Author Interviews, Rheumatology / 11.11.2019

MedicalResearch.com Interview with: Kelly Gavigan, MPH Manager, Research and Data Science CreakyJoints  MedicalResearch.com: What is the background for this study? Response: Over the past fifteen years, there have been significant improvements in quality of life among people living with rheumatic and musculoskeletal disease with the introduction of biologics and targeted therapies. However, despite a variety of treatments to try, patients often seek non-pharmacological alternative and complementary treatments, such as marijuana for medical use (MMU), to help manage their condition and symptoms. MMU is becoming increasingly available in the United States as different states legalize it under specific circumstances. Legal or not, according to a survey conducted by CreakyJoints using the ArthritisPower Research Registry (n=1,059 participants), people with arthritis are trying marijuana for medical use.  (more…)
Author Interviews, Pain Research, Rheumatology / 11.11.2019

MedicalResearch.com Interview with: Féline PB Kroon MD Department of Rheumatology Leiden University Medical Centre LUMC · MedicalResearch.com: What is the background for this study? Response: Hand osteoarthritis (OA) is a prevalent joint condition that causes pain, functional disability, and decreased quality of life, for which patients frequently consult health-care providers. Symptoms usually fluctuate over time, with episodes of joint swelling and erythema. Evidence from previous studies has shown that inflammation plays an important role in the disease, being an important predictor for pain and radiographic damage progression. Therefore, we hypothesized that inflammation could be a treatment target in OA, and we investigated this using prednisolone, a potent anti-inflammatory drug. The aim of the HOPE study was to investigate the clinical efficacy and safety of a six-week course of prednisolone 10 mg daily in patients with painful hand OA who had evidence of synovial inflammation. (more…)
Author Interviews, Gout, Kidney Disease, Rheumatology, Transplantation / 10.11.2019

MedicalResearch.com Interview with: Megan Francis-Sedlak, PhD Director of Medical Affairs Horizon Therapeutics Lake Forest, Illinois MedicalResearch.com: What is the background for this study? Response: The prevalence of gout is more than ten-fold greater among patients who have undergone a kidney transplant than the general population as post-transplant medications to prevent organ rejection can contribute to increased uric acid levels. Overall studies have shown this can lead to higher rates of uncontrolled gout among this vulnerable population with organ transplants. While we have seen higher mortality rates for patients who have received a kidney transplant with uncontrolled gout compared to kidney transplant patients without uncontrolled gout, we wanted to evaluate the impact of gout on transplant-related complications to better inform patient care and treatment approaches.  (more…)
Author Interviews, Genetic Research, Kidney Disease, Mineral Metabolism, Pediatrics / 10.11.2019

MedicalResearch.com Interview with: Tracy McGregor, MD MSCI Alnylam Pharmaceuticals Cambridge, Massachusetts  MedicalResearch.com: What is the background for this study?
  • Lumasiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of primary hyperoxaluria type 1 (PH1). PH1 is a rare life-threatening disease in which a enzymatic deficiency in the liver results in pathologic overproduction of oxalate, often leading to recurrent kidney stones and a progressive decline in kidney function, which typically culminates in end-stage renal disease (ESRD).Patients with ESRD are at a risk of systemic oxalosis, with oxalate depositing throughout the body, including the eyes, skin, bones, and the heart. Complications associated with ESRD and/or systemic oxalosis can be fatal. For patients with ESRD treatment options are limited and include intensive dialysis as a bridge to a dual liver/kidney transplant, highlighting the unmet need for new treatment options. 
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Author Interviews, Brigham & Women's - Harvard, Cost of Health Care, Dermatology, JAMA, Rheumatology / 09.11.2019

MedicalResearch.com Interview with: Emily S. Ruiz, MD, MPH Director, High-Risk Skin Cancer Clinic, Dana Farber/Brigham and Women’s Cancer Center Assistant Professor, Harvard Medical School, Dermatology Brigham And Women's Faulkner Hospital  MedicalResearch.com: What is the background for this study? Response: Innovation in oncology has led to increased development and market entry of anticancer drugs. For example, from 2009 to 2013, the US FDA approved 51 oral and systemic anticancer drugs for 63 indications. Prices for anticancer drugs have risen faster than inflation over time, especially for older drugs, and prices in the US have largely been set by market forces rather than novelty or efficacy. Understanding the evolving cancer economic landscape requires consideration of annual and cumulative rates of change for key metrics, such as total spending, drug cost per beneficiary, out-of-pocket cost, and utilization. This study sought to weigh the proportional impacts of rising drug costs and utilization on increased Medicare Part D spending for a cohort of oral anticancer drug utilized from 2013-2017.  (more…)
Author Interviews, JAMA, Sexual Health, STD, Technology, UCSD / 09.11.2019

MedicalResearch.com Interview with: Alicia Nobles, PhD, MS Research Fellow Department of Medicine UC San Diego  MedicalResearch.com: What is the background for this study? Response: Sexually transmitted diseases (STDs) are at record-high rates according to the Centers for Disease Control. Between STDs being highly stigmatized infections and people lacking access to health care, people may elect to turn to social media to connect with others. This is precisely why social media sites are so popular - because they do allow for people to talk with others rapidly. Reddit, a social media site that rivals Twitter with 330 million active users and is the 6th most visited website in the United States, is organized into online communities, many of which discuss health topics. We monitored all r/STD (www.reddit.com/r/STD/) posts, where users can find “anything and everything STD related,” from its inception in November 2010 through February 2019.   (more…)
Author Interviews, Pediatrics, Weight Research / 09.11.2019

MedicalResearch.com Interview with: Jennifer Panganiban, MD Division of Gastroenterology, Hepatology and Nutrition Director, Non Alcoholic Fatty Liver Disease Clinic Children's Hospital of Philadelphia MedicalResearch.com: What is the background for this study? Response: Obesity now affects 1 in 5 children and adolescents in the United States with an estimated prevalence of 13.7 million. We know that this is not only an issue in the US but a worldwide epidemic. Lifestyle modification is the primary treatment of obesity, which can be successful but is limited. Off-label use of medications for weight loss in youth is increasing secondary to the limited availability of FDA approved medications for weight-loss.  (more…)
Author Interviews, Pediatrics, Weight Research / 07.11.2019

MedicalResearch.com Interview with: Kai Ling Kong, PhD, MS Assistant Professor Division of Behavioral Medicine Department of Pediatrics School of Medicine and Biomedical Sciences State University of New York at Buffalo MedicalResearch.com: What is the background for this study? Response: The deleterious effects that obesity has on an individual’s health and the difficulty of reversing it in adults are well-known, ranging from diabetes and heart disease to cancer. For these reasons, obesity prevention in babies and children in populations at high risk is increasingly seen as a critical way to address the obesity epidemic. However, most studies on factors that contribute to obesity in very young children haven’t focused on the populations most at risk. Now an ongoing longitudinal University at Buffalo study being presented Nov. 5 in Las Vegas at ObesityWeek is among the first to explore how mother-infant behaviors during feeding and active play (non-feeding situations) affect infants and children in families with low socioeconomic status. Infants of mothers exhibiting less warmth during free play interactions when infants were 7 months old were associated with steeper body mass index trajectories while the infants of mothers exhibiting more warmth during these interactions were not. (more…)
Author Interviews, Cancer Research, HPV, JAMA, OBGYNE / 07.11.2019

MedicalResearch.com Interview with: Rachel L. Winer, PhD Professor Department of Epidemiology School of Public Health HPV Research Group University of Washington Seattle, WARachel L. Winer, PhD Professor Department of Epidemiology School of Public Health HPV Research Group University of Washington Seattle, WA  MedicalResearch.com: What is the background for this study? Response: In the U.S., 25% of women do not receive recommended cervical cancer screening. Increasing screening participation is a high priority, because over half of the 12,000 cervical cancers diagnosed each year in the U.S. are in women who are underscreened. Currently available options for cervical cancer screening in the U.S. include Pap testing or HPV testing, either alone or in combination. HPV self-sampling is an emerging option for screening because HPV tests – unlike Pap tests – can be performed on either clinician- or self-collected samples, with similar accuracy. Internationally, several countries (including Australia and the Netherlands) include HPV self-sampling as a cervical cancer screening option for underscreened women.  (more…)
Author Interviews, Endocrinology, Stem Cells, Thyroid Disease / 05.11.2019

MedicalResearch.com Interview with: Terry Davies, MD Co-Director, The Thyroid Center at Mount Sinai Union Square Professor, Medicine, Endocrinology, Diabetes and Bone Disease Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? What are the main findings? Response: Many tissues contain stem cells that are responsible for regeneration and repair after injury. The mechanism of thyroid regeneration and the role of thyroid stem cells in this process is poorly understood. This an exploration of how the thyroid gland repairs itself. Using a mouse model we found that a damaged gland can correct itself within 4 weeks and this involves a rapid increase in stem cells driving the repair.  (more…)
Author Interviews, Beth Israel Deaconess, Emergency Care, Health Care Systems, JAMA / 05.11.2019

MedicalResearch.com Interview with: Laura Burke, MD, MPH Department of Emergency Medicine Beth Israel Deaconess Medical Center Boston, MA 02215Laura Burke, MD, MPH Department of Emergency Medicine Beth Israel Deaconess Medical Center Boston, MA 02215  MedicalResearch.com: What is the background for this study? Response: There has been a lot of attention to the growing intensity and costs of emergency care, but relatively little study of how outcomes have changed in recent years for patients using the ED. We examined 30-day mortality rates for traditional Medicare beneficiaries age 65 and older using the emergency department (ED) from 2009-2016 and also examined how their rates of hospitalization have changed over time.   (more…)
AHA Journals, Author Interviews, Blood Pressure - Hypertension, Heart Disease / 05.11.2019

MedicalResearch.com Interview with: Rachel E. Climie PhD INSERM U970, Paris Cardiovascular Research Center (PARCC) Integrative Epidemiology of Cardiovascular Disease Team, University de Paris, Paris, France.  MedicalResearch.com: What is the background for this study? Response: It is well known that physical activity (PA) is beneficial for cardiovascular health. However, little consideration is given as to whether different domains of PA have differing associations with health outcomes. Indeed, recent work has shown that high amounts of PA at work are associated with increased risk of early death, however the underlying mechanisms are unknown. In this study, we explored the relationship between physical activity at work, during leisure time and as structured sport with baroreflex sensitivity. We distinguished between the mechanical (dependent on the stiffness of the arterial wall) and neural (nerve impulses sent by the receptors on the walls of the artery) components of the baroreflex. Importantly, baroreflex sensitivity is crucial for short- term blood pressure control and reduced baroreflex function is related to higher risk of cardiac mortality and sudden death.  (more…)
Author Interviews, Environmental Risks, JAMA, Pediatrics, Schizophrenia / 04.11.2019

MedicalResearch.com Interview with: Henriette Thisted Horsdal Senior Researcher Department of Economics and Business Economics AARHUS University Henriette Thisted Horsdal PhD Senior Researcher Department of Economics and Business Economics AARHUS University  MedicalResearch.com: What is the background for this study? Response: Recent studies have suggested that exposure to nitrogen dioxide during childhood is associated with elevated risk of subsequently developing schizophrenia. We know that schizophrenia has a genetic component, and that individuals with higher genetic loading for schizophrenia tend to live in more densely urban areas. It is not known whether the increased risk associated with exposure to nitrogen dioxide during childhood is owing to a greater genetic liability among those exposed to highest nitrogen dioxide levels. Exposure to nitrogen dioxide during childhood and genetic liability (as measured by a polygenic risk score) for schizophrenia were independently associated with increased schizophrenia risk.  (more…)
Accidents & Violence, Author Interviews, JAMA, Ophthalmology, Pediatrics / 03.11.2019

MedicalResearch.com Interview with: Joyce Nanjinga Mbekeani, M.B.B.S. Associate Professor Department of Ophthalmology and Visual Sciences Montefiore Medical Center, Bronx, New York MedicalResearch.com: What is the background for this study? Response: The United States has the highest incidence of gun violence, of all affluent, OECD countries. Thus, firearms are a major public health concern, ranking second among causes of pediatric trauma-related injuries that result in significant morbidity and mortality. However, most scientific reports addressing pediatric firearm-related eye injuries have evaluated non-powder (recreational) firearm injuries. Our study used the large National Trauma Data Bank (NTDB) to study firearm-related eye injuries for all types of firearms from all intentions of injury. The NTDB collects de-identified submissions of trauma admissions from over 900 facilities in the US.  (more…)
Author Interviews, Cancer Research, Gender Differences, JAMA / 02.11.2019

MedicalResearch.com Interview with: Nina Niu Sanford, M.D. Assistant Professor Dedman Family Scholar in Clinical Care UT Southwestern Department of Radiation Oncology Dallas TX MedicalResearch.com: What is the background for this study? Response: Minority racial/ethnic groups present at later stages of cancer and have worse stage-specific survival rates.  Cultural competency represents a single element within the dynamic and trans-disciplinary field of health disparities, but is an important modifiable factor for both providers and health organizations that could be associated with disparities in cancer outcomes. There have been longstanding initiatives and training requirements in medical education specifically designed to improve provider cultural competency over the past couple of decades, and the American Society of Clinical Oncology (ASCO) has recently outlined goals for improving cultural competency within its policy statement on cancer disparities. Moreover, ASCO health disparity policies have recently highlighted the association between racial/ethnic disparities in cancer outcomes and a “lack of access to high-quality care that is understanding and respectful of diverse traditions and cultures plays a significant role.”  Given the above, we wished to assess access to culturally competent providers among patients with cancer by race/ethnicity. (more…)
Author Interviews, Genetic Research, JAMA, Ophthalmology / 02.11.2019

MedicalResearch.com Interview with: Professor Jeremy A. Guggenheim School of Optometry & Vision Sciences Cardiff University, UKProfessor Jeremy A. Guggenheim School of Optometry & Vision Sciences Cardiff University, UK MedicalResearch.com: What is the background for this study? Response: Near-sightedness (myopia) usually develops during childhood and necessitates the use of glasses or contact lenses to correct blurry distance vision. It is also a risk factor for sight-threatening disorders such as glaucoma, retinal detachment and macular degeneration. Promising treatments designed to slow the progression of myopia are becoming available. Building on previous research suggesting that some individuals are genetically predisposed to near-sightedness, we investigated whether a genetic test could identify children at risk of developing myopia.  (more…)
Author Interviews, Cost of Health Care, JAMA / 01.11.2019

MedicalResearch.com Interview with: Rena M. Conti, PhD, Associate Professor Department of Markets, Public Policy and Law Questrom School of Business Boston University Boston, MA 02215 Co-Authors: Sayeh S. Nikpay, PhD Melinda B. Buntin, PhD Vanderbilt University School of Medicine MedicalResearch.com: What is the background for this study? Response: The federal 340B program provides deep discounts on the acquisition cost of prescription drugs for participating hospitals and places no limits on what hospitals charge patients and insurers.  Congress intended 340B profits generated from hospital participation to subsidize the provision of safety net care for patients residing in the community. This study is the first to estimate the size of profits hospitals participating in the 340B drug discount program collect from Medicare patients for the outpatient clinic administration of prescription drugs. (more…)
Author Interviews, JAMA, Osteoporosis, Weight Research / 01.11.2019

MedicalResearch.com Interview with: Radhika Seimon, PhD Research Fellow at the University of Sydney Amanda Salis, PhD - Professor of Obesity Research at the University of Sydney Senior Research Fellow National Health and Medical Research Council of Australia  MedicalResearch.com: What is the background for this study? Response: Total meal replacement diets are severely energy-restricted diets that involve replacing all or almost all foods with nutritionally replete meal replacement products such as shakes, soups, or bars (i.e. total diet replacement). They are the most effective dietary treatment for obesity, resulting in greater short- and long-term weight loss compared with conventional food-based diets. However, there are concerns that total meal replacement diets may adversely affect body composition, notably lean mass and bone mineral density. (more…)
Author Interviews, Education, NEJM, Surgical Research / 31.10.2019

MedicalResearch.com Interview with: Ryan J. Ellis, MD MS General Surgery Resident Surgical Outcomes and Quality Improvement Center (SOQIC) Northwestern Medicine  MedicalResearch.com: What is the background for this study? Response: Burnout has emerged as a significant problem affecting the entire healthcare workforce and it has been likely to myriad downstream problems such as increases in medical errors, alcoholism, and depression. Despite the attention on clinician burnout, there are significant gaps in our understanding of how the workplace environment may lead to burnout. Moreover, there are particular concerns about the workplace environment in training, specifically with regards to abuse, discrimination, and harassment. We had the opportunity to survey all U.S. general surgery residents to comprehensively define the frequency of workplace mistreatment and its relationship with burnout and suicidal thoughts among surgical residents. (more…)
Author Interviews, Cancer Research, JAMA, Melanoma, Surgical Research, Weight Research / 30.10.2019

MedicalResearch.com Interview with: Magdalena Taube, PhD Institute of Medicine, Dept of Molecular and Clinical Medicine Sahlgrenska Academy at Gothenburg University Wallenberg laboratory Gothenburg Sweden  MedicalResearch.com: What is the background for this study? Response: Obesity is a cancer risk factor, and bariatric surgery in patients with obesity is associated with reduced cancer risk. However, evidence of an association among obesity, bariatric surgery and skin cancer is limited. In this study we used data from the Swedish Obese Subjects (SOS) study– a prospective controlled intervention trial examining bariatric surgery outcomes – to analyze the impact of bariatric surgery on skin cancer incidence. (more…)
Author Interviews, Columbia, Infections / 30.10.2019

MedicalResearch.com Interview with: Barun Mathema PhD Assistant Professor,Epidemiology Mailman School of Public Health Columbia University MedicalResearch.com: What is the background for this study? Response: In 2005 a major outbreak of extensively drug-resistant tuberculosis (XDR-TB) causing over 90% mortality was reported in rural town of Tugela Ferry, KwaZulu-Natal, South Africa. The strain that caused the outbreak was resistant to all first and most second line antibiotics. This strain has since been recovered throughout the district and accounts for over 79% of all XDR-TB. We were interested in understanding the basic epidemiological and evolutionary forces that enabled this strain to proliferate. More simply, when and where this strain emerged, and how and why it became dominant.  (more…)
Author Interviews, Heart Disease, Race/Ethnic Diversity / 30.10.2019

MedicalResearch.com Interview with: Michelle Morse, MD, MPH Founding Co-Director, EqualHealth Soros Equality Fellow Assistant Professor, Harvard Medical School Co-Founder, Social Medicine Consortium  MedicalResearch.com: What is the background for this study?
  • Response: Frontline clinicians have a unique vantage point to identify and characterize inequities in care. This study was inspired by internal medicine residents’ first-hand clinical experiences of black and Latinx patients who were frequently admitted to the general medicine service, as opposed to the cardiology service, with an ultimate diagnosis of HF.
  • Research has shown that structural inequities are pervasive throughout healthcare delivery systems and across many services, within both the inpatient and outpatient arenas. We hope other institutions and clinicians will be equally committed to addressing inequities in their own contexts, systems, and care settings and that patients will identify opportunities for self-advocacy in their care.
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Accidents & Violence, Author Interviews, JAMA, Pediatrics / 29.10.2019

MedicalResearch.com Interview with:   Carole Stipelman MD MPH Associate Professor of Pediatrics Physician Informatics Team Medical Director, University Pediatric Clinic Salt Lake City, Utah     MedicalResearch.com: What is the background for this study? What are the main findings? 
  • Guns are the second leading cause of death in children and adolescents.
  • 6 million children live in homes with at least one gun that is loaded and unlocked.
  • Safe storage of guns increases when physicians speak with parents about how to prevent children from having access to guns. However, these conversations happen infrequently.
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Author Interviews, Biomarkers, Schizophrenia / 29.10.2019

MedicalResearch.com Interview with: Dr.  Takeo Yoshikawa MD PhD RIKEN Center for Brain Science Japan MedicalResearch.com: What is the background for this study? What are the main findings?
  • Currently available drugs for schizophrenia are the dopamine D2 receptor blockers. These compounds were serendipitously discovered over half-century ago. But about 30% of schizophrenia are resistant to the dopamine D2 receptor blockers. In spite of these conditions, pharmaceutical companies have abandoned the development of new drugs. This is because we do not know the principle of drug design.
  • Therefore, we need to understand the molecular underpinning of as-yet unknown schizophrenia pathophysiology. Schizophrenia is diagnosed by only patients’ symptoms, not by biological examination. To search for biological underpinning for schizophrenia using experimental animals, we thought that we should examine an endophenotype (biological trait) relevant to schizophrenia. Then we targeted prepulse (PPI) performance.
  • Here, dampened PPI is considered as a biological marker of psychiatric disorders, typically of schizophrenia. Importantly, PPI can be measured using the same behavioral paradigm between experimental animals and human.
  • C57BL/6 (B6) inbred mouse shows higher (better) prepulse inhibition (PPI) performance, while C3H/He (C3H) inbred mouse shows lowered (worse ) PPI. We premised that C3H mouse is “schizophrenia-prone” and B6 is not. To know the molecular basis for differential PPI levels between the two inbred mouse strains, we performed comprehensive protein expression level analysis (proteomics analysis) using the brains of B6 and C3H mice.
  • The expression levels of Mpst, a hydrogen sulfide (H2S)-producing enzyme, is elevated in C3H mouse compared to B6 mouse. Biochemical analysis also supported the elevated H2S production in C3H mouse compared to B6.
  • The examination of human samples including postmortem brains, iPS-derived neural stem cells (neurospheres) and hair follicle cells, gave evidence that H2S production system is indeed up-regulated in schizophrenia.
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Addiction, Author Interviews, Mental Health Research, Technology / 29.10.2019

MedicalResearch.com Interview with: Zsolt Demetrovics PhD and Orsolya Király PhD Department of Clinical Psychology and Addiction Institute of Psychology ELTE Eötvös Loránd University MedicalResearch.com: What is the background for this study? Response: Gaming disorder has recently been recognized by the World Health Organization (WHO) as a mental disorder. Research examining gaming motivations and mental health among video gamers and in relation with gaming disorder is increasing but different types of gamers such as recreational gamers and esport gamers are not commonly distinguished. Esport is form of electronic sport and refers to playing video games in a professional (competitive) manner in sports-like tournaments. Much like in the case of traditional sports, esport players and teams are sponsored, tournaments are broadcasted and followed by large audiences and have large financial prizes. Therefore, being an esports player in now a real career opportunity for teenagers and young adults who like playing video games.  (more…)
Author Interviews, Exercise - Fitness, Heart Disease, Hip Fractures, JAMA, Menopause / 28.10.2019

MedicalResearch.com Interview with: Jean Wactawski-Wende PhD Dean, SUNY Distinguished Professor Department of Epidemiology and Environmental Health School of Public Health and Health Professions University of Buffalo MedicalResearch.com: What is the background for this study? What are the main findings?  Response: This study included data from the Women’s Health Initiative, a prospective study of postmenopausal women from across the United States. We assessed physical activity in 77,206 women over an average of 14 years of follow-up. Approximately 1/3 of these women (average age 63.4 years) had at least one fracture occur. Higher physical activity levels were associated with  lower risk of hip and total fracture. Even levels of activity that were moderate, including regular walking and doing household chores, were beneficial.  (more…)
Author Interviews, Mental Health Research / 26.10.2019

massage-therapyThousands of people are diagnosed with a psychiatric disorder each year. The National Alliance on Mental Illness estimates that 18.5% percent of the adult population in the U.S. experiences a mental condition in any given year. As the epidemic of mental disorders threatens to engulf many more, those affected are resorting to holistic treatment approaches like meditation and massage therapy. In the following post, we’ll explain how massage is being used to treat psychiatric disorders and the resulting benefits. (more…)
Author Interviews, Dermatology / 25.10.2019

MedicalResearch.com Interview with: Dr. Stephan Weidinger, MD, MaHM Professor of Dermatology Christian-Albrechts-Universit Kiel  MedicalResearch.com: What is the background for this study? What are the main findings? Response: Relatively little is known about the epidemiology and burden of Atopic Dermatitis (AD) in children, adolescents and adults, however, there is increasing evidence that the disease is highly prevalent also in these age groups. Further, very little is known about the disease severity strata. Severity, however, largely defines treatment needs. The EPI-CARE (EPIdemiology of Children with Atopic dermatitis Reporting on their Experience) study was a cross-sectional web-based study of the prevalence and burden of AD in both children and adolescents. It was performed globally across Europe, North America (US, Canada), Latin America (Argentina, Brazil, Colombia, Mexico), Asia (Japan, Taiwan), the Middle East (Israel, Kingdom of Saudi Arabia, Turkey, the United Arab Emirates) and Russia, and used very stringent definitions of AD and the same methodology across age groups. We first analyzed the adolescent data, and it turned out that the prevalence of active Atopic Dermatitis is higher than expected, ranging from 9.29% in the US and 14.7% in Europe. Of note, almost 50% of the adolescents with current AD reported an overall moderate to severe disease activity, and the majority reported a multidimensional burden that includes not only the skin symptoms associated with AD, but also sleep disturbances, symptoms of anxiety/depression, and reductions in quality‐of‐life and productivity. Adolescents also reported a high burden of coexisting atopic diseases that increased with AD severity – 68.6% of those with moderate AD and 81% of those with severe AD reported at least one coexisting atopic disease. atopic dermatitis substantially affects the life of patients and their families, and this burden is higher with greater AD severity. (more…)
Author Interviews, Environmental Risks, Occupational Health, Pulmonary Disease / 24.10.2019

MedicalResearch.com Interview with: Orianne Dumas, PhD INSERM Aging and Chronic Diseases, Epidemiological and Public Health Approaches,Villejuif, University de Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux France  MedicalResearch.com: What is the background for this study? Response: Exposure to cleaning products and disinfectants is common at work and at home and remains more frequent among women. Exposure levels are particularly high in the health care industry. The respiratory health risks associated with exposure to cleaning products and disinfectants are increasingly recognized. Although investigators have primarily focused on asthma, the irritant properties of many chemicals contained in disinfectants support the study of a broader range of respiratory effects, such as chronic obstructive pulmonary disease (COPD). (more…)