Author: Marie Benz MD FAAD
07 Feb Can Propranolol Reduce Nicotine Cravings?
MedicalResearch.com Interview with: [caption id="attachment_31790" align="alignleft" width="133"]
Dr. Lin Lu[/caption]
Lin Lu, M.D. Ph.D.
Director/Professor, Institute of Mental Health and Peking University Sixth Hospital
Director/Professor, National Institute on Drug Dependence, Peking University
Beijing China
MedicalResearch.com: What is the background for this study?
Response: Nicotine addiction is the leading preventable cause of mortality, and causes over 6 million deaths each year. One fundamental mechanism that maintain smoking relapse in smokers is the persistence of memories of both nicotine reward and nicotine-associated conditioned stimulus (CS, e.g. ashtray,cigarette lighters, etc.).Preclinical studies suggest that the drug reward memories can be reactivated by nicotine-associated CS undergo an unstable stage, named memory reconsolidation, and that pharmacological or behavioral manipulations that interfere with reconsolidation inhibit subsequent drug relapse.
However, most of the translational studies targeting reconsolidation stages of the drug reward memory have not been successful.One important reason is that when participants were exposed to nicotine-associated CS to induce memory reconsolidation, the pharmacological or behavioral manipulations only interfere with the reconsolidation of memories selectively associated with the reactivated CS, without affecting other CSs.
However, in real life, smoking is associated with multiple CSs that vary across individuals. Thus, a key question is how to interfere with reconsolidation of multiple nicotine-associated memories . In the present study, we introduce a novel memory reconsolidation interference procedure in which we reactivated multiple nicotine reward memories in rats and human smokers by acute exposure to nicotine (the UCS) and then interfered with memory reconsolidation using the noradrenergic blocker propranolol, an FDA-approved drug.
06 Feb Better Means to Reduce Breast Density Needed To Decrease Breast Cancer Risk
MedicalResearch.com Interview with: [caption id="attachment_31761" align="alignleft" width="133"]
Natalie Engmann[/caption]
Natalie Engmann, MSc
PhD Candidate, Epidemiology and Translational Science
Department of Epidemiology & Biostatistics
University of California, San Francisco
MedicalResearch.com: What is the background for this study?
Response: Breast density is well-established as a strong risk factor for breast cancer. Our study looked at what proportion of breast cancer cases in the entire population can be attributed to risk factors routinely collected in clinical practice, including breast density, measured using the clinical Breast Imaging and Reporting Scale (BI-RADS) categories.
06 Feb Severe Clostridium difficile Infections May Be Better Treated With Vancomycin
MedicalResearch.com Interview with: [caption id="attachment_31754" align="alignleft" width="200"]
Dr. Vanessa Stevens[/caption]
Vanessa W. Stevens, PhD
IDEAS 2.0 Center, Veterans Affairs (VA) Salt Lake City Health Care System
Division of Epidemiology, Department of Internal Medicine
University of Utah School of Medicine
Salt Lake City, Utah
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Although metronidazole remains the most commonly used drug to treat Clostridium difficile infection (CDI), there is mounting evidence that vancomycin is a better choice for some patients. Most previous studies have focused on primary clinical cure, but we were interested in downstream outcomes such as disease recurrence and mortality. We found that patients receiving metronidazole and vancomycin had similar rates of recurrence, but patients who were treated with vancomycin had lower risks of all-cause mortality. This was especially true among patients with severe Clostridium difficile.
06 Feb Variable Effects of Vitamin C on Post-Operative Atrial Fibrillation
MedicalResearch.com Interview with: [caption id="attachment_25990" align="alignleft" width="180"]
Dr. Harri Hemilae[/caption]
Harri Hemilä, MD, PhD
Department of Public Health
University of Helsinki
MedicalResearch.com: What is the background for this study?
Response: I have a long term interest in vitamin C. Previously I have shown that it alleviates exercise-induced bronchoconstriction (EIB) (http://dx.doi.org/10.1186/1710-1492-10-58 ) and shortens the duration of colds ( http://dx.doi.org/10.1371/journal.pmed.0020168 ). Now I had been following the literature and I noted that a number of randomized trials were being published about vitamin C for preventing post-operative atrial fibrillation (POAF). Therefore I reasoned that it is worthwhile to analyze that set of trials
06 Feb Our ‘Motor Signature’ Is a Window Into Mental Health
MedicalResearch.com Interview with: [caption id="attachment_31745" align="alignleft" width="150"]
Dr. Piotr Słowiński[/caption]
Dr. Piotr Słowiński
Department of Mathematics
College of Engineering
Mathematics and Physical Sciences,
Research Fellow
University of Exeter
MedicalResearch.com: What are the main findings?
Response: In an earlier study, we have found that every person has an individual style of moving (its own individual motor signature) and that people who have similar motor signatures are better in coordinating with each other (http://rsif.royalsocietypublishing.org/content/13/116/20151093). In the current study, we show that both these characteristics, own motor signature, and quality of interaction with others, have potential to give and insight into person's mental health condition.
Assessment of motor symptoms is already a part of a clinical interview during a neurological evaluation by an expert psychiatrist. Our method, if confirmed in clinical trials, would speed up such examination and would allow for better allocation of the valuable time of medical professionals (for example, for more advanced tests in cases of diagnostic uncertainty). Additionally, it could allow for monitoring and personalization of treatment.
06 Feb The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome
[caption id="attachment_31709" align="alignleft" width="200"]
Dr. Dan Hu[/caption]
MedicalResearch.com Interview with:
Dan Hu (Helen), MD. PhD. FAHA. FACC. FHRS.
Research Scientist II, Associate Professor
Clinical Consultant of Molecular Genetic Department
SCRO Chair of Stem Cell Center
Masonic Medical Research Laboratory
Utica, NY 13501
MedicalResearch.com: What is the background for this study?
Response: Short QT Syndrome (SQTS) is a rare genetic disease characterized by an abnormally short QT interval in subjects with structurally normal hearts. It is a recognized cause of cardiac rhythm disorders, including both atrial and ventricular arrhythmias, and sudden cardiac death (SCD). As an inherited channelopathy, the molecular basis for SQTS has been associated with mutations in 6 genes: KCNH2 (IKr, SQTS1), KCNQ1 (IKs, SQTS2), and KCNJ2 (IK1, SQTS3), which encode different potassium channels; CACNA1C, CACNB2b and CACNA2D1 (SQTS4-6), which encode the L-type calcium channel (ICa). This study sought to evaluate the phenotypic and functional expression of an apparent hotspot mutation associated with SQTS.
06 Feb Smaller and More Stable Than Stem Cells, Exosomes Can Preserve Retinal Cell Function
MedicalResearch.com Interview with: [caption id="attachment_31736" align="alignleft" width="180"]
Dr. Ben Mead[/caption]
Ben Mead, BSc, MRes, PhD
Section of Retinal Ganglion Cell Biology
Laboratory of Retinal Cell and Molecular Biology
National Eye Institute, National Institutes of Health
Bethesda, Maryland 20892
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Retinal ganglion cells (RGC) in the back of the eye transmit visual information to the brain, via long thread-like extensions called axons, which make up the optic nerve. Loss of these cells is the leading cause of irreversible blindness and can occur through trauma or degenerative diseases, such as glaucoma or optic neuritis. While no treatment yet exists to directly protect RGC from death, mesenchymal stem cells, a type of stem cell isolated from adult bone marrow, have shown therapeutic efficacy in various animal models and are currently undergoing clinical trials.
In this study, we aimed to isolate exosomes, which are small, membrane-enclosed vesicles secreted by bone marrow stem cells (BMSC) and that we believe are associated with the therapeutic effect of BMSCs. Injecting these exosomes into the eyes of animals following an optic nerve injury, was associated with significant neuroprotection of RGC, as well as preservation of RGC function. The protective effects of exosomes appeared to be through their delivery of microRNA, molecules that interfere with or silence gene expression.
06 Feb Brain-Reward Circuit Both Under and Over Responsive in Addiction and Gambling
MedicalResearch.com Interview with: [caption id="attachment_31739" align="alignleft" width="141"]
Dr. Guillaume Sescousse[/caption]
Guillaume Sescousse, PhD
Senior post-doc
Donders Centre for Cognitive Neuroimaging
The Netherlands
with collaborators Maartje Luijten, PhD,
and Arnt Schellekens, MD PhD
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: People with an addiction process rewards in their brain differently from people who are not addicted. However, whether this is associated with “too much” or “too little” brain activity is an open question. Indeed, past research has produced conflicting findings.
In order to get a reliable answer, we have combined 25 studies investigating brain reward sensitivity in more than 1200 individuals with and without addiction to various substances such as alcohol, nicotine or cocaine but also gambling. By analyzing the brain images from these studies, we have discovered an important difference in brain activity between expecting a reward and receiving a reward. Compared with non-addicted individuals, individuals with substance or gambling addiction showed a weaker brain response to anticipating monetary rewards. This weaker response was observed in the striatum, a core region of the brain reward circuit, possibly indicating that individuals with an addiction have relatively low expectations about rewards. In contrast, this same region showed a relatively stronger response to receiving a reward in individuals with substance addiction compared with non-addicted individuals. Many addiction rehab centres, such as Avante, offer targeted addiction relief strategies to help a specific person with their addiction.
This stronger response possibly indicates a stronger surprise to getting the reward, and is consistent with low expectations. This same effect was not found among people addicted to gambling.
06 Feb Study Validates Good Quality Care Provided By Foreign-Trained Doctors
Posted at 16:10h
in Author Interviews, BMJ, Brigham & Women's - Harvard, Education, Outcomes & Safety
MedicalResearch.com Interview with:
[caption id="attachment_31685" align="alignleft" width="180"]
Dr. Yusuke Tsugawa[/caption]
Yusuke Tsugawa, MD, MPH, PhD
Research Associate at Department of Health Policy and Management
Harvard T.H. Chan School of Public Health
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Prior evidence has been mixed as to whether or not patient outcomes
differ between U.S. and foreign medical graduates.
However, previous studies used small sample sizes or data from a small number of states.
Therefore, it was largely unknown how international medical graduates
perform compared with US medical graduates.
To answer this question, we analyzed a nationally representative
sample of Medicare beneficiaries admitted to hospitals with a medical
condition in 2011-2014. Our sample included approximately 1.2 million
hospitalizations treated by 40,000 physicians. After adjusting for
severity of illness of patients and hospitals (we compared physicians
within the same hospital), we found that patient treated by
international medical graduates had lower mortality than patients
cared for by US medical graduates (adjusted 30-day mortality rate
11.2% vs 11.6%, p<0.001). We observed no difference in readmissions,
whereas costs of care was slightly higher for international medical
graduates.
03 Feb New Compounds May Extend Efficiency of Sunscreens
[caption id="attachment_31720" align="alignleft" width="200"]
Dr. Diego Sampedro[/caption]
MedicalResearch.com Interview with:
Dr. Diego Sampedro PhD
Department of Chemistry, Centro de Investigación en Síntesis Química (CISQ)
Universidad de La Rioja
Logroño, Spain
MedicalResearch.com: What is the background for this study?
Response: Skin cancer is currently the most common type of cancer. While it implies a relatively low mortality rate, the reported cases of all types of skin cancer have been steadily increasing for the last decades. The ozone layer depletion and longer sunlight exposure times due to outdoors activities contribute to this increase. Solar light is well-known to lead to several skin cellular problems, including DNA damage, mutations, oxidative stress, sunburn and immune suppression. These deleterious effects of sunlight may be mitigated by the use of sunscreens.
Sunscreens are inorganic or organic substances that are directly applied onto the skin, designed to minimize light transmission into the skin, mainly in the ultraviolet region of the solar spectrum. However, serious concerns exist about the safety of several commercial sunscreens components, as well as several drawbacks due to the lack of stability, biodegradability and effectiveness for skin protection. Thus, the development of new (and more efficient) types of sunscreens is of critical importance with a great potential impact in public health and industrial applications.
02 Feb Annual CT Lung Cancer Screening Among Former Smokers Remains Underutilized
MedicalResearch.com Interview with: [caption id="attachment_31705" align="alignleft" width="138"]
Dr. Ahmedin Jemal[/caption]
Ahmedin Jemal, DVM, PHD
Vice President, Surveillance and Health Services Research
American Cancer Society, Inc.
250 Williams St.
Atlanta, GA 30303
MedicalResearch.com: What is the background for this study?
Response: In December 2013, the United States Preventive Services Task Force (USPSTF) recommended annual screening for lung cancer with low dose computed tomography (LDCT) for current or former heavy smokers who quit within the past 15 years.
A previous study estimated that only 2-4% of heavy smokers received LDCT for lung cancer screening in 2010 in the United States. We sought to determine whether lung cancer screening among high risk smokers increased in 2015, following the USPSTF recommendation in 2013.
02 Feb Donated Tissue Provides Surgeons Improved Ways to Repair and Reconnect Damaged or Severed Nerves
MedicalResearch.com Interview with: [caption id="attachment_31726" align="alignleft" width="250"]
Karen Zaderej[/caption]
Karen Zaderej
CEO, AxoGen
Karen Zaderej joined AxoGen in May 2006. She has served as President, Chief Executive Officer and a member of the Board of Directors of AxoGen, Inc. since May 2010. Prior to her current role, she served as Chief Operating Officer from October 2007 to May 2010 and as Vice President of Marketing and Sales from May 2006 to October 2007. From October 2004 to May 2006, Karen worked for Zaderej Medical Consulting, a consulting firm she founded that helped medical device companies build and execute successful commercialization plans. From 1987 to 2004, Karen worked at Ethicon, Inc., a Johnson & Johnson company, where she held senior positions in marketing, business development, research & development, and manufacturing. Karen is a Director of SEBio, a non-profit supporting the life science industry in the southeastern United States. Karen earned an MBA from the Kellogg Graduate School of Business at Northwestern University and a Bachelor of Science degree in Chemical Engineering from Purdue University.
MedicalResearch.com: Please tell us about yourself and how you became CEO at AxoGen.
Response: I met Jamie Grooms, co-founder of AxoGen, in 2005 and we had one of those meetings that change your life. Jamie is a serial entrepreneur and loves to start businesses. He had tried to make nerves in the past but had been unsuccessful. When he saw new technology at the University of Florida that explained some of the issues in regenerating nerves, he decided to found a company focused on nerve repair. In parallel, I had been in business development and strategic marketing for Johnson & Johnson and we had looked at the nerve repair market. We determined there was a significant unmet need in nerve repair, but we could not find any technology at that time that solved the surgical need. Several years later, I left J&J and started a consulting business focused on market development and commercialization of early stage med tech companies. Jamie and I met, and I found the technology I had been looking for years earlier. We had an exciting conversation about the potential to improve the lives of patients with nerve injuries. I saw the possibility to create an entire new segment in med tech, one dedicated to nerve repair. With that great potential in front of me, I closed my consulting business, moved to Florida, and joined the AxoGen team.
01 Feb Best Case/Worst Case Framework Helps Surgeons Communicate With Frail Seriously Ill Patients
MedicalResearch.com Interview with: [caption id="attachment_31637" align="alignleft" width="189"]
Dr. Margaret Schwarze[/caption]
Margaret L Schwarze, MD, MPP
Associate Professor
Division of Vascular Surgery
University of Wisconsin
MedicalResearch.com: What is the background for this study?
Response: Surgery can have life-altering consequences for frail older adults, yet many undergo an operation during the last year of life. Surgeons commonly rely on informed consent to disclose risks of discrete complications; however, this information is challenging for patients to interpret with respect to their goals and values.
Our research group developed a communication framework, called Best Case/Worst Case, to change how surgeons communicate with patients facing serious illness. Surgeons use the framework to describe the best, worst, and most likely scenarios to present a choice between valid treatment alternatives and help patients imagine how they might experience a range of possible treatment outcomes.
01 Feb Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer
Posted at 22:44h
in ASCO, Author Interviews, Cancer Research, Colon Cancer, Genetic Research, Journal Clinical Oncology
MedicalResearch.com Interview with:
Matthew B Yurgelun, M.D
Instructor in Medicine, Harvard Medical School
Dana-Farber Cancer Institute
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: It has long been known that hereditary factors play a key role in colorectal cancer risk. It is currently well-established that approximately 3% of all colorectal cancers arise in the setting of Lynch syndrome, a relatively common inherited syndrome that markedly increases one’s lifetime risk of colorectal cancer, as well as cancers of the uterus, ovaries, stomach, small intestine, urinary tract, pancreas, and other malignancies. Current standard-of-care in the field is to test all colorectal cancer specimens for mismatch repair deficiency, which is a very reliable means of screening for Lynch syndrome. The prevalence of other hereditary syndromes among patients with colorectal cancer has not been known, though other such factors have been presumed to be quite rare.
01 Feb Over 100 Genetic Signals Influence Blood Pressure
MedicalResearch.com Interview with: [caption id="attachment_31612" align="alignleft" width="180"]
Dr. Helen Warren[/caption]
Helen R Warren PhD
Analysis, Statistics, Genetic Epidemiology
Queen Mary, University of London
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This study analysed data from UK Biobank, which is a large cohort including over 500,000 male and female participants from across the UK, aged 40-69 years. We performed a genetic association study for blood pressure, which analysed ~140,000 individuals of European ancestry (as currently interim genetic data is only available for ~150,000 participants).
Our study identified 107 genetic regions associated with blood pressure, which had not been previously reported at the time of our analysis. All our new findings were robustly validated within independent replication data resources, comprising a large, total sample size of up to 420,000 individuals.
01 Feb E-Cigs Linked To Adverse Cardiac Effects
MedicalResearch.com Interview with: [caption id="attachment_31634" align="alignleft" width="101"]
Dr. Holly Middlekauff[/caption]
Holly R. Middlekauff, MD
Professor
UCLA Division of Cardiology
David Geffen School of Medicine
UCLA
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: E-cigarettes are the fastest rising tobacco product in the US today, but almost nothing is known about their cardiovascular effects. Rather than wait decades for epidemiological data in e-cigarette users to become available, we reasoned that investigations into the known mechanisms by which tobacco cigarettes increase heart disease would provide insights into the health risks of e-cigarettes.
We focused on 2 critical mechanisms:
1) cardiac adrenaline activity, and
2) oxidative stress, measured in chronic e-cigarrete users compared to matched, healthy controls.
The major findings were that, compared to healthy controls, e-cig users had increased cardiac adrenaline activity (measured by a technique called "heart rate variability"). Furthermore, compared to healthy controls, the e-cig users had increased susceptibility to oxidative stress.
01 Feb Investigational Compound Improves Gut Microbiome Without Long-Term GI Symptoms
MedicalResearch.com Interview with: [caption id="attachment_31681" align="alignleft" width="200"]
Dr. Fernando Azpiroz[/caption]
Fernando Azpiroz, MD, PhD
Chief of the Department of Digestive Diseases
University Hospital Vall d’Hebron
Autonomous University of Barcelona, Spain
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This open-label, single-arm study, included 26 healthy volunteers who did not have gastrointestinal (GI) symptoms or a history of GI disorders, and were not required to change their diets during treatment. Twenty participants were included in the main evaluation and six were included as control subjects.
Participants in the main study were given HOST-G904 (2.8 g/day) for three weeks, during which time they followed their usual diet. In the evaluation periods (three-day periods immediately before, at the beginning and at the end of the administration), the participants followed a standardized low-fiber diet with one portion of high-fiber foods, at which time the investigators measured the following:
(1) number of daytime gas evacuations for two days;
(2) volume of gas evacuated; and
(3) microbiome composition (as measured by fecal Illumina MiSeq sequencing).
01 Feb Simulating Tumour Growth and Angiogenic Response Towards Improving Delivery of Cancer Therapies
MedicalResearch.com Interview with: [caption id="attachment_31687" align="alignleft" width="186"]
Vasileios Vavourakis[/caption]
Vasileios Vavourakis
Marie Skłodowska-Curie Fellow
Centre for Medical Image Computing
Department of Medical Physics & Biomedical Engineering
Front Engineering Building, Malet Place
University College London
WC1E 6BT, London, UK
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: It is already known that chemical factors play an important role in pathological angiogenesis, the process whereby cancer induces the formation of new blood vessels to provide it with nutrients. However, there is little knowledge about how mechanical forces induced by tumour growth affect the development and functionality of this pathological vasculature. By developing a mathematical & computational model – also referred in the research community as in-silico model – of the physical and chemical interactions occurring during angiogenic cancerous growth, we aimed to provide insights about how mechanical forces influence cancer-induced angiogenesis. The most important finding of our study is that mechanical forces play a key role in solid tumour-induced angiogenesis.
01 Feb Oxytocin During Labor Linked to Increased Risk of Postpartum Depression
MedicalResearch.com Interview with: [caption id="attachment_31675" align="alignleft" width="186"]
Dr. Kristina Deligiannidis[/caption]
Kristina M. Deligiannidis, MD
Associate Professor
Center for Psychiatric Neuroscience
The Feinstein Institute for Medical Research
Director, Women’s Behavioral Health
Zucker Hillside Hospital Northwell Health
Associate Professor
Psychiatry and Obstetrics & Gynecology
Hofstra Northwell School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Because of effects on social behavior, including maternal behavior, oxytocin has often been seen as a potential mediator of postpartum depression and anxiety.
The original objective of our study was to examine the relationship between the use of synthetic oxytocin during and after labor and the development of depressive and anxiety disorders within the first year postpartum. We hypothesized that women exposed to synthetic oxytocin before or during labor would have a reduced risk of postpartum depressive and anxiety disorders compared with those without any exposure. Our findings told the opposite story.
We found that peripartum synthetic oxytocin exposure was associated with an increase in risk for the development of postpartum depression and anxiety.
01 Feb Arriving Late To Appointment Can Shorten Your Visit With The Doctor
MedicalResearch.com Interview with: Chester G. Chambers, Ph.D. Director, Enterprise Risk Management Program, Johns Hopkins Carey Business School Joint Appointment in Anesthesiology and Critical Care Medicine Maqbool Dada, Ph.D. Joint Appointment in Anesthesiology and Critical Care Medicine John Hopkins Medicine Kayode Ayodele Williams, M.B.A., M.B.B.S., M.D Medical Director : Blaustein Pain Treatment Center Associate Professor of Anesthesiology and Critical Care Medicine John Hopkins Medicine MedicalResearch.com: What is the background for this study? What are the main findings? Response: The result is based on a retrospective analysis of three specialty clinics in the Johns Hopkins System: a private practice low-volume clinic with one physician and no residents; a medium volume clinic that used one attending physician for each clinic session and included residents; and a high-volume clinic with multiple attending physicians and several residents. Our main finding is that physicians adjust face time based on congestion in the clinic, and seem to do this without always knowing they are doing it. Patients who arrive early and whose service begins before their appointment times, tend to get more face-time then other patients. This is similar to other service systems in which first-line providers speed-up when they see long queues at their stations.This is important because most of the prior research in this setting assumed that this never takes place. We verified that it does happen in multiple settings and the changes in processing rates are statistically significant. This means we need to rethink many earlier conclusions about how clinics run.01 Feb Multifaceted Interventions Improve Cancer Screening Among Marginalized Groups
MedicalResearch.com Interview with: [caption id="attachment_31694" align="alignleft" width="141"]
Dr. Sheila Dunn[/caption]
Sheila F. Dunn, MD, MSc
Scientist, Women's College Research Institute
Director, Family Practice Health Centre
Staff Physician, Department of Family and Community Medicine
Women's College Hospital
Associate Professor, Department of Family and Community Medicine
University of Toronto
MedicalResearch.com: What is the background for this study?
Response: Despite organized cervical and breast cancer screening programs, inequities in screening remain. In Ontario, women who are newcomers, especially those of South Asian and East Asian origin, have much lower screening rates than Canadian-born women.
In order to address these inequities the CARES program used a multi-faceted community-based intervention to increase knowledge and promote cervical and breast cancer screening among newcomer and otherwise marginalized women in Toronto, Ontario, Canada. We reached out to women in the target groups through a network of community agencies. Women attended group educational sessions co-led by peers who spoke their language. Access to screening was facilitated through group screening visits, a visit health bus and on-site Pap smears. Administrative data were used to compare screening after the education date for CARES participants with a control group matched for age, screening status and area of residence.
01 Feb Childhood Antibiotic Use Linked To Higher BMI At Age 3
MedicalResearch.com Interview with: [caption id="attachment_31548" align="alignleft" width="142"]
Dr. Melissa N. Poulsen[/caption]
Melissa N. Poulsen, PhD, MPH
Postdoctoral Fellow
Johns Hopkins Bloomberg School of Public Health
Geisinger Center for Health Research
MedicalResearch.com: What is the background for this study?
Response: Several past studies report positive associations between early childhood antibiotic use (particularly in the first year of life) and body mass index (BMI) later in childhood. Studies have also observed positive associations with prenatal antibiotic use and BMI, but without information on childhood antibiotics, such studies cannot rule out an underlying causal relationship between prenatal antibiotic exposure and early childhood antibiotic use.
No study to date has concurrently evaluated prenatal and early childhood antibiotic exposure. We used mother-child linked electronic health record data to determine whether prenatal and childhood antibiotic use are independently associated with BMI at age 3 years.
01 Feb Exposure to Violence, Psychological Distress, and Gun Carrying Among Male Adolescents
MedicalResearch.com Interview with: Joan A. Reid, Ph.D., LMHC Assistant Professor Criminology Program DAV 266 University of South Florida St. Petersburg MedicalResearch.com: What is the background for this study? What are the main findings? Response: Firearm-associated homicide and suicide are leading causes of death among American youth (i.e., 10-24 years old), with disproportionately high rates observed among male youth of color. Notably, gun violence and psychological problems are often conflated in public discourse regarding gun violence and prevention. However, few studies have assessed the impact of exposure to violence, either as a witness or a victim, when exploring the association between gun-carrying behavior and psychological distress.31 Jan Key Gene Linked To Brain Plasticity and Learning Identified
MedicalResearch.com Interview with: [caption id="attachment_31658" align="alignleft" width="180"]
Dr. Keerthi Krishnan[/caption]
Keerthi Krishnan PhD
Cold Spring Harbor Laboratory
Cold Spring Harbor, New York 11724
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Rett Syndrome is diagnosed as a neurodevelopmental disorder in girls, caused mainly by mutations in the gene MECP2. Many previous studies, including mine, have shown that mutations in MECP2 result in improper communication between nerve cells in the brain during sensitive periods of development. However, it was unclear if the same mechanisms were responsible for cognitive and behavioral problems found in adulthood.
In this paper, we have utilized a natural, learned response called pup retrieval behavior to study adult neural plasticity in a female mouse model of Rett Syndrome. With some learning, adult female mice will gather scattered pups to the nest, in response to distress calls from the pups. We found that the Rett Syndrome model mice with reduced MECP2 protein do not gather pups efficiently. This is due to the abnormal formation of structures called perineuronal nets on a specific type of neurons (called parvalbumin+ GABAergic neurons) that block plasticity and prevent learning of the appropriate response. Furthermore, the same neural and molecular mechanisms found earlier in development were also found to mediate learning in adulthood.
31 Jan How Many Calories Do You Add To Your Coffee or Tea?
MedicalResearch.com Interview with: [caption id="attachment_31650" align="alignleft" width="165"]
Dr. Ruopeng An[/caption]
Ruopeng An, PhD
Assistant Professor
Department of Kinesiology and Community Health
College of Applied Health Sciences
University of Illinois at Urbana-Champaign
Champaign, IL 61820
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Coffee and tea are among the most widely consumed beverages in U.S. adults.1,2 Unlike other popular beverages including alcohol and sugar-sweetened beverages that are typically consumed in isolation, many people prefer drinking coffee and tea with add-ins like sugar or cream. These add-in items are often dense in energy and fat but low in nutritional value. Drinking coffee and tea with add-ins on a regular basis might impact an individual’s daily energy/nutrient intake and diet quality.3 The 2015-2020 Dietary Guidelines for Americans suggests that “coffee, tea, and flavored waters also can be selected, but calories from cream, added sugars, and other additions should be accounted for within the eating pattern.”4
To our knowledge, no study has been conducted to assess consumption of coffee and tea with add-ins in relation to daily energy and nutrient intake at the population level. Bouchard et al. examined the association between coffee and tea consumption with add-ins and body weight status rather than energy/nutrient intake, and consumption was measured by a few frequency-related questions instead of a 24-hour dietary recall.5
The purpose of this study was to examine consumption of coffee and tea with add-ins (e.g., sugar, cream) in relation to energy, sugar, and fat intake among U.S. adults 18 years of age and above. Data came from 2001-2012 National Health and Nutrition Examination Survey (NHANES), comprising a nationally-representative (biennially) repeated cross-sectional sample of 13,185 and 6,215 adults who reported coffee and tea consumption in in-person 24-hour dietary recalls, respectively.
31 Jan Kids Confide More In Their Pets Than Their Siblings
MedicalResearch.com Interview with: Matthew Cassels PhD candidate, Developmental Psychiatry University of Cambridge Cambridge UK MedicalResearch.com: What is the background for this study? Response: Around 70% of UK families with young children own a pet. However, the impact of pets on children’s lives is understudied and poorly understood. Researchers in the field of Human-Animal Interaction have been working towards addressing this gap in our understanding by focusing on the role of pets in our lives. Compared to the owners of other pets, dog owners have been found to be more likely to derive a sense of safety, companionship, and security from their pets, and to perceive them as more responsive and affectionate. Factors that contribute to differences in the quality of human-animal relationships are of great interest because the magnitude of the benefits derived from these relationships is related to their quality. Pets may be especially significant to young people, aiding them in their social and emotional development, and serving as important substitutes for human attachment figures. Children consider their relationships with their pets as among their most important, report strong emotional bonds with their pets, spontaneously list pets when asked to name close friends and providers of social support, report turning to their pets when feeling sad, identify pets more often than humans as providers of comfort, and rely on their pets as playmates and confidants.31 Jan IV Etelcalcetide (Parsibiv®) Can Treat Elevated PTH in Dialysis Patients More Effectively Than Oral Medication
MedicalResearch.com Interview with: [caption id="attachment_31640" align="alignleft" width="120"]
Dr. Geoffrey Block[/caption]
Geoffrey A. Block, MD
Director of Research at Denver Nephrology
Denver, Colorado
MedicalResearch.com: What is the background for this study?
Response: Secondary hyperparathyroidism is a chronic and progressive disorder characterized by elevations in parathyroid hormone (PTH). It is seen in most patients with advanced chronic kidney disease and has been associated with a number of important adverse health effects such as bone pain, fracture, premature cardiovascular disease, abnormal heart enlargement, pathologic calcium accumulation in blood vessels and tissues and premature death.
Currently there are several classes of drugs used to treat high PTH but each are associated with challenging side effects which limit their effectiveness. Active vitamin D compounds are effective in lowering PTH but do so at the expense of causing elevations in other minerals such as calcium and phosphorus which are felt to be harmful.
An oral drug known as cinacalcet (Sensipar®) is in the class of medicine known as ‘calcimimetics’ and reduces PTH and simultaneously reduces calcium and phosphorus however it must be taken daily due to its short half-life and is commonly associated with nausea when first initiated or the dose is increased. Clinical trials with cinacalcet are suggestive though not conclusive of a beneficial effect on improving cardiovascular events and prolonging life.
30 Jan Therapeutic Hypothermia After In-Hospital Cardiac Arrest in Children
MedicalResearch.com Interview with: [caption id="attachment_31628" align="alignleft" width="200"]
Victoria Pemberton[/caption]
Victoria Pemberton, RNC, MS, CCRC
Program Officer
Division of Cardiovascular Sciences
National Heart, Lung, and Blood Institute, NIH
Bethesda, Maryland
MedicalResearch.com: What is the background for this study? What are the main findings?
- Previous studies have examined cardiac arrest when it occurs outside of the hospital in both children and adults, with current guidelines recommending hypothermia (body cooling) or normothermia (maintenance of normal body temperature) after such an arrest. This trial addresses pediatric cardiac arrest in a hospital setting, for which no previous data existed. Because children who experience an in-hospital cardiac arrest differ significantly from children who arrest outside of the hospital, it is important to test these treatments in this population.
- The trial found no significant differences in survival and neurobehavioral functioning a year after cardiac arrest between children assigned to the hypothermia arm and those assigned to normothermia.