MedicalResearch.com Interview with: Ian Gilron, MD, MSc, FRCPC
Director of Clinical Pain Research
Professor of Anesthesiology & Perioperative Medicine,
Biomedical & Molecular Sciences, and
Center for Neuroscience Studies Queen's University
Kingston General Hospital, Kingston, Ontario, Canada
Medical Research: What are the main findings of the study?Dr. Gilron: Pain is the most common symptom which prevents recovery from surgery. Even with the best available treatments today, many patients still suffer from moderate to severe pain after surgery.
Antidepressants - drugs used to treat depression - are also proven effective for treating chronic pain due to nerve disease and fibromyalgia. However, there has been much less research on the effects of antidepressant drugs on pain after surgery.
Our group conducted a systematic review of all published clinical trials of antidepressant for post surgical pain.
Slightly more than half of these studies suggested some benefit of these drugs but the details of this review led us to conclude that there is not yet enough evidence to recommend these medications for post surgical pain treatment.
Given the possibility that these medications could be useful treatments for pain after surgery, we believe that future studies of higher scientific quality and which involve larger numbers of patients should be carried out in the hopes of finding safer and more effective treatments for pain after surgery.
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MedicalResearch.com Interview with: Ying Wang PhD
Epidemiology Post-Doc Fellow
American Cancer Society Inc
Atlanta, GA 30303
Medical Research: What are the main findings of the study?Dr. Wang: Previous studies suggest that higher intake of fruits and vegetables are associated with lower risk of breast cancer risk, especially estrogen receptor (ER) negative (ER-) tumors that are more aggressive and difficult to treat. We found that postmenopausal women who had higher intake of flavones, a subgroup of flavonoids that are widely distributed in fruits and vegetables, had lower risk of breast cancer. Furthermore, higher intake of flavan-3-ols which is high in non-herbal tea was associated with lower risk of ER- but not ER positive breast cancer.
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MedicalResearch.com Interview with: Dr. Richard Sharpe PhD
Study - Health and Housing
European Centre for Environment and Human Health
University of Exeter Medical school
Knowledge Spa, Royal Cornwall Hospital
Truro, Cornwall,
Medical Research: What are the main findings of the study?
Dr. Sharpe: By systematically reviewing the findings from 17 studies across 8 different countries, we've found that increased levels of the fungal species Penicillium, Aspergillus, and Cladosporium can pose a significant health risk to people with asthma. The presence of these fungi in the home can worsen symptoms in both children and adults.
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MedicalResearch.com Interview with: Donna Warren Morris, RDH, Med
Professor, Dean's Academy of Distinguished Teaching Scholars
Houston, TX 77054
Medical Research: What are the main findings of the study?Answer: Power toothbrushes can harbor microorganisms that have been shown to cause disease and infections. A solid-head design was found to have less growth of microorganisms than two others with hollow head designs.
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The American College of Chest Physicians released an expert consensus statement, Care of the Critically Ill and Injured During Pandemics and Disasterswhile the global health-care community cares for patients with the Ebola virus.Three of the authors discussed this important statement with MedicalResearch.com.
Asha V. Devereaux, MD, MPH
Sharp Hospital
Coronado, CA
Jeffrey R. Dichter, MD
Allina Health, Minneapolis, MN
and Aurora Health, Milwaukee, WI
Niranjan Kissoon, MBBS, FRCP(C)
BC Children's Hospital and Sunny Hill Health Centre
University of British Columbia, Vancouver, Canada
Medical Research: What are the main ethical concerns and criteria for evaluating who may be eligible for treatment during a pandemic or disaster?
Dr. Asha Devereaux: The main ethical concerns regarding eligibility for treatment during a pandemic will be access to limited or scarce resources.Who should get treatment and who decides will be some significant questions whenever there is a scarcity of healthcare resources. Transparency and the fairness of the ethical framework for decision-making will need to be made public and updated based upon the changing dynamics of resources and disease process.
Dr. Niranjan Kissoon: There is work to be done in this area and engagement of citizens, government, medical community, ethicists and legal experts in the process is important.
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MedicalResearch.com Interview with: Dr. Asha Bowen FRACP
Menzies School of Health Research
Charles Darwin University
Darwin, NT, Australia
Medical Research: What are the main findings of the study?Dr. Bowen: The Skin Sore Trial found that short courses (3 days of twice daily dosing or 5 days of once daily dosing) of oral co-trimoxazole worked just as well for treating impetigo in remote Indigenous Australian children as the standard treatment with an intramuscular injection of penicillin (BPG). Despite many randomised controlled trials (RCTs) on this common infection of childhood, few have been conducted where impetigo is severe and endemic and with over 100 million children affected at any one time, ongoing research is needed. This is only the second RCT to study impetigo in children where the problem is endemic and often severe. In our study, 70% of children had severe impetigo with a median of 3 body regions affected. BPG injections are painful and we knew from previous studies that not many children were receiving them. Our study confirmed that 30% of children had injection site pain 48 hours after receipt of the injection and 5 children ran away when they found out that they were randomised to the injection arm of the study.
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MedicalResearch.com Interview with: Christopher D. Anderson, MD, MMSc
Neurocritical Care | Acute Stroke
Center for Human Genetic Research
Massachusetts General Hospital
Harvard Medical School
Broad Institute of Harvard and MIT
Medical Research: What are the main findings of the study?Dr. Anderson: Previous studies have linked Apolipoprotein E (APOE) epsilon variants with spontaneous intracerebral hemorrhage (ICH) particularly in the lobar (cortical and subcortical) regions of the brain, but it was not known whether this association would extend to warfarin-related ICH, or whether the risk of intracerebral hemorrhage on warfarin would be multiplicatively compounded by APOE epsilon allele status. Our results demonstrate that APOE e2 and e4 variants are associated with more than a two-fold risk of lobar ICH for patients on warfarin, in comparison to warfarin-exposed individuals without ICH. This observed association was strongest when analyzing subjects with definite or probable Cerebral Amyloid Angiopathy (CAA), as defined by the Boston Criteria. No association between APOE e2 or e4 and non-lobar ICH was identified following our replication phase. Furthermore, we did not detect an interaction between APOE status and warfarin status in ICH subjects using a case-only design.
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MedicalResearch.com Interview with: Gayatri Patel, MD, MPH
Division of General Medicine
UC Davis Medical Center
Medical Research: What are the main findings of the study?Dr. Patel: In this systematic review and meta-analysis, we sought to determine the effectiveness of photodynamic therapy (PDT) for the treatment of actinic keratoses relative to other common treatments. We included only randomized controlled trials and preformed a meta-analysis on homogenous studies. The primary finding of the study was that PDT has a better chance of removing actinic keratoses on the face or scalp than treatment with cryotherapy.
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MedicalResearch.com Interview with:Philip Haycock, PhD
Post-Doctoral Research Assistant
MRC Integrative Epidemiology Unit
University of Bristol
Bristol, BS8 2BN, UK
Medical Research: What are the main findings of the study?Dr. Haycock: We found that shorter telomeres were significantly associated with risk of coronary heart disease and that the association was independent of conventional vascular risk factors, including age, sex, body mass index, smoking, history of diabetes, blood pressure and lipid markers.
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MedicalResearch.com Interview with: Christopher Mantyh, M.D.
Associate Professor of Surgery
Chief of Colorectal Surgery
NSQIP Surgical Champion
Duke University Medical Center
Medical Research: What are the main findings of the study? Dr. Mantyh: Specific perioperative bundles can drastically reduce surgical site infections in colorectal surgery patients.
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MedicalResearch.com Interview with:
Cintia Cercato, MD, PhD and
Emerson Leonildo Marques
University of São Paulo in Brazil
Medical Research: What are the main findings of the study?Answer:The major findings are that the cerebral metabolism of the obese compared to normal weight people is increasing. The fact that it can be increased means a greater chance of Alzheimer's disease, but bariatric surgery can reduce cerebral metabolism of obese.
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MedicalResearch.com Interview with: Vanessa Er PhD
School of Social and Community Medicine
University of Bristol and Bristol Nutrition BRU
Medical Research: What are the main findings of the study?Dr. Er: We found that men who had optimal intake of three nutrients- calcium, selenium and foods rich in lycopene- had a lower risk of prostate cancer. Mainly, men who ate over 10 servings/week of tomatoes and tomato-based products had 18% reduction in risk of developing prostate cancer. We also found that the risk of prostate cancer was lower in men who had high intake of fruits and vegetables.
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MedicalResearch.com Interview with: Elizabeth Goodman BA
Division of Oncology
The Children’s Hospital of Philadelphia
Philadelphia, Pennsylvania
Medical Research: What are the main findings of the study?Answer: Weekend hospital admission for pediatric patients newly diagnosed with leukemia was associated with a longer length of stay, slightly longer wait to start chemotherapy and higher risk for respiratory failure; however, weekend admissions were not linked to an increased risk for death.
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MedicalResearch.com Interview with: Dr. Mauricio Farez
Department of Neurology, Raúl Carrea Institute for Neurological Research
Buenos Aires, Argentina
Medical Research: What are the main findings of the study?
Dr. Farez: Our study shows that patients with Multiple Sclerosis (MS) with moderate to high sodium (salt) intake have also increased disease activity (more clinical relapses and more lesions on MRIs).
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MedicalResearch.com Interview with: Jennifer A. Reich PhD
University of Colorado Denver
Department of Sociology
Denver, CO 80208
Medical Research: What are the main findings of the study?Dr. Reich: Public health practitioners have been concerned about rising rates of vaccine refusal and hesitance. This study examines how mothers account for the decision to delay or opt out of vaccines. This study shows that contrary to popular representation, these mothers are not ignorant, but rather see themselves as experts on their own children and as best qualified to decide whether their children need vaccines. They also trust that their intensive mothering practices, including extended breastfeeding, consumption of organic foods, and social monitoring of their children will protect them against disease.
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MedicalResearch.com Interview with: Ziad A. Memish, M.D.
Alfaisal University
Riyadh Saudi Arabia
Medical Research: What are the main findings of the study?Dr. Memish: This is an important study as we looked at the secondary transmission of MERS-CoV among household/family contacts. Of the total study population of 280 contacts from 26 clusters collected over 6 months period last year, only 12 family contacts were positive for MERS-CoV.
Knowing that 7 (2.5%) were positive by PCR, only additional 5 probable secondary transmission were identified by serology which is a very small fraction missed by PCR. (more…)
MedicalResearch.com Interview with: Jerry Spivak, M.D
Professor of Medicine and Oncology
Director, Center for the Chronic Myeloproliferative Disorders
John Hopkins Medicine
Medical Research: What are the main findings of the study?Dr. Spivak: The main findings of this study are that polycythemia vera occurs in two clinical forms: an indolent form in which only phlebotomy may be necessary and a more aggressive form requiring myelosuppressive therapy and that these two forms of the disease can be distinguished genetically.
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MedicalResearch.com Interview with: Dr. Frank B. Hu
Department of Nutrition
Harvard School of Public Health
Boston, MA
Medical Research: What are the main findings of the study?Dr. Hu:in this study among approximately 5000 patients with type 2 diabetes followed for up to 10 years, longer duration of sulfonylurea therapy was associated with a higher risk of coronary heart disease. The continuous sulfonylurea therapy for 10 years was associated with almost two times greater risk of coronary heart disease compared with nonusers. However, given the observational nature of the study, we cannot make causal inference from these findings.
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MedicalResearch.com Interview with: Opeolu Adeoye, MD MS FACEP FAHA
Associate Professor, Emergency Medicine and Neurosurgery
Division of Neurocritical Care
University of Cincinnati
Cincinnati, OH 45267
Medical Research: What are the main findings of the study?Dr. Adeoye : Despite adequate access of the US population to hospitals that can deliver acute stroke care, only 4% of stroke patients in the US received tPA, the only approved medication for treating acute ischemic stroke.
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MedicalResearch.com Interview with: Manpreet K. Singh, MD MS
Assistant Professor of Psychiatry and Behavioral Sciences
Akiko Yamazaki and Jerry Yang Faculty Scholar in Pediatric Translational Medicine
Stanford University School of Medicine
Medical Research: What are the main findings of the study?Dr. Singh: Our research team used a monetary incentive delay paradigm to measure fronto-limbic activity and connectivity associated with anticipation and receipt of reward and loss in healthy offspring of parents with bipolar I disorder. We found that compared to youth offspring without any family history of psychopathology, high-risk offspring had aberrant prefrontal and cingulate activations and connectivity during reward processing. Further, greater striatal, amygdalar, and insula activations while anticipating and receiving rewards and losses were associated with greater novelty-seeking and impulsivity traits in high-risk youth.
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MedicalResearch.com Interview with Prof Richard McManus MA PhD FRCGP
NIHR School for Primary Care Research,
Nuffield Department of Primary Care Health
Sciences, University of Oxford,
Oxford, Oxfordshire United Kingdom
Medical Research: What are the main findings of the study?Prof. McManus: The TASMIN-SR clinical trial followed 552 patients with an average age of 70 and high blood pressure with pre-existing cardiovascular disease, diabetes or chronic kidney disease.
After training in how to self-monitor blood pressuring using a readily available device, patients took readings twice each morning for the first week of each month, and following an individualised management plan were able to request additional medication from their general practitioner without the need for consultation.
At the end of the study, patients who self-managed had significantly lower blood pressure (by 9.2 / 3.4 mmHg) than those who were visiting their GP for blood pressure monitoring, which would be expected to lower stroke risk by around 30% if sustained.
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MedicalResearch.com Interview with: Dr. Ralph Joseph Diclemente PhD
Behavoral Sciences & Health School Of Public Health
Emory University Atlanta Georgia
Medical Research: What are the main findings of the study? Dr. DiClemente: In our study of 701 African American girls we observed significant and durable reductions in laboratory-confirmed sexually transmitted infections (50% reduction in chlamydial infections and a 60% reduction in gonorrhea) among girls in our intervention group relative to the comparison condition over a 36-month follow-up period. In addition, we observed significant increases in condom use during sex and reductions in sex while using drugs or alcohol. The key finding is the durability of the results - 3 years in the life of an adolescent is a long period.
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MedicalResearch.com Interview with: Craig A Umscheid, MD, MSCE, FACP
Assistant Professor of Medicine and Epidemiology
Director, Center for Evidence-based Practice
Medical Director, Clinical Decision Support
Chair, Department of Medicine Quality Committee
Senior Associate Director, ECRI-Penn AHRQ Evidence-based Practice Center
University of Pennsylvania, Philadelphia, PA 19104
Medical Research: What are the main findings of the study?Dr. Umscheid: We found that targeted automated alerts in electronic health records significantly reduce urinary tract infections in hospital patients with urinary catheters. In addition, when the design of the alert was simplified, the rate of improvement dramatically increased.
Approximately 75 percent of urinary tract infections acquired in the hospital are associated with a urinary catheter, which is a tube inserted into the bladder through the urethra to drain urine. According to the Centers for Disease Control and Prevention, 15 to 25 percent of hospitalized patients receive urinary catheters during their hospital stay. As many as 70 percent of urinary tract infections in these patients may be preventable using infection control measures such as removing no longer needed catheters resulting in up to 380,000 fewer infections and 9,000 fewer deaths each year.
Our study has two crucial, applicable findings. First, electronic alerts do result in fewer catheter-associated urinary tract infections. Second, the design of the alerts is very important. By making the alert quicker and easier to use, we saw a dramatic increase in the number of catheters removed in patients who no longer needed them. Fewer catheters means fewer infections, fewer days in the hospital, and even, fewer deaths. Not to mention the dollars saved by the health system in general.
In the first phase of the study, two percent of urinary catheters were removed after an initial “off-the-shelf” electronic alert was triggered (the stock alert was part of the standard software package for the electronic health record). Hoping to improve on this result in a second phase of the study, we developed and used a simplified alert based on national guidelines for removing urinary catheters that we previously published with the CDC. Following introduction of the simplified alert, the proportion of catheter removals increased more than seven-fold to 15 percent.
The study also found that catheter associated urinary tract infections decreased from an initial rate of .84 per 1,000 patient days to .70 per 1,000 patient-days following implementation of the first alert and .50 per 1,000 patient days following implementation of the simplified alert. Among other improvements, the simplified alert required two mouse clicks to submit a remove-urinary-catheter order compared to seven mouse clicks required by the original alert.
The study was conducted among 222,475 inpatient admissions in the three hospitals of the University of Pennsylvania Health System between March 2009 and May 2012. In patients’ electronic health records, physicians were prompted to specify the reason (among ten options) for inserting a urinary catheter. On the basis of the reason selected, they were subsequently alerted to reassess the need for the catheter if it had not been removed within the recommended time period based on the reason chosen.
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MedicalResearch.com Interview with: Dr. Manuel Serrano PhD
Tumour Suppression Group
CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain.
Medical Research: What are the main findings of the study?Dr. Serrano: We investigated the contribution of rare genetic variation to human exceptional longevity (EL, individuals with ≥100 years of age) by exome-sequencing long-lived siblings in three different families where exceptional longevity clustered. We found only one gene that harbored rare variants that was likely to contribute to human longevity across all three families and this gene was the Apolipoprotein B gene (APOB). We further found that the frequency of these rare APOB variants associated with familial exceptional longevity was greater in a cohort of 206 nonfamilial cases of exceptional longevity compared to the control population, though this association did not reach statistical significance. In addition, we found rare variants in many genes within individual families that are likely to contribute to human longevity given previous studies in animals.
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MedicalResearch.com Interview with Ronald C Gentile, MD, FACS, FASRS
Professor of Ophthalmology
Chief, Ocular Trauma Service (Posterior Segment)
Surgeon Director
The New York Eye and Ear Infirmary of Mount Sinai
New York, NY 10003
President: operationrestorevision.org
Medical Research: What are the main findings of the study?Dr. Gentile:We had three main findings in our study on the microbiological spectrum and antibiotic sensitivity in endophthalmitis over the past twenty- five years at the New York Eye and Ear Infirmary of Mount Sinai.
First Finding: The first main finding of the study was that there has not been any major change in the types of organisms causing endophthalmitis over the past 25 years. The most common cause of endophthalmitis in the study was bacteria, 95%, with most, 85%, being Gram-positive bacteria. The most prevalent organisms isolated were coagulase-negative staphylococcus, making up about 40% of the cases. This was followed by Streptococcus viridans species in about 12% and Staphylococcus aureus in about 11%. Gram-negative organisms accounted for about 10% and fungi for about 5%.
Second Finding: The second main finding of the study was that the current empiric intravitreal antibiotics used for treating endophthalmitis, vancomycin and ceftazidime, continue to be an excellent choice. The overwhelming majority of microorganisms causing endophthalmitis are susceptible to this combination. Over 99% of the Gram-positive isolates were susceptible to the vancomycin and about 92 percent of the Gram-negative isolates were susceptible to ceftazidime.
Third Finding: The third main finding of the study was that there was increasing microbial resistance to eight antibiotics including cefazolin, cefotetan, cephalothin, clindamycin, erythromycin, methicillin/oxacillin, ampicillin, ceftriaxone and decreasing microbial resistance to three antibiotics including gentamicin, tobramycin, and imipenem. For example, Staph Aureus isolates resistant to methicillin increased from 18% in the late 1980s to just over 50% this past decade while gentamicin-resistance endophthalmitis isolates decreased during the same time period from 42% to 6%.
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MedicalResearch.com Interview with:Susan Miller, PhD
Professor of Health Services, Practice and Policy (Research) at the Center for Gerontology and Health Care Research
The Warren Alpert Medical School of Brown University
Medical Research: What are the main findings of the study?Prof. Miller: Upon introduction of culture change, the nursing homes that implemented culture change most extensively produced statistically significant improvements in the percent of residents on bladder training programs, the percent of residents who required restraints, the proportion of residents with feeding tubes, and the percent with pressure ulcers. They also showed a nearly significant reduction in resident hospitalizations. No quality indicator became significantly worse.
Among homes that implemented less culture change, the only significant improvement occurred in the number of Medicare/Medicaid health-related and quality of life survey deficiencies. Urinary tract infections and hospitalizations got slightly worse.
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MedicalResearch.com Interview with: Dr. Peter Godsk Jørgensen
Copenhagen City Heart Study
Frederiksberg Hospital, Frederiksberg, Denmark
Medical Research: What are the main findings of your study?Dr. Jørgensen: In the coming decades, a larger and larger proportion of the population will be aged 65 years or above. At present, no risk prediction models have been developed specifically for estimation of risk in this population. ECG changes are easily recognized and identify subclinical signs of end-organ disease. Our data reveal that not only are ECG changes a very frequent finding that independently predicts cardiovascular disease, they significantly improve risk prediction when added to the most used European and US risk models. Thus, our data demonstrate that adding ECG changes will correctly reclassify more than one third of the persons aged 65 years and above without cardiovascular disease.
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MedicalResearch.com Interview with Steven M. Bradley, MD, MPH
Veterans Affairs, Eastern Colorado Health CareSystem
Denver, Colorado
Medical Research: What are the main findings of the study?Dr. Bradley: In 539 hospitals participating in the CathPCI Registry that performed elective coronary angiography on more than 500,000 patients, 22% of patients were asymptomatic at the time of coronary angiography. We observed marked variation in the hospital rate of angiography performed in asymptomatic patients, ranging from 0.2% to 66.5%, suggesting broad variation in the quality of patient selection for coronary angiography across hospitals. Additionally, hospitals with higher rates of asymptomatic patients at diagnostic angiography also had higher rates of inappropriate PCI, due to greater use of PCI in asymptomatic patients. These findings suggest that patient selection for diagnostic angiography is associated with the quality of patient selection for PCI as determined by Appropriate Use Criteria. By addressing patient selection upstream of the catheterization laboratory, we may improve on the optimal use of both angiography and PCI.
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Medical Research Interview with: Brian Dannemann, MD, FACP
Senior Director, JNJ Pharmaceutical Research and Development
Titusville, NJ 08560
MedicalResearch: What are the main findings of the study?Dr. Dannemann : The final investigational 120-week results from the TMC207-C208 Phase 2 study demonstrated that bedaquiline (SIRTURO®) showed nearly twice an many patients in the bedaquiline group as in the placebo group were cured on the basis of the World Health Organization (WHO) outcome definitions for Multidrug-Resistant Tuberculosis which was statistically significant (38 of 66 patients [58%] and 21 of 66 patients [32%] respectively; p = 0.003).
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MedicalResearch Interview with:
Michael B. Rothberg, MD, MPH
Department of Internal Medicine
Medicine Institute, Vice Chair for Research
Cleveland Clinic, Cleveland, Ohio
Medical Research: What are the main findings of the study?Dr. Rothberg:In this randomized study we found that when people are presented with no information about the benefits of elective PCI, most assumed that it would prevent a heart attack. Unfortunately, this is incorrect, so people may choose to have the procedure based on false information. We also found that simply telling them that PCI would not prevent a heart attack successfully dispelled this belief for most, but not all, participants. Explaining why PCI does not prevent heart attacks in this circumstance was the most effective way to change people's beliefs. We also found that most people were willing to take medications, but when they were told that PCI does not prevent heart attacks, they were more likely to agree to medication.
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