Author Interviews, HIV, NIH, PLoS / 18.01.2018
Brief Interruption of HIV Treatment Did Not Lead To Irreversible Expansion of Viral Reservoir
MedicalResearch.com Interview with:
Tae-Wook Chun, Ph.D.
National Institutes of Health
Bethesda, MD 20892
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: While antiretroviral therapy (ART) has improved the clinical outcome for people living with HIV, persistence of viral reservoirs in the peripheral blood and lymphoid tissues remains a hurdle to complete eradication of virus and cure of the infection. We know the vast majority of people living with HIV will experience plasma viral rebound within weeks of cessation of therapy. Considering that current research on the treatment of people living with HIV has been heavily focused on developing strategies aimed at achieving sustained virologic remission in the absence of ART, it is of great interest to investigate whether treatment interruption results in expansion of the viral reservoir and/or damage to the immune system. Using data from a recently concluded trial that employed short-term analytical treatment interruption (ATI), we found that, as expected, HIV DNA increased in the CD4+ T cells of individuals living with HIV during the treatment interruption phase. However, the size of the HIV reservoirs as well as immune parameters returned to baseline 6–12 months after the participants resumed ART. (more…)