Author Interviews, Weight Research / 10.04.2014
Diet-Induced Obesity: EPO Has Anti-Inflammatory Effect on White Adipose Tissue
MedicalResearch.com Interview witih:
Dr. Constance Tom Noguchi, Ph.D.
Molecular Medicine Branch
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 and
Dr. Mawadda Al-Naeeli
Department of Biological Sciences, Ohio University
MedicalResearch.com: What are the main findings of the study?
Answer: The main findings of our study are:
1) EPO treatment has an anti-inflammatory effect on white adipose tissue macrophage population during diet-induced obesity in addition to its associated metabolic improvements on glucose tolerance and insulin sensitivity in vivo.
2) In this model of obesity, EPO treatment was found to reduce M1-like [pro-inflammatory] and increased M2-like [anti-inflammatory] macrophages in visceral white adipose tissue depot.
3) In addition, EPO decreased circulating inflammatory monocytes.
4) These anti-inflammatory effects of EPO were found to be driven, at least in part, by direct EPO-R response in macrophages via Stat3 activation, where EPO effects on M2 but not M1 macrophages required interleukin-4 receptor/Stat6 axis.
5) The anti-inflammatory effects of EPO are not restricted to treatment with exogenous high dose EPO (1000U/kg), but also include endogenous physiological EPO levels as demonstrated by the series of studies conducted using ΔEpoR mice with EPO-R restricted to erythroid cells.
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