Author Interviews, Diabetes, Kidney Disease / 30.03.2014
Diabetic Kidney Disease: Potential New Therapeutic Target Discovered
MedicalResearch.com Interview with:
Dr. Paolo Fiorina, MD PhD
Assistant Professor, Division of Nephrology,
Harvard Medical School
and
Dr. Roberto Bassi
Post-doctoral research fellow
Nephrology Department at Children's Hospital Boston.
MedicalResearch.com: What are the main findings of the study?
Dr. Fiorina: It is common knowledge that type 2 diabetes is a worldwide epidemic and that diabetic nephropathy has become the leading cause of renal failure in the western world. One of the main drivers and worsening factors for the diabetic kidney disease is proteinuria associated with various degrees of tubular damage, and unfortunately, therapies to halt or prevent this complication are not available so far. Our findings show that B7-1 when expressed on podocytes (a specific subset of renal cells) determines alterations in podocytes function and morphology, predisposing individuals with T2D to the loss of proteins into the urine. We also demonstrate that Abatacept, an immunomodulatory drug currently employed for the treatment of a variety of autoimmune diseases, is able to specifically target this malignant pathway, preventing podocytes cellular alterations in vitro and proteinuria development in two murine models of diabetic nephropathy in vivo.
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