Author Interviews, Health Care Systems / 29.09.2025
Healing Spaces Need Healthy Systems: Why Infrastructure Reliability Is Critical in Healthcare
Healthcare environments are designed to promote healing, deliver precision care, and maintain safety for both patients and providers. But behind every high-performing hospital or clinic is a network of critical infrastructure systems that make healing possible. From HVAC and electrical systems to pressure controls and filtration, these elements are foundational to quality care. When any of these systems falter, the consequences are immediate and far-reaching.
Downtime in a healthcare facility isn’t just an inconvenience; it’s a direct threat to patient outcomes, staff safety, and operational continuity. The physical infrastructure in hospitals and clinics is subjected to some of the most demanding conditions of any commercial setting. Continuous occupancy, sensitive medical equipment, stringent air quality standards, and fluctuating occupancy loads place immense pressure on HVAC and power systems. Unlike many other buildings, there is little margin for error in healthcare environments. Every degree of temperature, every change in humidity, and every interruption in ventilation can impact recovery times, increase infection risk, or delay life-saving procedures.
Dr. Casale[/caption]
Thomas B. Casale, M.D.
Professor of Medicine and Pediatrics
Chief of Clinical and Translational Research
Division of Allergy and Immunology
USF Health Morsani College of Medicine
University of South Florida
Tampa, Florida
MedicalResearch.com: What is the background for this study?
Response: The data leading to FDA approval of neffy came from extensive pharmacokinetic and pharmacodynamic studies. As with previous epinephrine delivery devices, the FDA asked for data showing that after delivery of neffy the epinephrine blood levels and expected changes in pulse and blood pressure were similar to those achieved with injectable formulations of epinephrine. neffy performed as expected with blood levels of epinephrine bracketed by those achieved with EpiPen and a needle and syringe along with increases in pulse and blood pressure compatible with the epinephrine levels measured.
Additionally, clinicians are interested in whether neffy would perform similarly in real clinical situations. The data from the neffy experience program provides real-world assurance that neffy can effectively treat acute allergic reactions. Given the large number of patients and the similar findings to those achieved with injectable epinephrine in previous studies, the data should provide assurance that neffy can be an effective substitute for injectable epinephrine in patients that desire a needle-free option.