Author Interviews, Diabetes, Diabetologia, Infections, Pediatrics / 11.01.2017
Enteroviruses Linked To Development of Type 1 Diabetes in Children
MedicalResearch.com Interview with:
Dr. Hanna Honkanen PhD
University of Tampere.
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The association between enteroviruses and type 1 diabetes has been suggested for long and analyzed in several studies. However, only few studies have been able to study this association at the time when the disease process starts, which happens several months or years before type 1 diabetes is diagnosed.
Our study made this possible since it was based on a large cohort of children who were followed from birth and samples were collected already before the disease process had started (prospective DIPP-study in Finland). Enterovirus infections were detected by analyzing the presence of viral nucleic acids in longitudinal stool sample series. Infections were found more frequently in case children who developed islet autoantibodies compared to control children. This excess was detected several months before islet autoimmunity appeared. This study is the largest such study carried out so far. The results suggest that enterovirus infections may contribute to the initiation of the disease process that eventually leads to type 1 diabetes.
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