This work suggests that amyloid interplay between alpha-synuclein and Pmel may be one of the underlying mechanisms as to how...
Lone elderly living has proven to hasten the onset of age-related dementia and increases the chance of severe falls....
Sarah Windle[/caption]
Sarah Windle, MPH
PhD Student in Epidemiology
Department of Epidemiology, Biostatistics, and Occupational Health
McGill University (Montréal, Québec, Canada)
MedicalResearch.com: What is the background for this study?
Response: Concerns have been raised about the potential for increases in impaired driving following the legalization of recreational cannabis use in Canada in October 2018. Data from Statistics Canada suggest that cannabis use in the previous three months increased among adults (15 and older) from 14% before legalization in 2018 to 17% in 2019. Among those users with a driver’s license, 13% reported driving within two hours of cannabis use. While this proportion remained the same before and after legalization, this indicates that the absolute number of individuals who reported driving within two hours of use has increased following legalization (due to an increase in the number of users).
Dr. Pollard[/caption]
Michael S. Pollard Ph.D
Senior Sociologist; Professor
Pardee RAND Graduate School
MedicalResearch.com: What is the background for this study?
Response: The Centers for Disease Control and Prevention (CDC) has traditionally been a highly trusted source of public health information, and conveying information to the public about the vaccine and broader pandemic response is critical. This study examines changes in levels of public trust in the CDC between May and October, 2020, in light of the numerous challenges the CDC initially faced during the COVID-19 pandemic: technical problems with their COVID-19 testing kits, mixed messaging about the pandemic and mitigation strategies, and public commentary and interference by people in the Trump administration, for example.
Dr. Nguyen[/caption]
Dr. Thanh Nguyen MD
Director of Interventional Neurology/ Neuroradiology
Boston Medical Center
MedicalResearch.com: What is the background for this study?
Response: During the first wave of the COVID-19 pandemic in the spring of 2020, there were many regional and sometimes national reports of declines in stroke and myocardial infarction volumes. Our goal was to understand whether these declines were also seen for other neurological emergencies such as subarachnoid hemorrhage hospitalizations and ruptured aneurysm endovascular treatments.
Dr. Liedtke[/caption]
Wolfgang Liedtke, M.D., Ph.D.
Professor (tenured) of Neurology, Anesthesiology and Neurobiology
Dr. Ottesen Kennair[/caption]
Leif Edward Ottesen Kennair, Phd
Professor, Department of Psychology
Norwegian University of Science and Technology
Trondheim, Norway
MedicalResearch.com: What is the background for this study?
Response: We have two important lines of research running parallel: 1) research into casual sex research. Over several papers inspired by previous evolutionary studies on casual sex we map the proximate mechanisms involved in regret. However, the adaptive function of regret: more adaptive future choices, was not addressed. This is something that most people and most regret researchers just take for granted. Bendixen et al 2017, Kennair et al 2016, 2018. 2) Research into how worry and rumination is not adaptive and how changing metacognitions about these mental processes are helpful here and now, and how discontinuing these processes is an efficient treatment of GAD and MDD. Kennair et al 2017. Solem et al 2019.
We found that it was important to question whether regret indeed was adaptive and affected more adaptive future short-term sexual choices. However, this demands a longitudinal design and such data are not easy to collect.
MedicalResearch.com Interview with: [caption id="attachment_57059" align="alignleft" width="200"] Jill Sommerville[/caption] Jill Sommerville M.Sc. Director of Medical at WaterWipes MedicalResearch.com: What is the background for this...
Dr. Chien-Wen Tseng[/caption]
Chien-Wen Tseng, M.D., M.P.H., M.S.E.E.
The Hawaii Medical Service Association Endowed Chair
Health Services and Quality Research
Professor, and Associate Research Director
Department of Family Medicine and Community Health
University of Hawaii John A. Burns School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Age-related hearing loss cannot be reversed and can be a significant problem for older adults. Four out of 10 adults who are age 70 and older report hearing loss and it can worsen isolation, cognitive decline, and quality of life, as well as interfere with someone’s ability to live independently. There are simple screening tests to detect hearing loss, so the Task Force did an extensive review of whether there are health benefits to screening for hearing loss in people who do not have symptoms before they notice any hearing problems.
The Task Force determined that there is not enough evidence to recommend for or against screening for hearing loss in adults who are age 50 and older and do not have signs or symptoms of hearing loss. This is an I statement.
Prof. Mainous[/caption]
Arch G. Mainous III, PhD
Professor
Department of Health Services Research, Management and Policy
Professor and Vice Chair for Research
Department of Community Health and Family Medicine
University of Florida
MedicalResearch.com: What is the background for this study?
Response: We are always concerned about infections from antibiotic resistant bacteria. When the bacteria are resistant to our current treatments this lengthens the time and severity of the illness. Staphylococcus aureus is a major cause of community and healthcare associated infections. These range from skin infections to invasive infections and even death. Methicillin-resistant S. aureus (MRSA) is of particular concern and is a burden on the health care system. Importantly, patients colonized, not infected, with MRSA are more likely to develop MRSA infections and patients with MRSA infections have increased risk of hospital length of stay and even death.
We are always concerned about infections from antibiotic resistant bacteria. When the bacteria are resistant to our current treatments this lengthens the time and severity of the illness. Staphylococcus aureus is a major cause of community and healthcare associated infections. These range from skin infections to invasive infections and even death. Methicillin-resistant S. aureus (MRSA) is of particular concern and is a burden on the health care system. Importantly, patients colonized, not infected, with MRSA are more likely to develop MRSA infections and patients with MRSA infections have increased risk of hospital length of stay and even death.
Prof. D'Aiuto[/caption]
Francesco D’Aiuto
Professor/Hon Consultant
Head of Periodontology Unit
UCL Eastman Dental Institute
MedicalResearch.com: What is the background for this study?
Response: This study was set out to further our understanding of the link between gum disease and high blood pressure. Recent evidence suggested that individuals with gum disease had a 20-70% increased risk of hypertension and systemic inflammation seemed to be a driver in mediating this association. Further research on the matter was needed. We recruited two relatively large groups of otherwise healthy participants (without a confirmed diagnosis of hypertension) who had gum disease one and healthy gums the other.
We found that diagnosis of periodontitis (gum disease) was consistently linked to higher systolic blood pressure independent of other cardiovascular risk factors.
The first step that you should take to finding inner peace is to practice yoga and meditation regularly. Yoga and meditation can give you the chance to slow down and reflect, as well as to clear your mind of the worries and negative thoughts that are concerning you. Not only this, but deep breathing is also an important aspect of both yoga and meditation as this can help you to ground yourself and to reconnect with the world around you.
Dr. Dashti[/caption]
Hesam Dashti, PhD
Brigham and Women's Hospital, Harvard Medical School
Senior Computational Scientist
The Broad Institute of MIT and Harvard
MedicalResearch.com: What is the background for this study? What parameters does the SARS2 score take into consideration?
Response: While complex models have been developed for predicting the severity of COVID-19 from the medical history, laboratory, and imaging results of patients, simplified models with similar accuracy would be more practical for individualizing the decision making, especially when detailed medical history of patients is not readily available. In this study, we developed the SARS2 risk equations for estimating risk of hospitalization of patients with COVID-19 and also the risk of mortality among hospitalized patients. The “SARS2” risk equations are named for their input variables: Sex, Age, Race, Socioeconomic and Smoking status.
To develop and validate the models, we used the electronic records from 12,347 patients who tested positive for COVID-19 at the Mass General Brigham medical centers in Massachusetts between 02/26/2020 and 07/14/2020 to construct derivation and validation cohorts for estimating 1) risk of hospitalization within 30 days of COVID-19 positive PCR test, and 2) for the hospitalized patients, risk of mortality within approximately 3 months.
Dr. Sinha[/caption]
Pranay Sinha, MD
Section of Infectious Diseases
Boston University School of Medicine
MedicalResearch.com: What is the background for this study?
Response: We hypothesized that mitigation measures such as physical distancing and mask wearing instituted in Boston would reduce transmission of common respiratory viruses such as influenza, Rhinovirus, and Parainfluenzavirus. We compared the rate of detection of such viruses at Boston Medical Center on comprehensive respiratory panels in the ambulatory, emergency room, and hospital settings in 2020 to rates in the previous five years.
Dr. Meyer, J.D.[/caption]
Michelle N. Meyer, PhD, JD
Assistant Professor & Associate Director, Research Ethics, Center for Translational Bioethics & Health Care Policy
Faculty Co-Director, Behavioral Insights Team, Steele Institute for Health Innovation
Assistant Professor of Bioethics
Geisinger Commonwealth School of Medicine
Geisinger, PA
MedicalResearch.com: What is the background for this study?
Response: Earlier research had found people are less likely to say they'll receive a COVID-19 vaccine offered to them under an Emergency Use Authorization (EUA) than one offered to them following full FDA approval. Earlier surveys had also found that only around 30% of health care workers intended to receive a COVID-19 vaccine. Because the public often looks to local health care workers for health advice, and in most prioritization schemes they were slated to be offered vaccines first, this was quite concerning for the prospect of achieving population immunity. Commenters had warned that if the FDA chose to make COVID-19 vaccines available under EUAs, that substantial efforts would need to be made to ensure trust. On Dec. 4, 2020, an announcement about anticipated vaccine availability was emailed to all 23,784 Geisinger employees, who were asked to indicate their intention to receive a vaccine when one was available to them and the reasons for any hesitation they might have.
Dr. Grant[/caption]
Leilah K. Grant, PhD
Postdoctoral Research Fellow in Medicine
Brigham and Women’s Hospital
Harvard Medical School
MedicalResearch.com: What is the background for this study?
Response: The prevalence of obesity increases in women around the age of menopause which increases the risk of diseases like diabetes and heart disease. Changes in hormones, like estrogen, are thought to contribute to weight gain during menopause, but other common symptoms of menopause such as sleep interruption may also play a role. While short sleep is known to adversely affect metabolism, little is known about the metabolic consequences of the type of sleep disruption most common in menopausal women – increased nighttime awakenings (i.e., sleep interruption) caused by hot flashes, but no change in overall sleep duration. We therefore did this study to see how an experimental model menopause-related sleep interruption would affect metabolic outcomes that may contribute to weight gain. 
Dr. Rettew[/caption]
David C. Rettew, MD
Child & Adolescent Psychiatrist
Associate Professor of Psychiatry and Pediatrics
University of Vermont Larner College of Medicine
MedicalResearch.com: What is the background for this study?
Response: Our group, the Wellness Environment Scientific Team at the University of Vermont, hadn’t planned to look at COVID at the outset of this study and instead were going to look at mental health and engagement in wellness activities in college students across a semester. The pandemic disrupted that plan when students were abruptly sent home but fortunately, they continued to do their daily app-based ratings of their mood, stress levels, and engagement in healthy activities. We then realized we had some interesting pre-COVID to COVID data that was worth exploring. 
Dr. DeMartino[/caption]
Patrick DeMartino MD
Pediatric Hematology and Oncology Fellow
Doernbecher Children's Hospital
Oregon Health & Science University
MedicalResearch.com: What is the background for this study?
Response: Dozens of gene therapies are expected to be on the market within a decade or so. Much has been written about the high prices of the therapies currently on the market (exceeding $1 million). However, only a small number of patients are eligible for these existing therapies each year. Gene therapy for sickle cell disease (SCD) appears promising and would potentially apply to a relatively large number of individuals in the U.S. We sought to explore potential affordability challenges associated with a gene therapy for SCD.
Dr. Leuchter[/caption]
Richard K. Leuchter, MD
Resident Physician
Department of Internal Medicine
UCLA Health
MedicalResearch.com: What is the background for this study?
Response: There has been significant research demonstrating racial healthcare disparities among patients with COVID-19, but less exploring how the COVID-19 pandemic has affected the healthcare of racial & ethnic minority groups without COVID-19. It is important to understand the ways in which the pandemic has exacerbated the inequitable delivery of healthcare in order to design policies to address these racial injustices.
We focused on potentially avoidable hospitalizations, which are admissions to a hospital (not for COVID-19) that likely could have been prevented through timely and high-quality outpatient care. Prior research has shown that avoidable hospitalizations are markers for access to outpatient care, and expose patients to preventable financial burden, separate them from their families, and put them at risk for hospital-acquired infections.
Prof.Auger[/caption]
Nathalie Auger
Professeure agrégée de clinique
École de santé publique - Département de médecine sociale et preventive
University of Montreal
MedicalResearch.com: What is the background for this study?
Response: COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been a major public health concern. The number of infected pregnant women continues to increase. Pregnant women and infants are particularly susceptible to COVID-19 because the physiologic changes of pregnancy involve cardiovascular, respiratory, and immune changes that may alter the response to SARS-CoV-2 infection. Fetuses may be exposed to SARS-CoV-2 during critical periods of development. The nature of the association between COVID-19 and pregnancy outcomes remains unclear and meta-analyses of pregnant women with COVID-19 are lacking.
Smoking and heart disease partially account for the mortality gap between women and men....
Sungchul Park, MPH PhD
Assistant Professor, Health Management and Policy
Dornsife School of Public Health
Drexel University
Philadelphia, PA 19104
MedicalResearch.com: What is the background for this study?
Response: Evidence suggests that a significant share of health care costs in the US is of low value. In some cases, low-value care can be associated with harmful patient outcomes. Thus, decreasing use of low-value care is a major goal for Medicare given the potential to decrease costs and harms. Compared with traditional fee-for-service Medicare (TM), Medicare Advantage (MA) is more strongly financially incentivized to decrease use of low-value care.
Response: Dizziness and imbalance are common among US adults and increases the risk of serious injuries. However, research related to balance overwhelmingly focuses on functional outcomes among older adults, therefore our understanding on how balance function may affect the long-term health outcomes in adults of different age group is limited.
MedicalResearch.com: What are the main findings?
Response: We found that balance disorder affects nearly 2/3 of older Americans (65+ yr) as well as 1/3 of those middle-aged (50-64 yr). Our study, for the first time, found that for middle-aged and older Americans, their overall and sensory-specific balance disorders (visual, proprioceptive, and vestibular) were associated with higher mortality risks driven by cancer and CVD death over 12 years.
Matt Spick[/caption]
Matt Spick, Post-Graduate Researcher
University of Surrey
Faculty of Engineering and Physical Sciences
Guildford, UK
MedicalResearch.com: What is the background for this study? Are you measuring lipids or the virus?
Response: In this study, we aimed to detect what the virus does to us, rather than the virus itself. The gold standard for detecting COVID-19 is the RT-PCR test, but by their nature, PCR tests only provide diagnostic information, and at times during the pandemic the availability of PCR tests has been a bottleneck for the identification of the disease. Our goal was to investigate a novel method for the diagnosis of COVID-19, at the same time as learning more about what the disease does to us through lipidomics.
When someone is anxious, their adrenaline is pumping, and they tend to engage in shallow breathing. Regular abdominal breathing can...
Benjamin E. Gewurz MD, PhD
Broad Institute of MIT and Harvard, Cambridge,
Division of Infectious Disease, Department of Medicine, Brigham and Women’s Hospital,
Department of Microbiology, Harvard Medical School
Boston, MA
MedicalResearch.com: What is the background for this study?
Response: When the Covid-19 virus infects cells, it takes over and redirects our cells resources towards the projection of virus building blocks and new viruses. Building blocks include large amounts of RNAs that encode for the viral proteins, much as the mRNA vaccines direct our bodies to make the spike protein. We wondered how the virus changes cell metabolism in order to support the synthesis of vast amounts of viral RNAs within hours of infection.
Anne Cust[/caption]
Anne Cust | PhD, Professor of Cancer Epidemiology
The University of Sydney
Faculty of Medicine and Health
Sydney School of Public Health
MedicalResearch.com: What is the background for this study? Are the screeners specially trained, use full body photographs, dermoscopy etc?
Response: The Melanoma High-risk Clinic Study was developed to optimise the early detection of new melanomas in people at high risk of developing melanoma. A previous single-centre study observed fewer excisions and healthcare costs, thinner melanomas and better quality of life when surveillance of high risk patients was conducted in a melanoma dermatology clinic with a structured surveillance protocol involving 6-monthly full body examinations aided by total body photography (TBP) and sequential digital dermoscopy imaging (SDDI). The initial pilot study was performed in a single tertiary referral specialist centre using trained dermatologists who routinely used the diagnostic interventions.
Our objective was to examine longer-term sustainability and expansion of the program to multiple practices including a primary care skin cancer clinic setting. The hypothesis was that the outcomes would be similar if using the same protocol and diagnostic tools. The participating doctors were trained to follow the protocol, which included instruction on how to respond and interpret changing lesions, but not in use of dermoscopy or skin examinations, which were routinely and consistently used in all clinics prior to the study commencing. There were 593 participants assessed as very high risk of melanoma who participated in the Melanoma High-risk Clinic Study from 2012-2018. Nearly all of the participants had had a previous melanoma and had additional melanoma risk factors. 57% were male and the median age at study entry was 58 years.
Dr. Wong[/caption]
John B. Wong, M.D.
Chief Scientific Officer,
Vice Chair for Clinical Affairs
Chief of the Division of Clinical Decision Making
Primary Care Clinician
Department of Medicine
Tufts Medical Center
MedicalResearch.com: What is the background for this study?
Response: Lung cancer is the leading cause of cancer death for both men and women in the United States. More than 200,000 people are diagnosed with this devastating disease each year. Smoking is the leading cause of lung cancer, resulting in the vast majority of lung cancers in the United States.
Dr. Salloway[/caption]
Stephen Salloway, M.D., M.S.
Director of Neurology and the Memory and Aging Program, Butler Hospital
Martin M. Zucker Professor of Psychiatry and Human Behavior
Professor of Neurology, Alpert Medical School of Brown University
Providence, RI 02906
MedicalResearch.com: What is the background for this study?
Response: This 78 week phase 2 study tested donanemab in patients with early Alzheimer’s disease. Donanemab is a an anti-amyloid monoclonal antibody that targets the N3 pyroglutamate epitope.
MedicalResearch.com: What are the main findings?
Response: The drug produced a substantial lowering of amyloid plaques and showed a slowing in cognitive decline. Key innovations included using PET scans to ensure all patients were amyloid positive and had a moderate level of tau build-up and switching from drug to placebo once the amyloid level was below the expected cut-off for Alzheimer’s disease.
There were no new safety signals. The main side-effect was amyloid-related imaging abnormalities (ARIA) that have been seen with other anti-amyloid treatments. ARIA is managed with regular safety MRI scans. Donanemab is now being tested in a larger phase 3 trial that could lead to regulatory approval.
If you have low self-esteem you might be reluctant to try new things for fear it will make you feel...