Dr. Winterdahl[/caption]
Michael Winterdahl PhD
Associate Professor in Neuroimaging,
Department of Nuclear Medicine and PET Center
Aarhus University, Denmark
MedicalResearch.com: What is the background for this study?
Response: Opioids and dopamine mediate the rewarding effects of drugs. We aimed to determine whether the intake of palatable food could lead to changes in the brain similar to those triggered by addictive substances, so we studied the effects of repeated intermittent access to sugar on opioid and dopamine receptors in porcine brain using neuroimaging.
Dr. DeFilippis[/caption]
Ersilia DeFilippis, MD
Second-year cardiology fellow
Columbia University Irving Medical Center and
NewYork-Presbyterian
MedicalResearch.com: What is the background for this study?
Response: Marijuana use has been increasing significantly and is the most commonly illicit drug used in the United States. In recent years, more states have been legalizing its use for both recreational and medicinal purposes. We have all seen news reports regarding the rise of vaping-related health hazards. Yet, data are limited regarding the cardiovascular effects of marijuana which is what drove us to explore this topic.
Prof. Andrea On Yan LUK[/caption]
Prof. Andrea On Yan LUK (陸安欣)
Associate Professor, Department of Medicine & Therapeutics
Faculty of Medicine, The Chinese University of Hong Kong
Specialist in Endocrinology, Diabetes and Metabolism
Honorary Associate Consultant, Hospital Authority
MedicalResearch.com: What is the background for this study?
Response: The overall mortality in people with diabetes has declined in many developed countries but little is known about the mortality trend in Asia. In this study, we examined the trend in mortality rates using a territory-wide database of 770,000 people with diabetes in Hong Kong.
Dr. Engzell[/caption]
Per Engzell PhD
Postdoctoral Prize Research Fellow
Nuffield College, University of Oxford
Annelise Madison[/caption]
Annelise Madison
Lead author of the study
Graduate Student in Clinical Psychology
Ohio State
MedicalResearch.com: What is the background for this study?
Response: Recently, there have been some reports of cognitive problems among those using proton pump inhibitors (PPIs). Some breast cancer survivors use PPIs during and after treatment to manage gastrointestinal side effects of cancer treatment or to prevent damage to the gut lining.
We were interested in whether PPI use among breast cancer survivors related to cognitive problems. We conducted secondary analyses on data from three studies with breast cancer survivors. We found that breast cancer survivors taking PPIs reported cognitive problems that were between 20-29% worse than those reported by non-users.
Dr. Graboyes[/caption]
Evan M. Graboyes, MD
Surveillance and Health Services Research
American Cancer Society, Atlanta, Georgia
Department of Otolaryngology–Head & Neck Surgery
Medical University of South Carolina, Charleston
MedicalResearch.com: What is the background for this study?
Response: Prior studies have shown that Medication Expansions under the Patient Protection and Affordable Care Act (ACA) are associated with a decrease in uninsured individuals and increases in the percentage of nonelderly patients diagnosed with localized (stage I-II) cancer, primarily for cancers for which effective screening tests exist.
Because no screening test exists for head and neck squamous cell carcinoma (HNSCC), access to care for physical examination and tissue-based biopsy- and thus health insurance coverage- are critical for the timely recognition of symptoms, early disease stage at diagnosis, and treatment initiation.
However, the downstream association of changes in health insurance coverage following Medicaid expansion under the ACA with stage at diagnosis and time to treatment initiation, key metrics for access to care for HNSCC, remain unknown.
Dr. Maldonado Lopez[/caption]
Rafael Maldonado Lopez MD PhD
Full professor
Departament de Ciències Experimentals i de la Salut
Universitat Pompeu Fabra
Barcelona
MedicalResearch.com: What is the background for this study?
Response: Endometriosis is a common, chronic and painful disease caused when the endometrium grows outside of the uterine cavity. These growths mainly affect organs in the pelvis causing pain and infertility, symptoms that are often accompanied with anxiety, depression, loss of working ability, and a substantial impact on quality of life. Current treatments include hormonal therapy and surgery, but the effectiveness of these treatments is rather limited, often have important unwanted side effects, and patients usually rely on self-management strategies. Therefore, there is an urgent need for researching new possible therapeutic approaches.
Dr. Paul Young[/caption]
Dr. Paul Young MBChB, BSc (Hons), FCICM
Medical Director of the Wakefield Hospital ICU
Head of the Intensive Care Research Unit
Wellington Hospital
MedicalResearch.com: What is the background for this study?
Response: Proton pump inhibitors (PPIs) are among the most widely prescribed drugs in the intensive care unit (ICU) in the world. Many, if not most, prescriptions of PPIs in the ICU are for stress ulcer prophylaxis. Although PPIs are used most widely for this indication, histamine-2 receptor blockers (H2RBs) are used in preference to PPIs in some ICUs. This practice variation, which appears to be largely dependent on clinician preference rather than based on patient-specific factors, has continued for decades. The PPIs vs. H2RBs for Ulcer Prophylaxis Therapy in the Intensive Care Unit (PEPTIC) trial results raise the possibility that PPIs, the most commonly used medicines for stress ulcer prophylaxis, may be responsible for a clinically important increase in the risk of death that, in global health terms could equate to many tens of 1000s of deaths per year.
Dr. Danziger[/caption]
John Danziger, MD
Harvard Medical Faculty Physicians, Nephrology
Beth Israel Deaconess Medical Center
MedicalResearch.com: What is the background for this study?
Response: Racial health disparities have long been described, extending even into the highest levels of medical care, namely the Intensive Care Unit (ICU).
Accordingly, we wanted to know whether improvements in ICU care seen over the last decade are equally observed in minority and non-minority serving hospitals.
Dr. Herrera-Escobar[/caption]
Juan P. Herrera-Escobar, MD, MPH
Research Director, Long-term Outcomes in Trauma
Center for Surgery and Public Health, Brigham and Women's Hospital
Instructor in Surgery, Harvard Medical School
MedicalResearch.com: What is the background for this study?
Response: Firearm injuries are a pressing public health problem in the United States. Until now, most of the research on this problematic has focused on mortality, which of course is critical, but is only one piece of the story. For every person who dies from a firearm injury, three survive every year. As trauma systems continue to improve and save more lives every year, our attention should start shifting to the impact that firearm injuries have on survivors.
Dr. Howell[/caption]
Elizabeth A. Howell, MD, MPP
Director of The Blavatnik Family Women’s Health Research Institute
Mount Sinai Health System Vice Chair for Research
Professor in the Department of Obstetrics, Gynecology, and Reproductive Science
Associate Dean for Academic Development
Professor Department of Population Health Science and Policy
Icahn Mount Sinai, New York
MedicalResearch.com: What is the background for this study?
Response: Previous research has demonstrated racial and ethnic disparities in severe maternal morbidity rates in hospitals and that between-hospital differences -- i.e., Black and Latina mothers receiving care at hospitals with worse outcomes -- explain a sizable portion of these disparities. However, less attention has been paid to within-hospital disparities -- whether Black and Latina mothers have worse outcomes than White mothers who deliver in the SAME hospital.
In this paper, we set out to measure within-hospital racial and ethnic disparities and to evaluate the potential contribution of insurance type to these disparities.
Our study question was based on the observation that women with Medicaid can follow different care pathways than women with private insurance. Pregnant women insured by Medicaid are often seen by resident physicians with attending coverage that may differ from attending physicians caring for commercially insured women. In addition, Medicaid reimbursement for delivery hospitalization is far less than that for commercially insured.
Dr. Villanueva Rodriguez[/caption]
Augusto Villanueva Rodriguez, MD, PhD
Icahn School of Medicine at Mount Sinai
New York, NY
MedicalResearch.com: What is the background for this study?
Response: There is limited understanding of the extent of molecular heterogeneity in liver cancer. This cancer is the second most lethal tumor and the fourth cause of cancer-related mortality worldwide.
Most patients diagnosed at advanced stages have a dismal survival, as most of them will develop resistance to systemic therapies. One of the potential mechanisms for this relates to the presence of different tumor clones within the same tumor nodule. This heterogeneity has been barely studied in liver cancer and our study provides a comprehensive analysis of the extent and potential clinical implications of intra-tumoral heterogeneity (ITH) in liver cancer.
Dr. Courcoulas[/caption]
Anita P. Courcoulas MD, MPH, FACS
Anthony M. Harrison MD Chair and
Professor of Surgery
Chief, MIS Bariatric & General Surgery
University of Pittsburgh Medical Center
MedicalResearch.com: What is the background for this study?
Response: Fewer published studies in bariatric surgery address long term adverse outcomes or problems that can occur after different operations. In addition, a lack of standardized reporting of potential adverse events limits the understanding of these issues.
This paper results from one of the largest studies of bariatric surgery ever undertaken and includes both gastric bypass and gastric sleeve, the 2 most common operations performed in the U.S. and worldwide at the current time. This study leverages large data sets from the electronic health record linked to insurance claims and death indices. This is real-world data coming from a population-based cohort of 33,560 adults at 10 sites in 4 clinical data research networks throughout the U.S., so it may be different from data that accrues from a longitudinal observational study or randomized trial. Patients and other important stakeholders in bariatric surgery were critical to the design, conduct, and dissemination of results from this study.
Dr. Mehra[/caption]
Mandeep R. Mehra, MD, MSc, FRCP
The William Harvey Distinguished Chair in
Advanced Cardiovascular Medicine
Medical Director, Heart and Vascular Center
Brigham and Women’s Hospital
Executive Director
Center for Advanced Heart Disease
Brigham and Women’s Hospital
Professor of Medicine, Harvard Medical School
MedicalResearch.com: What is the background for this study?
Response: Left Ventricular assist devices meaningfully prolong survival in patients with heart failure who are no longer responsive to guideline-directed medications.
The MOMENTUM 3 trial tested a new generation device, the HeartMate 3 pump, to a more commonly used pump, the HeartMate II device. This trial showed the superiority of the new heart pump and found that survival free of a disabling stroke or need to place a second pump is improved considerably.
In this prespecified analysis of the trial, we compared patients who were considered as eligible for transplantation to those considered ineligible for heart transplantation. We showed that these categories are associated with similar superiority of the HeartMate 3 pump compared to the control pump despite the categorization into these discrete buckets.
UK researchers
Dr. Diaz[/caption]
Lucia Diaz, M.D., is chief of pediatric dermatology, dermatology residency associate program director and assistant professor of medicine and pediatrics at Dell Medical School. She is also co-director of the dermatology-rheumatology combined clinic at Dell Children’s Medical Center.
[caption id="attachment_52796" align="alignleft" width="150"]
Dr. Jaquez[/caption]
Sasha Jaquez, Ph.D. is a pediatric psychologist at Dell Children's Medical School/Dell Children's Medical Center and specializes in seeing children with chronic medical illness, including skin disorders.
[caption id="attachment_52791" align="alignleft" width="294"]
DermNet-NZ Image Trichotillomania[/caption]
MedicalResearch.com: What is the background for this study?
Response: Trichotillomania (TTM) can be an extremely disabling chronic condition that impacts the psychosocial development of children.
It is classified by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as an obsessive-compulsive disorder, where a person recurrently pulls out hair from any region of their body resulting in hair loss. Recognizing this disorder and being informed of treatment options allows medical providers to correctly diagnose and intervene early in the disease course. We reviewed the psychosocial impacts of pediatric trichotillomania and the current evidence-based interventions used in the population.
Dr. Frame[/caption]
Leigh Frame, PhD, MHS
Director for the Integrative Medicine Program
School of Medicine and Health Sciences
George Washington University
MedicalResearch.com: What is the background for this study?
Response: As food consumed in the U.S. becomes more and more processed, obesity may become more prevalent. Through reviewing overall trends in food, we concluded that detailed recommendations to improve diet quality and overall nutrition are needed for consumers, who are prioritizing food that is cheaper and more convenient, but also highly processed.
When comparing the U.S. diet to the diet of those who live in "blue zones" - areas with populations living to age 100 without chronic disease - the differences are stark. Many of the food trends we reviewed are tied directly to a fast-paced U.S. lifestyle that contributes to the obesity epidemic we are now facing.
Dr. Sanz-Moreno[/caption]
Prof. Victoria Sanz-Moreno
Professor of Cancer Cell Biology
Cancer Research UK Senior Fellow and Cancer Research UK Werth Trust Fellow
Barts Cancer Institute- a Cancer Research UK Centre of Excellence
Queen Mary University of London
MedicalResearch.com: What is the background for this study?
Response: Malignant melanoma- a cancer of the skin- has very poor survival rates despite being at the forefront of personalised medicine. This is mostly due to therapy resistance.
Our current study indicates that melanoma cells escape anti-cancer drugs by changing their internal skeleton (cytoskeleton) – opening up new therapeutic venues for melanoma.
Dr. Parsons[/caption]
Kellogg Parsons, MD, MHS
Professor of Urology
Moores UC San Diego Comprehensive Cancer Center
MedicalResearch.com: What is the background for this study?
Response: Clinical guidelines for prostate cancer, circulated widely in the public domain, endorse the consumption of diets high in micronutrient-enriched vegetables. Drawing on expert opinion, epidemiological studies, and small preclinical experiments, these recommendations propose that vegetable-enriched diets may decrease cancer progression and death among prostate cancer survivors. However, data from randomized clinical trials focused on actionable clinical endpoints has been lacking.
We utilized a specific behavioral intervention, grounded in the field of social psychology, to “nudge” patients with prostate cancer toward healthier food choices. The intervention is telephone-based, like a call center: patient-focused, convenient, and simple.
Dr. Tung[/caption]
Elizabeth Tung MD MS
Section of General Internal Medicine
Instructor of Medicine
University of Chicago
MedicalResearch.com: What is the background for this study?
Response: Medicare provides hospital ratings for all Medicare-certified hospitals in the U.S. based on quality metrics, including mortality, patient experience, hospital readmissions, and others. While ratings are important for comparing hospitals, there's been some concern that some of these quality metrics are outside a hospital's control, especially for hospitals taking care of vulnerable or socially complex patient populations. Take "timeliness of care" as a quality metric, for instance--this measure includes emergency room wait times. But in places that are medically underserved and have very few emergency rooms, these wait times will inevitably be much higher. What this means is that hospitals taking care of medically underserved populations end up getting lower quality ratings, even though they're addressing health disparities by filling an access gap.
Dr. Sheetz[/caption]
Kyle Sheetz, MD
Clinical Year 4
Resident, General Surgery
Michigan Medicine
MedicalResearch.com: What is the background for this study?
Response: There are concerns that robotic surgery is increasing for common surgical procedures with limited evidence and unclear clinical benefit. Prior studies describing the use of robotic surgery relied upon claims or billing data to identify robotic operations from laparoscopic or open ones. This may lead to inaccuracies as claims data may not provide specific codes for robotic operations.
Dr. Bojesen[/caption]
Stig E Bojesen
Professor, chief physician, dr.med.sci.
Dept of Clinical Biochemistry, Herlev Gentofte Hospital
Copenhagen University Hospital
Department of Clinical Medicine
University of Copenhagen
MedicalResearch.com: What is the background for this study?
Response: Before this study, we did not know the value of an incidental finding of lymphopenia of an otherwise healthy individual from the general population. This is curious since lymphocyte count is a very simple measurement done almost every time you have a blood test done.
Simon Borghs[/caption]
Simon Borghs MSc
RWE Strategy Lead of Neurology
UCB: Union Chimique Belge
MedicalResearch.com: What is the background for this study?
Response: Epilepsy is an episodic disease and so is associated with a more or less unpredictable occurrence of health care encounters. These encounters are costly and so reducing them, or their unpredictability, could be cost saving.
The objective was to assess one half of this equation, that is the actual cost of those encounters to insurers. This could prompt insurers to consider addressing possible interventions in epilepsy to reduce the number of encounters
Dr. Ko[/caption]
Naomi Y Ko, MD
Director, Inpatient Medical Operations
Assistant Professor of Medicine, Department of Medicine
Boston University School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The background for this study is to help understand the association between risk of more advanced cancer in racial minorities and insurance.
Dr. Cengel[/caption]
Keith A. Cengel, M.D., Ph.D.
Associate Professor of Radiation Oncology
Hospital of the University of Pennsylvania
MedicalResearch.com: What is the background for this study?
Response: FLASH radiotherapy involves delivering the treatment dose at a rate that is 1000s of times faster than standard radiotherapy. Scientists have studied the differential biological effects of various dose rates for dose rates for the past ~80 years, but the unique effects of FLASH dose rates have only been appreciated in the last few years.
While the mechanism(s) and applications of FLASH radiotherapy remain an area of active investigation, t is clear so far that FLASH dose rates can provide similar levels of tumor control with less toxicity to normal tissues when compared to the same dose of radiotherapy delivered at a standard dose rate.
Olujimi A. Ajijola, MD, PhD[/caption]
Olujimi A. Ajijola, MD, PhD
Neurocardiology Research Center of Excellence
Cardiac Arrhythmia Center
University of California, Los Angeles
MedicalResearch.com: What is the background for this study?
Response: It hadn’t been understood why some people with basic heart failure might live longer than others despite receiving the same medications and medical device therapy. Through this research we set out to determine whether a biomarker of the nervous system could help explain the difference. This study revealed a biomarker that can specifically predict which patients with “stable” heart failure have a higher risk of dying within one to three years.
Dr. Bahrami[/caption]
Shahram Bahrami, PhD
NORMENT Centre, Institute of Clinical Medicine
Division of Mental Health and Addiction
Oslo University Hospital
Oslo, Norway
MedicalResearch.com: What is the background for this study?
Response: We know that patients with severe mental disorders such as schizophrenia, bipolar disorder and major depression have shorter life span than the rest of the population, largely due to comorbid cardiovascular diseases. The increased risk seems related to lifestyle including diet and physical activity and medicines, while the mechanisms are not fully understood. Different studies have shown increased weight (high body mass index) in many people with mental disorders. Yet very little is known about genetic variants jointly in influencing major psychiatric disorders and body mass index. Thus, we investigated if there are overlapping genetic risk variants between body mass index and the mental disorders schizophrenia, bipolar disorders and major depression.