Won Young Kim, MD PhD
Department of Emergency Medicine
Asan Medical Center
University of Ulsan College of Medicine
Seoul, Korea
MedicalResearch.com: What is the background for this study?
Response: Neurological symptoms of carbon monoxide (CO) poisoning can manifest not only immediately but also as late as 2 to 6 weeks after successful initial resuscitation as delayed neurological sequelae (DNS). To date, no reliable methods of assessing the probability of DNS after acute CO poisoning have been developed, which make it difficult to research the pathophysiology of DNS and targeting prevention.
Dr. Basson[/caption]
Marc D. Basson, MD, PhD, MBA
Professor of Surgery, Pathology, and Biomedical Science
Senior Associate Dean for Medicine and Research
University of North Dakota School of Medicine & Health Sciences
Grand Forks, ND 58202
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There are now several studies that describe the use of antibiotics without surgery to manage acute uncomplicated appendicitis.
This entails a prolonged treatment course and has a substantial rate of failure and recurrence, but in patients in whom it succeeds surgery can be avoided. Many surgeons resist offering this choice because they perceive it as substandard compared to surgery, which is rapid, and when it goes well (as it usually does) has no failure or recurrence rate. Instead of debating the statistics, we decided to ask people what they would prefer if they had appendicitis and why.
We found that about nine tenths of people would choose surgery, but about one tenth would choose antibiotics, with some subtle distinctions depending on the characteristics of the people we asked. (For instance, surgeons, doctors in general, and people who knew someone who had previously had appendicitis were all a bit more likely to opt for surgery.) Furthermore, we found that the key issue for most people was not the prolonged treatment course but the rates of failure and recurrence with antibiotics.
Following the landing of a U.S. Marine Core MV-22, Naval Medical Research Unit – Dayton (NAMRU-Dayton) welcomes crew members at Wright-Patterson Air Force Base, December 19, 2017. NAMRU-Dayton has been tasked as the lead agency for the Navy to investigate tilt-rotor aircrafts potential effects of flight and vibration on aircrews. Pictured with the USMC Air Test and Evaluation Squadron Two One crew is the coordination team: Ms. Elizabeth Miller, U.S. Air Force School of Aerospace Medicine; Captain Rees Lee, Commanding Officer of NAMRU-Dayton; and Lieutenant Commander Matthew Doubrava, Senior Medical Officer at NAMRU-Dayton. (U.S. Navy photo by Public Affairs, Naval Medical Research Unit - Dayton)[/caption]
Lieutenant Commander Matthew Doubrava
Senior Medical Officer, Naval Medical Research Unit
Dayton, Ohio
MedicalResearch.com: What is the background for this research? What types of problems will be investigated using the Osprey?
Response: The U.S. Marine Corps V-22 Osprey tilt-rotor aircraft will be used to conduct static aerospace medical research in an effort to provide solutions toward preventing musculoskeletal injury to tilt-rotor aircraft crew and en route care training at Wright-Patterson Air Force Base. Naval Medical Research Unit – Dayton (NAMRU-Dayton) has been tasked as the lead agency for the Navy to investigate tilt-rotor aircrafts potential effects of flight and vibration on aircrews. NAMRU-Dayton scientists will be partnering with the U.S. Air Force School of Aerospace Medicine, who will be investigating en route care training to figure out the best way for the crew to use the aircraft for that purpose.
Madeline Sterling M.D., M.P.H.
Fellow, Department of Medicine
Weill Cornell Medical College - New York Presbyterian Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Heart Failure currently affects 5.8 million people in the United States and is becoming increasingly common as the population ages. Because it has no cure and tends to get progressively worse, physicians recommend that patients control their symptoms by taking multiple medications, maintain a diet low in salt, monitor their weight and blood pressure, and watch for changes in their symptoms.
At the most basic level, in order to understand and follow these instructions, heart failure patients must be able to hear them. Hearing loss, however, had not been studied in heart failure. There are a lot of chronic diseases in which hearing loss is more common than in the general population, including coronary heart disease, hypertension, and diabetes. And many adults with heart failure also have these conditions. So, we thought it would be important to understand if hearing loss was prevalent among adults with heart failure, especially since so much of heart failure management revolves around effective communication between patients and their healthcare providers.
Arthur J. Reynolds, PhD
Institute of Child Development
University of Minnesota, Minneapolis
MedicalResearch.com: What is the background for this study?
Response: Educational attainment is the leading social determinant of health. Higher attainment measured by years of education or postsecondary attainment is linked to lower cardiovascular disease risk; lower rates of smoking, diabetes, and hypertension; and higher economic well-being.
Evidence on the long-term effects of early childhood programs on educational attainment is mixed. Some studies show impacts on high school graduation but not college attainment, the reverse pattern, or no measurement into adulthood. No studies of large-scale public programs have assessed impacts beyond young adulthood. Whether duration of participation over ages 3 to 9 is linked to mid 30s attainment also has not been investigated.
Yo-El Ju, MD
Assistant Professor of Neurology
Sleep Medicine Section
Washington University School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The background for this study is that prior studies have shown that people with Alzheimer's Disease have poor circadian clock function, for example sleeping during the day and being awake or agitated at night. Autopsy studies have shown that people with Alzheimer's Disease have degeneration in the "clock" part of their brains. In this study, we wanted to examine whether there were any circadian problems much earlier in Alzheimer's Disease, when people do not have any memory or thinking problems at all.
We measured circadian function in 189 people with an actigraph, which is an activity monitor worn like a watch, for 1-2 weeks. Brain scans and studies of cerebrospinal fluid were used to determine who had preclinical Alzheimer's Disease, meaning they have the brain changes of Alzheimer's but do not have symptoms yet.
[caption id="attachment_39693" align="alignleft" width="200"] Emanuele Di Angelantonio[/caption] MedicalResearch.com Interview with: Emanuele Di Angelantonio MPhl Department of Public Health and Primary Care School of Clinical Medicine University of Cambridge MedicalResearch.com: What is the background for this study? What are the main findings? Response: This systematic review supports and expands previous research suggesting that living kidney donors have no increased risk for several major chronic...
In the United States, hepatitis A, hepatitis B and hepatitis C are the most common types, but also included are hepatitis D and E.
Tyler Seibert, MD, PhD
Radiation Oncology
Center for Multimodal Imaging & Genetics
UC San Diego
MedicalResearch.com: What is the background for this study?
Response: Prostate cancer is an extremely common condition in men. Many die from it each year, and many others live with debilitating pain caused by prostate cancer. Screening for prostate cancer with prostate-specific antigen (PSA) testing can be effective, but there are concerns with the test.
Ning Liu PhD Student
Senior Research Analyst at ICES
Institute of Health Policy, Management and Evaluation
Institute for Clinical Evaluative Sciences
University of Toronto
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Previous studies suggested intergenerational tendencies between a mother and her daughter in fertility patterns, such as when they give birth to a child for the first time, or the total number of children they have during their lifetime.
We explored whether there is also an intergenerational tendency for induced abortion practices between a mother and her teen daughter.
To do so, we used anonymized records of 431,623 daughters and their mothers, and found that a teenage daughter was twice as likely to have an induced abortion if her mother had had an induced abortion.
Matilda W. Nicholas, MD, PhD
Duke Dermatology
Durham, North Carolina
MedicalResearch.com: What is the background for this study?
Response: I have found many physicians overwhelmed by the electronic messaging feature in Electronic Health Record systems (EHRs). I found there was very little published about this phenomenon, particularly for specialists. So, we set out to take a look at the volume and effect these systems have.
MedicalResearch.com: What are the main findings?
Response: We found that, on average, clinicians receive 3.24 messages per patient visit, for an average of about 50 messages per full day of clinic. The number of messages also correlated with poor reported work life balance for dermatologists.
Dr. Pusztai[/caption]
Lajos Pusztai, M.D, D.Phil.
Professor of Medicine
Director of Breast Cancer Translational Research
Co-Director of the Yale Cancer Center Genetics, Genomics and Epigenetics Program
Yale School of Medicine
New Haven, CT 06511
MedicalResearch.com: What is the background for this study?
Response: Overall, about 85% of newly diagnosed stage I-III breast cancer patients will not die of their disease, and this roughly equates to an 85% cure rate. Of course cure rates are higher for stage I cancers and lower for stage III cancers. An 85% overall cure rate is good but not good enough, we continuously try to develop new therapies hoping to push these rates to 90%...,95%...etc. However, it is not possible to cure a patient twice over. For example, if surgery plus endocrine therapy cures all patients, the addition of chemotherapy cannot improve on it no matter how effective it is. If surgery plus endocrine therapy cures 95%, adding the perfect chemo to this treatment can only bring about a 5% improvement, and very good chemo that would push cure from 95% to 97%, would require a very large trial including many thousands of patients.
This is an increasingly common scenario in modern breast cancer adjuvant trials (where the goal is to improve survival and cure); the control arm that receives the current standard of care invariably does better than expected and the experimental arm only improves outcome by 1-3% that does not reach statistical significance. The painful conclusion from these trials is that we do not know if the new drug actually works or not because there were not enough events to demonstrate an effect.
Of course, a lot of patients in the study were also exposed to a new drug with all of its associated toxicities who could not possibly benefit from it.
Dr. Efstathiou[/caption]
Jason Alexander Efstathiou, D., PH.D
Director, Genitourinary Division
Department of Radiation Oncology
Clinical Co-Director, The Claire and John Bertucci Center for Genitourinary Cancers Multidisciplinary Clinic
Massachusetts General Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: When surgery has probably failed to cure a patient, the best prospective data supports the use of postoperative radiation therapy.
The debate now centers on the optimal timing of such post-prostatectomy radiation therapy; is it adjuvant (ART) for all (with adverse pathologic features) or early salvage (ESRT) for some (who experience biochemical failure)?
New technique enables rapid calibration of the BrainGate brain-computer interface.[/caption]
David Brandman, MD, PhD
Postdoctoral research associate (neuroengineering), Brown University
Senior neurosurgical resident
Dalhousie University
BrainGate Website
MedicalResearch.com: What is the background for this study?
Response: People with cervical spinal cord injuries, ALS, or brainstem stroke, may lose some or all of their ability to use their arms or hands. In some cases, they may even lose the ability to speak. One approach to restoring neurologic function is by using a brain computer interface (BCI). BCIs record information from the brain, and then translate the recorded brain signals into commands used to control external devices. Our research group and others have shown that intracortical BCIs can provide people with tetraplegia the ability to communicate via a typing interface, to control a robotic limb for self-feeding, and to move their own muscles using functional electrical stimulation. Use of a BCI generally requires the oversight of a trained technician, both for system setup and calibration, before users can begin using the system independently.
An open question with intracortical BCIs is how long it takes people to get up and running before they can communicate independently with 2 dimensional cursor control. The goal of this study was to systematically examine this question in three people with paralysis. As part of the ongoing BrainGate2 clinical trial, each study participant (T5, T8, and T10) had tiny (4x4 mm) arrays of electrodes implanted into a part of their brain that coordinates arm control. Each participant used motor imagery – that is, attempted or imagined moving their body – to control a computer cursor in real time.
David Kaufman, ScD
Director, Slone Epidemiology Center, Boston Universit
Professor of Epidemiolog
Boston University School of Public Health
MedicalResearch.com: What is the background for this study?
Response: Ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most-used medicines in the US, but, if too much is taken, can cause harm.
This was an internet-based diary study. 1326 individuals who reported taking an ibuprofen medication in the preceding month completed a daily diary of their NSAID use for one week. The daily dosage ingested was computed from the diary, which allowed us to determine whether a user exceed the recommended daily maximum dose.
Dr Andrew Turner
Reader in Environmental Science (Biogeochemistry and Toxicology)
School of Geography, Earth and Environmental Sciences
University of Plymouth, UK
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The study arose through a larger investigation into hazardous substances in consumer plastics, both old and new.
The main finding of the present research was the widespread occurrence of restricted elements in old plastic toys, and in particular cadmium, lead and bromine (the latter an indicator of the presence of flame retardants); in many cases, these elements could migrate from the plastic under conditions simulating the human digestive system.
MedicalResearch.com Interview with:
Bruno Sauce, PhD and
Louis D. Matzel, PhD
Department of Psychology, Program in Behavioral and Systems Neuroscience
Rutgers University
New Jersey, USA
MedicalResearch.com: What is the background for this study?
Response: Scientists have known for decades that intelligence has a high heritability, which means that much of the individual differences in IQ we see in people are due to genetic differences. Heritability is a value that ranges from 0.0 (meaning no genetic component) to 1.0 (meaning that the trait is completely heritable). For example, the heritability of breast cancer is estimated at 0.27; the heritability of body mass index is 0.59; and the heritability of major depression is 0.40. In comparison, the heritability of IQ is estimated to be as high as 0.8 – quite a high value!
More recently, however, there have been studies showing that intelligence has a high malleability: the studies cover cognitive gains consequent to adoption/immigration, changes in IQ’s heritability across life span and socioeconomic status, gains in IQ over time from societal and scientific progress, the slowdown of age-related cognitive decline, the gains in intelligence from early education, differences in average IQ between countries due to wealth and development, and gains in intelligence that seem to happen from working memory training.
Intelligence being both highly heritable and highly malleable is seemingly paradoxical, and this paradox has been the source of continuous controversy among scientists.
Why does it matter? Because IQ predicts many important outcomes in life, such as academic grades, income, social mobility, happiness, marital stability and satisfaction, general health, longevity, reduced risk of accidents, and reduced risk of drug addiction (among many other outcomes). A clear understanding of the genetic and environmental causes of variation in intelligence is critical for future research, and its potential implications (and applications) for society are immense.
MedicalResearch.com Interview with: [caption id="attachment_39645" align="alignleft" width="200"] Dr. Taku Inohara[/caption] Taku Inohara MD Department of Cardiology, Keio University School of Medicine Tokyo, Japan Duke Clinical Research Institute, Duke University Medical Center Durham, NC MedicalResearch.com: What is the background for this study? What are the main findings? Response: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly prescribed for high-risk...
Dr. Lei Deng PhD
Postdoctoral researcher
Institute for Biomedical Sciences at Georgia State University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Influenza A viruses evade human herd immunity by genetic hypervariation. Annual influenza epidemics are estimated to cause about 3 to 5 million cases of severe illness, and about 290,000 to 650,000 deaths. Vaccination is still the most effective way to prevent diseases, but current influenza vaccines provide limited protections against mismatched circulating virus strains. This drives scientists to develop universal influenza vaccines that can induce broad immune responses against all influenza A virus infections.
We used biochemistry and nanotechnology to generate a double-layered protein nanoparticle universal influenza vaccine. The layered nanoparticle contains genetically modified influenza virus components without irrelevant carry/structural proteins and chemicals and confers strong and long-lasting immunity in laboratory mice against H1N1, H3N2, H5N1 and H7N9 infections. We also explain the protection mechanism of antibody dependent cell-mediated cytotoxicity (ADCC) and antibody dependent cell-mediated phagocytosis (ADCP) play the main role in the immune protection.
Anne G. Wheaton, Ph.D.
Epidemiologist
Centers for Disease Control and Prevention
National Center for Chronic Disease Prevention and Health Promotion
Division of Population Health
Epidemiology and Surveillance Branch
Atlanta, GA 30341-3717
MedicalResearch.com: What is the background for this study?
Response: Insufficient sleep among children and adolescents is associated with an increased risk for obesity, diabetes, injuries, poor mental health, and attention and behavior problems.
In previous reports, CDC had found that, nationwide, approximately two thirds of U.S. high school students report sleeping <8 hours per night on school nights. CDC conducted this study to provide state-level estimates of short sleep duration on school nights among middle school and high school students using age-specific recommendations from the American Academy of Sleep Medicine (AASM). AASM has recommended that children aged 6–12 years should regularly sleep 9–12 hours per 24 hours and teenagers aged 13–18 years should sleep 8–10 hours per 24 hours for optimal health.
Dr. Mocco[/caption]
Dr. J. Mocco, MD
Professor Neurosurgery
Mount Sinai Beth Israel
Mount Sinai St. Luke's and Mount Sinai West
The Mount Sinai Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Numerous trials have demonstrated that Endovascular therapy is strongly beneficial for emergent large vessel stroke patients.
The majority of patients in those trials were treated with Stent retrievers. COMPASS was designed to evaluate a different type of Endovascular therapy called aspiration Thrombectomy.
Dr. Caselli[/caption]
Richard J. Caselli MD
Department of Neurology
Mayo Clinic Arizona
Scottsdale, AZ
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Personality changes are common in patients with a variety of dementing illnesses, and underlie the behavioral disturbances that complicate the course of dementia patients. We have a been conducting a large longitudinal study of cognitive aging in individuals at genetically defined risk for Alzheimer’s disease (AD) based on their APOE genotype, and have been administering a large battery of neuropsychological tests as well as the gold standard personality questionnaire (the NEO-PI-R) in order to determine whether personality changes during the transition from normal cognition/preclinical AD to mild cognitive impairment.
Prof. McKenna[/caption]
Prof. Robert McKenna PhD
Department of Biochemistry and Molecular Biology
College of Medicine, University of Florida
Gainesville, Florida 32610
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Carbonic anhydrase IX (CA IX) is an enzyme that is typically only found in the GI tract, but is overexpressed in cancerous tissue. This enzyme functions to regulate the pH of tumor cells, so we hypothesize that disruption of this role will lead to tumor cell death.
This study analyzes the inhibition of CA IX using an artificial sweetener, acesulfame potassium (AceK). Our research provides a structural perspective to understand the selectivity of aceK for CA IX over an off-target enzyme, CA II. We discovered that aceK binds directly to an active site zinc in CA IX whereas the sweetener anchors through a zinc-bound water in CA II.
Dr. Frank de Vocht
Senior Lecturer in Epidemiology and Public Health Research
Academic Lead Year 1 MBChB (MB21) ‘Foundations of Medicine’ Programme
Population Health Sciences
Bristol Medical School
University of Bristol
MedicalResearch.com: What is the background for this study?
Response: We were interested in prospectively investigating whether people who drink alcohol in the general population (so not patients), and who indicated that the were planning to reduce their consumption or complete stop drinking in the near future would, on average, succeed and have reduced consumption six months later.
Dag Alnaes, PhD
Norwegian Centre for Mental Disorders Research
KG Jebsen Centre for Psychosis Research
Division of Mental Health and Addiction, Oslo University Hospital
Oslo, Norway
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The transition from childhood to adulthood is characterized by swift and dramatic changes, both in our environment and in our brains. This period of life also coincides with the onset of many mental disorders.
To gain a better understanding of why, the clinical neurosciences must attempt to disentangle the complex and dynamic interactions between genes and the environment and how they shape our brains. The ultimate goal is to be able to predict which individuals are at risk before clinical symptoms appear. Advanced brain imaging has been proposed to represent one promising approach for such early detection, but there is currently no robust imaging marker that allows us to identify individuals at risk with any clinically relevant degree of certainty.
Our study shows that self-reported early signs of mental illness are associated with specific patterns of brain fiber pathways in young people, even if they may not fulfill criteria for a formal diagnosis or are currently in need of treatment.
Associate Professor, Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases,
The Feinstein Institute for Medical Research
Associate Professor, Department of Molecular Medicine,
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Scientists have known for years that an ancient species of fish called the lamprey has a remarkable ability to rebuild their spinal cord after it’s been severed. After the lamprey spinal cord is cut, they recover from paralysis to fully swimming again in about twelve weeks, without taking any medicines or other treatments. We are studying the lamprey because we want to know the recipe of molecular ingredients that supports successful recovery after spinal cord injury.
The genome of this animal was reported about 5 years ago, in a publication led by my colleagues Dr. Jeramiah Smith at the University of Kentucky and Dr. Weiming Li at Michigan State University. It turns out that many aspects of the lamprey genome are similar to ours, particularly in the central nervous system. Therefore, we think it is a reasonable expectation that what we learn from lamprey could give us some relevant clues about what might be different about the responses in mammals and other animals that are not good at regenerating their spinal cord.
In this study, we found that the expression of many genes in the spinal cord and brain of lampreys change during their recovery from spinal cord injury. Some of the genes that get activated are similar to what happens when our peripheral nervous system is injured, which is better at regenerating than the central nervous system. We also identified that a pathway called the Wnt pathway plays an important role in the regeneration and recovery process. This is a large, complex network of genes that are important in many biological processes, from embryological development in fruit flies to cancer in humans.
Dr. Saunders-Pullman[/caption]
Rachel Saunders-Pullman, MD, MPH
Associate Professor of Neurology
Icahn School of Medicine at Mount Sinai
Chief, Movement Disorders, Mount Sinai Beth Israel
Co-Director Clinical/Translational Research and Research Mentoring
Movement Disorders, Department of Neurology,
Mount Sinai Beth Israel
New York, NY 10003
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There is a diversity in causes of Parkinson’s Disease (PD), and this may lead to heterogeneity in drug response. While LRRK2 PD due to G2019S mutations may fully mimic idiopathic PD (IPD), cross-sectional study suggests that the course may be slightly milder than IPD. Further, the pathology is heterogeneous with a minority not demonstrating Lewy bodies, and this may also correspond to less severe non-motor features.
To better understand the course of PD associated with the G2019S LRRK2 mutation (the most common LRRK2 mutation), we evaluated motor and cognitive progression in individuals enrolled in the LRRK2 Ashkenazi Jewish Consortium. Subjects were recruited from a Center in Tel Aviv, Israel, Sourasky Medical Center, and from two centers in New York, Columbia University and Mount Sinai Beth Israel. 144 participants were LRRK2 mutation carriers and 401 were not. We utilized all study visits, and constructed linear mixed-effects models to estimate the association between harboring the LRRK2 mutation and rate of change of both motor features- as assessed by the Unified Parkinson’s Disease Rating Scale (UPDRS), and cognition, as measured by the Montreal Cognitive Assessment Scale (MoCA). Models adjusted for sex, site, age, disease duration and (for the motor models) cognitive score.
We found a small but significant difference in rate of progression, with LRRK2 PD progressing at 0.69 points/year, and IPD at 1.06 points/year. While the cognitive decline was also less in the LRRK2 PD (-0.10 vs. -0.19 in the IPD, this difference was not statistically different (p=0.08).
MedicalResearch.com Interview with: [caption id="attachment_39573" align="alignleft" width="149"] Dr. Molina[/caption] Brooke S. G. S Molina, PhD Professor of Psychiatry, Psychology and Pediatrics University of Pittsburgh MedicalResearch.com: What is the background for this study? What are the main findings? Response: There has been inconsistency across previous studies of children with ADHD and their risk of substance use in...