Alzheimer's - Dementia, Author Interviews, Nutrition / 14.11.2022
Polyphenols in Hops Studies for Role in Alzheimer’s Disease Prevention
MedicalResearch.com Interview with:
Alessandro Palmioli PhD
Cristina Airoldi PhD
Department of Biotechnology and Biosciences,
University of Milano-Bicocca, NeuroMI,
Center for Neuroscience, University of Milano-Bicocca
MedicalResearch.com: What is the background for this study?
Response: We started many years ago by studying some natural and synthetic molecules that were able to counteract the early stages of this disease. With a view to early prevention, we wondered if these molecules could be routinely taken with the diet or dietary supplements. So our studies focused on the search for bioactive molecules present in food and edible plants.
Hops are very rich in polyphenolic compounds, and for this reason it is historically used for the production of beer, but also for the preparation of herbal teas and infusions, and its uses in traditional medicine are known. In recent years we have also collected interesting results on Coffee, Sage, Radix Imperatoriae, Cocoa and Cinnamon extracts.
Response: We started many years ago by studying some natural and synthetic molecules that were able to counteract the early stages of this disease. With a view to early prevention, we wondered if these molecules could be routinely taken with the diet or dietary supplements. So our studies focused on the search for bioactive molecules present in food and edible plants.
Hops are very rich in polyphenolic compounds, and for this reason it is historically used for the production of beer, but also for the preparation of herbal teas and infusions, and its uses in traditional medicine are known. In recent years we have also collected interesting results on Coffee, Sage, Radix Imperatoriae, Cocoa and Cinnamon extracts.
Dr. Dai[/caption]
Dr. Hongying Daisy Dai, PhD
Professor and Associate Dean of Research
The College of Public Health
University of Nebraska Medical Center.
MedicalResearch.com: What is the background for this study?
Response: Tobacco use landscape has been changing in the United States with fewer combustible cigarette smokers and more e-cigarette and other emerging tobacco users. Nicotine concentration level is a key product characteristic of modern e-cigarette products and high-nicotine vaping devices have recently become available. This study seeks to examine whether biomarkers of exposure to tobacco-related toxicants have changed since 2013 among adult nicotine e-cigarette users, non-nicotine e-cigarette users, and cigarette smokers.
Dr. Shan[/caption]
Zhilei Shan, MD, PhD
Postdoctoral fellow on Nutritional Epidemiology
Harvard T.H. Chan School of Public Health
MedicalResearch.com: What is the background for this study?
Response: Unhealthy sleep behaviors and sleep disturbances are associated with higher risk of multiple diseases and mortality. The current profiles of sleep habits and disturbances, particularly the differences between workdays and free days, are unknown in the contemporary US.
MedicalResearch.com: What are the main findings?
Response: In this nationally representative cross-sectional analysis with 9004 adults aged 20 years or older, differences in sleep patterns between workdays and free days were observed. The mean sleep duration was 7.59 hours on workdays and 8.24 hours on free days (difference, 0.65 hour). The mean sleep and wake times were at 11:02 PM and 6:41 AM, respectively, on workdays and 11:25 PM and 7:41 AM, respectively, on free days (differences, 0.23 hour for sleep time and 1.00 hour for wake time). With regard to sleep disturbances, 30.5% of adults experienced 1 hour or more of sleep debt,46.5% experienced 1 hour or more of social jet lag, 29.8% had trouble sleeping, and 27.2% experienced daytime sleepiness.
Sean M Hughes MA
Department of Obstetrics and Gynecology
University of Washington
Seattle, WA
MedicalResearch.com: What is the background for this study?
Response: Young women are at elevated risk of getting sexually transmitted infections at the age when they typically start to have sexual intercourse. It’s not known whether this elevated risk is a consequence of behavioral factors (such as choices around use of barrier protection), physiological factors (such as a difference in the immune system) or a combination of both. In this study, we investigated a physiological factor: the immune system in the vagina.
Dr. van der Velde[/caption]
Jeroen van der Velde, PhD
Leiden University Medical Center
Dept. Clinical Epidemiology, C7-102
Leiden, The Netherlands
MedicalResearch.com: What is the background for this study?
Response: We hypothesized that, in addition to the amount of physical activity, the pattern in which physical activity is accumulated over the day is relevant for metabolic health.
Several studies previously showed beneficial effects of interrupting sedentary periods with short periods of activity (breaks in sedentary time) on glucose control. In addition, very recently it has been argued that the timing of physical activity during the day may be relevant for metabolic health. This was mainly shown in animal studies and intervention studies with supervised high intensity exercise training in men with impaired glucose control or type 2 diabetes. If timing of physical activity matters in a ‘free-living’ setting in the general population is largely unknown.
Therefore, our aim was to investigate associations of timing of physical activity and breaks in sedentary time with liver fat content and insulin resistance in a middle-aged population.
Dr. White[/caption]
Alexandra J. White, PhD, MSPH
Stadtman Investigator
Epidemiology Branch
National Institute of Environmental Health Sciences
National Institutes of Health
Research Triangle Park, NC
MedicalResearch.com: What is the background for this study? What is the chemical primarily used in hair straighteners?
Response: Hair products such as dye and chemical straighteners contain several different chemicals that may act as carcinogens or endocrine disruptors and thus may be important for cancer risk. Straighteners in particular have been found to include chemicals such as phthalates, parabens, cyclosiloxanes and metals and may release formaldehyde when heated. Previous research has suggested that hair dye and chemical straighteners are related to other hormone-sensitive cancers such as breast and ovarian cancer, but no previous study has considered how they are related to uterine cancer risk.
Dr. Wong[/caption]
Mitchell Wong, MD PhD
Professor of Medicine
Executive Vice Chair for Research Training
Department of Medicine
Executive Co-Director, Specialty Training and Advanced Research (STAR) Program
Director, UCLA CTSI KL2 Program
UCLA Division of General Internal Medicine and Health Services Research Los Angeles, CA 90024
MedicalResearch.com: What is the background for this study?
Response: It is estimated that social factors like poverty, education, and housing have a large impact on health. Yet, there are few interventions that exist to directly address those issues. Schools are a promising solution since society already invests heavily in education and schools are an everyday part of most children’s lives.
Dr. Robbins[/caption]
Rebecca Robbins, Ph.D.
Instructor in Medicine
Associate Scientist, Division of Sleep and Circadian Disorders
Investigator, Division of Sleep and Circadian Disorders
Departments of Medicine and Neurology
Brigham and Women's Hospital
MedicalResearch.com: What is the background for this study?
Response: Teens face myriad challenges to sleep, ranging from biological factors, including a preference for later bedtimes and increased need for sleep, to social factors, including social pressures and increased academic workloads, all limiting teenagers in their ability to keep a healthy sleep schedule.
In a nationally representative sample, we explored the prevalence of another potential barrier to sleep among teens, which are a set of beliefs that are held in the population, yet are actual counter to scientific principles regarding sleep and circadian rhythms.
Dr. Malin[/caption]
Steven K. Malin, PhD, FACSM (he/him)
Associate Professor
Department of Kinesiology and Health | School of Arts and Sciences
Division of Endocrinology, Metabolism and Nutrition | Robert Wood Johnson Medical School
Institute of Translational Medicine and Science
New Brunswick, NJ 08901
MedicalResearch.com: What is the background for this study?
Response: Type 2 diabetes is a condition where blood glucose (sugar) is elevated in the blood. This can be problematic as it leads to blood vessel damage and the promotion of cardiovascular disease. Nearly 30 million people in the U.S. have type 2 diabetes, making it a major public health issue. The cause is not entirely clear, but many, including our team view insulin resistance as a central culprit.
Insulin resistance is when the body does not respond well to the hormone insulin. Insulin is vital because it promotes glucose uptake into tissues, like skeletal muscle. Two reasons that are often used to explain the development of insulin resistance include: poor diet (e.g. high sugar and/or high fat coupled with excess calories) and a lack of physical activity. However, more recently, a lack of sleep has been raised as another critical behavioral factor contributing to insulin resistance. Thus, targeting a healthy diet, activity and sleep pattern is thought to prevent the transition from health to insulin resistance and type 2 diabetes.
Dr. Orkaby[/caption]
Ariela Orkaby, MD, MPH
Geriatrics & Preventive Cardiology
Associate Epidemiologist
Division of Aging, Brigham and Women's Hospital
Assistant Professor of Medicine, Harvard Medical School
MedicalResearch.com: What is the background for this study?
Response: As the population is living longer, there is increased risk of frailty and vulnerability. Frailty is defined as reduced physiological reserve and decreased ability to cope with even an acute stress. Up to half of adults over the age of 85 are living with frailty and preventative measures are greatly needed. We tested the effect of vitamin D and marine omega-3 fatty acid supplementation on the risk of developing frailty in healthy older adults in the US enrolled in the VITamin D and OmegA-3 TriaL (VITAL) trial.
Dr. Jing Li[/caption]
Jing Li, PhD
Assistant Professor of Health Economics
The Comparative Health Outcomes, Policy and Economics (CHOICE) Institute
University of Washington School of Pharmacy
MedicalResearch.com: What is the background for this study?
Response: Dementia and other cognitive impairment are highly prevalent among older adults in the U.S. and globally, and have been linked to deficiencies in decision-making, especially financial decision-making. However, little is known about the extent to which older adults with cognitive impairment manage their own finances and the characteristics of the assets they manage.
Dr. Han[/caption]
Meilan K Han MD, MS
Henry Sewall Professor of Medicine
Professor of Internal Medicine and Section Head
Division of Pulmonary and Critical Care Medicine, Medical School
University of Michigan
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: In the NIH sponsored SPIROMICS study we demonstrated that symptomatic, tobacco exposed individuals have frequent exacerbations. Many of these individuals are treated with the same inhaled medications that have shown benefit in COPD, but we don’t have any evidence basis for this practice.
Dr. Maki Inoue-Choi,[/caption]
Maki Inoue-Choi, Ph.D., M.S., R.D.
Staff Scientist
Metabolic Epidemiology Branch
National Institutes of Health
MedicalResearch.com: What is the background for this study?
Response: Tea is rich in bioactive compounds that can possibly protect against health conditions such as cancer and heart disease. A lower risk of death was seen among tea drinkers than non-drinkers in previous studies, but these were largely in populations where green tea drinking is common. In contrast, the studies in populations where black tea drinking is more common have been limited and the findings from these studies have been inconsistent.
