ADHD, Author Interviews, Lancet, MRI, Neurological Disorders / 01.03.2017
Subtle Differences in Brain Volume Detected On MRI In ADHD
MedicalResearch.com Interview with:
M. (Martine) Hoogman PhD.
Postdoc and PI of ENIGMA-ADHD
Radboud universitair medisch centrum
Department of Human Genetics
Nijmegen, The Netherlands
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There are many neuro-imaging studies aimed at investigating structural brain changes related to ADHD, but the results are often inconclusive.
There are two main reasons for this:
1) the small sample size of the studies and
2) the heterogeneous methods used.
We tried to address these issues by forming an international collaboration to provide a sample size sufficient to detect even small effects in volume differences. And in addition, we analyzed all the raw scans again using homogenized methods. There are data of more than 1700 patients (aged 4-63 years of age) and more than 1500 healthy controls in our dataset, coming from 23 sites around the world. We studied the possible volume differences between cases and controls of 7 subcortical regions and intracranial volume by performing mega- and meta-analysis.
(more…)