Author Interviews, Cancer Research, Infections / 27.01.2016
Antimicrobial and Anticancer Properties of Nisin Explored
MedicalResearch.com Interview with:
Yvonne Kapila, DDS, PhD
Professor, Division of Periodontics
Department of Periodontics and Oral Medicine
University of Michigan School of Dentistry
Ann Arbor, MI
Medical Research: What is the background for this study? What are the main findings?
Dr. Kapila: Our research showed that the preservative nisin induces cancer cell death. When tested on normal control cells to see if they were affected, the control cells were not affected. Thus, the most recent project began in order to find out more details as to why this occurred. We used a cancer mouse model (head and neck cancer) to show that nisin can retard tumor growth and extent the life of these mice.
Another thing that we published about the preservative is nisin’s role on biofilms. Biofilms are communities of bacteria that can cause diseases. Nisin has been tested in bacterial biofilms that contain bacteria that cause gum disease and dental decay and nisin has been found to be effective in this setting as well.
In laboratory settings, nisin is also cytotoxic to superbugs, including the most resistant bugs found in hospitals, and therefore nisin holds promise for several therapeutic applications.
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