Author Interviews, COVID -19 Coronavirus, Pharmaceutical Companies / 02.04.2020
Texas Biomed Launches Multi-Species Study to Accelerate COVID-19 Drug Testing
MedicalResearch.com Interview with:
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Dr. Schlesinger[/caption]
Dr. Larry Schlesinger MD
Professor, President and CEO
Texas Biomed
MedicalResearch.com: What is the background and mission of Texas Biomed?
Response: Texas Biomedical Research Institute (Texas Biomed) is a not-for-profit, independent research institute with a strong history of pioneering, biomedical breakthroughs that have contributed to the world of science and human health for nearly 80 years. The Texas Biomed mission is to pioneer and share scientific breakthroughs that protect you, your families and our global community from the threat of infectious diseases. Texas Biomed is capitalizing on its strengths – outstanding collaborative scientists and unique assets and resources. Texas Biomed is home to the nation’s only privately-owned BSL4 facility, five fully outfitted BSL3 facilities with the latest technologies and the Southwest National Primate Research Center (SNPRC). The Institute focuses on a core understanding of the basic biology of infectious diseases, animal model development, and studies to move therapies and vaccines to human clinical trials. The Institute’s independent, nonprofit business model moves science from the bench to clinical trials faster and with less bureaucracy.
Dr. Schlesinger[/caption]
Dr. Larry Schlesinger MD
Professor, President and CEO
Texas Biomed
MedicalResearch.com: What is the background and mission of Texas Biomed?
Response: Texas Biomedical Research Institute (Texas Biomed) is a not-for-profit, independent research institute with a strong history of pioneering, biomedical breakthroughs that have contributed to the world of science and human health for nearly 80 years. The Texas Biomed mission is to pioneer and share scientific breakthroughs that protect you, your families and our global community from the threat of infectious diseases. Texas Biomed is capitalizing on its strengths – outstanding collaborative scientists and unique assets and resources. Texas Biomed is home to the nation’s only privately-owned BSL4 facility, five fully outfitted BSL3 facilities with the latest technologies and the Southwest National Primate Research Center (SNPRC). The Institute focuses on a core understanding of the basic biology of infectious diseases, animal model development, and studies to move therapies and vaccines to human clinical trials. The Institute’s independent, nonprofit business model moves science from the bench to clinical trials faster and with less bureaucracy.

Dr. Bin Cao[/caption]
Bin Cao, Yeming Wang, Guohui Fan,
Lianghan Shang, Jiuyang Xu, DingyuZhang, Chen Wang
on behalf of LOTUS-China Study Group
China-Japan Friendship Hospital; Wuhan Jintinyan Hospital;
Institute of Respiratory Medicine, Chinese Academy of Medical Science
MedicalResearch.com: What is the background for this study?
Response: In the past two months, the outbreak of Coronavirus Disease 2019 (COVID-19) has been spreading rapidly across the world. Science and technology is the most powerful weapon for human to fight against diseases, especially in such a pandemic setting. Seeking for effective antiviral medication is the most critical and urgent among the many scientific tasks in the pandemic.
At the most critical moment in the fight against COVID-19, Chinese clinical scientists have stepped forward under extremely difficult research conditions to carry out clinical trials in antiviral treatment including lopinavir–ritonavir and remdesivir, in a swift, decisive and effective manner. These trials have attracted worldwide attention.
Recently, the Lopinavir–ritonavir Trial for suppression of SARS-CoV-2 in China (LOTUS-China) has been completed, which, with great clinical significance, can provide strong evidence for the treatment of COVID-19 both in China and around the world.

Dr. Kooraki[/caption]
Soheil Kooraki MSR MS, MD
on behalf of Dr. Ali Gholamrezanezhad MD and co-authors
Department of Radiological Sciences,
David Geffen School of Medicine, University of California at Los Angeles
Los Angeles, California
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: COVID19 is a novel strain of the coronavirus family causing pneumonia. Two similar strains were discovered in 2003 and 2012 to cause the so-called SARS and MERS outbreaks, respectively. Radiologists need to be prepared for the escalating incidence of COVID-19. We reviewed the literature to extract the epidemiologic and imaging features of SARS and MERS in comparison with known imaging features of COVID-19 pneumonia to have a better understanding of the imaging features of the COVID19 pneumonia in acute and post-recovery stages.


Dr. Marra[/caption]
Alexandre R. Marra, MD PhD
Iowa Infection Prevention Research Group
University of Iowa Carver College of Medicine
Division of Medical Practice, Hospital Israelita Albert Einstein
São Paulo, Brazil
MedicalResearch.com: What is the background for this study?
Response: This is a comprehensive systematic literature review evaluating the burden of C. difficile infections in the U.S healthcare system. The literature has diverse studies with variable outcomes. Thus, we only included incidence estimates derived from multicenter studies. In our meta-analysis to calculate incidence, data were pooled only with denominators using the same unit (patient-days) to avoid comparisons with different denominators. For length of stay (LOS), we only included studies that used advanced statistical methods (e.g., propensity score matching).
