Author Interviews, COVID -19 Coronavirus, Critical Care - Intensive Care - ICUs, Lancet, Pulmonary Disease / 26.08.2021

MedicalResearch.com Interview with: Jie Li, PhD, RRT, RRT-ACCS, RRT-NPS, FAARC Department of Cardiopulmonary Sciences Division of Respiratory Care Rush University, Chicago MedicalResearch.com: What is the background for this study? Response: Prone positioning has been shown to improve oxygenation and reduce mortality in intubated patients with acute respiratory distress syndrome (ARDS), as placing patients on their stomachs can help open alveoli and reduce ventilation to perfusion mismatch. At early pandemic, clinicians tried prone positioning for non-intubated patients with COVID-19 and found improvement in oxygenation. However, the evidence for patient outcomes such as intubation or mortality is still lacking. Thus we organized this international, multicenter, randomized controlled meta-trial, with 41 hospitals in 6 countries participated. (more…)
Author Interviews, Duke, JAMA, Nursing, Sexual Health, STD / 12.08.2021

MedicalResearch.com Interview with: Vincent Guilamo-Ramos, PhD MPH, LCSW, RN, ANP-BC, PMHNP-BC, AAHIVS, FAAN Vincent Guilamo-Ramos is dean and professor at the Duke University School of Nursing, vice chancellor for nursing affairs, Duke University, and director of the Center for Latino Adolescent and Family Health (CLAFH) at Duke. Dr. Guilamo-Ramos served as a member of the National Academies of Sciences, Engineering, and Medicine (National Academies) Committee on Prevention and Control of STIs in the U.S. that wrote the recent consensus study report. He also serves as a member of the Presidential Advisory Council on HIV/AIDS (PACHA) and the HHS Panel on Antiretroviral Guidelines for Adults and Adolescents. MedicalResearch.com: What is the background for this study? Response: The National Academies of Sciences, Engineering, and Medicine (National Academies) recently released a consensus study report on prevention and control of sexually transmitted infections (STIs) in the United States. The report entitled “Sexually Transmitted Infections: Adopting a Sexual Health Paradigm” includes a strong emphasis on adolescents and young adults as an important priority population for the response to record-level STI rates that have reached an all-time high for the sixth year in a row in 2019. The report also highlights the well-supported and crucial role of parents in addressing STIs and promoting sexual health among adolescents and young adults. In this new Viewpoint article, my co-authors and I, who contributed to the National Academies report as committee members or consultants, discuss the practical implications for health care professionals of engaging parents in adolescent sexual health services. (more…)
COVID -19 Coronavirus, PLoS / 07.08.2021

MedicalResearch.com Interview with: Melanie Bell, PhD, MS Professor Mel and Enid Zuckerman College of Public Health The University of Arizona MedicalResearch.com: What is the background for this study? Response: In May 2020 my colleagues began a cohort study called CoVHORT, which  aimed to investigate the impacts of the SARS-Cov-2 pandemic among residents of Arizona. The current study on long covid is a sub-study which included all CoVHORT participants who had a confirmed positive COVID-19 test, were not hospitalized, and had symptom data 30 days are longer since the test. We wanted to investigate the prevalence of long covid, also known as post-acute sequalae of COVID-19 (PASC) amongst people who did not experience severe acute infection. Although the definition is still evolving in the research community, we defined PASC as continuing to experience at least one symptom 30 days or longer post-acute infection. (more…)
Author Interviews, COVID -19 Coronavirus, Occupational Health, Weight Research / 01.08.2021

MedicalResearch.com Interview with: https://www.newtopia.com/Jeff Ruby, JD, MBA, Founder and Chief Executive Officer Leonard Fensterheim, MPH Vice President of Analytics MedicalResearch.com: What is the background for this study? What are common weight-change findings during the pandemic?  Obesity has been linked to increased risk of serious complications and the need for costly medical utilization – all of which has been exacerbated by the COVID-19 pandemic. There has been an increase of imposed restrictions that impact healthy lifestyles – the closing of gyms as an example – leading to additional stress and the complete disruption of daily lives. It’s no surprise that many people have gained weight since the beginning of the pandemic. According to the Centers for Disease Control and Prevention (CDC), before the pandemic, about 40% of Americans had obesity in the United States. This was already an alarming figure, but given that the American Psychological Association found that 42% of U.S. adults report undesired weight gain, with an average gain of 29 lbs. since the start of the pandemic, we expect that percentage has continued to grow. Against this backdrop, Newtopia sought to evaluate the impact of a guided habit change program on weight loss for 12 months during the COVID-19 pandemic. Method:
  • This was a retrospective study that looked at 1436 participants who began participating in the Newtopia experience in early 2020.
  • This analysis focused on weight change and was restricted to those participants with a body mass index >
  • 52% of participants were female, and the average age of the total study population was 46.5 years old (±10.6).
  • The percentage of participants with a 4.3% weight reduction after 12 months was assessed. This has been shown to be associated with meaningful reduction in healthcare costs.
  • The average weight loss and the percentage BMI decrease was also assessed.
  Outcomes:
  • 77% of participants lost weight.
  • 44% of participants had a weight loss of >3%.
  • Average weight loss was 4.2% (p<.0001).
  • 22% of obese participants dropped a BMI category.
Despite the challenges of the Covid-19 pandemic, individuals participating in the Newtopia habit change experience still achieved impactful weight loss. (more…)
Author Interviews, Cognitive Issues, COVID -19 Coronavirus, Imperial College, Lancet / 28.07.2021

MedicalResearch.com Interview with: Dr. Adam Hampshire PhD Faculty of Medicine Department of Brain Sciences Imperial College London MedicalResearch.com: What is the background for this study? Response: During 2020 I was leading a study that sought to map the distribution of cognitive abilities and aspects of mental health across the UK population. The study generated a lot of interest because it was a collaboration with BBC2 Horizon, leading to ~390,000 participants. When the pandemic began to escalate in the UK a number of my colleagues at Imperial and elsewhere contacted me to note that the study could be used to investigate the impact of both the pandemic and direct illness on daily life, mental health and cognition. I had been thinking along similar lines so decided to add questionnaires about peoples' experiences with the pandemic and Covid-19 illness. (more…)
Allergies, Author Interviews, COVID -19 Coronavirus, JAMA, Vaccine Studies, Vanderbilt / 27.07.2021

MedicalResearch.com Interview with: Kimberly G. Blumenthal, MD, MSc Massachusetts General Hospital The Mongan Institute Boston, MA 02114 Matthew S. Krantz, MD Division of Allergy, Pulmonary and Critical Care Medicine Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee   MedicalResearch.com: What is the background for this study? Response: During the initial COVID-19 vaccine campaign with healthcare workers in December 2020, there was an unexpected higher than anticipated rate of immediate allergic reactions after Pfizer and Moderna mRNA vaccines.  This prompted both patient and provider concerns, particularly in those with underlying allergic histories, on the associated risks for immediate allergic reactions with the mRNA vaccines. Because of the significantly improved effectiveness of two doses of an mRNA vaccine compared to one dose, it was important to determine if those who experienced immediate allergic reaction symptoms after their first dose could go on to tolerate a second dose safely.    (more…)
Author Interviews, Cancer Research, COVID -19 Coronavirus, JAMA, Prostate Cancer, Race/Ethnic Diversity / 23.07.2021

MedicalResearch.com Interview with: Andres F. Correa, MD Assistant Professor Department of Surgical Oncology, and Adrien Bernstein, MD Second Year Urologic Oncology Fellow Fox Chase Cancer Center MedicalResearch.com: What is the background for this study? Response: Unfortunately, it has been well-established that historically Black Americans experience increased cancer specific mortality compared to white patients. In prostate cancer specifically studies have shown that when access to care is equitable this gap resolves. This suggests that biological factors are not driving these differences but rather the result of the complex interplay of social determinants and systemic inequities in our healthcare system. Early in the pandemic, multiple studies demonstrated that minority communities disproportionately shouldered poor COVID-19 outcomes.  On March 13th 2020, the American College of Surgeons recommended against elective procedures; however, the definition of an elective oncologic case was left to the discretion of the provider. As prostate cancer treatment can be safely deferred up to a year follow diagnosis, management of prostate cancer during the initial lockdown period of the COVID-19 Pandemic provided a useful analysis of the differential restrictions placed on non-emergent health care during the Pandemic. (more…)
Author Interviews, COVID -19 Coronavirus, JAMA / 15.07.2021

MedicalResearch.com Interview with: Michael Ohl, MD, MSPH Associate Professor of Internal Medicine-Infectious Diseases Roy J. and Lucille A. Carver College of Medicine University of Iowa MedicalResearch.com: What is the background for this study? Response: The background is that remdesivir was approved for treatment in 2020 largely based on the results of the Adaptive COVID-19 Treatment Trial 1 (ACTT-1), which found that remdesivir treatment was associated with more rapid recovery from illness among people hospitalized with COVID-19. The intention was that - even if remdesivir did not lead to substantial improvements in survival-  it could help people to recover more quickly and be discharged from hospital sooner, potentially opening scare hospital pends to treat more patients during the pandemic.   (more…)
Author Interviews, Infections / 11.07.2021

MedicalResearch.com Interview with: Juliana Menezes MSc “I am a PhD student at the Faculty of Veterinary Medicine of the University of Lisbon. I do my research at the Centre for Interdisciplinary Research in Animal Health under the Supervision of Professor Constança Pomba, the head of the Antibiotic Resistance Lab. The Idea for this work came from my supervisor, that has been working in the field of antibiotic resistance for a while and was leading a research project, the Pet-Risk consortium (http://petrisk.fmv.ulisboa.pt/) which main goal was to evaluate sharing of resistant bacteria between animal and humans (namely ESBL). Following this idea, we thought that would be important to evaluate colistin resistance in animals.” MedicalResearch.com: What is the background for this study? Response: With the global spread of multi-drug carbapenem resistant Gram-negative bacteria, colistin is a last-resort antimicrobial to treat ICU patients in hospitals. Thus, WHO has classified Colistin as a Highest Priority Critically Important Antimicrobial for human medicine, therefore, resistance represents a serious concern among physicians and scientists.  Increasing trends and prevalence of colistin resistance have been observed worldwide, and the studies are mainly focused on food-producing animals or hospitalized humans, suggesting an exchange of pathogenic bacteria and/or mobile genetic elements between different reservoirs. The rational for this study is the importance to evaluate colistin resistance in companion animals as they are living in direct contact with humans in the community. (more…)
Author Interviews, CDC, COVID -19 Coronavirus, Heart Disease, JAMA, UCSD / 01.07.2021

MedicalResearch.com Interview with: Margaret Ryan MD MPH Medical Director of Defense Health Agency Immunization Healthcare Division Pacific Region Office, San Diego CA Clinical Professor at the University of California San Diego MedicalResearch.com: What is the background for this study? What are the main findings? Response: Military clinicians, especially those in the Defense Health Agency Immunization Healthcare Division, first became aware of a few cases of myocarditis following COVID-19 vaccination in early Feb 2021.  These cases included young men who presented with chest pain a few days after 2nd dose of mRNA (Pfizer or Moderna) vaccine.  As more young people became eligible for 2nd doses of vaccine, more cases were identified.  By late April, the military had identified 23 cases of myocarditis, with remarkably similar presentations, after COVID-19 vaccination.  This case series is described in the current issue of JAMA Cardiology. (more…)
Author Interviews, COVID -19 Coronavirus, Environmental Risks / 30.06.2021

MedicalResearch.com Interview with: Els M. Broens DVM, PhD, Dipl. ECVM, EBVS European Veteirnary Specialist in Veterinary Microbiology Associate Professor / Director VMDC Department Biomolecular Health Sciences (Clinical Infectiology) Faculty of Veterinary Medicine | Utrecht University MedicalResearch.com: What is the background for this study? Response: Several events have demonstrated that SARS-CoV-2 can infect animals, felines and mustelids in particular. In companion animals these are currently considered to be incidents with a negligible risk for public health since the main force of the pandemic is transmission between humans. However, it is urgent to understand the potential risk of animal infections for public health in the later stages of the pandemic when SARS-CoV-2 transmission between humans is greatly reduced and a virus reservoir in animals could become more important. Incidental cases have shown that COVID-19 positive owners can transmit SARS-CoV-2 to their dog or cat. The close contact between owners and their dogs and cats and the interaction between dogs and cats from different households raises questions about the risk for pets to contract the disease and also about role of these animals in the transmission of SARS-CoV-2. (more…)
Author Interviews, COVID -19 Coronavirus, Vaccine Studies / 22.06.2021

MedicalResearch.com Interview with: Dr Boby Varkey Maramattom MD,DM, FRCP, FRCPE Fellow in Critical care neurology (Mayo Clinic) Lead Consultant Neurologist Aster Medcity, Kochi, Kerala Associate Director- Clinical Research Centre, Aster Medcity. Convener, Neurocritical care subsection Indian academy of Neurology  (IAN) MedicalResearch.com: What is the background for this study? Response:  Approximately 2-3 months after the vaccination programme commenced in India, we began to notice an uptick in the incidence of Guillain-Barré Syndrome (GBS) in our community. All the cases that presented to us during this period had almost the same clinical presentation. They presented within a few days ( usually within 1-2 weeks) of the first dose of the ChAdOx1-S/nCoV-19 vaccine. Most of the patients were women and it seemed to involve the middle aged to elderly age groups. As a result of this observation, we started to compile the clinical findings of these patients and collate them. (more…)
Author Interviews, Infections / 22.06.2021

MedicalResearch.com Interview with: Dr. Rafael Kroon Campos PhD Department of Microbiology and Immunology University of Texas Medical Branch Galveston, TX MedicalResearch.com: What is the background for this study? What are the main findings? Response: The COVID-19 pandemic is affecting millions of people. COVID-19 is a disease that primarily affects the lungs, but it also affects other organs and tissues, including heart and olfactory receptors. There is a growing body of evidence showing that COVID-19 can affect reproductive health by reducing androgen hormones, sperm counts and causing pain and discomfort in the testes. The virus that causes this disease is named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is unknown whether these symptoms are caused by direct virus testes infection or a byproduct of the immune system fighting the virus. (more…)
COVID -19 Coronavirus / 15.06.2021

MedicalResearch.com Interview with: Jonathan Baktari, MD CEO of e7health.com Dr. Baktari, CEO discusses the COVID-19 Delta COVID-19 variant and his insights into pandemic concerns and control. MedicalResearch.com: What is meant by the 'Delta' variant?  Are there differences in the clinical presentation or complications?  Response: Variants are now given Greek lettering for everyone and the Delta variant represents the variant from India. Pulmonary reports indicate it is much more contagious and there are reports of increased hospitalization with this variant.  MedicalResearch.com: Where is the variant currently found and where is it likely to spread? Response: Obviously India, but it has taken over as the dominant strain in England and it is about 6% of the strains in the United states and growing. (more…)
Author Interviews, CDC, COVID -19 Coronavirus, JAMA, Pediatrics / 11.06.2021

MedicalResearch.com Interview with: Angela P. Campbell, MD, MPH Medical Officer Epidemiology and Prevention Branch in the Influenza Division MIS-C Incidence Authorship Group CDC MedicalResearch.com: What is the background for this study?
  • Response: Multisystem inflammatory syndrome in children (MIS-C) is a serious condition associated with COVID-19 where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, and gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. Not all children with MIS-C have the same symptoms.
  • It is still not known exactly how MIS-C may be linked to prior COVID-19 infection. However, 99% of cases in the CDC national surveillance system tested positive for COVID-19. The remaining 1% were around someone with COVID-19.
  • MIS-C incidence might vary by certain patient characteristics, such as such as race, ethnicity, age, sex and geographic location.
  • In this study we estimated the rate of MIS-C cases overall in the general population as well as the rate of MIS-C cases among those with COVID-19.
(more…)
Author Interviews, COVID -19 Coronavirus, Johns Hopkins, Nutrition / 04.06.2021

MedicalResearch.com Interview with: Dr. Hyunju Kim Ph.D. Johns Hopkins School of Public Health MedicalResearch.com: What is the background for this study? Response: In the past few months, we have learnt that individuals with comorbidities (obesity, type 2 diabetes, cardiovascular disease, hypertension) are at higher risk of Covid-19. The etiology of these conditions is largely driven by poor nutrition and unfavorable lifestyle choices, yet no study examined whether dietary habits play a role in Covid-19 infection, severity of symptoms, and duration of illness. (more…)
Author Interviews, COVID -19 Coronavirus, Sleep Disorders, Technology / 03.06.2021

MedicalResearch.com Interview with: Michele Ferrara, PhD. Professor of Psychobiology and Physiological Psychology Chair of the Psychology Didactic Council Department of Biotechnological and Applied Clinical Sciences University of L'Aquila MedicalResearch.com: What is the background for this study? Response: During the current period of social distancing, the pervasive increase in the use of electronic devices (smartphones, computers, tablets and televisions) is an indisputable fact. Especially during the long lockdown period of Spring 2020, technologies played a pivotal role in coping with the unprecedented and stressful isolation phase. However, exposure to backlit screens in the hours before falling asleep can have serious repercussions on sleep health: on the one hand, by mimicking the effects of exposure to sunlight, and thus interfering with the circadian rhythm of the hormone melatonin, and on the other hand, counteracting the evening sleepiness due to the emotionally and psycho-physiologically activating contents. In light of this assumption, we decided to test longitudinally during the third and the seventh week of lockdown a large Italian sample (2123 subjects) through a web-based survey. We assessed sleep disturbances/habits and the occurring changes of electronic device usage in the 2 hours before the sleep onset. (more…)
Author Interviews, COVID -19 Coronavirus, Vaccine Studies / 23.05.2021

MedicalResearch.com Interview with: Jonathan Baktari, MD CEO of e7health.com Dr. Baktari dicusses COVID-19 vaccinations as well as the nine vaccinated New York Yankees have now tested positive for COVID-19.  They all received the J&J vaccine. MedicalResearch.com:  There are nine known COVID positive results among members of the Yankees, previously immunized with the J&J vaccine.  Do you know if the players have become ill or just tested positive on routine testing? Response: Only 1 out of the 9 was mildly symptomatic and were all picked up as part of MLB testing protocol. MedicalResearch.com: Do you know how long after they were vaccinated that they tested positive?  Do you know of other incidences of positive reactions after vaccinations?  Response: According to MLB, all players tested positive after receiving the J&J vaccine.  All were at least 14 days after the vaccine was administered.  The 14 days post vaccination is when J&J is supposed to be effective in preventing serious illness and death. (more…)
Author Interviews, COVID -19 Coronavirus, Heart Disease, JACC, Social Issues / 12.05.2021

MedicalResearch.com Interview with: Kobina Hagan MBBS, MPH Postdoctoral Fellow Center for Outcomes Research, Houston Methodist Research Institute MedicalResearch.com: What is the background for this study? Response: Before the COVID-19 vaccination roll-out, risk mitigation guidelines including respiratory hygiene, social distancing, and job flexibility, were the most effective preventive measures against coronavirus transmission. Social determinants of health scholarships had identified social circumstances to limit adherence to these mitigation guidelines. Individuals with underlying cardiovascular disease are identified as high-risk phenotypes for severe COVID-19 outcomes. In addition, research efforts during the early and middle waves of the pandemic had identified coronavirus exposure risk as a greater mediator of the observed COVID-19 disparities, compared to clinical susceptibility from comorbidities. Yet, population-based evidence on the practice of these mitigation guidelines in this high-risk group were lacking. Consequently, we believed there was a need to robustly characterize COVID-19 risk mitigation practices among adults with cardiovascular disease in the nation. The COVID-19 Household Impact Survey was a survey conducted by the National Opinion Research Center at the University of Chicago, to provide statistics about health, economic security, and social dynamics of the US adult household population nationwide and for 18 geographic areas (10 states, 8 metropolitan statistical areas) between April and June 2020. This survey complemented the Household Pulse Survey by the Census Bureau. In this study we described the COVID-19 risk mitigation practices among patients with CVD and evaluated the association between cumulative social determinants of health burden (a measure of social adversity) and adherence these measures.  (more…)
Author Interviews, COVID -19 Coronavirus, Dermatology / 11.05.2021

MedicalResearch.com Interview with: Dr Monisha Madhumita Father Muller Medical College India MedicalResearch.com: What is the background for this study? hand-washing-eczema-dermatologyResponse: The COVID‐19 pandemic requires stringent adoption of hand hygiene practices. Health Care Workers (HCW) and the general population are at increased risk of irritation, dryness, redness and cracked hands (irritant dermatitis) due to frequent hand washing and the use of alcohol-based hand rubs. An effective hand sanitizer contains at least 60% alcohol to kill germs. Thus, it can be very drying to the skin. Transepidermal water loss (TEWL) is a way to measure the water lost from the skin. It is an essential parameter for characterizing skin hydration and protective function. Both of which are disrupted in irritant hand dermatitis. This research study was conducted on 582 participants: 291 health care workers and 291 healthy individuals of the general population. Measurements of TEWL were made using a noninvasive, closed- chamber system (VapoMeter) in a standardized environment. The study participants were asked to identify the challenges to compliance in hand hygiene practice (more…)
Author Interviews, Columbia, COVID -19 Coronavirus, Depression, Mental Health Research, PTSD / 07.05.2021

MedicalResearch.com Interview with: João Mauricio Castaldelli-Maia, MD, PhD (he/him) NIDA INVEST Drug Abuse Research Fellow Policy and Health Initiatives on Opioids and Other Substances (PHIOS) Department of Epidemiology Mailman School of Public Health Columbia University New York, NY 10032 MedicalResearch.com: What is the background for this study? Response:     It remains unclear whether COVID-19 is associated with psychiatric symptoms during or after the acute illness phase. Being affected by the disease exposes the individual to an uncertain prognosis and a state of quarantine. These factors can predispose individuals to the development of mental symptoms during or after the acute phase of the disease. There is a need for prospective studies assessing psychiatric symptoms in COVID-19 patients in the post-infection period. (more…)
Author Interviews, Cancer Research, COVID -19 Coronavirus, Technology / 05.05.2021

MedicalResearch.com Interview with: Saket Navlakha PhD Simons Center for Quantitative Biology Cold Spring Harbor Laboratory Cold Spring Harbor, NY  MedicalResearch.com: What is the background for this algorithm? How does it aide in patient care? Response: The machine learning algorithm helps to predict if and when a patient will develop severe COVID symptoms, based on information on how the patient presents on the day of infection. This could lead to improved patient outcomes, by getting a “heads up” on what may happen in the near future. (more…)
Author Interviews, CDC, Clots - Coagulation, COVID -19 Coronavirus, JAMA / 05.05.2021

MedicalResearch.com Interview with: Isaac See, MD Centers for Disease Control and Prevention COVID-19 Response Team Atlanta, Georgia MedicalResearch.com: What is the background for this study? Response: On February 27, 2021 the U.S. Food and Drug Administration (FDA) granted emergency use authorization for the Janssen/Johnson & Johnson (J&J) COVID-19 Vaccine in people 18 years of age or older in the United States.  The Janssen/J&J COVID-19 Vaccine uses a replication-deficient (i.e., cannot cause infections) human adenovirus vector.  In mid-March, the European Medicines Agency announced that they had conducted a preliminary investigation of cases of blood clots and low counts of blood cells called platelets in patients who had recently received the Oxford/AstraZeneca COVID-19 Vaccine, which uses a replication-deficient chimpanzee adenovirus vector.  This syndrome of blood clots and low platelet counts has been called thrombosis with thrombocytopenia syndrome, or TTS.  The European investigation showed that over 70% of their cases specifically involved blood clots in particular veins inside the brain, a condition caused cerebral venous sinus thrombosis (CVST), in addition to low platelet counts (thrombocytopenia is the medical term for low platelet counts). CVST is already a rare condition, and CVST with thrombocytopenia is even rarer.  By April 12, 2021, approximately 7 million doses of the Janssen/J&J COVID-19 Vaccine had been given in the United States, and six cases of CVST and thrombocytopenia after receipt of the Janssen/J&J COVID-19 Vaccine had been reported to the U.S. Vaccine Adverse Event Reporting System (VAERS), which is the U.S. national vaccine safety monitoring system.  The next day (April 13, 2021) CDC and FDA recommended a pause in use of the vaccine recommended to allow for further investigation of these events.  On April 23, 2021 data about the first 12 cases reported after authorization of the Janssen/J&J COVID-19 Vaccine were presented at an emergency meeting of the Advisory Committee on Immunization Practices (ACIP) to decide what to recommend regarding the Janssen COVID-19 vaccine.  The ACIP concluded that the benefits of resuming Janssen COVID-19 vaccination among persons aged 18 years or older outweighed the risks and reaffirmed its interim recommendation under the FDA’s Emergency Use Authorization.  The FDA’s Emergency Use Authorization includes a new warning for rare clotting events among women aged 18 to 49 years. Our report provides clinical details about these first reported 12 U.S. cases of CVST and thrombocytopenia following receipt of the Janssen COVID-19 Vaccine. (more…)
Author Interviews, COVID -19 Coronavirus, Technology / 04.05.2021

MedicalResearch.com Interview with: Ramani “Ram” Peruvemba, MD, FASA Co-founder and CMO of HSR.health MedicalResearch.com: Would you tell us about your background?  Response: I am a dual-board certified Anesthesiologist and Pain Management physician, currently serving as the co-founder and CMO of HSR.health. I am a Health IT expert and well-versed in the clinical, regulatory, and policy issues surrounding healthcare. I leverage my expertise, professional networks, and insights to HSR.health to bring health risk information to industry. As a clinician, I formerly served as Vice Chairman of the board for the largest anesthesia provider in Maryland and led them through a private equity transaction that helped elevate our group onto a national platform. I have also served on the advisory boards of QSSI corp, a Health IT firm involved in the construction of Healthcare.gov and ultimately sold to Optum, as well as Welldoc, a digital health leader that developed the only FDA approved digital health solution for the management of diabetes. Through my role on the Maryland Health Services Cost Review Commissions Advisory Council, I play a key role in the development and implementation of the unique value based hospital payment system, the Total Cost of Care Model, in conjunction with CMS and CMMI. I currently serve on the board of the Maryland State Medical Society, MedChi, as chairman of the medical policy council, and am the President of the Maryland Society of Anesthesiologists. Most recently, I’m proud to share that I was named a 2021 Top 100 Healthcare Innovator for my leadership in HSR.health's efforts supporting COVID-19 pandemic response globally. (more…)
Author Interviews, Cancer Research, Gender Differences, HPV, JAMA, Vaccine Studies / 27.04.2021

MedicalResearch.com Interview with: Michelle M. Chen, MD/MHS Clinical Lecturer Department of Otolaryngology-Head and Neck Surgery University of Michigan MedicalResearch.com: What is the background for this study? Response: HPV is the most common sexually transmitted infection in the United States and associated with several malignancies including oropharyngeal, cervical, vaginal, vulvar, penile, and anal cancers. In 2020, the FDA expanded the indications for HPV vaccination to include the prevention of oropharyngeal cancer, which is the most common HPV-associated malignancy and about 80% of oropharyngeal cancer patients are male. HPV vaccination rates are closely tracked for adolescents but less is known about vaccination rates for young adults. The goal of our study was to understand HPV vaccinations for young adult men and women, ages 18-21.  (more…)
Author Interviews, COVID -19 Coronavirus, JAMA, OBGYNE, Pediatrics / 23.04.2021

MedicalResearch.com Interview with: Aris Papageorghiou MBChB, MRCOG Professor of Fetal Medicine and the Clinical Research Director Oxford Maternal and Perinatal Health Institute University of Oxford MedicalResearch.com: What is the background for this study? Response: Our study was really guided by a key question: does Covid-19 in pregnancy increase the risk of adverse maternal and neonatal outcomes as compared with pregnant women who do not have the infection? The question is highly relevant because of the known deleterious effects of other coronavirus infections in pregnancy, e.g. SARS (severe acute respiratory syndrome) and MERS-CoV (Middle East respiratory syndrome coronavirus). In order to answer this question we undertook this multinational cohort study. (more…)
Author Interviews, COVID -19 Coronavirus, Environmental Risks / 23.04.2021

MedicalResearch.com Interview with: Margaret J. Hosie BVM&S, MRCVS, BSc. PhD. Professor of Comparative Virology MRC-University of Glasgow Centre for Virus Research United Kingdom  MedicalResearch.com: What is the background for this study? Response: SARS-CoV-2 is a new coronavirus of animal origin that recently jumped to humans and has spread rapidly across the world. It is likely that SARS-CoV-2 will establish as an endemic virus of humans, which has the potential to be transmitted to animals that live in close proximity to humans. There have been sporadic reports of infections in pet cats in households with COVID-19 patients, which demonstrates that cats are susceptible to SARS-CoV-2 infection and could act as virus reservoirs. (more…)
Author Interviews, COVID -19 Coronavirus, JNCI, Johns Hopkins, Respiratory, Vaccine Studies / 22.04.2021

MedicalResearch.com Interview with: Joel N. Blankson, MD, PhD Department of Infectious Diseases Associate Professor Cellular and Molecular Medicine Program Johns Hopkins MedicalResearch.com: What is the background for this study? Which vaccines did you evaluate? Response: Prior studies from several groups including our own have found T cell cross-recognition of peptides from SARS-CoV-2 and the common cold coronaviruses. We asked whether as a result of this cross-reactivity, immunization with the SARS-CoV-2 vaccine would also enhance T cell responses to the common cold coronaviruses. Prior studies also suggested that antibodies elicited from the mRNA vaccines had a reduced ability to neutralize the emerging variants of concern. Most of the study participants had received the Pfizer vaccine, but a few had received the Moderna vaccine.  (more…)
Author Interviews, COVID -19 Coronavirus, Environmental Risks / 22.04.2021

MedicalResearch.com Interview with: Masoud Jahandar Lashaki, Ph.D. Assistant Professor Department of Civil, Environmental and Geomatics Engineering Florida Atlantic University MedicalResearch.com: What is the background for this study? Response: Toilet flushing can generate large quantities of microbe-containing aerosols depending on the design and water pressure or flushing energy of the toilet. Based on previous reports, a variety of different pathogens which are found in stagnant water or in waste products (e.g., urine, feces, and vomit) can get dispersed widely via such aerosolization, including the legionella bacterium responsible for causing Legionnaire’s disease, the Ebola virus, the norovirus which causes severe gastroenteritis (food poisoning), and the Middle East Respiratory Syndrome coronavirus (MERS-CoV). Based on previous reports, such airborne dispersion is suspected to have played a key role in the outbreak of viral gastroenteritis aboard a cruise ship, where infection was twice as prevalent among passengers who used shared toilets compared to those who had private bathrooms. Similarly, transmission of norovirus via aerosolized droplets was linked to the occurrence of vomiting or diarrhea within an aircraft restroom, as passengers and crew who got infected subsequently were more likely to have visited restrooms than those that were not infected. The participants in the study reported that all of the restroom surfaces appeared to be clean, which indicates that infection is likely to have occurred via bioaerosols suspended within the restroom. Although many of these studies blamed flush-generated aerosols for disease outbreak, a limited number of them quantified the presence of such aerosols. Consequently, we decided to conduct this study to demonstrate the spike in aerosol concentrations following flushing.  (more…)
Author Interviews, COVID -19 Coronavirus, Education, Pediatrics / 16.04.2021

MedicalResearch.com Interview with: Jared Bullard MD FRCPC Associate Professor, Departments of Pediatrics & Child Health and Medical Microbiology & Infectious Diseases Max Rady College of Medicine Rady Faculty of Health Sciences Cadham Provincial Laboratory Children’s Hospital Research Institute of Manitoba MedicalResearch.com: What is the background for this study? Response: Children are well known to transmit epidemic/endemic respiratory viruses like influenza. Initial public health policy was based on that children were likely to transmit SARS-CoV-2 effectively within a community and subsequently in-person school and extracurricular activities were suspended. Initial research did not show a clear association with children driving transmission. The purpose of our study was to take respiratory samples from both children and adults with COVID-19 (all had SARS-CoV-2 detected by RT-PCR) and compare those samples by their ability to grow in cell culture and amount of virus in samples. We took 175 samples from children (97 younger than 10 years of age and 78 between 11-17 years) and compared them to 130 adult samples from the same communities in Manitoba experiencing outbreaks of COVID-19.  (more…)