Accidents & Violence, Author Interviews, NEJM / 02.01.2014

MedicalResearch.com Interview with: Sheila G. Klauer, Ph.D Virginia Tech Transportation Institute MedicalResearch.com: What are the main findings of the study? Dr.Klauer: We found that novice drivers are especially at risk of crash/near-crash involvement when engaging in secondary tasks that take their eyes off of the forward roadway.  This includes tasks with wireless devices such as texting, dialing, and reaching for the device as well as reaching for any object, eating, and looking at objects along the roadway.  We also found that the prevalence of engaging in these high risk tasks increases over time which concerns traffic safety researchers.  This is particularly concerning with the proliferation of highly capable smart phones where teens can do not only texting but also sending pictures, watching video, skype, etc. (more…)
Author Interviews, Education, Nutrition, Sugar / 02.01.2014

Sohyun Park, PhD, Division of Nutrition, Physical Activity, and Obesity National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention Atlanta, GA 30341MedicalResearch.com Interview with: Sohyun Park, PhD, Division of Nutrition, Physical Activity, and Obesity National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention Atlanta, GA 30341 MedicalResearch.com:  What are the main findings of the study? Dr. Park: Nearly 1 out of 3 U.S. adults (30.5%) consumed sugar-sweetened beverages at least 1 time per day; 20% consumed sugar-sweetened beverages at least 2 times per day. About 8 out of 10 adults agreed that drinking sugar-sweetened beverages can contribute to weight gain. However, 8 of 10 adults also did not know the actual calorie content of a 24-oz fountain soda. After controlling for sociodemographic factors, adults who were neutral (neither agreed nor disagreed) that drinking sugar-sweetened beverages can contribute to weight gain were more than 1-and-a-half times more likely to consume sugar-sweetened beverages at least 2 times per day. Conversely, knowledge about the calorie content of a 24-oz fountain soda was not associated with sugar-sweetened beverage intake. (more…)
Alzheimer's - Dementia, Author Interviews, JAMA, Lipids / 02.01.2014

MedicalResearch.com Interview with: Dr. Bruce Reed PhD Professor of Neurology, Associate Director UC Davis Alzheimer's Disease Center Davis, CA 95616 Dr. Bruce Reed PhD Professor of Neurology, Associate Director UC Davis Alzheimer's Disease Center Davis, CA 95616 MedicalResearch.com: What are the main findings of the study? Dr. Reed: We found that high LDL cholesterol and low HDL cholesterol in blood  were both associated with higher amyloid deposition in the brain.  This is potentially very important because the deposition of amyloid seems to be a critical step that kicks off a whole chain of events that eventually lead to Alzheimer's disease.  It is widely believed (although not proven) that if this deposition of amyloid could be blocked that we could greatly decrease the incidence of Alzheimer's.  The connection to cholesterol is exciting because we know a fair amount about how to change cholesterol levels.  A great deal more research needs to be done, but this does suggest a potential new path toward trying to prevent AD. (more…)
Author Interviews, CHEST, Critical Care - Intensive Care - ICUs, Respiratory / 02.01.2014

MedicalResearch.com Interview with: Dr Simone Gattarello Vall d’Hebron Hospital, Critical Care Department Universitat Autonoma de Barcelona and Medicine Department, Spain MedicalResearch.com: What are the main findings of the study? Dr. Gattarello: The main findings from the present study are a 15% decrease in ICU mortality due to severe community-acquired pneumonia caused by Streptococcus pneumoniae in the last decade; moreover, several changes in antibiotic prescription practices were detected and an association between improved survival and both earlier antibiotic administration and increased combined antibiotic therapy were identified. In summary, in severe pneumococcal pneumonia combined antibiotic therapy and early antibiotic administration are associated with lower mortality. (more…)
Author Interviews, Duke, JAMA, Pediatrics, Sexual Health / 31.12.2013

Stewart C. Alexander, PhD Department of Medicine Duke University Medical Center Durham, North CarolinaMedicalResearch.com Interview with: Stewart C. Alexander, PhD Department of Medicine Duke University Medical Center Durham, North Carolina MedicalResearch.com: What are the main findings of the study? Dr. Alexander: Adolescents are reluctant to talk about sex with their doctors and won't raise the topic with their doctors. For physicians, there are common and valid barriers to talking about sexuality with adolescents, including time pressures and discomfort with the topic. Two-thirds of adolescents in our study had some sexuality talk during their annual visit, lasting 36 seconds long. Girls, African Americans, and older teens were more likely to receive sexuality talk. Additionally, longer visits and visits where the physician talked confidentially with their adolescent patient were more likely to have sexuality talk. Our study suggest that sexuality conversations in annual visits can be improved. (more…)
Author Interviews, Heart Disease, Kidney Disease / 31.12.2013

Dr Amitava Banerjee NIHR Clinical Lecturer in Cardiovascular Medicine University of Birmingham UK MedicalResearch.com Interview with: Dr Amitava Banerjee NIHR Clinical Lecturer in Cardiovascular Medicine University of Birmingham UK MedicalResearch.com: What are the main findings of the study? This was the first long-term study in individuals with atrial fibrillation to consider the impact of renal function, as measured by eGFR, on stroke/thromboembolism, mortality and bleeding in the same population concurrently. Answer: There were three main findings of our study.
  • First, patients with worsening renal function had more severe risk factor profiles and had higher rates of stroke/thromboembolism, mortality and bleeding.
  • Second, individuals receiving oral anticoagulation had lower rates of stroke/thromboembolism and mortality than those not receiving anticoagulation at all levels of renal function measured by eGFR, suggesting that anticoagulation has benefit in even patients with low eGFR.
  • Third, renal function was not an independent predictor of stroke/thromboembolism at 1 year after adjustment for baseline characteristics. (more…)
Annals Internal Medicine, Author Interviews, CT Scanning, Lung Cancer / 31.12.2013

dr_harry_j_dekonigMedicalResearch.com Interview with: Harry J de Koning, MD PhD Professor of Public Health & Screening Evaluation Rotterdam, The Netherlands. MedicalResearch.com: What are the main findings of the study? Dr. de Koning: Annual CT screening for lung cancer has a favorable benefit-to-harm ratio for individuals ages 55 through 80 years with 30 or more pack-years’ exposure to smoking. It would lead to 50% (model ranges, 45% to 54) of cases of cancer being detected at an early stage (stage I/II), 575 screenings examinations per lung cancer death averted, a 14% (range, 8.2% to 23.5%) reduction in lung cancer mortality, 497 lung cancer deaths averted, and 5250 life-years gained per the 100 000-member (1950-) cohort. Harms would include 67 550 false-positive test results, 910 biopsies or surgeries for benign lesions, and 190 overdiagnosed cases of cancer (3.7% of all cases of lung cancer [model ranges, 1.4% to 8.3%]), again for a 100 000-member (1950-) cohort. (more…)
Author Interviews, Colon Cancer, Gastrointestinal Disease / 31.12.2013

MedicalResearch.com Interview with: Chia-Hung Kao, MD Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taiwan. MedicalResearch.com: What are the main findings of the study? Answer: Colonic diverticular disease and colorectal cancer shared certain characteristics. Some previous studies aimed to identify their epidemiological correlation. However, their results were discrepant and insufficiently strong to draw firm conclusion. In our nationwide population-based retrospective cohort study, we found that the previously diagnosed colonic diverticular disease is not associated with an elevated risk of colorectal cancer after the first year of a diagnosis of colonic diverticular disease (adjusted HR, 0.96). The increased risk in the first year may be due to misclassification and screening effect. (more…)
Author Interviews, Cognitive Issues, JAMA, Mayo Clinic, Thyroid Disease / 31.12.2013

Ajay K Parsaik, MD, MS Department of Psychiatry and Behavior Sciences The University of Texas Medical School, Houston Department of Neurology and Mayo Alzheimer’s Disease Research Center, Mayo Clinic, Rochester, MinnesotaMedicalResearch.com Interview with: Ajay K Parsaik, MD, MS Department of Psychiatry and Behavior Sciences The University of Texas Medical School, Houston Department of Neurology and Mayo Alzheimer’s Disease Research Center, Mayo Clinic, Rochester, Minnesota MedicalResearch.com: What are the main findings of the study? Dr. Parsaik: Main findings of our study are that clinical and subclinical hypothyroidism is not associated with mild cognitive impairment in an elderly population after accounting for possible confounding factors and interactions. (more…)
Author Interviews, BMJ, Brigham & Women's - Harvard, Hospital Readmissions, Medical Research Centers / 31.12.2013

Dr. Jacques Donzé MD PhD Research Associate Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital Harvard Medical School, Boston, MA 02115, USADivision of General Internal Medicine, Bern University Hospital, 3010 Bern, SwitzerlandMedicalResearch.com Interview with: Dr. Jacques Donzé MD PhD Research Associate Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital Harvard Medical School, Boston, MA 02115, MedicalResearch.com: What are the main findings of the study? Dr. Donzé: In a large retrospective cohort study, we identified the primary diagnoses of 30-day potentially avoidable readmissions in medical patients according to the most common comorbidities. Interestingly, almost all of the top five diagnoses of potentially avoidable readmissions for each comorbidity were possible direct or indirect complications of that comorbidity. Patients with cancer, heart failure, and chronic kidney disease had a significantly higher risk of potentially avoidable readmission than those without those comorbidities. Also, when readmitted, patients with chronic kidney disease had a 20% higher risk of having the readmission be potentially avoidable. (more…)
Author Interviews, Ophthalmology, Transplantation, UT Southwestern / 31.12.2013

Dr. Jerry Y. Niederkorn, Ph.D. George A. and Nancy P. Shutt Professorship in Medical Sciences Royal C. Miller Chair in Age-Related Macular Degeneration Research Professor of Ophthalmology and Microbiology Vice Chair, Research (Department of Ophthalmology) Department of Ophthalmology, University of Texas Southwestern Medical Center Dallas, TXMedicalResearch.com Interview with: Dr. Jerry Y. Niederkorn, Ph.D. George A. and Nancy P. Shutt Professorship in Medical Sciences Royal C. Miller Chair in Age-Related Macular Degeneration Research Professor of Ophthalmology and Microbiology Vice Chair, Research (Department of Ophthalmology) Department of Ophthalmology, University of Texas Southwestern Medical Center Dallas, TX FN-γ Blocks CD4+CD25+ Tregs and Abolishes Immune Privilege of Minor Histocompatibility Mismatched Corneal Allografts MedicalResearch.com: What are the main findings of the study? Dr. Niederkorn: These findings indicate that a combination of two simple maneuvers increases the acceptance of corneal transplants. In the past, there was no clear benefit in performing tissue matching of the cornea donor’s major histocompatibility complex (MHC) with the recipient of the corneal transplant. However, our study in experimental animals revealed that blocking a single immune system molecule called interferon-gamma (IFN-γ) combined with matching the corneal transplant donor with the transplant recipient’s MHC gene complex reduced the risk of rejection to less than 10% in the total absence of anti-rejection drugs. This study revealed that blocking this single immune system molecule promoted the development of immune system cells called T regulatory cells (Tregs) that suppressed the lymphocytes that are responsible for attacking organ transplants. (more…)
Allergies, Author Interviews, JAMA, OBGYNE / 29.12.2013

MedicalResearch.com Interview with: Michael C. Young, M.D. Associate Clinical Professor of Pediatrics Harvard Medical School Division of Allergy & Immunology Children's Hospital Boston MedicalResearch.com: What are the main findings of the study? Dr. Young: We found an association between increased maternal peripregnancy consumption of peanuts/ tree nuts and reduced risk of nut allergies in the offspring. (more…)
Author Interviews, Electronic Records / 29.12.2013

MedicalResearch.com Interview with: Leo Anthony Celi, MD, MS, MPH Massachusetts Institute of Technology Cambridge, MA 02139 Leo Anthony Celi, MD, MS, MPH Massachusetts Institute of Technology Cambridge, MA 02139 MedicalResearch.com: What are the main findings of the study? Dr. Celi: The main take home point from the paper is that we know little about how drug perform in the real world. Which patients truly benefit? Which patients are harmed? How do drugs interact with different acute (such as critical illness) and chronic conditions? These questions are almost never answered during pre-marketing research due to cost. We need a better system of following the life cycle of drugs post-marketing. Clinical databases provide us with this opportunity. (more…)
Author Interviews, JAMA, Ophthalmology / 29.12.2013

MedicalResearch.com Interview with: Dr. Yang Liu MedicalResearch.com Interview with: Dr. Yang Liu Preceptor and David A. Sullivan, MS, PhD, FARVO Senior Scientist, Schepens Eye Research Institute Associate Professor, Department of Ophthalmology Harvard Medical School Boston, MA, USA 02114 Founder, Tear Film & Ocular Surface SocietyDr. David A. Sullivan, MS, PhD, FARVO Senior Scientist, Schepens Eye Research Institute, Associate Professor, Department of Ophthalmology Harvard Medical School Boston, MA, USA  02114 MedicalResearch.com: What is the main finding of the study? Answer: We discovered that azithromycin (AZM) can directly stimulate the function of human meibomian gland epithelial cells. Given this finding, it is possible that this antibiotic may prove beneficial as a treatment for meibomian gland dysfunction (MGD), which is the leading cause of dry eye disease in the world. (more…)
Author Interviews, General Medicine, Race/Ethnic Diversity / 29.12.2013

Aisha T. Langford, PhD, MPH Postdoctoral Fellow VA Health Services Research and Development Service (HSR&D & U-M Center for Bioethics and Social Sciences in Medicine (CBSSM) 2800 Plymouth Road, NCRC Building 16, Room 400S-15 Ann Arbor, MI 48109MedicalResearch.com Interview with: Aisha T. Langford, PhD, MPH Postdoctoral Fellow VA Health Services Research and Development Service & U-M Center for Bioethics and Social Sciences in Medicine Ann Arbor, MI 48109 MedicalResearch.com: What are the main findings of the study? Dr. Langford: The main and perhaps most interesting finding was that there were no racial/ethnic differences in cancer clinical trial enrollment, refusal rates, or "no desire to participate in research" as the reason given for clinical trial refusal; however, patients over the age of 65 had lower odds of being enrolled in a clinical trial. Additionally, higher odds of having physical/medical conditions were associated with older age, males, and non-Hispanic blacks. (more…)
Author Interviews, Infections / 28.12.2013

Anders P. Hakansson, Ph.D. Assistant Professor of Microbiology Department of Microbiology and Immunology Buffalo, NY 14214MedicalResearch.com Interview with: Anders P. Hakansson, Ph.D. Assistant Professor of Microbiology Department of Microbiology and Immunology Buffalo, NY 14214 MedicalResearch.com: What are the main findings of the study: Dr. Hakansson: During the last couple of years we have shown that Streptococcus pneumoniae, a common colonizer of the nasopharynx in small children and elderly that sometimes cause respiratory infections such as middle ear infections and pneumonia, and Streptococcus pyogenes, a common colonizer of the oropharynx and also the cause of strep throat and skin infections, colonize us humans by forming biofilms; intricate bacterial communities. Biofilms have been studied for a long time but these specific organisms have not been shown to form biofilms during colonization until recently. As biofilms are much more resistant to environmental stresses and antibiotics, we were interested to see whether biofilms formed by these organisms could survive in the environment. The main reason for doing the experiments was that CDC guidelines indicate that spread of these organisms between individuals occur solely by inhalation of bacteria-containing droplets after coughing or sneezing. The risk of spread through surfaces has been estimated to be very low as laboratory experiments over the last 40 years have shown that these bacteria die very rapidly on surfaces. These studies were not, however, done with biofilm bacteria. Laura Marks in the laboratory with help from Ryan Reddinger therefore first tested how long biofilm bacteria could survive on plastic surfaces and found that rather than hours these bacteria were alive even after a month and could be used to successfully colonize animals. This made us interested in understanding if these bacteria survive better on hands, a common way to spread bacteria. And just as on inanimate surfaces, the biofilms survived much better on hands than bacteria grown in laboratory media. Based on these results, we were allowed to sample bacteria from stuffed toys, books, crib linens and others surfaces in a day care center early in the morning before the children arrived, and found both S. pneumoniae and S. pyogenes on these items. The results of the study indicate that these bacteria can survive in the environment longer than we have previously thought and may therefore play a role in spread between individuals. (more…)
Author Interviews, Gastrointestinal Disease, University of Pennsylvania / 26.12.2013

dr_henry_p_parkmanMedicalResearch.com Interview Invitation with Henry P. Parkman, MD Professor, Medicine Director, GI Motility Laboratory Temple University, Philadelphia, Pennsylvania
MedicalResearch.com: What are the main findings of the study? Dr. Parkman: Gastroparesis remains a challenging syndrome to manage with few effective treatments and a lack of rigorously controlled trials. Tricyclic antidepressants are often used to treat refractory symptoms of nausea, vomiting, and abdominal pain.  Evidence from well-designed studies for this is lacking. However, in this study, among patients with idiopathic gastroparesis, the use of nortriptyline compared with placebo for 15 weeks did not result in improvement in overall symptoms. These findings do not support the use of nortriptyline for idiopathic gastroparesis. (more…)
Author Interviews, JAMA, Pain Research, Pediatrics / 26.12.2013

Scott W. Powers, PhD APBB Division of Behavioral Medicine and Clinical Psychology and Division of Neurology, Cincinnati Children’s Hospital Medical Center Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OhioMedicalResearch.com Interview with: Scott W. Powers, PhD APBB Division of Behavioral Medicine and Clinical Psychology and Division of Neurology, Cincinnati Children’s Hospital Medical Center Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio MedicalResearch.com: What are the main findings of the study? Dr. Powers: Cognitive behavioral therapy plus amitriptyline resulted in greater reductions in days with headache and migraine-related disability compared with the use of headache education plus amitriptyline.  Children and adolescents with chronic migraine began the study with an average of 21 days with headache per 28 days and disability measured in the severe range.  After 20 weeks of treatment, 2 out of 3 participants in the CBT group had a 50% or greater reduction in headache days and 3 out of 4 had a reduction in disability to the mild to none range. (more…)
Author Interviews, NEJM, Orthopedics, Surgical Research / 26.12.2013

MedicalResearch.com Interview with: Raine Sihvonen, M.D. From the Department of Orthopedics and Traumatology Hatanpää City Hospital, Tampere Finland MedicalResearch.com: What are the main findings of the study? Dr. Järvinen: The main finding of the study is that arthroscopic partial meniscectomy is not superior over sham-surgery (placebo) when treated patients with knee pain attributable to degenerative  meniscus tear, even in the `best-case-scenario, that is patients with no knee OA. (more…)
Author Interviews, Diabetes, Education, Lancet, Nutrition / 23.12.2013

Prof. Raj S Bhopal Bruce and John Usher Professor of Public Health Edinburgh Ethnicity and Health Research Group, Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH89AGMedicalResearch.com Interview with: Prof. Raj S Bhopal Bruce and John Usher Professor of Public Health Edinburgh Ethnicity and Health Research Group, Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH89AG MedicalResearch.com: What are the main findings of the study? Prof. Bhopal: In a randomised controlled trial, a tailored, family orientated intervention whereby dietitians worked in the family home to provide diet and exercise advice in people at high risk of developing diabetes, had a modest but potentially important effect in reducing weight at the end of the three-year intervention, by 1.6 kg more than in the control group. (more…)
Author Interviews, General Medicine, PLoS / 23.12.2013

Dr. Beate Wieseler
 Head of Department Dept. Drug Assessment Institute for Quality and Efficiency 
in Health Care (IQWiG)
Im Mediapark Köln GermanyMedical Research.com Interview with: Dr. Beate Wieseler
 Head of Department Dept. Drug Assessment Institute for Quality and Efficiency 
in Health Care (IQWiG)
Im Mediapark Köln Germany MedicalResearch.com: What are the main findings of the study? Dr. Wieseler: Our study shows that unpublished clinical study reports, i.e. reports submitted to regulatory authorities during the approval procedure for a drug, provide substantially more information on patient-relevant outcomes than publicly available sources, i.e. articles published in medical journals and reports published in online clinical trial registries. (A “patient-relevant outcome” is an outcome describing morbidity, mortality or health-related quality of life.) (more…)
Author Interviews, Gastrointestinal Disease, JAMA, Johns Hopkins, Surgical Research / 22.12.2013

Nita Ahuja, MD Departments of Surgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, MarylandMedicalResearch.com Interview with: Nita Ahuja, MD Departments of Surgery and Oncology, Johns Hopkins University School of Medicine Baltimore, Maryland MedicalResearch.com: What are the main findings of the study? Dr. Ahuja: Across the nation, laparoscopic colectomy is performed about as frequently as open colectomy, despite being associated with a lower complication rate and a lower overall hospital cost. On the other hand,  an exponentially growing prevalence was found with robotic colectomy, a procedure that has so far demonstrated only equivalent outcomes with laparoscopic colectomy but a higher overall cost. (more…)
Author Interviews, Breast Cancer, Nutrition / 21.12.2013

Adana A.M. Llanos, PhD, MPH Assistant Professor, Department of Epidemiology RBHS-School of Public Health Rutgers, The State University of New Jersey Piscataway, NJ 08854MedicalResearch.com Interview with: Adana A.M. Llanos, PhD, MPH Assistant Professor, Department of Epidemiology RBHS-School of Public Health Rutgers, The State University of New Jersey Piscataway, NJ 08854 MedicalResearch.com: What are the main findings of the study? Dr. Llanos: Our longitudinal study examined the effects of both tomato-rich and soy-rich diets in a group of 70 postmenopausal women who participated in the study at The Ohio State University Comprehensive Cancer Center. For 10 weeks, women ate tomato products containing at least 25 milligrams of lycopene daily. For a separate 10-week period, the participants consumed at least 40 grams of soy protein daily. Before each test period began, the women were instructed to abstain from eating both tomato and soy products for two weeks. We examined the dietary intervention effects on hormone biomarkers known to be associated with obesity, namely adiponectin and leptin. After the tomato-rich diet participants' levels of adiponectin climbed nine percent. The effect was slightly stronger in women who had a lower body mass index. (more…)
Author Interviews, Parkinson's / 21.12.2013

Priv. Doz. Dr. Carsten Buhmann Department of Neurology University Medical Center Hamburg-Eppendorf, Hamburg, Germany.MedicalResearch.com Interview with: Priv. Doz. Dr. Carsten Buhmann Department of Neurology University Medical Center Hamburg-Eppendorf Hamburg, Germany. MedicalResearch.com: What are the main findings of the study? Answer: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has no negative but rather a beneficial effect on driving in patients with Parkinsons´s disease (PD). Driving not only was superior in even more clinically affected PD patients with DBS compared with PD patients without DBS but also patients with DBS drove better with stimulation than with levodopa. This might reflect favorable driving-relevant nonmotor effects due to STN-DBS. (more…)
Author Interviews, OBGYNE / 21.12.2013

MedicalResearch.com Interview with: Jean-Louis Serre EA 2493 ‘Pathologie Cellulaire and Génétique, de la Conception à la Naissance’, Université de Versailles, Saint Quentin en Yvelines, France SFGH (Société Française de Génétique Humaine), Villejuif, France and Jean-Pierre Siffroi Commission de Génétique, Fédération Française des CECOS, UMR S933 INSERM/Université Pierre et Marie Curie (UPMC), Paris, France MedicalResearch.com: What are the main findings of the study? Answers:
  • Anonymous sperm donation may lead to unions between relatives, especially between half-siblings and to an increase of both consanguinity and the frequencies of recessive diseases. We made an evaluation of the actual consequences of anonymous sperm donation in France and we concluded that they can be considered as negligible when compared to those due to false paternities, four times higher.
  • The risk of inadvertent unions between half-sibs is often advocated and we showed that it may be estimated to as few as one case every 10 years. Consequently, the main level of consanguinity in the French population is not modified and unions between first cousins within the sub-population from Mediterranean origin remain the main source of consanguinity.
(more…)
Alzheimer's - Dementia, Author Interviews, Cognitive Issues / 21.12.2013

MedicalResearch.com Interview with: Dr. Alan B. Zonderman PhD Cognition Section Laboratory of Personality and Cognition, NIA Gerontology Research Center Baltimore, MD 21224-6825 MedicalResearch.com: What are the main findings of the study? Dr. Zonderman: In a prospective population-based 5-year follow-up study the authors examined the rate at which participants converted from mild cognitive impairment to dementia or reverted from mild cognitive impairment to normal cognitive performance.  As has been common, they found elevated risk for dementia associated with mild cognitive impairment, but also found elevated risk for dementia among those who reverted (temporarily) to normal cognitive performance. (more…)
Author Interviews, Breast Cancer, Chemotherapy / 20.12.2013

MedicalResearch.com Interview with: Prof. Dr. med. Sibylle Loibl MD Unit Head of Medicine & Research Member of Management Board Associate Professor University Frankfurt GBG Forschungs GmbH
 Neu-Isenburg MedicalResearch.com: What are the main findings of the study? Dr. Loibl: We could demonstrate that patients with a HER2+ primary breast cancer harbouring a PIK3CA mutation are less likely to achieve a pathological complete response after treatment with an anthracycline/taxane containing therapy in combination with trastuzumab and lapatinib, than patients whose tumours does not harbour the mutation (so called wild type). This difference was largest in the group with HER2+, HR + tumours. The pCR rate in this cohort was as low as 6.3%. Looking at the differences in another study with either trastuzumab or lapatinib anti-HER2 treatment is seems as patients with a PIK3CA mutated tumour have a low pCR rate irrespective of the antiHER2 treatment, whereas the patients with a wild type tumour benefit from trastuzumab and the double blockade. (more…)