Author Interviews, Depression, Genetic Research, JAMA / 19.04.2019
DNA Copy Number Variants Linked to Increased Risk of Depression
MedicalResearch.com Interview with:
Dr Kimberley Kendall MBBCh
Wellcome Trust Clinical Research Fellow
Professor James Walters
MRC Centre for Neuropsychiatric Genetics and Genomics
Professor, Division of Psychological Medicine and Clinical Neurosciences
Cardiff University
MedicalResearch.com: What is the background for this study?
Response: Copy number variants (CNVs) are the deletion or duplication of large sections of DNA. Large, rare CNVs have been shown to increase the risk of neurodevelopmental disorders including autism spectrum disorder (ASD), intellectual disability (ID), attention deficit/hyperactivity disorder (ADHD) and schizophrenia. However, the impact of these CNVs on risk of depression was unclear from the existing literature. (more…)