Author Interviews, Cancer Research, Gastrointestinal Disease, Genetic Research / 03.05.2021
Crohn’s Disease: Genetic and Cellular Mechanisms Identified
MedicalResearch.com Interview with:
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Dr. Cho[/caption]
Judy H. Cho, MD,
Dean of Translational Genetics
Director of The Charles Bronfman Institute for Personalized Medicine
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study? Would you briefly describe Crohn's disease? Whom does it primarily affect?
Response: Crohn’s disease is a chronic inflammatory intestinal disease, which affects ~3 million Americans a year. Its most typical age of onset ranges from 15-30 years, and many of those diagnosed also exhibit frequent abnormal healing and complications that constrict the digestive tract. The highest risk genetic mutations that increase risk for Crohn’s disease are found in the gene NOD2; these were first reported 20 years ago. Biological mechanisms by which NOD2 mutations drive Crohn’s disease, and especially fibrotic complications, have been incompletely described up until this point. Further, the reasons why many patients fail to respond to the commonly administered anti-TNF treatments also remain incompletely understood.
Dr. Cho[/caption]
Judy H. Cho, MD,
Dean of Translational Genetics
Director of The Charles Bronfman Institute for Personalized Medicine
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study? Would you briefly describe Crohn's disease? Whom does it primarily affect?
Response: Crohn’s disease is a chronic inflammatory intestinal disease, which affects ~3 million Americans a year. Its most typical age of onset ranges from 15-30 years, and many of those diagnosed also exhibit frequent abnormal healing and complications that constrict the digestive tract. The highest risk genetic mutations that increase risk for Crohn’s disease are found in the gene NOD2; these were first reported 20 years ago. Biological mechanisms by which NOD2 mutations drive Crohn’s disease, and especially fibrotic complications, have been incompletely described up until this point. Further, the reasons why many patients fail to respond to the commonly administered anti-TNF treatments also remain incompletely understood.
Dr. Hong-Sheng Wang[/caption]
Hong-Sheng Wang PhD
Department of Pharmacology and Systems Physiology
University of Cincinnati
College of Medicine, Cincinnati
MedicalResearch.com: What is the background for this study? What is the significance of tritan?
Response: Bisphenol A (BPA) is used widely in the manufacturing of consumer plastic goods. Researchers and the general public increasingly recognize the potentially harmful effect of BPA. These days BPA-based polycarbonate plastic water bottles have all but disappeared in most US stores, replaced by various BPA-free bottles including Tritan bottles.
Tritan is a plastic that is not based on BPA or BPA analogues. In earlier studies, we unexpectedly found transient release of BPA from some Tritan bottles. Similar results have been reported in a past study. We wanted to figure out why the BPA release from Tritan bottles, and how consumers can best clean their bottles.
As a specialized healthcare position where you will be responsible for the health and wellbeing of patients, nurses are required to hold a degree and a license before they can begin work. To qualify as a registered nurse, you will need to obtain a BSN degree, which typically takes around four years when studying full-time. However, if you already have a bachelor’s degree in another subject, there is an option that will allow you to become a nurse in half the time; accelerated nursing programs are designed for those who already have a bachelor’s degree and want a quick career change into nursing. The 
Dr. Yun Liu[/caption]
Yun Liu, PhD
Google Health
Palo Alto, California
MedicalResearch.com: What is the background for this study? Would you describe the system? Does it use dermatoscopic images?
Response: Dermatologic conditions are extremely common and a leading cause of morbidity worldwide. Due to limited access to dermatologists, patients often first seek help from non-specialists. However, non-specialists have been reported to have lower diagnostic accuracies compared to dermatologists, which may impact the quality of care.
In this study, we built upon prior work published in 
Prof. Reich[/caption]
Prof. Kristian Reich, MD, PhD
Professor for Translational Research in Inflammatory Skin Diseases
Institute for Health Services Research in Dermatology and Nursing
University Medical Center Hamburg-Eppendorf
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Complete skin clearance is an important treatment goal for patients with psoriasis and is closely associated with treatment satisfaction and improved quality of life. However, it remains an unmet need for many patients.
The interleukin (IL)-17 isoforms IL-17A and IL-17F play central roles in psoriasis pathophysiology and are overexpressed in psoriatic tissues. Existing biologic therapies, such as secukinumab, inhibit IL-17A only. However, increasing evidence indicates that IL-17F contributes independently to the pathobiology of plaque psoriasis, and that blocking both IL-17A and IL-17F may lead to more complete suppression of inflammation and superior clinical outcomes, compared with blocking IL‑17A alone.
Bimekizumab is a humanized monoclonal IgG1 antibody that has been designed to selectively inhibit IL-17F in addition to IL-17A.
Dr. Gamboa Madeira[/caption]
Sara Gamboa Madeira
Medical Doctor - General & Family Physician
PhD Student - EnviHealth&Co - Faculty of Medicine
Lisbon University
MedicalResearch.com: What is the background for this study?
Response: One in every five employees work in shifts across Europe1. Shift work have been associated with an increased risk for several cardiovascular diseases2 and three main mechanism have been proposed: unhealthy behaviours, disturbed sleep, and circadian misalignment.
This study focused on the role of circadian misalignment, which we assessed via social jetlag. Social jetlag is calculated using the Munich Chronotype Questionnaire3 by the difference between sleep behaviour on free-days (mainly driven by the individual “biological clock”, also called chronotype) and sleep behaviour on workdays (mainly drive by the “social clock”, namely work schedules). Chronotype is an individual feature which ranges from early/morning people to late/evening people (from proverbial lark to owls), with the majority of the population falling in between as a Gaussian distribution. Therefore higher levels of social jetlag mean a greater mismatch between what your biological clock need (e.g. go to sleep at 9pm) and what your social obligations impose on you (e.g. work until midnight).
Dr. Ulhas Nair[/caption]
Nishanth Ulhas Nair, Ph.D.
Affiliation: Staff Scientist at Cancer Data Science Laboratory, Center for Cancer Research
National Cancer Institute (NCI), National Institutes of Health (NIH)
Bethesda, Maryland, USA. Date: April 22, 2021
Dr. Raffit Hassan and Dr. Eytan Ruppin at the National Cancer Institute (NCI) are the senior authors of this study.
MedicalResearch.com: What is the background for this study?
Response: Malignant mesothelioma is an aggressive cancer with limited treatment options and poor prognosis. An in-depth knowledge of genetic, transcriptomic and immunogenic events involved in mesothelioma is critical for successful development of prognostics and therapeutic modalities. In this study we aim to address this by exploring a new large scale patient tumor dataset of 122 mesothelioma patients, called NCI mesothelioma patient data, along with their genomic, transcriptomic, and phenotypic information. Unlike previous large-scale studies which have been focused on malignant pleural mesothelioma patients, our dataset contains an approximately equal representation of malignant pleural and peritoneal mesothelioma patients which allows to identify any differences between them.
Prof. Papageorghiou[/caption]
Aris Papageorghiou MBChB, MRCOG
Professor of Fetal Medicine and the Clinical Research Director
Oxford Maternal and Perinatal Health Institute
University of Oxford
MedicalResearch.com: What is the background for this study?
Response: Our study was really guided by a key question: does Covid-19 in pregnancy increase the risk of adverse maternal and neonatal outcomes as compared with pregnant women who do not have the infection?
The question is highly relevant because of the known deleterious effects of other coronavirus infections in pregnancy, e.g. SARS (severe acute respiratory syndrome) and MERS-CoV (Middle East respiratory syndrome coronavirus).
In order to answer this question we undertook this multinational cohort study.
Dr. Hosie[/caption]
Margaret J. Hosie BVM&S, MRCVS, BSc. PhD.
Professor of Comparative Virology
MRC-University of Glasgow Centre for Virus Research
United Kingdom
MedicalResearch.com: What is the background for this study?
Response: SARS-CoV-2 is a new coronavirus of animal origin that recently jumped to humans and has spread rapidly across the world. It is likely that SARS-CoV-2 will establish as an endemic virus of humans, which has the potential to be transmitted to animals that live in close proximity to humans. There have been sporadic reports of infections in pet cats in households with COVID-19 patients, which demonstrates that cats are susceptible to SARS-CoV-2 infection and could act as virus reservoirs.
Dr. Blankson[/caption]
Joel N. Blankson, MD, PhD
Department of Infectious Diseases
Associate Professor
Cellular and Molecular Medicine Program
Johns Hopkins
MedicalResearch.com: What is the background for this study? Which vaccines did you evaluate?
Response: Prior studies from several groups including our own have found T cell cross-recognition of peptides from SARS-CoV-2 and the common cold coronaviruses.
We asked whether as a result of this cross-reactivity, immunization with the SARS-CoV-2 vaccine would also enhance T cell responses to the common cold coronaviruses.
Prior studies also suggested that antibodies elicited from the mRNA vaccines had a reduced ability to neutralize the emerging variants of concern.
Most of the study participants had received the Pfizer vaccine, but a few had received the Moderna vaccine. 
Dr. Lashaki[/caption]
Masoud Jahandar Lashaki, Ph.D.
Assistant Professor
Department of Civil, Environmental and Geomatics Engineering
Florida Atlantic University
MedicalResearch.com: What is the background for this study?
Response: Toilet flushing can generate large quantities of microbe-containing aerosols depending on the design and water pressure or flushing energy of the toilet. Based on previous reports, a variety of different pathogens which are found in stagnant water or in waste products (e.g., urine, feces, and vomit) can get dispersed widely via such aerosolization, including the legionella bacterium responsible for causing Legionnaire’s disease, the Ebola virus, the norovirus which causes severe gastroenteritis (food poisoning), and the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
Based on previous reports, such airborne dispersion is suspected to have played a key role in the outbreak of viral gastroenteritis aboard a cruise ship, where infection was twice as prevalent among passengers who used shared toilets compared to those who had private bathrooms. Similarly, transmission of norovirus via aerosolized droplets was linked to the occurrence of vomiting or diarrhea within an aircraft restroom, as passengers and crew who got infected subsequently were more likely to have visited restrooms than those that were not infected. The participants in the study reported that all of the restroom surfaces appeared to be clean, which indicates that infection is likely to have occurred via bioaerosols suspended within the restroom.
Although many of these studies blamed flush-generated aerosols for disease outbreak, a limited number of them quantified the presence of such aerosols. Consequently, we decided to conduct this study to demonstrate the spike in aerosol concentrations following flushing. 
Dr. Virani[/caption]
Senior & Corresponding Author
Salim S. Virani, MD, PhD, FACC, FAHA, FASPC
Professor, Section of Cardiovascular Research
Director, Cardiology Fellowship Training Program
Baylor College of Medicine
Staff Cardiologist, Michael E. DeBakey Veterans Affairs Medical Center
Co-Director, VA Advanced Fellowship in Health Services Research & Development Michael E. DeBakey VA Medical Center, Houston, TX
Investigator, Health Policy, Quality and Informatics Program
Michael E. DeBakey Veterans Affairs Medical Center HSR&D Center of Innovation
Houston, TX
MedicalResearch.com: What is the background for this study?
Response: Atherosclerotic cardiovascular disease (ASCVD), defined as ischemic heart disease (IHD), ischemic cerebrovascular disease (ICVD), or peripheral arterial disease (PAD), is the leading cause of death globally. Particularly in young ASCVD patients, secondary prevention with antiplatelet therapy and statins are extremely important in reducing disease burden.
Prof. Monsonego Ornan[/caption]
Efrat Monsonego Ornan, Ph.D
Head of School of Nutritional Sciences
Institute of Biochemistry and Nutrition
The Robert H. Smith Faculty of Agriculture,
Food and Environment
The Hebrew University of Jerusalem
MedicalResearch.com: What is the background for this study?
Response: Food supplies in recent decades have been dominated by heavily processed, ready-to-eat products. Essentially, 75% of all world food sales are of processed foods. Over the past 30 years, children’s ultra-processed food intake has increased markedly, with 50% of the children in the US consuming these foods. Only in the US does UPF comprise 58% of energy intake, of which 90% is derived from added sugars. This reflects children’s excessive consumption of food and drink that are high in fat and refined sugars but do not provide appropriate levels of the proteins, vitamins and minerals required for growth.
The negative health outcomes of excessive consumption of Ultra-processed food are well known, include obesity, metabolic syndrome and diabetes, and considered as the current world epidemic; the fact that children, during their postnatal development period (birth to adolescent), are the target of the Ultra-processed food industry is very disturbing in terms of public health. Bone development and growth are the characteristic phenomena of the childhood period. Yet, in spite of the huge importance of nutrition to bone development, the impact of Ultra-processed food consumption on skeleton development during childhood has never been studied directly, and this was the purpose of our study.
To this end, we used young rats which are an excellent pre-clinical model for growth and fed them with either the recommended diet for their age or a diet comprised of a typical Ultra-processed meal (a roll, hamburger, tomatoes, lettuce, ketchup and French fries) and a caloric soft drink. 
Dr. McPeek Hinz[/caption]
Eugenia McPeek Hinz MD MS FAMIA
Associate CMIO - DHTS
Duke University Health System
MedicalResearch.com: What is the background for this study?
Response: Clinician burnout rates have hovered around 50% for much of the past decade. Burnout is a significant concern in healthcare for its effects on care givers and associated downstream adverse implications on patient care for quality and safety. The ubiquitous presence of Electronic Health Records (EHR) along with the increased clerical components and after hours use has been a significant concern for contributing to provider burnout. 
Dr. Kruger[/caption]
Daniel J. Kruger Ph.D.
Research Investigator, Population Studies Center
University of Michigan
MedicalResearch.com: What is the background for this study?
Response: Thorstein Veblen coined the terms “conspicuous consumption” and “conspicuous leisure” to describe the wasteful habits of the upper classes in amassing and displaying expensive goods that did not have inherent practical benefits and devoting time to pursuits such as sports and fine arts. The purpose of these socially conspicuous displays and behaviors was to advertise one’s membership in the upper, leisure class, as only the very wealthy could afford them. Veblen was inspired in part by Charles Darwin’s theory of biological evolution. Darwin himself was greatly puzzled by what he considered wasteful investments of energy in elaborate physiological displays. He saw these features as the greatest threat to his theory of natural selection. Why would something like the peacock’s tail feathers evolve, as they actually threatened survival because of their impediment to foraging and avoiding predators? Darwin was so troubled by this dilemma that the sight of a peacock’s tail feather would make him feel sick. Darwin later realized that these features provided a reproductive advantage, leading to his theory of sexual selection, including the processes of inter-sexual selection and intra-sexual competition. 
Dr. Bullard[/caption]
Jared Bullard MD FRCPC
Associate Professor, Departments of Pediatrics & Child Health and Medical Microbiology & Infectious Diseases
Max Rady College of Medicine
Rady Faculty of Health Sciences
Cadham Provincial Laboratory
Children’s Hospital Research Institute of Manitoba
MedicalResearch.com: What is the background for this study?
Response: Children are well known to transmit epidemic/endemic respiratory viruses like influenza. Initial public health policy was based on that children were likely to transmit SARS-CoV-2 effectively within a community and subsequently in-person school and extracurricular activities were suspended.
Initial research did not show a clear association with children driving transmission. The purpose of our study was to take respiratory samples from both children and adults with COVID-19 (all had SARS-CoV-2 detected by RT-PCR) and compare those samples by their ability to grow in cell culture and amount of virus in samples.
We took 175 samples from children (97 younger than 10 years of age and 78 between 11-17 years) and compared them to 130 adult samples from the same communities in Manitoba experiencing outbreaks of COVID-19. 
Dr. Sickbert-Bennett[/caption]
Emily Sickbert-Bennett PhD, MS, CIC, FSHEA
Director, Infection Prevention, UNC Hospitals
Administrative Director, Carolina Antimicrobial Stewardship Program, UNC Hospitals
Associate Professor of Medicine-Infectious Diseases, UNC School of Medicine
Associate Professor of Epidemiology, UNC Gillings School of Global Public Health
MedicalResearch.com: What is the background for this study?
Response: Recently public health officials have recommended doubling masks, although the 
Dr. Dunietz[/caption]
Galit Levi Dunietz MPH, PhD
Assistant Professor
Dr. Braley[/caption]
