Abuse and Neglect, Circadian Rhythm, Heart Disease, Lancet, Surgical Research / 03.11.2017
Matching Time of Day To Patient’s Biorhythm May Improve Surgical Outcomes
MedicalResearch.com Interview with:
Prof David Montaigne MD
Faculté de Médecine de Lille H Warembourg
Lille, France
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: It is well known for many decades that cardiovascular diseases exhibit a diurnal variation with for instance higher incidence of myocardial infarction in the early morning as opposed to the evening. Although studies on circadian gene knock-out and mutant mice argue for a biorhythm in myocardial ischemia-reperfusion tolerance, whether a biorhythm in the myocardial tolerance to ischemia, exists in humans was unclear because of conflicting reports in the context of myocardial infarction.
We demonstrated for the first time in humans that the myocardial tolerance to ischemia-reperfusion is different along the day, in line with rodent experiments performed in the early 2010s.
We demonstrated that this biorhythm is clinically meaningful and that it can be targeted as a cardioprotective strategy.
In this topic, Rever-alpha is of specific interest. It belongs at the same time to circadian genes and nuclear receptor families: being a nuclear receptor, it is a feasible pharmacological target, conversely to other circadian genes.
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