Author Interviews, JAMA, Kidney Disease, Salt-Sodium / 03.01.2024

MedicalResearch.com Interview with: Lu Qi, MD, PhD, FAHA Interim Chair, Department of Epidemiolog HCA Regents Distinguished Chair and Professor Tulane University School of Public Health and Tropical Medicine Director, Tulane University Obesity Research Center Director, Tulane Personalized Health Institute New Orleans, LA 70112 MedicalResearch.com: What is the background for this study? Response: Adding salt to foods is a behavior reflecting long-term preference to salty diets. High sodium intake is a major risk factor for chronic kidney disease. In our previous studies, we have found that adding salt to foods at the table is related to various disorders including cardiovascular diseases, diabetes, and mortality.  (more…)
Author Interviews, Brigham & Women's - Harvard, Dental Research, JAMA, Respiratory / 18.12.2023

MedicalResearch.com Interview with: Michael Klompas MD, MPH, FIDSA, FSHEA Hospital Epidemiologist Brigham and Women’s Hospital Professor of Medicine and Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute MedicalResearch.com: What is the background for this study? Can teeth be safely brush in patients who are comatose, intubated or have NG tubes? Response: Pneumonia is thought to occur when secretions from the mouth get into the lungs.  Since there are many microbes in the mouth, there’s a risk that secretions from the mouth that get into the lungs will lead to pneumonia.  Toothbrushing may lower this risk by decreasing the quantity of microbes in the mouth. It is indeed safe and appropriate to brush the teeth of someone who is comatose, intubated, or who has an NG tube.  Indeed, our study found that the benefits of toothbrushing were clearest for patients receiving mechanical ventilation. (more…)
Author Interviews, Cancer Research, Case Western, Colon Cancer, JAMA / 07.12.2023

MedicalResearch.com Interview with: Nathan A. Berger, M.D. Distinguished University ProfessorHanna-Payne Professor of Experimental MedicineProfessor of Medicine, Biochemistry, Oncology and GeneticsDirector, Center for Science, Health and SocietyCase Western Reserve University School of Medicine   Rong Xu, PhD Professor, Biomedical Informatics Director, Center for Artificial Intelligence in Drug Discovery Case Western Reserve University School of Medicine     MedicalResearch.com: What is the background for this study? Response: 75% of the US Population has overweight or obesity and 15% has Type 2 Diabetes. Both overweight/obesity and diabetes promote increased incidence and worse prognosis of colorectal cancer. The new GLP1RA drug class are rapidly becoming the most effective treatment for both diabetes and overweight/obesity. By controlling diabetes and overweight/obesity, we hypothesized that the GLP1RAs might be effective at reducing incidence of colorectal cancer. (more…)
Author Interviews, Cancer Research, Cost of Health Care, JAMA, Pharmacology / 17.11.2023

MedicalResearch.com Interview with: Lisa-Marie Smale, PharmD PhD Candidate Clinical Pharmacy Radboud University Medical Center Department of Pharmacy Nijmegen, the Netherlands Lisa-Marie Smale, PharmDPhD Candidate Clinical PharmacyRadboud University Medical CenterDepartment of PharmacyNijmegen, the Netherlands   MedicalResearch.com: What is the background for this study? Response: Cancer drugs are not always fully used by patients, while these drugs are mostly expensive and environmentally damaging, both in production and (waste) disposal. Therefore we investigated whether unused drugs of patients can be collected, verified of quality by a pharmacy, to be redispensed to other patients instead of being disposed of. We were interested whether such an approach ultimately leads to lower environmental impacts and costs. (more…)
Author Interviews, Dermatology, JAMA, Surgical Research / 16.11.2023

MedicalResearch.com Interview with: Peter C. Minneci, MD Chair of Surgery at Nemours Children’s Health Delaware Valley MedicalResearch.com: What is the background for this study?  Would you briefly explain the symptoms/course of pilonidal disease?  Response: Pilonidal disease is relatively common and affects up to 1% of the population starting in adolescence and up until young adulthood. Pilonidal disease occurs when cysts or sinuses form between the buttocks. It is believed to be an inflammatory reaction to hair or debris that gets caught in the crease of the buttocks. Risk factors for the condition include a sedentary lifestyle, hygiene and obesity. Pilonidal disease can be intermittent or chronic and recurs about 33% of the time, with 80% of recurrences taking place within a year of initial treatment. These recurrences contribute to a high degree of psychosocial stress in patients, who often miss school or sports and may avoid social activities. Pilonidal cysts may become infected, in which case patients must take antibiotics or undergo surgery.   Standard treatment for pilonidal disease involves removal of hair with razors or creams, as well as recommendations such as keeping the area clean. In recent years, some practitioners have begun using laser epilation as an additional strategy to prevent recurrence by providing more durable hair removal. However, it’s important to point out that this is not covered by insurance. In addition, as a provider, I have found that my patients that do have the means to pay often don’t comply with the number of sessions needed to fully remove the hair due to many different factors including pain and discomfort during the procedure.   (more…)
Alzheimer's - Dementia, Author Interviews, Genetic Research, JAMA, Stanford / 07.11.2023

MedicalResearch.com Interview with: Michael E. Belloy, PhD Department of Neurology and Neurological Sciences Stanford University, Stanford, California MedicalResearch.com: What is the background for this study? Response: Apolipoprotein E (APOE)*2 and APOE*4 are, respectively, the strongest protective and risk-increasing, genetic variants for late-onset Alzheimer disease. As such, one’s APOE genotype is highly relevant towards clinical trial design and Alzheimer’s disease research. However, most insights so far are focused on the associations of these APOE genotypes with Alzheimer’s disease risk in non-Hispanic white individuals. One important aspect of our work is that we really increased sample sizes for non-Hispanic Black, Hispanic, and East Asian individuals, so that we now have better understanding of the associations of APOE genotypes with Alzheimer’s disease risk in these groups. In complement, we also did the largest investigation to date on the role of ancestry on the associations of APOE genotypes with Alzheimer’s disease risk. The scale of our study was thus a critical factor in generating novel insights. (more…)
Author Interviews, Environmental Risks, JAMA, McGill, Mental Health Research / 06.11.2023

MedicalResearch.com Interview with: Niki Hosseini-Kamkar PhD Postdoc, McGill University MedicalResearch.com: What is the background for this study? Response: Our primary question was: Do adults with a history of childhood trauma have altered brain responses to psychological challenges? Previous evidence indicated that this can occur in laboratory animals, but it has been unclear whether it occurs in humans. (more…)
Author Interviews, Cognitive Issues, Exercise - Fitness, JAMA / 01.11.2023

MedicalResearch.com Interview with: Peter A. Harmer, PhD, MPH, AT-Ret, FACSM Senior Associate Research Scientist Oregon Research Institute MedicalResearch.com: What is the background for this study? Response: Decline in various aspects of cognitive function, such as memory, executive function, and multitasking ability is common as we age. The rate and extent of decline varies among older adults but approximately 20% of those aged 65+ will experience clinically relevant mild cognitive impairment, which places them at increased risk of progressing to Alzheimer’s disease or related dementias. It is also associated with decreased mobility, increased risk of falls and impaired capacity for complex activities of daily living. Research has shown that physical and mental activity may attenuate the decline and that combined physical/mental challenges may be more effective than either alone but up to this point there has been little quality clinical evidence. Building on previous successful studies with our established tai ji quan therapy, we developed a cognitively-enhanced training tai ji quan protocol to determine its effectiveness in enhancing global cognition and dual-task walking compared to our standard tai ji quan program and a stretching program in adults 65+ with mild cognitive impairment or self-reported memory concerns. (more…)
Author Interviews, Cancer Research, JAMA, Lung Cancer, NIH, Race/Ethnic Diversity, Stanford / 01.11.2023

MedicalResearch.com Interview with: Summer S Han, PhD Associate Professor Quantitative Sciences Unit Stanford Center for Biomedical Informatics Research (BMIR) Department of Neurosurgery and Department of Medicine Department of Epidemiology & Population Health (by Courtesy) Stanford University School of Medicine Dr. Eunji Choi PhD Instructor, Neurosurgery Department: Adult Neurosurgery Stanford University School of Medicine   MedicalResearch.com: What is the background for this study?
  • Lung cancer is the leading cause of cancer death in the United States, killing about 127,000 people annually, but it can be treatable if detected early.
  • Low-dose computed tomography, or CT scan, has been shown to significantly reduce the number of lung cancer deaths. But because the radiation delivered by the scans can be harmful (they use on average about 10 times the radiation of standard X-rays), only those people at relatively high risk for lung cancer should be screened. The two biggest risk factors for lung cancer are exposure to tobacco smoke and age. Current national guidelines that rely on age and smoking exposure to recommend people for lung cancer screening are disproportionally failing minority populations including African Americans, according to a new study led by researchers at Stanford Medicine.
  • In 2021, the national guidelines by the U.S. Preventive Services Task Force (USPSTF) issued revised recommendation guidelines on lung cancer screening, lowering the start age from 55-year to 50-year and the smoking pack-year criterion from 30 to 20, compared to the 2013 USPSTF criteria. In comparison to the 2013 criteria, the new modifications have been shown to lessen racial disparities in screening eligibility between African Americans and Whites. However, potential disparities across other major racial groups in the U.S., such as Latinos, remains poorly examined.
  • Meanwhile, risk prediction model assesses a person’s risk score of developing an illness, such as lung cancer.
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Author Interviews, COVID -19 Coronavirus, JAMA, Pediatrics / 26.10.2023

MedicalResearch.com Interview with: Neeraj Sood, PhD Verna and Peter Dauterive Hall University Park Campus University of Southern California Los Angeles, CA MedicalResearch.com: What is the background for this study? What are the main findings? Response: We conducted this study to inform school COVID-19 policies. The main findings are that the median duration of infectivity after a positive COVID-19 test in children is 3 days. The median duration of infectivity does not vary with vaccination.  (more…)
Author Interviews, Emory, Infections, JAMA, MRSA / 10.10.2023

MedicalResearch.com Interview with: Dr. John Jernigan, MD MS Clinical Associate Professor of Medicine Division of Infectious Diseases Emory University School of Medicine Branch Chief Epidemiology, Research and Innovations Branch CDC Center for Disease Control MedicalResearch.com: What is the background for this study? Response: Staphylococcus aureus commonly causes infections in ICUs. One approach to preventing these infections is using nasal mupirocin plus chlorhexidine gluconate (CHG) bathing for ICU patients. This practice is known to prevent methicillin-resistant Staphylococcus aureus (MRSA) infections and all-cause. bloodstream infections.  This practice has been broadly adopted in ICUs in the US, but adoption of mupirocin as a universal topical antibiotic has been slowed by concerns for engendering mupirocin resistance. This cluster-randomized trial in adult ICUs was conducted to assess whether universal nasal antiseptic povidone-iodine (iodophor), to which minimal S. aureus resistance is expected, was an acceptable alternative to universal nasal mupirocin for reducing S. aureus and MRSA clinical cultures in the setting of daily CHG bathing. Those who received chlorhexidine (CHG) bathing with mupirocin had an 18% reduction in risk of Staphylococcus aureus clinical cultures and a 15% reduction in risk of methicillin-resistant S. aureus (MRSA) clinical cultures compared to patients who received CHG bathing with intranasal iodophor.  These results show that using mupirocin for nasal decolonization may be preferred over iodophor because it is more effective at preventing S. aureus infections. (more…)
Author Interviews, Breast Cancer, JAMA, OBGYNE, Surgical Research / 04.10.2023

MedicalResearch.com Interview with: Gabriele Martelli, MD Breast Unit, Surgery Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy MedicalResearch.com: What is the background for this study? Response: Approximately 8% of breast cancer cases are associated with pathogenic germline variants of the BRCA1 or BRCA2 genes. Women with a pathogenic BRCA1 variant have lifetime risks of breast or ovarian cancer of 45% to 80% and 30% to 60%, respectively. Women with a pathogenic BRCA2 variant have lifetime risks of breast or ovarian cancer of 35% to 60% and 10% to 25%, respectively. BRCA1 breast cancer is often more aggressive than sporadic disease, while BRCA2 breast cancer is often of similar aggressivity to sporadic disease. However, few studies have investigated outcomes of breast-conserving surgery, prophylactic mastectomy, or prophylactic salpingo-oophorectomy in patients with BRCA1/2 breast cancer. We conducted a cohort study to assess outcomes of breast-conserving surgery vs mastectomy, prophylactic mastectomy vs no prophylactic mastectomy, and prophylactic salpingo-oophorectomy vs no prophylactic salpingo-oophorectomy in patients with BRCA1/2 breast cancer. (more…)
Accidents & Violence, ADHD, Author Interviews, Columbia, JAMA / 04.10.2023

MedicalResearch.com Interview with: Guohua Li, MD, DrPH Finster Professor of Epidemiology and Anesthesiology Columbia University Irving Medical Center MedicalResearch.com: What is the background for this study? How was the ADHD diagnosis determined? Response: The reported prevalence of ADHD in children and young adults in the United States has more than doubled since the 1990s because of improved diagnosis.  Currently, ADHD affects about 13 percent of children under 18 years of age and eight percent of adults under 45 years of age.  Little is known about the prevalence of ADHD in older adults although it is estimated that ADHD symptoms may persist throughout the lifespan in about one-third of children diagnosed with the disorder.  Diagnostic criteria for adulthood ADHD include having five or more relevant symptoms, adverse impact on social, academic, and occupational activities,  and onset of symptoms before age 12. In this study, ADHD status is determined based on an affirmative response to the question of whether the participant had ever had ADHD or had ever been told by a doctor or other health professional that he or she had ADHD. (more…)
Author Interviews, Blood Pressure - Hypertension, JAMA, OBGYNE, USPSTF / 26.09.2023

MedicalResearch.com Interview with: Esa M. Davis, M.D., M.P.H , F.A.A.F.P Professor of Medicine and Family and Community Medicine Associate Vice President of Community Health and Senior Associate Dean of pPopulation Health and Community Medicine University of Maryland School of Medicine Dr. Davis joined the U.S. Preventive Services Task Force in January 2021 Esa M. Davis, M.D., M.P.H , F.A.A.F.P Professor of Medicine and Family and Community Medicine Associate Vice President of Community Health and Senior Associate Dean of pPopulation Health and Community Medicine University of Maryland School of Medicine Dr. Davis joined the U.S. Preventive Services Task Force in January 2021 MedicalResearch.com: What is the background for this study? Response: Hypertensive disorders of pregnancy, including gestational hypertension, preeclampsia, and eclampsia, are among the leading causes of serious complications and death for pregnant people in the United States. Pregnant women and pregnant people of all genders should have their blood pressure measured at each prenatal visit to help find and prevent serious health issues related to hypertensive disorders of pregnancy.  (more…)
Author Interviews, JAMA, OBGYNE, Pediatrics / 03.09.2023

MedicalResearch.com Interview with: Dr Robert Eves Research Associate at Universität Bielefeld Honorary research fellow at the University of Warwick Guest researcher at DIW Berlin MedicalResearch.com: What is the background for this study? Response: When an infant is born their birthweight percentile is often calculated. This indicates how big the infant is relative to other infants born at the same gestational age (weeks of pregnancy). In long-term follow-up of at-risk infants, being born below the 10th percentile has been considered a risk factor for later cognitive development. However, we thought that this above or below the 10th percentile cut-off was unlikely to reflect the true association between birthweight percentiles and later cognitive development. First of all, we thought that it was unlikely that there would be a dramatic difference between someone born at the 9th vs. 11th percentile. Secondly, we wanted to determine if there was a point when birthweight percentiles could get too large (i.e is there a Goldilocks effect, maybe you should not be too small but not too big either) (more…)
Author Interviews, HIV, JAMA, STD, USPSTF / 01.09.2023

MedicalResearch.com Interview with: James Stevermer, M.D., M.S.P.H.Vice chair for clinical affairs Professor of family and community medicine University of Missouri Medical director of MU Health Care Family Medicine–Callaway Physicians, Dr. Stevermer joined the U.S. Preventive Service Task Force in January 2021. MedicalResearch.com: What is the background for this study? Response: HIV continues to be a significant public health issue. The good news is that PrEP is a safe, highly effective way to help prevent HIV in people at increased risk. There are now two ways people can take PrEP – as a pill or as a shot. We encourage healthcare professionals to have a conversation with their patients about their individual risk for HIV and determine if they should consider taking whichever form of PrEP would work best for them. (more…)
Author Interviews, Gender Differences, JAMA, Surgical Research, Vanderbilt / 30.08.2023

MedicalResearch.com Interview with: Christopher Wallis, MD, PhD Assistant Professor of Urology Department of Surgery University of Toronto and Urologic Oncologist Mount Sinai Hospital   MedicalResearch.com:  Could you give a little context - what was the question you were looking at?
  • We have been studying how the primary treating surgeons sociocultural characteristics impact the recovery of patients they are looking after.
  • Specifically, we have been studying the effect of surgeon sex on outcomes such as death, complications and readmission after common and complex surgeries. These are outcomes that are important to patients and the health system.
  • Previously, we showed that patients with a female surgeon had better short term (30 day) outcomes than similar patients having surgery with a man. This study asked the question of whether the sex of a patient’s surgeon affects patients’ longer term outcomes at 90 days and 1 year, after surgery.
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Author Interviews, Columbia, Gender Differences, JAMA, OBGYNE, Surgical Research / 24.08.2023

MedicalResearch.com Interview with: Jason D. Wright, MD, FACOG, FACS Sol Goldman Associate Professor Chief, Division of Gynecologic Oncology Vice Chair of Academic Affairs, Department of Obstetrics and Gynecology Columbia University College of Physicians and Surgeons New York, New York 10032 MedicalResearch.com: What is the background for this study? Response: There is growing recognition that gender-affirming surgery (GAS) is safe and that the procedures are associated with favorable long term outcomes. Prior work has explored the use of inpatient procedures and shown that the rates of GAS have risen, but there is little contemporaneous data to examine more recent inpatient and outpatient use of GAS. This is particularly important as changes in insurance regulations may have increased access for these procedures. We examined temporal trends in performance of inpatient and outpatient GAS and examined age-specific trends in the types of procedures performed over time. (more…)
Author Interviews, JAMA, OBGYNE, Pediatrics, USPSTF / 09.08.2023

MedicalResearch.com Interview with:x Wanda K. Nicholson, M.D., M.P.H., M.B.A. Senior Associate Dean for Diversity, Equity, and Inclusion Professor of Prevention and Community Health Milken Institute School of Public Health George Washington University Vice chair of the U.S. Preventive Services Task Force MedicalResearch.com: What is the background for this study? Response: Neural tube defects are when a baby’s spinal cord or brain don’t develop properly during pregnancy, which can cause serious complications including disability and death. The good news is that taking folic acid supplements before and during early pregnancy is proven to help prevent this from happening. (more…)
Author Interviews, Blood Pressure - Hypertension, JAMA, Pediatrics / 08.08.2023

MedicalResearch.com Interview with: Tammy M. Brady, MD, PhD  (she/her/hers) Vice Chair for Clinical Research, Dept of Pediatrics Associate Director, Welch Center for Prevention, Epidemiology, and Clinical Research Associate Professor of Pediatrics, Division of Pediatric Nephrology Medical Director, Pediatric Hypertension Program Johns Hopkins University Baltimore, MD 21287     MedicalResearch.com: What is the background for this study? What are the main findings? Response: Accurate BP measurement is key to identification and treatment of hypertension which serves ultimately to prevent cardiovascular disease.  Our study describes substantial measurement error that can occur in a common office and home BP measurement scenario: use of a regular cuff size for all individuals regardless of arm size.  Many office triage measurements occur without individualized cuff selection and most home BP devices come with one cuff size – and our study shows that using a regular cuff size for people who have larger arms – those who require a large adult cuff or an extra-large adult cuff – can lead to blood pressure readings that are almost 5 and 20 mmHg greater than their actual BP, respectively.  Those require a small adult cuff can have BP readings that are almost 4 mmHg lower than their actual BP. (more…)
Author Interviews, JAMA, Ovarian Cancer / 04.08.2023

MedicalResearch.com Interview with: Zai LabRafael Amado, M.D. President, head of Global Oncology Research and Development Zai Lab MedicalResearch.com: What is the background for this study? Response: Zai lab is focused on discovering and developing innovative therapies that will help address medical conditions where there are serious unmet needs. Advanced ovarian cancer, with a low survival and high recurrence rate, is a key focus of our oncology R&D research. In addition to our own discovery program, as part of our open innovation model we partner with companies to license drugs for patients in China and co-develop therapies to address leading causes of cancer death. We currently have a license and collaboration agreement with GSK for the development and commercialization of ZEJULA (niraparib) in mainland China, Hong Kong, and Macau. PRIME was a follow-on study to a previously conducted study called PRIMA, which demonstrated clinical benefit of niraparib in newly diagnosed patients with advanced ovarian cancer regardless of biomarker status. The PRIMA study enrolled a population at high risk of recurrence. Thirty-five percent of patients in PRIMA received an individualized starting dose (ISD) of niraparib based on their baseline weight and platelet count. To further evaluate the efficacy and safety of niraparib with an ISD in a broad population, we decided to conduct the PRIME study. We wanted to explore further whether we could decrease toxicity using an ISD and how it would affect clinical outcomes. The Phase 3 PRIME study was conducted at 29 hospitals in mainland China. PRIME was a randomized, placebo-controlled trial designed to evaluate the efficacy and safety of niraparib at an ISD as first-line maintenance therapy in a broad range of patients with newly diagnosed advanced ovarian cancer. All patients in PRIME received an ISD based on their baseline body weight and platelet count. (more…)
Author Interviews, Education, JAMA, Race/Ethnic Diversity, Yale / 01.08.2023

MedicalResearch.com Interview with: Mytien Nguyen, MS Department of Immunobiology, Yale School of Medicine New Haven, Connecticut MedicalResearch.com: What is the background for this study? Response: Physician-scientists are critical for innovative translational research. Combined MD-PhD training programs are essential for developing physician-scientists. Although racial and ethnic diversity of MD-PhD matriculants has increased over the past decade, little is known about how attrition rates differ by race and ethnicity. (more…)
Aging, Author Interviews, Geriatrics, Hearing Loss, JAMA / 31.07.2023

MedicalResearch.com Interview with:   Nicholas S. Reed, AuD PhD Assistant Professor | Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health     MedicalResearch.com: What is the background for this study? Response: To date, national estimates of hearing loss have often been based on self-report, which is a fine metric in its own right but underestimates the prevalence of hearing loss against criterion standard measures, and most studies with criterion-level hearing measures are limited to relatively younger samples of older adults. For example, some previous nationally representative samples don't allow reporting age data over 80 years because there aren't enough participants in that age group. It is not surprising given that it is difficult to design nationally representative studies that truly allow older adults (80+ years) to participate and measuring hearing can be onerous. However, understanding the prevalence of hearing loss in this age group is vital for public health and policy planning efforts to address hearing loss at the national level.  (more…)
Author Interviews, JAMA, Lipids, Pediatrics, USPSTF / 26.07.2023

MedicalResearch.com Interview with: Li Li, M.D., Ph.D., M.P.H Walter M. Seward Professor Chair of Family Medicine Director of population health University of Virginia School of Medicine Editor-in-chief of The BMJ Family Medicine Dr. Li joined the U.S. Preventive Services Task Force in January 2021 MedicalResearch.com: What is the background for this study? What are the main findings? Response: The Task Force reviewed the latest available evidence to evaluate whether screening all children and adolescents who are 20 years old or younger for high cholesterol improves their heart health into adulthood. At this time, there is not enough evidence to determine whether or not screening all kids is beneficial, so we are calling for additional research on the effectiveness of screening and treatment of high cholesterol in kids and teens. (more…)
Author Interviews, Education, JAMA / 20.07.2023

MedicalResearch.com Interview with: Cassandra Kelleher, MD Surgical Director, Fetal Care Program Surgical Director, Neonatal Intensive Care Unit Physician Investigator (Cl) Surgery, Mass General Research Institute Associate Professor of Surgery Harvard Medical School MedicalResearch.com: What is the background for this study? Response: Physicians practicing in academic hospitals have unique responsibilities. They are not only expected to treat patients, but also to conduct research to improve treatments for future patients, and to train future physicians. Diverse healthcare teams have better patient outcomes and lower healthcare costs. Women physicians, for example, are more likely to practice patient-centered care, and through their teaching and research work at academic medical centers, they help to disseminate and normalize novel approaches to practicing medicine. For these reasons, gender diversity in academic medicine is important for the quality of healthcare in the future. (more…)
Author Interviews, Genetic Research, JAMA, Pediatrics / 17.07.2023

MedicalResearch.com Interview with: Prof. Jonathan Davis, MD, Chief of Newborn Medicine Tufts Medical Center and   Jill Maron, MD, MPH Chief of Pediatrics Women & Infants Hospital of Rhode Island   MedicalResearch.com: What is the background for this study? Response: The Genomic Medicine for Ill Neonates and Infants (GEMINI) trial was designed to be the first comparative study to explore the diagnostic yield, clinical utility and time to diagnosis between whole genomic sequencing (WGS) and a targeted genomic sequencing panel specifically designed to detect gene disorders that present in early life. GEMINI was a US based study that enrolled 400 hospitalized infants, along with their available parents, suspected of having an undiagnosed genetic diagnosis. Every participant underwent testing on each platform simultaneously, allowing us to better understand the limitations and advantages of each approach. (more…)
Anesthesiology, Author Interviews, Cannabis, JAMA, Opiods, Surgical Research, University Texas / 10.07.2023

MedicalResearch.com Interview with: Paul Potnuru, MD Assistant Professor Anesthesiology, Critical Care and Pain Medicine The John P. and Kathrine G. McGovern Medical School The University of Texas Health Science Center at Houston UTHealth MedicalResearch.com: What is the background for this study? Response: The use of cannabis is on the rise in the United States, as it becomes increasingly legally accepted and is viewed as harmless. Furthermore, the potency of cannabis is steadily increasing over time. There is some evidence from previous studies that compared to non-users, cannabis users require more anesthetics, have higher pain after surgery that requires more opioids, and have an increased risk of postoperative nausea and vomiting. Given this context of increased usage and potential risks during surgery, we conducted a study to examine the impact of cannabis use on patients undergoing surgery. (more…)
Author Interviews, Hepatitis - Liver Disease, JAMA, Statins / 07.07.2023

MedicalResearch.com Interview with: Carolin Victoria Schneider, MD Physician-Scientist at RWTH Aachen Former Postdoctoral Fellow at UPenn, Rader Lab MedicalResearch.com: What is the background for this study? Response: Our study was prompted by the ongoing global health crisis related to liver disease, which claims over 2 million lives annually. We noted the emerging literature suggesting the hepatoprotective properties of statins, which include anti-inflammatory, antiproliferative, antiangiogenic, and immunomodulatory effects. However, we noticed a significant gap in understanding these effects in the context of the general population, especially among individuals without a history of known liver disease. Together with our excellent first author Mara Vell, I embarked on a journey aimed to fill this significant knowledge gap. (more…)
Author Interviews, JAMA, OBGYNE / 07.07.2023

MedicalResearch.com Interview with: Dorothy A. Fink, MD Deputy Assistant Secretary for Women's Health Director, Office on Women's Health US Department of Health & Human Services Rockville, MD MedicalResearch.com: What is the background for this study? Response: Delivery-related mortality in U.S. hospitals has decreased for all racial and ethnic groups, age groups, and modes of delivery while the prevalence of severe maternal mortality (SMM) increased for all patients, with higher rates for racial and ethnic minority patients of any age. This study specifically looked at inpatient delivery-related outcomes and found a 57% decrease from 2008-2021. The decreasing mortality rates within the inpatient delivery setting demonstrated as statistically significant and a welcome finding for all women. This study also looked with greater granularity at the impact of race, ethnicity, and age. Mortality for American Indian women decreased 92%, Asian women decreased 73%, Black women decreased 76%, Hispanic women decreased 60%, Pacific Islander women decreased 79%, and White women decreased 40% during the study period. (more…)
Author Interviews, Depression, JAMA, Mental Health Research, NYU, USPSTF / 27.06.2023

MedicalResearch.com Interview with: Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Member of the U.S. Preventive Services Task Force   MedicalResearch.com: What is the background for this study? Response: Depression and anxiety disorders are common mental health conditions affecting the lives of many adults in the U.S. The Task Force cares deeply about the health of people nationwide, so we reviewed the latest evidence on how best to support the mental health of adults in primary care. MedicalResearch.com: What are the main findings? Response:  The evidence shows us that all adults should be screened for depression and those under 65 should also be screened for anxiety. These recommendations apply to everyone without signs or symptoms of depression or anxiety. We also strongly encourage anyone who has signs of depression or anxiety to talk with their clinician so that they can get the care they need. (more…)