Author Interviews, Hepatitis - Liver Disease / 09.05.2014
Hepatitis C: Patient Reported Outcomes After Treatment

- Patients with Hepatitis C (HCV) have a significant impairment of their health related quality of life including those related to activity and fatigue. Their work productivity is also impaired.
- Cirrhosis can add additional negative impact on some of these patient reported outcomes.
- During treatment, patients with cirrhosis who were treated with an interferon-free sofosbuvir and ribavirin containing regimen did experience mild decline in their patient related outcome scores. However, this decline was similar for HCV patients with or without cirrhosis.
- On the other hand, patients with cirrhosis who were treated with an interferon-containing regimen showed a significant decline in their patient reported outcomes scores compared to those with Hepatitis C and without cirrhosis.
- Nevertheless, at the end of week 12 follow up, there was no longer a significant deficit in PROs noted regardless of the treatment arm for patients with cirrhosis.
- Furthermore, for the patients (HCV and cirrhosis) who achieved a sustained virologic response at 12 weeks, there were significant improvements (compared to baseline) in some PRO scores.
- During treatment, changes in patient reported outcomes scores were similar between cirrhotics and non-cirrhotics for both treatment regimens (all p>0.05).