Author Interviews, NEJM, Pulmonary Disease / 07.09.2016
Real World Trial Show Efficacy of Fluticasone Furoate–Vilanterol for COPD in Clinical Practice
MedicalResearch.com Interview with:
Jørgen Vestbo DMSc FRCP FERS
Professor of Respiratory Medicine
Division of Infection, Immunity and Respiratory Medicine
University of Manchester
Education and Research Centre
University Hospital of South Manchester
Manchester
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Efficacy studies are limited in their usefulness to clinicians as there are often restricted inclusion criteria, with many exclusion criteria and patients are followed closely with high adherence to study treatment. They therefore show what the drugs can do but not necessarily what they do do in the real world.
Randomised studies in everyday practice, not limiting the entry (effectiveness trials) are therefore needed.
In our study we showed that it is feasible to do randomised studies in the “real world”.
Our study showed that a simple treatment with a once-daily combination of an inhaled corticosteroid and a long-acting beta-agonist (Breo/Relvar) was superior to the usual care chose by the patients’ general practitioners to manage their COPD.
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