MedicalResearch.com Interview with: Adam Glassman, M.S. Director, DRCRnet Coordinating Center Jaeb Center for Health Research Tampa, FL 33647 Medical Research: What is the background for...
MedicalResearch.com Interview with:
Julia Jaekel PhD
Department of Developmental Psychology
Ruhr-University Bochum in Germany
Medical Research: What is the background for this study? What are the main findings?
Dr. Jaekel: Recent reports suggest that delayed school entry (DSE) may be beneficial for children with developmental delays. However, studies of the effects of DSE are inconclusive. Our study investigated the effects of delayed school entry versus age-appropriate entry (ASE) in a large sample after minimizing selection bias and accounting for confounding effects of preschool knowledge. We found that delayed school entry has no effect on Year 1 teacher ratings of academic performance. In contrast, DSE children’s standardized mean test scores of mathematics, reading, writing and attention at 8 years of age were lower than ASE children’s mean scores.
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MedicalResearch.com Interview with:
Shai Mulinari Researcher, PhD
Sociology, Lund University
Medical Research: What is the background for this study? What are the main findings?
Dr. Mulinari : Over the past decade, several so-called whistleblower cases have spotlighted the illicit marketing practices of pharmaceutical companies in the US but relatively few similar cases have been brought in Europe. The reason for this discrepancy is unclear but one possibility is that the wider use of self-regulation in Europe encourages companies to comply with drug promotion rules and deters illicit conduct. But to date self-regulation of medicines promotion has been poorly studied.
We therefore investigated pharmaceutical industry self-regulation in the UK and Sweden. These are two countries often cited as places where self-regulation is effective. One of things that we found was that between 2004 and 2012 the Swedish and UK self-regulatory bodies ruled that 536 and 597 cases, respectively, were in breach of the country’s rules on medicines promotion; many of the violations in both countries concerned misleading claims about a drug’s effects. This equates to an average of more than one case per week in each country.
Charges incurred by companies because of these violations were equivalent to about 0.014% and 0.0051% of annual sales revenue in Sweden and the UK, respectively. Notably, nearly 20% of the cases in breach of the code of conduct in both countries were serious breaches.
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MedicalResearch.com Interview with:
Tess Harris
St George’s University of London
MedicalResearch: What is the background for this study?
Response: Physical activity is vital for both physical and mental health in older people, preventing at least 20 common health problems. Yet the majority of older people do not achieve the World Health Organisation physical activity guidelines for health of at least 150 minutes every week of at least moderate-to-vigorous intensity physical activity in bouts that each last at least 10 minutes. Brisk walking is a good way to achieve moderate intensity physical activity, with a low risk of harm. Pedometers can give you direct feedback on your step-count and accelerometers record both step-counts and the intensity of physical activity achieved. The PACE-Lift trial assessed whether an intervention to increase walking, comprising pedometer and accelerometer feedback, combined with physical activity consultations provided by practice nurses over a 3 month period, based on simple behaviour change techniques, could lead to sustained increases in physical activity in 60-75 year olds.
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MedicalResearch.com Interview with:
Sanziana Roman MD FACS
Professor of Surgery Duke University
Section of Endocrine Surgery
Director of the Endocrine Surgery Fellows and Scholars Program
Duke University School of Medicine
Chief, General Surgery and Associate Chief of Surgery for Clinical Affairs, DVAMC
Medical Research: What is the background for this study?
Dr. Roman: Adjuvant radioactive iodine (RAI) is commonly used in the management of differentiated thyroid cancer. The main goals of adjuvant RAI therapy are to ablate remnant thyroid tissue in order to facilitate long-term follow-up of patients, decrease the risk of recurrence, or treat persistent and metastatic lesions.
On the other hand, Adjuvant radioactive iodine ( therapy is expensive, with an average cost per patient ranging between $5,429.58 and $9,105.67. It also carries the burden of several potential complications, including loss of taste, nausea, stomatitis with ulcers, acute and/or chronic sialoadenitis, salivary duct obstruction, dental caries, tooth loss, epiphora, anemia, neutropenia, thrombocytopenia, acute radiation pneumonitis, pulmonary fibrosis, male infertility, and radiation-induced malignancies. Therefore, Adjuvant radioactive iodine ( should be used only for appropriately selected patients, for whom the benefits would outweigh the risks.
Based on current guidelines, adjuvant RAI is not recommended for patients with papillary thyroid cancers confined to the thyroid gland when all foci are ≤1 cm (papillary thyroid microcarcinoma, or PTMC). Similarly, Adjuvant radioactive iodine ( does not have a role in the treatment of medullary and anaplastic thyroid cancer. Given the fact that variation in treatments exist, our goal was to analyze patterns of inappropriate adjuvant RAI use in the U.S. in order to identify potential misuses leading to an increase of costs for the healthcare system and unnecessary patients’ exposure to risks of complications.
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MedicalResearch.com Interview with:
Sandra M Swain, MD, FACP, FASCO
Medical Director, Washington Cancer Institute
MedStar Washington Hospital Center
Washington DC 20010
MedicalResearch: What take-home message would you like the general public to understand about this new analysis from the Cleopatra study?
Potential Key Message Options:
MedicalResearch.com Interview with:
Dr. Rahul S. Desikan MD, PhD
Department of Radiologoy
University of California, San Diego School of Medicine
Medical Research: What is the background for this study? What are the main findings?
Dr. Desikan: The MAPT gene encodes the tau protein, which plays an integral role in Alzheimer's disease (AD) neurodegeneration. Though a number of studies have investigated this issue, the role of the MAPT gene in Alzheimer's disease is still unclear. In contrast, a number of studies have found a robust association between MAPT and increased risk for other 'tauopathies' like Parkinson's disease (PD). In our study, rather than evaluating all possible genetic loci, we only assessed shared genetic variants between Alzheimer's disease and PD. By using this type of approach, we were able to increase our statistical power for gene discovery in Alzheimer's disease.
We found genetic overlap between Alzheimer's disease and Parkinson's disease at a locus on chromosome 17 within the MAPT region. Our findings demonstrate that this MAPT associated locus increases risk for Alzheimer's disease, correlates with gene expression of MAPT and is associated with brain atrophy of the entorhinal cortex and hippocampus on longitudinal MRI scans.
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MedicalResearch.com Interview with:
Virender K. Rehan, MD
LA BioMed Lead Researcher
Medical Research: What are the main findings?
Dr. Rehan: A new study holds hope for reversing asthma caused by smoking during
pregnancy. The study, published online by the American Journal of Physiology
- Lung Cellular and Molecular Physiology, reported that a medication that
stimulates certain proteins in the body reversed airway damage in disease
models of asthma caused by prenatal exposure to nicotine.
This is the first study to indicate that the damage caused by exposure to
nicotine during pregnancy could actually be reversed. Earlier studies found
this medication could prevent nicotine-induced asthma when given during
pregnancy. Researchers at Los Angeles Biomedical Research Institute (LA
BioMed) conducted the study to determine if the lung and airway damage
caused by nicotine could be reversed and found it could be.
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MedicalResearch.com Interview with:
Eva E. Bolt MD
Physician researcher Dept. Public and Occupational Health
EMGO+ Institute for Health and Care Research (VU University Medical Center)
Medical Faculty Amsterdam, The Netherlands
Medical Research: What is the background for this study? What are the main findings?
Dr. Bolt: Three-quarter of all Dutch physicians have ever been asked by a patient to perform euthanasia. Each request for euthanasia calls for careful deliberation. Firstly, the physician needs to judge whether euthanasia would be possible within the limits of the law. Above that, a physician needs to decide whether performing euthanasia is in line with his personal believes and values. This study shows that cause of suffering is an important factor in this decision.
In the Netherlands, the euthanasia law gives physicians the possibility of performing euthanasia, if they adhere to strict rules. The euthanasia law is not restricted to certain diseases. However, this study shows that the attitude of physicians towards performing euthanasia varies by condition. Most Dutch physicians would consider granting a request for euthanasia in case of cancer (85%) or another severe physical disease (82%). In contrast, only four out of ten physicians would consider granting a request for euthanasia in case of early-stage dementia. One in three would consider it in case of advanced dementia or psychiatric disease, and one in four in case of a person who is tired of living without suffering from a severe disease.
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MedicalResearch.com Interview with:
Sean M. Murphy, Ph.D.
Assistant Professor Department of Health Policy & Administration
Washington State University
Medical Research: What is the background for this study? What are the main findings?
Dr. Murphy: Professional healthcare advice regarding excessive alcohol consumption has been shown to reduce demand in a controlled setting. However, success in a clinical trial isn’t always indicative of an intervention’s effectiveness in everyday use. Studies testing the effect of provider advice on alcohol demand in a non-controlled environment are few, and have failed to control for non-moderate drinkers. Therefore, it is possible that the estimated effect of professional-health advice primarily reflected moderate-drinkers’ responses. The distinction between moderate and non-moderate drinkers is an important one, as society bears a large cost for those who consume above-moderate quantities, while moderate drinkers have been shown to be relatively productive and healthy. Excise taxes may not be efficient given that they impose negative externalities on moderate drinkers, while excessive drinkers have been shown to be relatively unresponsive to price increases. We found that personalized information from a healthcare professional was negatively associated with reported alcohol consumption among both “risky” and “binge" drinkers. Moreover, we found that personalized drinking advice may have an impact on those who are reluctant to state that they were given such advice.
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MedicalResearch.com Interview with:
Karolina Szummer, MD, PhD
Section of Cardiology, Department of Medicine
Karolinska Institutet Karolinska University Hospital
Stockholm, Sweden
Please note: This work is comparing the anticoagulant fondaparinux with low-molecular-weight heparin (not heparin).
Medical Research: What is the background for this study? What are the main findings?
Dr. Szummer: Since the publication of the OASIS-5 trial in 2006, many hospitals chose to change their medical practice and start using fondaparinux instead of low-molecular-weight heparin in the treatment of myocardial infarctions. In this study from the nation-wide near-complete myocardial infarction registry we were able to follow how the use of fondaparinux instead of low-molecular-weight heparin translated in clinical life was associated to a reduction in bleeding events and death. It is a very satisfying study, that confirms that the randomized clinical trial results are transferred with improvements in outcome to the treated patients.
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MedicalResearch.com Interview with:
Karen Thorpe PhD
Professor, Developmental Psychology
Program Leader, Early Education and Development Group
Program leader, Sleep in Early Childhood Group
School of Psychology and Counseling
Queensland University of Technology Australia
MedicalResearch: What is the background for this study?
Professor Thorpe: Sleep is undoubtedly important not only for how well we think, feel and behave in our daily lives but also for longer-term health. In childhood, the quantity and quality of night-time and 24 hour sleep have consistently been identified as predictor of health. For example, night sleep predicts weight status. These findings have led to the hypothesis that increasing quantity of sleep through promoting daytime sleep would benefit child health. We sought to look for evidence on the independent effects of daytime sleep on child health, learning and behavior to assess whether this hypothesis was supported. (more…)
MedicalResearch.com Interview with:
Dr. Prashant Kumar PhD (Cantab), MTech, BEng, FHEA, FCPS, FCCT, CEng(IEI), MIEnvSc, MIAQM, MIAAPC
Senior Lecturer in Wind Engineering
Department of Civil and Environmental Engineering (C5)
Faculty of Engineering and Physical Sciences
University of Surrey, Guildford
Medical Research: What is the background for this study? What are the main findings?
Dr. Kumar: Pollution is disproportionately spread in urban areas due to scattered mobile and stationary sources. Exhaust emissions from vehicles are one of the major sources of air pollution in urban areas. When vehicles stop at red lights, they go through different driving cycles such as idling, acceleration and deceleration. At the same time, a number of other vehicles are also queuing at red lights, emitting further emissions – these emissions take more time to disperse, especially in built-up areas, and end up accumulating in the air at traffic lights. In our study, we found that because drivers were decelerating and stopping at lights, then revving up to move quickly when lights go green, peak particle concentration was 29 times higher than that during free flowing traffic conditions. We also found that while drivers spent just two per cent of their journey time passing through traffic intersections managed by lights, that short duration contributes to about 25 per cent of their total exposure to these harmful particles.
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MedicalResearch.com Interview with:
Alisa G. Woods, Ph.D., MS Assistant Professor
Biochemistry & Proteomics Group
Department of Chemistry & Biomolecular Science
Clarkson University, Potsdam, NY, 13699
Medical Research: What is the background for this study? What are the main findings?
Dr. Woods: Objective assessments for autism are greatly needed in order to understand autism cause and also to diagnose autism. Currently autism is diagnosed based on behavior, despite theories that autism may have a biological cause. We sought to develop a non-invasive biological test for autism, using saliva and mass spectrometry-based proteomics. We found nine statistically significant proteins that were elevated in the saliva of children with autism relative to typically developing controls and three proteins that were significantly decreased or absent.
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MedicalResearch.com Interview with:
Jon Ebbert, M.D.
Associate director for research
Mayo Clinic Nicotine Dependence Center
Medical Research: What is the background for this study? What are the main findings?
Dr. Ebbert: Some cigarette smokers prefer to reduce the number cigarettes that they smoke before quitting smoking completely. Previous studies have evaluated the use of nicotine replacement therapy and one smaller study looked at varenicline to help smokers quit through smoking reduction. We wanted to conduct a larger study with varenicline using a longer duration of treatment.
We enrolled cigarette smokers who had no intention of quitting in the next month but who were willing to reduce the number of cigarettes they smoked while working toward a quit attempt in the next 3 months.
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MedicalResearch.com Interview with:
Dr. med. Laurence Genton, FMH Médecine Interne
Médecin adjointe agrégée, chargée de cours
Nutrition Clinique
Hôpitaux universitaires de Genève
Genève
Medical Research: What is the background for this study? What are the main findings?
Response: Several studies have shown that body mass index is linked to mortality through a U- or J-curve, i.e. that a low and maybe a high body mass index are related to a higher risk of mortality in elderly people. However, body mass index consists of fat mass and fat-free mass, and the former studies cannot differentiate the impact of these body compartments. However, this differentiation may be important to guide our public health care strategies. For instance, fat and fat-free mass can both be reduced by hypocaloric diet and endurance exercise, while fat-free mass can be increased with adequate calorie and protein intakes, resistance exercise and anabolic treatments. Thus, this study aimed at evaluating the impact of fat mass and fat-free mass on mortality.
We found that body mass index and body composition did not predict mortality in older women. However, a high fat-free mass was associated with a lower risk of mortality in men, even when adjusting for body mass index. (more…)
MedicalResearch.com Interview with:
Dr Miranda Armstrong M.Phil.
Physical Activity Epidemiologist
Cancer Epidemiology Unit University of Oxford
Oxford, UK
Medical Research: What is the background for this study? What are the main findings?
Dr. Armstrong: Physical activity has generally been associated with reduced risk of heart disease. However, there is limited evidence on the associations between the frequency and durations of various activities with stroke and blood clots, especially in middle-aged women.
This is a very large study of 1.1 million middle-aged women, which confirms the benefits of moderate activity for reducing the risk of heart disease and stroke. Further to this, it shows that benefits may be more wide ranging than previously thought as the risk of blood clots was also lower in women reporting moderate activity when compared to inactive women. We found little evidence to suggest that activity more frequent than a few times per week provided further benefits in relation to these diseases.
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MedicalResearch.com Interview with:
Robert M Centor, MD, MACP
Chair ACP Board of Regents
Regional Dean, UAB Huntsville Regional Medical Campus
Huntsville, AL 35801
Professor, General Internal Medicine
UAB Birmingham, AL 35294-3407
Medical Research: What is the background for this study? What are the main findings?
Dr. Centor: European researchers have shown that Fusobacterium necrophorum, an obligate gram-negative anaerobe, likely causes approximately 10% of young adult pharyngitis. This same organism is the major cause of peritonsillar abscess in the age group (and this age group has the highest rate of peritonsillar abscess). The organism also causes around 80% of the Lemierre Syndrome. We knew of no US data evaluating the role of this bacteria as a cause of pharyngitis. The European studies also did not report the signs and symptoms of Fusobacterium pharyngitis. (more…)
MedicalResearch.com Interview with:
Dr. Alexander Turchin M.D.,M.S.
Director of Informatics Research
Division of Endocrinology, Brigham and Women’s Hospital
Boston, MA
Medical Research: What is the background for this study? What are the main findings?
Dr. Turchin: Hypertension is the most common risk factor for cardiovascular events. High blood pressure increases the risk for stroke, myocardial infarction, heart failure and kidney failure. Treatment of high blood pressure reduces these risks. However, our understanding of optimal treatment of hypertension is incomplete. In particular, there is little information to guide clinicians on how quickly they should achieve blood pressure control in their patients. There have been no clinical trials focusing on this question. Current guidelines are sparse and are based only on expert opinion.
Our study analyzed treatment of nearly 90,000 patients in primary care practices in the U.K. between 1986 and 2010. We found that patients whose blood pressure medications were adjusted within 1.4 months after systolic blood pressure reached over 150 mm Hg and whose blood pressure was re-assessed within 2.7 months after their treatment was adjusted had the lowest risk for acute cardiovascular events and death from any cause.
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MedicalResearch.com Interview with:
David S. Black, Ph.D., M.P.H.
Associate Professor of Preventive Medicine
Keck School of Medicine of USC.
Medical Research: What is the background for this study? What are the main findings?
Dr. Black: Sleep disturbances pose a significant medical and public health
concern for our nation’s aging population. An estimated 50% of people
aged 55 years and older suffer from some form of sleep problem,
including initiating and maintaining sleep. Sleep can be affected by a number of things. There are obvious factors like disturbances, dealing with insomnia or any form of aches and pains. But there is also one that many people have probably not considered. Traffic noise. Just like the factors listed previously, there is always a solution to a problem. There isn't anything that cannot be fixed. If you are someone that is having trouble sleeping due to the high level of traffic noises around your area, it may be best to look into a site like soundproofpanda.com to find a solution that can help reduce this issue and eventually provide you with a good's night sleep. Older adults report the highest prevalence of sleep problems compared to younger age groups when quantified by both self-report and biological assessment.
Moderate sleep complaints in older adults are often associated with
deficits in daytime functioning, including elevated levels of fatigue,
disturbed mood such as depressive symptoms and reduced quality of
life, and lead to the onset of clinical insomnia. Addressing moderate
sleep complaints and sleep-related daytime dysfunction using
community-accessible programs is a promising public health approach.
Our main findings indicate that the mindfulness training program,
which is available to the general community, resulted in improvement
in sleep quality at post-intervention relative to a highly active and
standardized sleep hygiene education program. Effect size for
improvement in sleep quality was large (0.89) and of clinical
relevance considering that effect sizes obtained from all types of
behavioral interventions on self-reported sleep quality outcomes
averages 0.76 in older adults. Meta-analyses comparing treatment
modalities indicate that the mean effect size for self-reported sleep
improvements resulting from pharmacotherapy (0.87) (i.e.,
benzodiazepines, benzodiazepine receptor agonists) and behavioral
therapy (0.96) are of medium-to-large magnitude in mixed-age adult
samples with primary insomnia. Thus, our observed changes are
consistent with previous studies and are at the level of a minimally
important difference for insomnia severity. The mindfulness program
also yielded relative improvements on sleep-related daytime
impairments of depression and fatigue symptoms that were of
medium-to-large effect size.
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MedicalResearch.com Interview with:
Xiao Xu, PhD Assistant Professor
Department of Obstetrics, Gynecology and Reproductive Sciences
Yale University School of Medicine and
Harlan M Krumholz MD, SM
Harold H. Hines, Jr. Professor of Medicine (Cardiology) and Professor of Faculty of Arts and Sciences, of Investigative Medicine and of Public Health (Health Policy); Co-Director, Clinical Scholars Program; Director, Yale-New Haven Hospital Center for Outcomes Research and Evaluation New Haven, CT 06510
Medical Research: What is the background for this study? What are the main findings?
Response: Prior research of heart attack has mostly examined older patients, while few studies have focused on younger patients. Although we know that younger women differ from men and older patients in heart attack etiology and mortality, there is limited data on non-mortality outcomes of younger women and factors influencing their recovery. Mental stress is a particularly relevant factor for younger women as prior research showed higher stress in women than in men and an inverse association between age and stress. Therefore, in this study, we compared women and men 18-55 years old with heart attack and examined gender difference in mental stress and its potential role in explaining the worse recovery in women.
We addressed these questions using data from the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) project, which is the largest prospective observational study of young and middle-aged women and men with heart attack and has comprehensive information on patients’ clinical and psychosocial characteristics. Our findings showed significantly higher stress in women than in men. Moreover, mental stress is associated with worse recovery in multiple health outcomes 1 month after heart attack, such as angina-specific and overall quality of life. The greater stress in women may partially contribute to their worse recovery.
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MedicalResearch.com Interview with:
Dr Syed M R Gillani
Diabetes Centre, New Cross Hospital,
Wolverhampton, UK
MedicalResearch: What is the background for this study?
Dr. Gillani: NHS is facing the greatest challenge of its history in the form of A&E pressures and bed availabilities. Unplanned admissions are considered one of the key reasons. With an aging population, multiple co-morbidities and increasing pressures on social and primary care, we need to develop a proactive strategy to deal with this situation. It is a high priority agenda for the DOH. Initiatives such as “named GP for over 75” and “directly enhanced services to avoid unplanned admissions” have been rolled out by DOH in the last 2 years. In order to find an innovative way to assist in reduction of unplanned admissions, we decided to conduct an audit on all recurrent unplanned admissions with diabetes in the hospital over 12 months period. Its objective was to determine any unmet patient needs during an index admission to explore potential of changes in the service and to utilize available resources more effectively in an attempt to prevent next hospital admission for that patient.
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MedicalResearch.com Interview with:
Dr. May Nour MD PhD
Neurology Fellow
UCLA
Medical Research: What is the background for this study? What are the main findings?
Dr. Nour: In October of 2014, results from the MR CLEAN trial were the first to demonstrate better functional outcomes in stroke patients as a result of endovascular therapy. Among patients whose stroke was caused by clot blocking a large vessel responsible for delivering blood to the vital tissue of the brain, the use of endovascular therapy, primarily utilizing second-generation clot retrieval devices, showed improved outcomes in most cases evaluated in combination with medical therapy, when compared to medical therapy alone. Currently, the standard of care involves delivery of intravenous tissue plasminogen activator (IV tPA) within a short time window (up to 3-4.5 hrs) with the intention of dissolving, rather than physically removing the clot as in the case of endovascular retrieval.
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MedicalResearch.com Interview with:
Joshua D. Safer MD, FACP
Director, Endocrinology Fellowship Training and Endocrinology Education
Boston University Medical Center
Associate Professor of Medicine and Molecular Medicine
Boston University School of Medicine
Medical Research: What is the background for this study? What are the main findings?
Dr. Safer: This is a review of the current medical literature in favor of the biologic nature of gender identity. The main barrier to medical care for transgender patients is lack of physicians with the knowledge and willingness to provide that care. A major concern of physicians is that this is a mental health issue, meaning that transgender hormone therapy and surgery may be too drastic a response to an individual who should be counseled instead. The review lays out the evidence to make it clear that a major component of gender identity is biologic even if we don’t have the exact details worked out. Therefore, counseling alone cannot address the disconnect between transgender individuals’ gender identity and their physical bodies.
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MedicalResearch.com Interview with:
Dr. Jeremy Van Raamsdon PhD
Laboratory of Aging and Neurodk egenerative Disease (LAND),
Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, Deptment of Translational Science and Molecular Medicine, Department of Genetics, Michigan State University, East Lansing, Michigan,Dep. of Biology, McGill University, Montreal, Quebec, Canada
Medical Research: What is the background for this study? What are the main findings?
Dr. Van Raamsdonk : The free radical theory of aging is one of the most widely accepted theories of aging. This theory suggests that reactive oxygen species (ROS), which are also known as free radicals, cause a type of damage, called oxidative damage, that accumulates over time to cause the functional decline associated with aging. ROS have also been proposed to play a role in many diseases including neurodegenerative disorders such as Parkinson’s disease and Huntington’s disease.
However, recent work has demonstrated that ROS are not necessarily detrimental. ROS perform functional roles in the body and thus it is possible to have too little ROS. We previously showed that increasing ROS by decreasing the levels of an antioxidant enzyme called superoxide dismutase (SOD) does not decrease lifespan even when all of the SOD genes are removed. We also showed that in some cases treatment with an antioxidant, such as Vitamin C, can lead to decreased lifespan. This finding is consistent with human clinical trials in which it has not been possible to show a beneficial effect of antioxidants on longevity.
In this paper we further examine the relationship between ROS and aging. We use a simple genetic model organism, the worm Caenorhabditis elegans, which has been used extensively in aging research, to determine how location impacts the effect of ROS on lifespan. We used a genetic approach to increase the levels of ROS in different parts of a cell and found that location is crucial in determining the effect of ROS on lifespan. Mildly increasing the levels of ROS in the mitochondria increases lifespan, while increasing ROS in the cytoplasm has the opposite effect of decreasing lifespan.
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