Author Interviews, COVID -19 Coronavirus, Genetic Research, JAMA / 11.08.2020
Genetic Change Detected in Brothers Helps Explain Why COVID-19 More Severe in Men
MedicalResearch.com Interview with:
Caspar van der Made, MD
Resident in Internal Medicine, PhD-student
Alexander Hoischen, PhD
Geneticist, Assistant professor,
Departments of Human Genetics and Internal Medicine
Radboud University Medical enter
Nijmegen, The Netherlands
First author Caspar van der Made is a resident in Internal Medicine and PhD-student on the topic of immunogenomics.
Alexander Hoischen is geneticist with a special focus on the application of genomic technologies in primary immunodeficiencies and last author of this study.
MedicalResearch.com: What is the background for this study?
Response: This study was initiated to investigate the presence of monogenic factors that predispose young individuals to develop a severe form of COVID-19. It has become clear that several general risk factors such as obesity, hypertension and diabetes mellitus increase the risk of developing severe coronavirus disease. However, even though differences in interindividual genetic make-up are thought to influence the immune response to SARS-CoV-2, such specific genetic risk factors had not yet been identified.
We therefore chose to study young brother pairs (sharing half of their genomes) without any general risk factors that nevertheless contracted severe COVID-19.
We hypothesized these highly selected case series may offer the most optimal chance of identifying a (possible X-linked) primary immunodeficiency specific to COVID-19. (more…)