19 Sep Large fluctuations in blood pressure associated with higher risk of heart disease and kidney failure
Posted at 22:24h
in Author Interviews, Blood Pressure - Hypertension, Heart Disease, JACC, Kidney Disease
MedicalResearch.com Interview with:
[caption id="attachment_28124" align="alignleft" width="120"]
Dr. Elvira Gosmanova[/caption]
Elvira Gosmanova MD
Department of Nephrology
University of Tennessee Health Science Center
Memphis TN, 38163
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: It has been long known that elevated blood pressure is a risk factor for numerous adverse health-related outcomes. However, the majority of individuals do not have blood pressure in a constant range.
In contrary, blood pressure measured in the same individual tends to fluctuate over time. Moreover, some individuals have more blood pressure fluctuation, as compared with others. The impact of fluctuation in blood pressure is still poorly understood. Smaller studies suggested that increased fluctuation in blood pressure may be associated with hazardous health outcomes. However, large scale studies were still lacking. Therefore, we conducted a study involving close to 3 million US veterans to investigate the association of increased visit-to-visit variability of systolic blood pressure (which was our measure of fluctuation of blood pressure over time) and all-cause mortality, and incident coronary heart disease, stroke, and end-stage renal disease.
We found that there was strong and graded increase in the risk of all the above outcomes with increasing visit-to-visit variability of systolic blood pressure.



















