Author Interviews, Cancer Research, JAMA, Pediatrics, Radiation Therapy / 01.03.2017
Reduction in Radiation Has Reduced Second Tumors in Pediatric Cancer Patients
MedicalResearch.com Interview with:
Lucie Turcotte, MD, MPH
University of Minnesota Masonic Children's Hospital
Division of Pediatric Hematology-Oncology
Assistant Professor
Minneapolis, MN 55455
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: We have observed dramatic improvements in the number of survivors of childhood cancer over the last 60 years. As more children are surviving, we have identified many important late health consequences of cancer therapy. One of the most devastating of these late health consequences is the diagnosis of a second cancer. As we have identified late effects, such as second cancers, we have modified therapy in an effort to prevent long-term sequelae of therapy, while still maintaining superior survival rates.
For this study, we utilized data from the Childhood Cancer Survivor Study (CCSS), which is a cohort of more than 23,000 survivors of childhood cancer from multiple centers in North America, who were initially diagnosed between 1970 and 1999. Our analysis focused on elucidating whether survivors diagnosed more recently were experiencing fewer second cancers, and determining whether a reduction in second cancers could be associated with treatment modifications.
The most important finding from this study is that the reductions in therapeutic radiation exposure that occurred between 1970-1999 resulted in a significant reduction in the second cancers experienced by survivors of childhood cancer.
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