MedicalResearch.com Interview with: Mary McGrae McDermott, MD Professor of Medicine Northwestern University Feinberg School of Medicine Contributing Editor, JAMA Home-Based Walking Exercise Intervention in Peripheral Artery Disease A Randomized Clinical Trial MedicalResearch.com: What are the main findings of the study? Answer: The goals trial found that a group-mediated cognitive behavioral intervention significantly improved six-minute walk performance, physical...
MedicalResearch.com Interview with:
Keith Summa MD/PhD Student
Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States of America
Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Pathology and Inflammation
MedicalResearch.com: What are the main findings of the study?
Answer: The main findings of the study were that disruption of circadian rhythms, which we achieved using independent genetic and environmental strategies in mice, leads to impaired function of the intestinal epithelial barrier. This loss of epithelial barrier integrity, which has been associated with numerous diseases, results in "gut leakiness," a phenomenon in which endotoxin from gut bacteria can cross the intestinal wall and enter circulation, promoting inflammation. In particular, using in a disease model of gut-derived endotoxemia and inflammation, alcoholic liver disease, we found the circadian disruption interacted with alcohol, leading to increased gut leakiness, inflammation and liver damage.
MedicalResearch.com Interview with
Dr. Juan Pablo Villablanca, MD
Director, Neuroradiology
Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica
The Natural History of Asymptomatic Unruptured Cerebral Aneurysms Evaluated Using CTA - Growth and Rupture Incidence and Correlation to Epidemiologic Risk Factors.
MedicalResearch.com: What are the main findings of the study?
MedicalResearch.com Interview with: Paul C. Schroy III, M.D., M.P.H. Professor of Medicine, Boston University School of Medicine Director of Clinical Research, GI Section, Boston Medical Center 85 East Concord Street, Room 7715 Boston, MA 02118 MedicalResearch.com: What are the main findings of the study? Dr. Schroy: Our study affirms the importance of race as an independent...
Dr Patrick Freund
Spinal Cord Injury Center Balgrist
University Hospital Zurich, University of Zurich
Forchstrasse 380
8008 Zurich, Switzerland
MedicalResearch.com: What are the main findings of the study?
Dr. Freund: Novel interventions targeting acute spinal cord injury (SCI) have entered clinical trials, but neuroimaging biomarkers reflecting structural changes within the central nervous system are still awaited. In chronic SCI, neuroimaging provided evidence of structural changes at spinal cord and brain level that could be related to disability. However, the pattern and time course of these structural changes and their potential to predict clinical outcomes is uncertain.
In a prospective longitudinal study, thirteen patients with acute traumatic SCI were assessed clinically and by longitudinal MRI (within five weeks of injury, after two, six and twelve months) and were compared to eighteen healthy controls. Cross-sectional cord area, cranial white matter (CST) and grey matter (cortex) volume decrease was evident at baseline and progressed over twelve months. Multi-parametric mapping of myelin sensitive magnetization transfer (MT) and longitudinal relaxation rate (R1) was reduced both within and beyond the areas of atrophic changes. Better neurological and functional outcomes were associated with less atrophic changes of the CST in both cord and brain.
MedicalResearch.com Interview with: Susan Swetter, MD
Professor of Dermatology
Director, Pigmented Lesion & Melanoma Program
Stanford University Medical Center & Cancer Institute
MedicalResearch.com Interview with: Miguel Ramalho-Santos, Ph.D.
University of California - San Francisco stem-cell scientist,
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
MedicalResearch.com: What are the main findings of the study?
Answer: We found that Vitamin C has a profound effect in the regulation of gene activity in cultured mouse embryonic stem cells. Vitamin C specifically enhances the action of enzymes called Tet's, which remove certain chemical modifications to DNA (methylation). In this way, Vitamin C makes cultured mouse embryonic stem cells behave more like the early cells in the embryo that they represent.
MedicalResearch.com Interview with
Dr. Karen E. Joynt, MD MPH
Cardiovascular Division
Brigham and Women's Hospital and VA Boston Healthcare System
Department of Health Policy and Management, Harvard School of Public Health
MedicalResearch.com: What are the main findings of the study?
Dr. Joynt: The main findings of the study were two-fold.
First, high-cost patients in Medicare (the top decile of spenders) are responsible for about 80% of inpatient spending in the Medicare program, so understanding more about these patients' patterns of care is really important.
Second, we found that only about 10% of acute-care spending for these high-cost Medicare patients were for causes that we generally think of as preventable in the short term, like uncontrolled diabetes, COPD, or heart failure.
The rest of the spending was for acute conditions that we generally don't think of as preventable (at least in the short term), such as orthopedic procedures, sepsis, and cancer.
MedicalResearch.com Interview with Dr. Kumar Dharmarajan MD MBA
Dr. Mitchell Jones, MD, PhD
Faculty of Medicine at McGill University in Montreal
MedicalResearch.com: What are the main findings of the study?
Dr. Jones: We had previously reported on the cholesterol lowering efficacy of bile salt hydrolase active L. reuteri NCIMB 30242 due to reduced intestinal sterol absorption.
However, the effects of bile salt hydrolase active L. reuteri NCIMB 30242 on fat soluble vitamins was previously unknown and was the focus of the study.
MedicalResearch.com Interview with:
Marloes Heijstek MD
University Medical Center, Wilhelmina Children's Hospital
Department of Pediatric Immunology and Rheumatology
Room number KC 03.063.0
P.O. Box 85090 Lundlaan 6
3508 AB Utrecht
MedicalResearch.com: What are the main findings of the study?
Dr. Heijstek: The main findings of our study are that MMR booster vaccination does not affect JIA disease, does not cause flares of arthritis and induces high rates of protective immunity.
MedicalResearch.com Interview with:
Marin L. Schweizer Ph.D.
Assistant Professor
University of Iowa Carver College of Medicine
Iowa City, IA, USA
MedicalResearch.com: What are the main findings of the study?
Dr. Schweizer: A clinical bundle that includes nasally screening cardiac and orthopedic surgery patients for S. aureus (both methicillin-resistant S. aureus and methicillin-susceptible S. aureus), decolonizing carriers, and changing antibiotic prophylaxis for MRSA carriers, can significantly reduce the number of gram-positive surgical site infections, S. aureus surgical site infections and MRSA surgical site infections.
MedicalResearch.com: Interview with: Dr. Harri Hemila
Department of Public Health,
University of Helsinki, Helsinki, Finland
MedicalResearch.com: What are the main findings of the study?
HH: Vitamin C administration may halve the exercise-induced FEV1 decline in people who suffer from exercise-induced bronchoconstriction.
MedicalResearch.com Interview Invitation Dr. Gang Hu, MD, PHD Pennington Biomedical Research Center, Baton Rouge, Louisiana MedicalResearch.com: What are the main findings of the study? Dr. Gang Hu: There is a U-shaped or inverse association between BP and the risk of CHD, and aggressive BP control (BP<120/70 mmHg) is associated with an increased risk...
MedicalResearch.com Interview with: Lilian Abbo, M.D. Associate Professor of Clinical Medicine Division of Infectious Diseases University of Miami Miller School of Medicine Medical Director of Antimicrobial Stewardship Program Jackson Memorial Hospital and University of Miami Hospita MedicalResearch.com: What are the main findings of the study? Dr. Abbo: We surveyed 744/1411 (53%) members of the Infectious Diseases Society...