outcomes in type 2 diabetic patients; stroke subtype analysis in our cohort showed that this association was only evident in ischemic stroke and TIA. We also observed a U-shaped relationship between variation of eGFR and post-stroke outcomes, that is, increased odds ratios were seen among those with low and high levels of eGFR. The cutoff points of eGFR associated with poor outcomes of stroke were eGFR<45 ml/min/1.73m2 and≥ 120 ml/min/1.73m2, respectively. (more…)
Author Interviews, Heart Disease, JAMA, Nutrition / 10.09.2013

MedicalResearch.com Interview with: Shanshan Li, MD, MSc, ScD Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts On behalf of Drs. Chuive, Flint, Pai, Forman, Hu, Willett, Mukamal and Rimm. MedicalResearch.com: What are the main findings of the study? Answer: In our prospective study of diet quality among MI survivors, we found that a higher diet quality post-MI, measured by Alternative Healthy Eating Index 2010, was associated with 24% lower death rate and 26% lower death rate from cardiovascular disease. Greater improvement of diet quality from pre- to post-MI was associated with 30% lower death rate and 40% lower cardiovascular disease death rate. In addition to reducing the bad fats intake, for example, saturated and transfat intake, MI patients also tended to reduce the good healthy polyunsaturated fats. (more…)
Author Interviews, Heart Disease / 07.09.2013

MedicalResearch.com Interview with: Jonathan Hsu, MD, MAS Cardiac Electrophysiology, Division of Cardiology University of California, San Diego (UCSD) MedicalResearch.com: What are the main findings of the study? Dr. Hsu: We found that the prevalence of cardiac perforation during modern day ICD implantation is 0.14%. We also found that specific patient and implanter characteristics predict cardiac perforation risk: older age, female sex, left bundle branch block, worsened heart failure class, higher left ventricular ejection fraction, and non-single chamber ICD implant are associated with a greater odds of perforation, whereas atrial fibrillation, diabetes, previous cardiac bypass surgery, and higher implanter procedural volume are associated with a lower odds of perforation. (more…)
Author Interviews, Duke, Heart Disease, Outcomes & Safety, Surgical Research / 05.09.2013

Marco D. Huesch, MBBS, Ph.D., Assistant professor at the USC Sol Price School of Public Policy Adjunct professor with Duke’s School of Medicine and Fuqua School of Business.MedicalResearch.com Interview with: Marco D. Huesch, MBBS, Ph.D. Assistant professor at the USC Sol Price School of Public Policy Adjunct professor with Duke’s School of Medicine and Fuqua School of Business. MedicalResearch.com: What are the main findings of the study? Answer: This study asked whether ‘learning by doing’ works backwards too, as ‘forgetting by not doing’. In an nutshell, the answer is ‘no’ among the Californian cardiac surgeons I examined with short breaks of around a month. (more…)
Author Interviews, Brigham & Women's - Harvard, JAMA, Kidney Disease, Medical Research Centers / 05.09.2013

MedicalResearch.com Interview with: Gearoid M. McMahon, MB, BCh Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Framingham Heart Study, National Heart, Lung, and Blood Institute, and Center for Population Studies, Framingham, Massachusetts MedicalResearch.com: What are the main findings of the study? Answer: This study examined the incidence, causes and outcomes of rhabdomyolysis in two large University Teaching hospitals. Rhabdomyolysis is a characterized by an increase in serum creatine phosphokinase (CPK) and results from muscle damage from a variety of causes. The most important complication of rhabdomyolysis is acute kidney injury which can result in a need for dialysis. Using a series of laboratory and clinical variables that are readily available on admission, we constructed a risk score that can predict with some accuracy the likelihood that a patient with rhabdomyolysis might die or need dialysis during an admission. The final variables included in the model were age, gender, the cause of rhabdomyolysis and the admission CPK, creatinine, phosphate, bicarbonate and calcium. One of the advantages of this study was, because we had access to data from two institutions, we were able to derive the risk score in one hospital and confirm its accuracy in the second institution. (more…)
Author Interviews, Blood Pressure - Hypertension, Brigham & Women's - Harvard, Medical Research Centers, PLoS, Social Issues / 05.09.2013

Bert Uchino PhD Department of Psychology and Health Psychology Program University of Utah, Salt Lake City, UtahMedicalResearch.com Interview with: Bert Uchino PhD Department of Psychology and Health Psychology Program University of Utah, Salt Lake City, Utah, MedicalResearch.com: What are the main findings of the study? Dr. Uchino: The main findings from our paper is that independent of one’s own social network quality, the quality of a spouse’s social network was related to daily life ambulatory blood pressure (ABP) levels. More specifically, the more supportive (positive) ties, and the less aversive (negative) or ambivalent (both positive and negative) ties in a spouse’s social network, the lower was one’s own ABP. In addition, looking at the social networks of couples as a whole showed that couples who combined had more supportive ties and less aversive or ambivalent ties showed lower ABP. (more…)
Author Interviews, Orthopedics, PLoS / 04.09.2013

Assistant Professor School of Biological & Population Health Sciences, Exercise & Sport Science Program College of Public Health and Human Sciences Oregon State University Corvallis, OR 97331Marc F. Norcross, PhD, ATC Assistant Professor School of Biological & Population Health Sciences, Exercise & Sport Science Program College of Public Health and Human Sciences Oregon State University Corvallis, OR 97331 MedicalResearch.com: What are the main findings of the study? Dr. Norcross: In the scientific community, there remains considerable disagreement over which direction of knee loading is most responsible for causing an anterior cruciate ligament (ACL) injury event. Many researchers tend to fall into one of three “camps” in which they believe quadriceps loading (sagittal plane), “knock-kneed” landing (frontal plane), or twisting (transverse plane) is the essential factor in the injury mechanism. However, we know from cadaver studies that combined loading from all of these different planes puts the most strain on the ACL. We found that men and women are equally likely to use a sagittal plane landing strategy that we believe increases the risk for ACL injury. However, females were about 3.6 times more likely than males to use a higher risk frontal plane landing strategy. This suggests that the increased likelihood of greater frontal plane loading in women coupled with the equal likelihood of using a high-risk sagittal plane strategy is likely at least partly responsible for women’s 2-6 times greater risk for ACL injury. (more…)
Author Interviews, Cost of Health Care, JAMA / 04.09.2013

Seth A. Seabury, PhD Department of Emergency Medicine, University of Southern California Los Angeles Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los AngelesMedicalResearch.com Interview with: Seth A. Seabury, PhD Department of Emergency Medicine, University of Southern California, Los Angeles Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles   MedicalResearch.com: What are the main findings of the study? Dr. Seabury: We studied the trends in the earnings of male and female physicians in the US from 1987-2010 using nationally representative data from the Current Population Survey (CPS). We found that, while the number of female physicians grew significantly, male physicians continue to have significantly higher earnings than female physicians. The difference in the median earnings of male physicians compared to female physicians actually increased from $33,840 in 1987-1990 to $56,019 in 2006-2010, though the difference across years was not statistically significant. Our approach controlled for differences in hours worked, so earnings gap was not driven by differences in work hours, though it could be explained by other factors we did not observe in our data (e.g., specialty choice). Looking at other occupations in the US health care industry, the male-female earnings gap was smaller for pharmacists and registered nurses and decreased over time, but was large and increased for physicians assistants. On the other hand, our numbers indicate that outside of the health care industry, the male-female earnings gap fell by more than 45%. Even though significant gender inequality persists across the US, female physicians do not appear to have benefited from the relative gains that female workers outside the health care industry have. (more…)
Author Interviews, HIV, Social Issues, UCLA / 03.09.2013

Sean D. Young, PhD, MS Assistant Professor In-Residence Center for Behavioral and Addiction Medicine Department of Family Medicine University of California, Los AngelesMedicalResearch.com Interview with: Sean D. Young, PhD, MS Assistant Professor In-Residence Center for Behavioral and Addiction Medicine Department of Family Medicine University of California, Los Angeles Dr. Young: Here's the main take-home point: There is a lot of excitement about the possibility of using technologies, big data, and mHealth to improve health outcomes and change behavior. However, 1) little work has been done on this topic using sound research methods (for example, studies have asked people to report whether a technology changed behavior rather than objectively measuring whether it actually changed behavior. (more…)
Author Interviews, Kidney Disease, University of Michigan / 03.09.2013

Afshinnia, Farsad, M.D., M.S. Research Fellow and Clinical Lecturer Department of Nephrology University of Michigan Health System MedicalResearch.com: What are the main findings of the study? Answer: Spontaneous Renal Artery Dissection (SRAD) is most commonly observed in middle aged individuals. Although SRAD can have no association with other comorbidities at the time of presentation, we have noticed association with a number of systemic disorders such as hypertension, cancer, congestive heart failure, and rheumatologic diseases. In particular clustering of Fibromascular dysplasia (FMD), Ehlers-Danlos syndrome, poly arteritis nodosa, Poland syndrome, and nail patella syndrome in our patients has been striking. The most commonly observed presenting symptom is sudden onset severe flank pain which may be spontaneous or following physical stress. Other presenting features may include uncontrolled hypertension, groin and/or testicular pain, headache, nausea, vomiting, fever, dysuria, hematuria and blurry vision. (more…)
Author Interviews, Exercise - Fitness, Menopause / 03.09.2013

MedicalResearch.com Interview with: Pascale Mauriège, PhD, Division of Kinesiology PEPS, Room 2148, Laval University, Québec, Canada G1K 7P4 MedicalResearch.com: What are the main findings of the study? Answer: 1) The impact of a 4-month brisk walking program (3 sessions/week of 45-min walking at 60% of heart rate reserve) on postmenopausal moderately obese (BMI=29-35 kg/m2) women’s perceived health, and more particularly the perceived ideal weight and stress level. 2) The existence of a relationship between improvements in perceived ideal weight and fat mass reduction in the walking group. 3) The lack of non respondents to our novel self-administered Short Perceived Health Questionnaire (SPHQ) that was completed within 2-3 min by all participant. 4) The good reproductibility for five of six items of the SHPQ, and the validation of three questions against generic tools. (more…)
Author Interviews, Heart Disease, Weight Research / 03.09.2013

MedicalResearch.com Interview with: Dr Søren Skøtt Andersen and Dr Michelle Schmiegelow Study done in collaboration between Roskilde University Hospital and Gentofte University Hospital in Denmark. MedicalResearch.com: What are the main findings of the study? Answer: The main finding of this study of young women was that a body mass index above or equal to 25 kg/m2 in metabolically healthy women was not associated with an increased risk of cardiovascular events (myocardial infarction or ischemic stroke) within 5 years of follow-up. A BMI >= 25 kg/m2 in women with any metabolic disorder was associated with a 4-fold significant increased risk of the end-point. As increasing BMI is strongly associated with risk of developing metabolic disorders, the key message of this study is to stress the importance of preventing the development of metabolic disorders in overweight/obese women during this possible "window of opportunity". (more…)
Author Interviews, Pediatrics / 03.09.2013

Professor Sheena Reilly PhD FASSA Associate Director, Clinical and Public Health Research Murdoch Childrens Research Institute Professor of Speech Pathology Department of Paediatrics, University of Melbourne Royal Children’s Hospital Flemington Road Parkville Victoria 3052 AustraliaProfessor Sheena Reilly PhD FASSA Associate Director, Clinical and Public Health Research Murdoch Childrens Research Institute Professor of Speech Pathology Department of Paediatrics, University of Melbourne Royal Children’s Hospital Flemington Road Parkville Victoria 3052 Australia MedicalResearch.com: What are the main findings of the study? Prof. Reilly: Stuttering was more common than previously thought. The cumulative incidence of stuttering by four years old was 11%, which is more than twice what has previously been reported. Developmental stuttering was associated with better language development, non-verbal skills with no identifiable effect on the child’s mental health or temperament by four years of age. (more…)
Author Interviews, Heart Disease, NEJM / 02.09.2013

MedicalResearch.com Interview with: Massimo Imazio, MD, FESC Dipartimento di Cardiologia/Cardiology Department Maria Vittoria Hospital-ASLTO2 via Cibrario 72 10141 Torino, Italy MedicalResearch.com: What are the main findings of the study? Dr. Imazio: In a multicenter, double-blind trial, eligible adults with acute pericarditis (idiopathic/viral, post-pericardiotomy syndromes and pericarditis related to a systemic inflammatory disease) were randomly assigned to receive either colchicine (at a dose of 0.5 mg twice daily for 3 months for patients weighing >70 kg or 0.5 mg once daily for patients weighing ≤70 kg) or placebo in addition to conventional anti-inflammatory therapy with aspirin or ibuprofen. The primary study outcome was incessant or recurrent pericarditis. After a mean follow-up of 22 months (minimum 18 months) the primary outcome occurred in 20 patients (16.7%) in the colchicine group and 45 patients (37.5%) in the placebo group (relative risk reduction in the colchicine group, 0.56; 95% confidence interval, 0.30 to 0.72; number needed to treat, 4; P<0.001). (more…)
Author Interviews, Heart Disease, Infections, JACC, Yale / 31.08.2013

Behnood Bikdeli, MD Yale/YNHH Center for Outcomes Research and Evaluation One Church St, Suite 200 New Haven CT 0651MedicalResearch.com Interview with: Behnood Bikdeli, MD Yale/YNHH Center for Outcomes Research and Evaluation One Church St, Suite 200 New Haven CT 0651 MedicalResearch.com: What are the main findings of the study? Dr. Bikdeli: We determined the trends in hospitalizations and mortality from endocarditis among US older adults from 1999 to 2010. Endocarditis is the most serious cardiovascular infection and our study that had a very large sample, signified the high burden of endocarditis in this time period. (more…)
Author Interviews, Diabetes, Weight Research / 31.08.2013

MedicalResearch.com Interview with: Monique Hedderson, PhD Research Scientist Kaiser Permanente Northern California Oakland, CA 94612Monique Hedderson, PhD Research Scientist Kaiser Permanente Northern California Oakland, CA 94612 MedicalResearch.com: What are the main findings of the study? Dr. Hedderson: It is fascinating to discover that metabolic abnormalities appear to be present, even years before pregnancy, in a large proportion of women who develop gestational diabetes. The findings from this study emphasize the importance of the pre-pregnancy period in future pregnancy outcomes. (more…)
Author Interviews, Case Western, Cleveland Clinic, Cost of Health Care, Pain Research, Surgical Research / 30.08.2013

MedicalResearch.com Interview with: Conor P. Delaney, MD MCh PhD FRCSI FACS FASCRS The Jeffrey L. Ponsky Professor of Surgical Education | Chief, Division of Colorectal Surgery | Vice-Chair, Department of Surgery | Director, CWRU Center for Skills and Simulation | Surgical Director, Digestive Health Institute | University Hospitals Case Medical Center | Case Western Reserve University | 11100 Euclid Avenue Cleveland, OH 44106-5047 MedicalResearch.com: What are the main findings of the study? Answer: Our goal was to see whether the transversus abdominis plane (TAP) block reduced complications and shortened the hospital stay of patients undergoing colorectal operations. The TAP block is a nerve block injection given at the conclusion of the operation which reduces pain in the operative area. Results showed that the mean hospital stay dropped to less than 2.5 days after the surgical procedure, significantly lower than the 3.7 days which the University Hospitals Case Medical Center Care pathway had already described for more than 1,000 consecutive patients. In our new study, we employed the TAP block and the Enhanced Recovery Pathway (ERP) on 100 patients. We found that 27 patients went home the next day and another 35 went home 48 hours after their operations. That is considerably better than the five or six days patients usually stay in the hospital after laparoscopic colorectal procedures, and certainly better than nine days often seen after an open operation. With a third of patients leaving the day after colorectal resection, we feel these results are significant. (more…)
Author Interviews, Duke, JAMA, Mental Health Research / 30.08.2013

MedicalResearch.com Interview with: Arif Khan, MD Medical Director, Northwest Clinical Research Center Adjunct Professor of Psychiatry Duke University Medical Center and Christine Khan, Psychiatric Nurse 1951 – 152nd Place NE Northwest Clinical Research Center Bellevue, WA 98007 MedicalResearch.com: What are the main findings of your study?
  1. The original idea set in early 20th century that psychiatric patients discharged from mental hospitals had a shortened life span or faced early death was supported by this analysis of psychiatric patients participating in research trials for new medications. There was no increased risk of early death or shortened life span for participating in these research clinical trials.
  2. Life span shortening or increased risk of early death is highest among patients with schizophrenia, followed by patients with major mood disorders such as Bipolar Mood Disorder and Major Depression. (more…)
Author Interviews, JACC, Kidney Disease, Vitamin C / 30.08.2013

MedicalResearch.com Interview with: Umar Sadat, MD, PhD Addenbrooke’s Hospital Cambridge, United Kingdom MedicalResearch.com: What are the main findings of the study? Dr. Sadat: Vitamin C offers significant nephroprotection against contrast induced-acute kidney injury (CI-AKI) in patients undergoing coronary angiography. Patients receiving Vitamin C were observed to have 33% less risk of CI-AKI compared to those receiving placebo or other treatment. (more…)
Author Interviews, BMJ, Outcomes & Safety, Rheumatology / 30.08.2013

MedicalResearch.com Interview with: Mwidimi Ndosi, PhD, MSc, BSc (Hons), RN. Academic & Clinical Unit for Musculoskeletal Nursing (ACUMeN) Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds England MedicalResearch.com: What are the main findings of the study? Answer: The aims of this study was to determine the clinical and cost-effectiveness of nurse-led care for people with rheumatoid arthritis. The main findings were: (i) Patients seeing clinical nurse specialists for their rheumatoid arthritis follow-up care do not get an inferior treatment. (ii) Nurse-led care is safe and in some aspects presents added value to patients (iii) Nurse-led care represents good value for money in terms of disease management for people with RA. (more…)
Alzheimer's - Dementia, Author Interviews, Genetic Research, JAMA / 30.08.2013

Ekaterina Rogaeva, PhD Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, CanadaDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaCambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, EnglandMedicalResearch.com Interview with: Ekaterina Rogaeva, PhD Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, CanadaDepartment of Medicine, University of Toronto, Toronto, Ontario, CanadaCambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, England MedicalResearch.com: What are the main findings of the study? Answer: We tested the hypothesis that late-onset Alzheimer disease (AD) might be in part explained by the homozygosity of unknown loci. In a genome-wide study of a Caribbean Hispanic population with noticeable inbreeding and high risk of AD we assessed the presence of long runs of homozygosity (ROHs) – regions where the alleles inherited from both parents are identical. Our results suggest the existence of recessive AD loci, since the mean length of the ROH per person was significantly longer in AD cases versus controls, and this association was stronger in familial AD. (more…)
Alcohol, Author Interviews, Breast Cancer, JNCI, OBGYNE / 30.08.2013

MedicalResearch.com Interview with: Ying Liu, MD, PhD Instructor, Division of Public Health Sciences Department of Surgery Washington University School of Medicine 660 South Euclid Ave Campus Box 8100 St. Louis, MO 63110 MedicalResearch.com: What are the main findings of the study? Answer: Alcohol intake between menarche (first menstrual period) and first pregnancy was consistently associated with increased risks of breast cancer and proliferative benign breast disease. For every 10 gram/day alcohol intake (approximately a drink a day) during this specific time period, the risk for breast cancer increased by 11% and the risk for proliferative benign breast disease increased by 16%. (more…)
Author Interviews, Depression, Exercise - Fitness / 30.08.2013

Jannique van Uffelen, PhD, MSc (epidemiology), MSc (human movement sciences), BHealth Senior Research Fellow Active Ageing INSTITUTE OF SPORT, EXERCISE & ACTIVE LIVING (ISEAL) VICTORIA UNIVERSITYMedicalResearch.com Interview with: Jannique van Uffelen, PhD, MSc (epidemiology), MSc (human movement sciences), BHealth Senior Research Fellow Active Ageing INSTITUTE OF SPORT, EXERCISE & ACTIVE LIVING (ISEAL) VICTORIA UNIVERSITY MedicalResearch.com: What are the main findings of the study? Answer: We examined the link between sitting-time and physical activity with current and future depressive symptoms in 8,950 mid aged women, who participated in the Australian Longitudinal Study on Women’s Health. Both high sitting-time and low physical activity levels were associated with higher risk of current depressive symptoms, and in combination, the risk further increased. Compared with women sitting ≤4 hours/day and meeting the physical activity recommendations of at least 150 minutes of moderate intensity activity per week, women who sat >7 hrs/day and who did no physical activity were three times as likely to have depressive symptoms. However, only lack of physical activity was associated with increased risk of future depressive symptoms, irrespective of sitting-time. Women who did no physical activity were 26% more likely to have future depressive symptoms than women meeting physical activity recommendations. (more…)
Author Interviews, BMJ, Case Western, Rheumatology / 29.08.2013

Dr Janet E Pope Division of Rheumatology, Department of Medicine The University of Western Ontario, St Joseph's Health Centre 268 Grosvenor Street, London, ON, Canada N6A 4V2MedicalResearch.com Interview with: Dr. Janet E Pope Division of Rheumatology, Department of Medicine The University of Western Ontario, St Joseph's Health Centre 268 Grosvenor Street, London, ON, Canada N6A 4V2   MedicalResearch.com: What are the main findings of the study? Dr. Pope: We performed a RCT of patients who were stable for 6 months of etanercept added to methotrexate (inadequate responders to Mtx) who were randomized to stopping Mtx or continuing Mtx to determine if in the next 6 months (and later as the trial continues) the response rate would be the same if Mtx was discontinued. Overall, Mtx + etanercept was not statistically equivalent to etanercept alone (ie non-inferiority did not occur); implying 6 months after stopping Mtx, the etanercept patients on monotherapy performed slightly less well than those on combination therapy. (more…)
Author Interviews, NEJM, OBGYNE / 29.08.2013

MedicalResearch.com Interview with: Ms. Mølgaard-Nielsen Statens Serum Institut Artillerivej 5, 2300 Copenhagen S, Denmark MedicalResearch.com: What are the main findings of the study? Answer: Use of oral fluconazole during early pregnancy did not increase the risk of birth defects overall in common therapeutic doses. We also looked at 15 individual birth defects of previous concern and oral fluconazole was not associated with an increased risk for 14 of these birth defects. However, we did see an increase in the risk of tetralogy of Fallot, an uncommon congenital heart defect, but the number of exposed cases was few. (more…)
Author Interviews, Blood Pressure - Hypertension, Health Care Systems, JAMA, UCSF / 29.08.2013

MedicalResearch.com Interview with: Dr. Marc Jaffe, MD Clinical Leader, Kaiser Northern California Cardiovascular Risk Reduction Program Clinical Leader, Kaiser National Integrated Cardiovascular Health (ICVH) Guideline Development Group Associate Clinical Professor of Medicine, UCSF Endocrinology and Internal Medicine Kaiser South San Francisco Medical Center 1200 El Camino Real South San Francisco, California 94080 MedicalResearch.com: What are the main findings of the study? Dr. Jaffe: In 2001, we set out to improve blood pressure control in among Kaiser Permanente (KP) members in Northern California, and we ended up creating one of the largest, community-based hypertension programs in the nation. The paper published in JAMA explores how we combined a number of innovations, including a patient registry, single-pill combination therapy drugs and more, to nearly double blood pressure control rates. If you had told us at the onset that blood pressure control among members would be more than 80 percent, and it was actually almost 90 percent in 2011, we wouldn’t have believed you. These results are truly incredible. During the study period, hypertension control increased by more than 35 percent from 43.6 percent to 80.4 percent in Kaiser Permanente Northern California between 2001 and 2009. In contrast, the national mean control rate increased from 55.4 percent to 64.1 percent during that period. (more…)