Author Interviews

17 Feb

Posted at 18:45h in Addiction, Author Interviews

MedicalResearch.com Interview with:

[caption id="attachment_58805" align="alignleft" width="150"]Harriet De Wit, PhD Professor of Psychiatry and Behavioral Neuroscience University of Chicago Harriet De Wit, PhD[/caption]

Harriet De Wit, PhD Professor of Psychiatry and Behavioral Neuroscience University of Chicago 

MedicalResearch.com:  What is the background for this study?    Response: There are numerous reports that psychedelics like LSD, taken in very small ‘microdoses’, help boost mood, cognitive function and productivity. The practice is popular in Silicon Valley and among media figures, who report remarkable beneficial effects from regular use of these microdoses. The possible antidepressant effects of LSD are plausible from a neurobiological perspective, as the drug acts directly on serotonin receptors, the same systems where SSRI’s act.  However, the effects of microdosing have not yet been validated in controlled research. In our study, we recruited healthy men and women to ingest repeated, low doses of LSD under double blind conditions.  They attended four laboratory sessions, separated by three to four days.  They were randomly assigned to one of three groups who received the same drug on all four sessions: placebo, 13 micrograms of LSD or 26 micrograms of LSD. Subjects were not told exactly what drug they were receiving until the end of the study.  We measured their mood, emotional reactivity and cognition.

16 Feb

Posted at 22:37h in Author Interviews, JAMA, OBGYNE, STD
MedicalResearch.com Interview with: [caption id="attachment_58781" align="alignleft" width="150"]Irene A. Stafford, M.S., M.D. Associate Professor Associate Program Director Maternal - Fetal Medicine Fellowship Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine McGovern Medical School at UTHealth Dr. Stafford[/caption] Irene A. Stafford, M.S., M.D. Associate Professor Associate Program Director Maternal - Fetal Medicine Fellowship Department of Obstetrics and Gynecology Division of Maternal Fetal Medicine McGovern Medical School at UTHealth Houston MedicalResearch.com:  What is the background for this study? Response: We have observed disproportionately high-rates syphilis in the US over the last several years, and here in Texas. As this is now leading to health alerts in our cities, it is key we bring attention to this infection regarding risks to the pregnant patient and her fetus. Syphilis carries a nearly 40% neonatal mortality rate, so testing and treating is key in preventing this devastating neonatal infection. We need to encourage and offer testing at intake to pregnancy care, and any time a patient desires to be tested for STI.  

16 Feb

Posted at 20:02h in Author Interviews, COVID -19 Coronavirus
MedicalResearch.com Interview with: https://vipstarnetwork.com/Johonniuss Chemweno CEO of VIPStarNetwork MedicalResearch.com:  What is the mission of VIP StarNetwork?  Response: VIP StarNetwork’s mission is to expand access to healthcare services and information, especially in underserved and underprivileged communities. Our comprehensive group of health experts, leading physicians, and healthcare executives are working to create a meaningful and safe environment to ensure that patients have equitable and streamlined access to vaccines and other forms of care.

16 Feb

Posted at 17:38h in Author Interviews, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58751" align="alignleft" width="200"]Izzuddin M Aris, PhD Assistant Professor Department of Population Medicine, Harvard Medical School Division of Chronic Disease Research Across the Lifecourse, Harvard Pilgrim Health Care Institute Boston, MA Dr. Aris[/caption] Izzuddin M Aris, PhD Assistant Professor Department of Population Medicine, Harvard Medical School Division of Chronic Disease Research Across the Lifecourse Harvard Pilgrim Health Care Institute Boston, MA MedicalResearch.com:  What is the background for this study?  Response: Puberty is a key stage during child development. Previous research indicates that children in the United States are entering puberty at younger ages. These children may be in danger of developing certain diseases, such as type 2 diabetes, later in life. A better understanding of how early life factors affect puberty development is important for combating earlier puberty onset. .

15 Feb

Posted at 19:20h in Author Interviews, Cost of Health Care, COVID -19 Coronavirus, JAMA
MedicalResearch.com Interview with: [caption id="attachment_54411" align="alignleft" width="148"]Kao-Ping Chua, M.D., Ph.D. Assistant Professor, Pediatrics, Medical School Susan B. Meister Child Health Evaluation and Research Center University of Michigan Dr. Kao-Ping Chua[/caption] Kao-Ping Chua, MD, PhD Assistant Professor, Department of Pediatrics Assistant Professor, Health Management and Policy School of Public Health University of Michigan MedicalResearch.com:  What is the background for this study? Response: In 2020, most insurers waived the cost of COVID-19 hospitalization for patients. In early 2021, many major insurers started to abandon those waivers. By August 2021, the vast majority of insurers had started billing patients for COVID-19 hospitalizations again.

10 Feb

Posted at 23:29h in Author Interviews, COVID -19 Coronavirus, Vaccine Studies
MedicalResearch.com Interview with: Carmit Cohen, PhD, MDV – Laboratory manager Infection Prevention and Control UNIT Sheba Medical Center MedicalResearch.com:  What is the background for this study?  Response: We, Professor Regev-Yochay research group, began this study when the first COVID-19 patients were diagnosed in Israel. We followed humoral immune response kinetics of recoverees in the first year of the pandemic for a year (before the introduction of the Delta variant) and compared them to a matched cohort of two doses Pfizer vaccinated that was followed for up to eight month (until they received the third dose).

08 Feb

Posted at 19:28h in Author Interviews, Cancer Research, Ophthalmology
MedicalResearch.com Interview with: [caption id="attachment_58765" align="alignleft" width="150"]Dr. Saundra Singh M.D., Ph.D. Founder & CEO/President Singh Biotechnology  Dr. Singh[/caption] Dr. Saundra Singh M.D., Ph.D. Founder & CEO/President Singh Biotechnology https://www.singhbiotechnology.com/       MedicalResearch.com: What is the mission of Singh Biotechnology?  
  • Our mission is to develop medicine and therapeutics that dramatically improve and save the lives of people worldwide suffering from diseases, including cancer.
MedicalResearch.com: What are the advantages of the Single Domain Antibody technology?
  • The average human antibody is 150 Kd in size and works on the outside of the cell. The advantage of the single domain nanobody is that it is significantly smaller, in fact, it is one-tenth the size (approximately 15 Kd) of the human antibody. A smaller nanobody is more useful therapeutically because, unlike many cancer drugs currently on the market, it can penetrate the blood-brain barrier, the blood-retina barrier, and the cell membrane. Moreover, our SBT-100 drug has been shown to be non-toxic in animal models.

08 Feb

Posted at 18:19h in Author Interviews, Environmental Risks, Fertility, OBGYNE
MedicalResearch.com Interview with: Gang Chen, MD, PhD Deputy chief of cardiovascular surgery Children's Hospital of Fudan University Shanghai, Chin  MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: Preterm birth is a crucial global health issue. The relation between fertility treatment and preterm birth of singletons have not been fully clarified. In this cohort study of over 14 million pregnant women included in the US National Vital Statistics, fertility treatment, including both assisted reproductive treatment (ART) and non-ART treatment, was found positively correlated with preterm birth in singletons and infants conceived after fertility treatment were more strongly associated with higher rates of very preterm and extremely preterm birth. 

04 Feb

Posted at 18:32h in Author Interviews, COVID -19 Coronavirus, Race/Ethnic Diversity, Vaccine Studies
MedicalResearch.com Interview with: [caption id="attachment_58758" align="alignleft" width="158"]Bianca V. Sanchez Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, Pennsylvania Bianca V. Sanchez[/caption] Bianca V. Sanchez Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, Pennsylvania MedicalResearch.com: What is the background for the study? Response: Hispanic populations have been disproportionately affected by the COVID-19 pandemic, as evident by their increased rate of infection with the virus, hospitalizations, and mortality. Previous literature has indicated that many of these individuals demonstrate increased rates of vaccine hesitancy, subsequently increasing their risk for infection. This study aimed to characterize the reasoning behind vaccine hesitancy in Hispanic populations in the hopes of addressing their concerns through targeted educational interventions.

04 Feb

Posted at 17:36h in Author Interviews, Environmental Risks, JAMA, OBGYNE, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58736" align="alignleft" width="200"]Anders Hviid M.Sc.,Dr.Med.Sci. Head of Department (acting), Professor of Pharmacoepidemiology, Department of Epidemiology Research Statens Serum Institut Dr. Hviid[/caption] Anders Hviid M.Sc.,Dr.Med.Sci. Head of Department (acting), Professor of Pharmacoepidemiology, Department of Epidemiology Research Statens Serum Institut MedicalResearch.com:  What is the background for this study?  Response: An unusually low number of extremely preterm births have been observed in some countries during the initial covid-19 lockdowns. We speculated that this could be because of fewer infections, reduced activity levels, less stress etc. These are also factors that change with the seasons, and we hypothesized that extremely preterm birth might be associated with seasonality.

04 Feb

Posted at 17:31h in Addiction, Author Interviews, Opiods, PLoS
MedicalResearch.com Interview with: Dr. Laurence Moss MD, PhD candidate Centre for Human Drug Research (CHDR) Department of Anesthesiology Leiden University Medical Centre (LUMC) Geert Jan Groeneveld​, MD, PhD Neurologist | Clinical Pharmacologist | Professor of Clinical Neuropharmacology CMO/CSO Centre for Human Drug Research Leiden, The Netherlands  MedicalResearch.com:  What is the background for this study?    Response: Opioid use disorder (OUD) is a major source of morbidity and mortality, and the opioid epidemic in the Unites States (but increasingly in Europe also) has been well documented and reported on by the media. The alarming rise in opioid related mortality is largely driven by the increasing use of fentanyl and fentanyl analogues, often surreptitiously mixed with heroin or other drugs such as psychostimulants or prescribed opioids. Opioid-induced respiratory depression in particular is a leading cause of opioid-related fatalities. Buprenorphine has been proven as an effective medication for the treatment of OUD. Buprenorphine is a semi-synthetic partial agonist for the opioid receptor that firmly binds to these receptors and displays only partial respiratory depressive effects, meaning it does not cause the complete cessation of breathing as is the case with other potent opioids such as fentanyl. Due to its firm receptor binding, we hypothesized that at sufficient buprenorphine receptor occupancy, the effect of fentanyl on respiration would be limited, even at high fentanyl doses. This study aimed to provide proof of principle for this hypothesis, and demonstrate whether buprenorphine could reduce fentanyl-induced respiratory depression.

03 Feb

Posted at 18:32h in Author Interviews, COVID -19 Coronavirus, JAMA, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_58722" align="alignleft" width="150"]Andrea B. Troxel, ScD (she/her/hers) Professor and Director, Division of Biostatistics Department of Population Health NYU Grossman School of Medicine NYU Langone Health Dr. Troxel[/caption] Andrea B. Troxel, ScD (she/her/hers) Professor and Director, Division of Biostatistics Department of Population Health NYU Grossman School of Medicine NYU Langone Health MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: This study represents an international collaboration across four continents and six countries, to pool information from studies in different patient populations to generate robust information about the possible benefits of convalescent plasma in treating COVID-19. Because the study was so large and the methods so rigorous, we were able to show that while CP doesn’t benefit all patients, it may have positive effects in certain subgroups.

03 Feb

Posted at 18:25h in AHA Journals, Author Interviews, Blood Pressure - Hypertension, Race/Ethnic Diversity, Social Issues
MedicalResearch.com Interview with: Xing Gao, MPH, lead author and doctoral candidate in Dr. Mujahid's research group Mahasin Mujahid, MS, PhD, FAHA Lillian E. I. and Dudley J. Aldous Chair in the School of Public Health Associate Professor of Epidemiology Director, Epidemiology & Biostatistics Master of Public Health Program UC Berkeley, School of Public Health MedicalResearch.com:  What is the background for this study?  What are the main findings?
  • ​​Hypertension is a major risk factor for cardiovascular diseases, and persistent racial and ethnic inequities in hypertension remain an urgent public health challenge.
  • Public health researchers need a more nuanced understanding of how structural factors contribute to these inequities, which has a direct application to improving the cardiovascular health of marginalized populations.
  • This study examined associations between racial residential segregation, a product of historical and contemporary racially discriminatory policies, and hypertension in a multi-racial cohort of middle-aged and older adults. 

03 Feb

Posted at 10:52h in Author Interviews, COVID -19 Coronavirus, Technology
MedicalResearch.com Interview with: [caption id="attachment_58711" align="alignleft" width="150"]Michael J. Mahan Ph.D Professor Dept of Molecular, Cellular, and Developmental Biology University of California, Santa Barbara, CA 93106-9625 Dr. Mahan[/caption] Michael J. Mahan Ph.D Professor Dept of Molecular, Cellular, and Developmental Biology University of California, Santa Barbara, CA 93106-9625 MedicalResearch.com:  What is the background for this study?  Response: A critical need exists in resource-poor settings for low-cost, low-tech, yet highly reliable and scalable testing for SARS-CoV-2 virus that is robust against circulating variants. 

03 Feb

Posted at 10:45h in Author Interviews, COVID -19 Coronavirus, JAMA, Pediatrics, Respiratory, Yale
MedicalResearch.com Interview with: [caption id="attachment_58724" align="alignleft" width="200"]Thomas Murray MD PhD Associate Professor, Yale School of Medicine Department of Pediatrics, Infectious Disease and Global Health Associate Medical Director, Infection Prevention Yale New Haven Children's Hospital Dr. Murray[/caption] Thomas Murray MD PhD Associate Professor, Yale School of Medicine Department of Pediatrics, Infectious Disease and Global Health Associate Medical Director, Infection Prevention Yale New Haven Children's Hospital MedicalResearch.com:  What is the background for this study?  Response: This study was performed by Yale- CARES (Children and Adults Research in Early Education Study Team) a multidisciplinary group of researchers that are interested in learning how the COVID-19 pandemic has impacted early child care programs in the US including the effects on both the children and those who care for them in this setting. This is important because when child care programs close it becomes very difficult for working families to find safe, affordable alternative care. We surveyed over 6000 child care workers from across the US in May/June 2020 with a follow up survey in May/June 2021. This includes both center based and home based child care programs. One question we were interested in was what things they were doing in their programs to reduce the risk of COVID-19. We then asked whether their program closed at any time in that year because of COVID-19.

03 Feb

Posted at 10:41h in AHA Journals, Author Interviews, Heart Disease, Social Issues, UCSD
[caption id="attachment_58733" align="alignleft" width="150"]Natalie Golaszewski, PhD Herbert Wertheim School of Public Health and Human Longevity Science University of California, San Diego  La Jolla, CA 92093 Dr. Golaszewski[/caption] MedicalResearch.com Interview with: Natalie Golaszewski, PhD Herbert Wertheim School of Public Health and Human Longevity Science University of California, San Diego La Jolla, CA 92093 MedicalResearch.com:  What is the background for this study?  Response: Social isolation and loneliness are growing public health concerns as they are associated with health conditions that increase the risk of cardiovascular disease including obesity, smoking, physical inactivity, poor diet, high blood pressure and high cholesterol.

02 Feb

Posted at 18:51h in Author Interviews, Heart Disease, JAMA, NYU/NYMC, USPSTF
MedicalResearch.com Interview with: [caption id="attachment_56129" align="alignleft" width="133"]Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Dr. Ogedegbe[/caption] Gbenga Ogedegbe, MD, MPH Dr. Adolph & Margaret Berger Professor of Population Health Director, Division of Health & Behavior Director Center for Healthful Behavior Change Department of Population Health NYU Langone Health NYU School of Medicine Member of the U.S. Preventive Services Task Force MedicalResearch.com:  What is the background for this study?  What are the main findings?  Response: Atrial Fibrillation (AFib) is the most common type of irregular heartbeat and a major risk factor for stroke, and it often goes undetected. For this recommendation, the Task Force evaluated whether screening adults over the age of 50 who do not have any signs or symptoms of AFib can help prevent strokes. In its evidence review, Task Force expanded its scope to include a search for studies on portable and wearable devices such as smartphones and fitness trackers in addition to electrocardiography (ECG). Despite this consideration, the Task Force found insufficient evidence to recommend for or against screening for AFib. This is consistent with the Task Force’s 2018 recommendation.

28 Jan

Posted at 00:07h in Author Interviews, COVID -19 Coronavirus, JAMA
MedicalResearch.com Interview with: [caption id="attachment_58730" align="alignleft" width="200"]Eva Petkova, PhD  Professor, NYU School of Medicine Department of Population Health Division of Biostatistics Department of Child and Adolescent Psychiatry New York, NY 10016 Senior Scientist, Nathan Kline Institute of Psychiatric Research Orangeburg, NY 10962 Dr. Petkova[/caption] Eva Petkova, PhD Professor, NYU School of Medicine Department of Population Health Division of Biostatistics Department of Child and Adolescent Psychiatry, New York, NY 10016 Senior Scientist, Nathan Kline Institute of Psychiatric Research, Orangeburg, NY 10962 MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: The COMPILE study is based on real-time collection of individual patient data from 8 international completed, terminated early and ongoing randomized clinical trials testing the efficacy of convalescent plasma for the treatment of hospitalized patients with COVID-19. Recruitment covered the period from March 2020 to March 2021 in Asia, Europe, North and South America. Total of 2369 patients were enrolled and data from 2341 patients were used in the analysis. COMPILE, the largest study of convalescent plasma for hospitalized COVID-19 patients to date, provided robust information on a diverse patient population, which allowed rigorous evaluation of questions related to convalescent plasma efficacy. The main findings are that convalescent plasma might have only a moderate efficacy on average, but that there is a huge heterogeneity in the benefits for individual patients.

27 Jan

Posted at 16:53h in Author Interviews, Dermatology, Emory, JAMA, Race/Ethnic Diversity
MedicalResearch.com Interview with: [caption id="attachment_58708" align="alignleft" width="150"]Howa Yeung, MD MSc | He/him/his Assistant Professor of Dermatology Emory University School of Medicine Atlanta, GA 30322 Dr. Yeung[/caption] Howa Yeung, MD MSc | He/him/his Assistant Professor of Dermatology Emory University School of Medicine Atlanta, GA 30322 MedicalResearch.com:  What is the background for this study?  Response: Asian Americans are the fastest growing racial group in the United States but are underrepresented in health research. Existing research often categorize Asian Americans into a single racial category, which may mask differences in health behaviors and outcomes subgroups. We sought to examine potential differences in skin cancer-related risk factors and screening among Asian Americans in a large, nationally representative study.

26 Jan

Posted at 11:14h in Author Interviews, COVID -19 Coronavirus, JAMA, Race/Ethnic Diversity
MedicalResearch.com Interview with: [caption id="attachment_58692" align="alignleft" width="200"]Tasleem J. Padamsee, PhD Co-Leader  C3-REACH -- Committed to Communities Collaborative: Research and Engagement to Advance beyond COVID to Health EquityPrincipal Investigator The Daughter Sister Mother Project: Empowering Women and their Healthcare Providers to Fight Familial Cancer Lead Qualitative Investigator WOW Project: Washington & Ohio Workers Study Assistant Professor Division of Health Services Management & Policy, College of Public Health Faculty Affiliate, James Comprehensive Cancer Center The Ohio State University Dr. Padamsee[/caption] Tasleem J. Padamsee, PhD Co-Leader  C3-REACH -- Committed to Communities Collaborative: Research and Engagement to Advance beyond COVID to Health EquityPrincipal Investigator The Daughter Sister Mother Project: Empowering Women and their Healthcare Providers to Fight Familial Cancer Lead Qualitative Investigator WOW Project: Washington & Ohio Workers Study Assistant Professor Division of Health Services Management & Policy, College of Public Health Faculty Affiliate, James Comprehensive Cancer Center The Ohio State University MedicalResearch.com:  What is the background for this study?  Response: This is a study about COVID-19 vaccine hesitancy in the United States. Although there has been a lot of discussion about vaccine hesitancy as a barrier to achieving high rates of COVID-19 vaccination, there have been few studies of changes in hesitancy - or how it might vary across groups. As COVID-19 vaccines were becoming available in the US there was a lot of discussion about worrisome rates of vaccine hesitancy, particularly among communities of color. Our team suspected, however, that these high rates might be short-lived, and that Black Americans in particular might become willing to use COVID-19 vaccines after a short period of time - as they became reassured that they would be safe, effective, and protect communities.

25 Jan

Posted at 23:11h in Author Interviews, CDC, COVID -19 Coronavirus, Emory, Heart Disease, JAMA
MedicalResearch.com Interview with: [caption id="attachment_58700" align="alignleft" width="200"] Dr. Oster[/caption] Matthew Oster, MD, MPH CDC COVID-19 Response CDC Center on Birth Defects and Developmental Disabilities Pediatric Cardiologist, Sibley Heart Center, Children’s Healthcare of Atlanta Emory University School of Medicine Emory University Rollins School of Public Health MedicalResearch.com:  What is the background for this study?  What are the main findings? Response: More than 192 million people ages 12 years and older in the U.S. received at least one dose of mRNA COVID-19 vaccines from December 2020 through August 2021. From this population, VAERS (the Vaccine Adverse Event Reporting System) received 1,991 reports of myocarditis,  1,626 of which met the case definition of myocarditis. Rates of myocarditis were highest following the second dose of an mRNA vaccine among males aged 12–15 years (70.7 per million doses of Pfizer), 16-17 years (105.9 per million doses of Pfizer), and 18–47 years (52.4 and 56.3 per million doses of Pfizer and Moderna, respectively). Of those with myocarditis, the median age was 21 years and the median time from vaccination to symptom onset was two days. Males accounted for 82% of patients for whom sex was known. Approximately 96% were hospitalized, 87% of whose symptoms had gone away by the time they were discharged from the hospital. Non-steroidal anti-inflammatory drugs (589/676, 87%) were the most common treatment.

24 Jan

Posted at 13:23h in Author Interviews, Kidney Disease, Rheumatology
[caption id="attachment_58695" align="alignleft" width="150"]Stephen Connelly, PhD, Chief Scientific Officer, Equillium Dr. Connelly[/caption] Stephen Connelly, PhD Co-founder & Chief Scientific Officer Equillium, Inc. San Diego, California MedicalResearch.com:  What is the background for this study?    Response: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that predominantly affects women in the reproductive age range. Approximately 50% of SLE patients experience lupus nephritis (LN), a serious complication that is accompanied by significant morbidity and mortality. Progression of LN to chronic kidney disease is common, with 10% of patients with LN developing end-stage kidney disease. T cells, play a central role in the pathogenesis of both SLE and LN by mediating tissue damage and enhancing the production of autoantibodies by promoting B cell differentiation, proliferation, and maturation. These T cells express CD6, a costimulatory receptor that through its binding to activated leukocyte cell adhesion molecule (ALCAM), expressed on immune cells and tissues, modulates both the activity and trafficking of effector T cells (Teff). The expression of both CD6 and ALCAM (CD6-ALCAM pathway) have been associated with pathogenic effector T cell activity and trafficking in multiple autoimmune and inflammatory diseases. Based on a comprehensive screen of more than 1100 urine proteins, soluble urinary ALCAM (uALCAM) was identified as one of only a few molecules that were elevated in the urine of patients with SLE with active renal involvement compared with patients with quiescent or no prior nephritis. However, no studies had been conducted to characterize the cellular sources of the soluble ALCAM and questions remained about the relevance of this protein and whether it was associated with the pathology of the disease.

23 Jan

Posted at 22:07h in Aging, Author Interviews, Dental Research, Geriatrics, NYU/NYMC
MedicalResearch.com Interview with: [caption id="attachment_58688" align="alignleft" width="200"]Bei Wu, PhD Dean's Professor in Global Health Vice Dean for Research Rory Meyers College of Nursing Affiliated Professor, College of Dentistry Co-Director, NYU Aging Incubator New York University New York, NY 10010 Dr. Bei Wu[/caption] Bei Wu, PhD Dean's Professor in Global Health Vice Dean for Research Rory Meyers College of Nursing Affiliated Professor, College of Dentistry Co-Director, NYU Aging Incubator New York University New York, NY 10010 MedicalResearch.com:  What is the background for this study?    Response: Social isolation and loneliness are global public health concerns. Social isolation is the lack of social contacts and having few people to have regular interactions; while loneliness is the distressing feeling of being alone or separated. Approximately 24% of community-dwelling older adults aged 65 and above are considered to be socially isolated in the United States, and 43% adults aged over 60 years old report feeling lonely. Increasing evidence suggests that social isolation and loneliness are risk factors for older adults’ health outcomes, such as depression, comorbidities, cognitive impairment and dementia, and premature mortality. However, one key limitation in the literature is that only a few studies have examined the impact of social isolation and loneliness on oral health.

20 Jan

Posted at 17:11h in Author Interviews, BMJ, Orthopedics
MedicalResearch.com Interview with: [caption id="attachment_58670" align="alignleft" width="150"]Prof. Matthew Costa Professor of Orthopaedic Trauma University of Oxford Honorary Consultant Trauma Surgeon, John Radcliffe Hospital, Oxford Prof. Costa[/caption] Prof. Matthew Costa Professor of Orthopaedic Trauma University of Oxford Honorary Consultant Trauma Surgeon, John Radcliffe Hospital, Oxford  MedicalResearch.com: What is the background for this study? Response: Fixation with metal implants provides reliable functional outcomes for patients after a manipulation of a displaced fracture of the distal radius, but such surgery carries risk for the patient and is expensive. A moulded plaster cast is a safer and cheaper intervention but may not provide the same functional outcome. It is not known which of these treatments is superior.

20 Jan

Posted at 17:07h in Author Interviews, Diabetes, NEJM, Pediatrics, Technology
MedicalResearch.com Interview with: [caption id="attachment_58667" align="alignleft" width="200"]Dr Julia Ware (née Fuchs) Clinical Research Associate Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories  and Medical Research Council Metabolic Diseases Unit, University of Cambridge Addenbrooke’s Hospital, Cambridge  Dr. Ware[/caption] Dr Julia Ware (née Fuchs) Clinical Research Associate Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit, University of Cambridge Addenbrooke’s Hospital, Cambridge MedicalResearch.com: What is the background for this study? Response: Management of type 1 diabetes is challenging in very young children, due to their high variability of insulin requirements and unpredictable eating and activity patterns. As a result, many young children do not meet the recommended glycemic targets, or only maintain recommended glycemic control with extensive caregiver input. This in turn leads to high management burden and reduced quality of life for the whole family. While the increasing use of continuous glucose-monitoring devices and insulin-pump therapy has led to reductions in the incidence of severe hypoglycaemia and diabetic ketoacidosis, and has been accompanied by modest improvements in glycemic control, the burden of management has remained high. Hybrid closed-loop systems (also called an artificial pancreas), in which an algorithm automatically adjusts insulin delivery on the basis of real-time sensor glucose levels, may address ongoing challenges in this age group. However, to date hybrid closed-loop studies involving very young children have been small and of short duration and the efficacy and safety of longer term use of a closed-loop system, as compared with standard therapy, was unclear.   To address this knowledge gap, we compared 16-week use of the Cambridge closed-loop algorithm with sensor-augmented pump therapy in children aged 1 to 7 years with type 1 diabetes in a multi-national randomised crossover study.

20 Jan

Posted at 16:57h in Author Interviews, Ophthalmology, PLoS
MedicalResearch.com Interview with: [caption id="attachment_58681" align="alignleft" width="263"]Jugnoo S Rahi  Professor of Ophthalmic Epidemiology and Honorary Consultant Ophthalmologist NIHR Senior Investigator Prof. Rahi[/caption] Prof. Jugnoo S Rahi Professor of Ophthalmic Epidemiology and Honorary Consultant Ophthalmologist NIHR Senior Investigator Head, Vision and Eyes Group UCL Head, Population Policy and Practice Research and Teaching Department GOS ICH UCL Director, Ulverscroft Vision Research Group  GOS Institute of Child Health UCL / Great Ormond Street Hospital NHS Foundation Trust Institute of Ophthalmology UCL / NIHR Moorfields Biomedical Research Centre Chair, Academic Committee Chair, British Ophthalmological Surveillance Unit Executive Committee Royal College of Ophthalmologists  MedicalResearch.com:  What is the background for this study?    Response: We hypothesised that if changing environmental factors, in particular educational experience, are accounting for increasing frequency of myopia in the UK, a cohort effect would be discernible in changing associations with myopia, with different profiles for childhood and adult-onset forms. We investigated this using the UK Biobank Study, a unique large contemporary adult population sample whose members, born over a period of more than three decades, have undergone a detailed ophthalmic examination. This affords the opportunity to analyse ‘historical’ cohorts covering a period of important socio-demographic, economic, and educational change in the UK from which current and emerging trends may be identified and examined. Drawing on our previous proof-of-concept study, we investigated whether there were differences between childhood-onset versus adult-onset myopia in temporal trends in both frequency and severity and in associations with key environmental factors.

19 Jan

Posted at 12:41h in Author Interviews, Multiple Sclerosis
MedicalResearch.com Interview with: [caption id="attachment_58674" align="alignleft" width="150"]Marcus Koch Dr. Koch[/caption] Marcus Koch MD PhD Associate Professor of Neurology Multiple Sclerosis Program University of Calgary MedicalResearch.com: What is the background for this study? Response: Primary progressive multiple sclerosis (PPMS) is the least common, but also the least treatable form of multiple sclerosis. PPMS does not react well to commonly used MS treatments. We believe that this is at least in part because PPMS is driven by other disease mechanisms. One disease mechanism that we believe is important in PPMS is microglial activation. Microglial cells are a type of cell in the brain and spinal cord that normally have beneficial functions, such as clearing debris or assisting repair after injury. In PPMS however, microglial cells are chronically active, and we believe that this chronic microglial activation contributes to tissue damage.

18 Jan

Posted at 21:57h in Author Interviews, Critical Care - Intensive Care - ICUs, JAMA, Pediatrics
MedicalResearch.com Interview with: [caption id="attachment_58650" align="alignleft" width="150"]Edward Bell, MD Professor of Pediatrics-Neonatology Vice Chair for Faculty Development, Stead Family Department of Pediatrics Roy J. and Lucille A. Carver College of Medicine University of Iowa Dr. Bell[/caption] Edward Bell, MD Professor of Pediatrics-Neonatology Vice Chair for Faculty Development, Stead Family Department of Pediatrics Roy J. and Lucille A. Carver College of Medicine University of Iowa MedicalResearch.com: What is the background for this study? Response: The National Institute of Child Health and Human Development, a branch of the National Institutes of Health (NIH), has supported the Neonatal Research Network (NRN) since 1986. The NRN, a group of US academic centers, is tasked with conducting research to improve the treatment and health outcomes of premature and critically-ill babies in US neonatal intensive care units (NICUs). Every few years, the NRN publishes reports on the survival rates and outcomes of surviving extremely premature babies, those born before 28 weeks of gestation. These reports help us to judge progress in the care and outcomes of these infants. This paper is the 9th in this series of reports but the first that includes not only survival and in-hospital outcomes but also outcomes at 2 years of age.