COVID -19 Coronavirus, PLoS / 07.08.2021
Long-Covid Symptoms Common Even In Asymptomatic or Mild Cases
MedicalResearch.com Interview with:
[caption id="attachment_57877" align="alignleft" width="95"] Dr. Bell[/caption]
Melanie Bell, PhD, MS
Professor
Mel and Enid Zuckerman College of Public Health
The University of Arizona
MedicalResearch.com: What is the background for this study?
Response: In May 2020 my colleagues began a cohort study called CoVHORT, which aimed to investigate the impacts of the SARS-Cov-2 pandemic among residents of Arizona. The current study on long covid is a sub-study which included all CoVHORT participants who had a confirmed positive COVID-19 test, were not hospitalized, and had symptom data 30 days are longer since the test. We wanted to investigate the prevalence of long covid, also known as post-acute sequalae of COVID-19 (PASC) amongst people who did not experience severe acute infection.
Although the definition is still evolving in the research community, we defined PASC as continuing to experience at least one symptom 30 days or longer post-acute infection.
Dr. Bell[/caption]
Melanie Bell, PhD, MS
Professor
Mel and Enid Zuckerman College of Public Health
The University of Arizona
MedicalResearch.com: What is the background for this study?
Response: In May 2020 my colleagues began a cohort study called CoVHORT, which aimed to investigate the impacts of the SARS-Cov-2 pandemic among residents of Arizona. The current study on long covid is a sub-study which included all CoVHORT participants who had a confirmed positive COVID-19 test, were not hospitalized, and had symptom data 30 days are longer since the test. We wanted to investigate the prevalence of long covid, also known as post-acute sequalae of COVID-19 (PASC) amongst people who did not experience severe acute infection.
Although the definition is still evolving in the research community, we defined PASC as continuing to experience at least one symptom 30 days or longer post-acute infection.
Dr. Ribeiro[/caption]
Fernando Ribeiro PhD
School of Health Sciences
Institute of Biomedicine - iBiMED
University of Aveiro
Aveiro, Portugal
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Resistant hypertension is a puzzling problem without a clear solution. The available treatment options to lower blood pressure, namely medication and renal denervation, have had limited success, making nonpharmacological strategies good candidates to optimize the treatment of this condition.
Exercise training is consistently recommended as adjuvant therapy for patients with hypertension, yet, it is with a great delay that the efficacy of exercise training is being tested in patients with resistant hypertension.
Having that in mind, the EnRicH trial was designed to address whether the benefits of an exercise intervention with proven results in hypertensive individuals are extended to patients with resistant hypertension, a clinical population with low responsiveness to drug therapy. Exercise training was safe and associated with a significant and clinically relevant reduction in 24-hour, daytime ambulatory, and office blood pressure compared with control (usual care).
Dr. Pierce[/caption]
John Pierce, PhD
Professor Emeritus
Department of Family Medicine and Public Health
Moores Cancer Center Director for Population Sciences
Co-leader of the Cancer Prevention program
UC San Diego
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Graphic Warning Labels are to be implemented in the US in July 2022, depending on litigation. This will be about 10 years after they were first proposed. Meanwhile, 120 other countries have implemented them already.
The FDA states that their purpose for the warnings is to provide a constant reminder to smokers about the health consequences of smoking, not to force them to quit.
In our study, 3 months of having cigarettes repackaged into graphic warning packs was associated with smokers thinking more about quitting and not getting as much pleasure out of their cigarettes. However, thinking about quitting is only the first step to conquering a nicotine addiction.
Dr. Lopez[/caption]
Maria Luisa S. Sequeira Lopez, MD, FAHA
Harrison Distinguished Professor in Pediatrics and Biology
University of Virginia
Charlottesville, VA 22908
MedicalResearch.com: What is the background for this study?
Response: The renin-angiotensin system (RAS) is crucial in the regulation of the blood pressure (BP). Synthesis and secretion of renin is the key regulated event in the operation of the RAS.
One of the main mechanisms that control renin synthesis and release is the baroreceptor mechanism whereby a decrease in blood pressure results in increased release of renin by juxtaglomerular (JG) cells.
In spite of its enormous importance, the nature and location of the renal baroreceptor was still unknown. This was due in great part to the lack of appropriate in vitro and in vivo models to confidently allow tracking of the fate and isolation of renin cells, and the lack of tools to study the chromatin in scarce cells.
Prof. Stewart[/caption]
Willie Stewart, MBChB, PhD, DipFMS, FRCPath, FRCP Edin
Consultant Neuropathologist
Honorary Professor
Department of Neuropathology
Queen Elizabeth University Hospital
Glasgow, UK
MedicalResearch.com: What is the background for this study?
Response: There is concern over the association between participation in contact sports and later life risk of dementia and associated neurodegenerative disease. Much of this comes from observations of a specific form of neurodegenerative pathology - chronic traumatic encephalopathy (CTE)- linked to history of traumatic brain injury (TBI) and repetitive head impacts in autopsy studies of relatively small numbers of former athletes, including boxers and soccer players. Nevertheless, although this brain injury linked pathology is described, surprisingly little is known about what this might mean for later life health, specifically risk of dementia.
In a previous study published from our programme of research looking at "Football's Influence on Lifelong health and Dementia risk' (the FIELD Study), we demonstrated that former professional soccer players had an approximately three-and-a-half-fold higher mortality from neurodegenerative disease than matched general population controls. However, these mortality data did not allow us to consider the relationships between varying head injury/impact exposure variables, such as player position and career length, and risk of neurodegenerative disease. 
MedicalResearch.com Interview with:
Eleonora Leucci, Ph.D Assistant Professor
Laboratory for RNA Cancer Biology
Department of Oncology
KU Leuven
MedicalResearch.com: What is the background for this study?
Response: Back in 2016, while I was characterising the RNA SAMMSON as essential for mitochondrial translation in melanoma, I noticed that its inhibition was causing cell death across a large spectrum of melanoma cell lines and models, irrespectively of their genetic background and cell state. At that time I still did not know why the effect was so pronounced on melanoma cells, but I knew that antibiotics of the tetracycline family could also block mitochondrial translation and I thought about repurposing them to treat melanoma.
Dane Kim[/caption]
Dane Kim, Dental Student
University of Pennsylvania School of Dental Medicine
MedicalResearch.com: What is the background for this study?
Response: This large study was inspired, in part, by a previous publication, Gustatory Function After Third Molar Extraction (Shafer et al. 1999), which examined the effect of third molar extractions on human taste function. Their work was based upon more severe extractions and followed patients only up to six months after their surgery. Studies examining taste function over a longer period, i.e., beyond six months from the surgery, were non-existent.
The Smell and Taste Center of Penn Medicine, which is the only center of its type in the United States, has a large unique database of patients who have been thoroughly tested for both smell and taste function. This provided us with the opportunity to compare data from hundreds of persons who had previously received third-molar extractions to those who had not received such extractions. Importantly, the extracts had occurred years before thee taste testing. 
Dr. Kelley[/caption]
Mireille E. Kelley Ph.D.
Staff Consultant for Engineering Systems Inc.
MedicalResearch.com: What is the background for this study?
Response: Youth and high school football players can sustain hundreds of head impacts in a season and while most of these impacts do not result in any signs or symptoms of concussion, there is concern that these repetitive subconcussive impacts may have a negative effect on the brain.
The results of this study are part of an NIH-funded study to understand the effects of subconcussive head impact exposure on imaging data collected at pre- and post-season time points. The present study leveraged the longitudinal data that was collected in the parent study to understand how head impact exposure changes among athletes from season to season and how that relates to changes measured from imaging.
Dr. Els Broens[/caption]
Els M. Broens DVM, PhD, Dipl. ECVM, EBVS
European Veteirnary Specialist in Veterinary Microbiology
Associate Professor / Director VMDC
Department Biomolecular Health Sciences (Clinical Infectiology)
Faculty of Veterinary Medicine | Utrecht University
MedicalResearch.com: What is the background for this study?
Response: Several events have demonstrated that SARS-CoV-2 can infect animals, felines and mustelids in particular. In companion animals these are currently considered to be incidents with a negligible risk for public health since the main force of the pandemic is transmission between humans. However, it is urgent to understand the potential risk of animal infections for public health in the later stages of the pandemic when SARS-CoV-2 transmission between humans is greatly reduced and a virus reservoir in animals could become more important.
Incidental cases have shown that COVID-19 positive owners can transmit SARS-CoV-2 to their dog or cat. The close contact between owners and their dogs and cats and the interaction between dogs and cats from different households raises questions about the risk for pets to contract the disease and also about role of these animals in the transmission of SARS-CoV-2.
Background: To identify individual-level factors associated with COVID-19-related impacts on recovery in 216 participants originally enrolled in the SUBLOCADE® (buprenorphine extended-release) clinical program.
Within the fifteen-month study 216 participants, during the period of September 2021 through January 2021, were asked how the COVID-19 crisis affected their recovery from substance use, utilizing self-reported measures.
Dr. Forbes[/caption]
Lisa Forbes, Ph.D, LPC, NCC
Clinical Assistant Professor
Counseling Program
University of Colorado Denver
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The most common mode of learning in tertiary education is lecture-based learning despite the knowledge that more active, engaged, and flexible approaches to teaching may better support the learning process. This study aimed to understand graduate students’ experiences with a playful pedagogy as an alternative approach to learning.
