Author Interviews, Infections, JAMA / 08.09.2020
Risk of Aortic Aneurysm or Aortic Dissection with Infections vs Fluoroquinolones
MedicalResearch.com Interview with:
Yaa-Hui Dong PhD
Faculty of Pharmacy
National Yang-Ming University
Taipei, Taiwan
MedicalResearch.com: What is the background for this study?
Response: Previous observational studies found that fluoroquinolones may be associated with more than 2-fold increased risk of aortic aneurysm or aortic dissection (AA/AD). However, these studies might not well address the influence of concurrent infection, which is also a suggested risk factor for AA. Moreover, most of these studies compared fluoroquinolone use versus no fluoroquinolone use, which might overestimate the risk with fluoroquinolones as patients on fluoroquinolones may have more severe infection versus those not on fluoroquinolones.
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