Author Interviews / 20.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50970" align="alignleft" width="108"]William R. Lovallo, Ph.D. Reseacher, University of Oklahoma College of Medicine Dr. Lovallo[/caption] William R. Lovallo, Ph.D. Reseacher, University of Oklahoma College of Medicine MedicalResearch.com: What is the background for this study? Response: We have been interested for some time in why some people are at high risk for alcoholism.  Most work in the field of addictions is focused on persons who are already impacted by their exposure to alcohol or drugs.  We wanted to know what they were like before that phase of their  lives.  So, in 1999 we began the Family Health Patterns Project to study healthy young adults 18-30 years of age with and without family histories of alcoholism but who were not alcoholics themselves.  A family history is the best known, and perhaps strongest, risk factor for future drinking problems. We asked ourselves are the two family-history groups different?  And if so, how are they different?  There was at that time little literature to build on so we decided to look at as many things as we could.  We began recruiting volunteers for our family-history positive and negative groups and evaluating them with a standard psychiatric interview, personality tests, measures of depressive mood and neuroticism, and measuring physiological reactivity to stress.  In doing so we also began collecting DNA and studying basic genetic variants to see if any of those might be revealing.
Author Interviews, Brain Cancer - Brain Tumors, Imperial College / 20.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50964" align="alignleft" width="149"]Georgios Giamas, (Dr. Biol. Hum.) Professor of Cancer Cell Signalling Director of Research and Knowledge Exchange University of Sussex -School of Life Sciences Visiting Professor, Imperial College, Londo Prof. Georgios Giamas[/caption] Georgios Giamas, (Dr. Biol. Hum.) Professor of Cancer Cell Signalling Director of Research and Knowledge Exchange University of Sussex -School of Life Sciences Visiting Professor, Imperial College, London MedicalResearch.com: What is the background for this study? Response: This study focuses on Glioblastoma (GBM), which is one of the most aggressive solid tumours for which treatment options and biomarkers are limited. MedicalResearch.com: What are the main findings? - Glioblastoma cells produce nanosized vesicles (aka: extracellular vesicles) that contain specific protein signatures, which can indicate the behaviour and phenotype of the respective cells of origin. -We have identified and described certain vesicle-associated biomarkers that correspond to the most aggressive brain cancers. -Our results can provide insights for the development of new diagnostic and therapeutic methods as well as personalized treatment strategies
Author Interviews, CDC, Infections, Ophthalmology / 20.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50953" align="alignleft" width="200"]Nuadum Konne Waterborne Disease Prevention Branch CDC Nuadum Konne[/caption] Nuadum Konne Waterborne Disease Prevention Branch CDC  MedicalResearch.com: What is the background for this study? What are the main findings?  Response: An estimated 45 million Americans enjoy the benefits of contact lens wear. Most of them practice some behaviors that put them at risk for serious eye infections. Surveys of contact lens wearers and eye care providers were conducted in 2018. One third of lens wearers recalled never hearing any lens care recommendations. Most eye care providers reported sharing recommendations always or most of the time.
Author Interviews, Hospital Acquired, JAMA / 20.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50892" align="alignleft" width="176"]Todd Campbell Lee MD MPH FACP FIDSA Consultant in Internal Medicine and Infectious Diseases Director, MI4 Clinical Trials Platform Associate Professor of Medicine, McGill University Montreal, Quebec Dr. Todd Lee[/caption] Todd Campbell Lee MD MPH FACP FIDSA Consultant in Internal Medicine and Infectious Diseases Director, MI4 Clinical Trials Platform Associate Professor of Medicine, McGill University Montreal, Quebec  MedicalResearch.com: What is the background for this study? Response: For a number of years people have been advocating for a move towards single-patient rooms in hospital design.  This was articulately argued for in an opinion piece by Detsky and Etchells in 2008 (https://jamanetwork.com/journals/jama/article-abstract/182433) as being important for a move to safe and patient-centered design. One of the major selling points has always been a reduction in the risk of nosocomial, or hospital-associated, infections given reduced opportunities for contamination between patients; however, only a few studies have specifically looked at this issue.  Overall, despite some strong work, many of these studies were limited by only looking at specific units, over limited periods of time,  and using before-after comparisons which did not account for change over time either within or outside of the institution. We knew that in 2015 our old hospital would close and within the same day all patients would be moved to a brand new hospital with 100% single patient rooms -- most of which have a private bathroom for patients and a separate hand-washing sink for staff.  So in 2014, we designed this study, obtained ethics review, and then waited patiently for several years to pass after the move so that we could rigorously evaluate the impact.  We looked at monthly rates of vancomycin-resistant Enterococcus (VRE) colonizations and infections, methicillin-resistant Staphylococcus aureus (MRSA) colonization and infections, and Clostridium (now Clostrideroides) difficile infections (CDI). We chose these because we had good long term data on their rates and because we could compare the rates over time before and after the move and contrast them with the province of Quebec as a whole.
Author Interviews, Nutrition / 20.08.2019

MedicalResearch.com Interview with: Leighton Ku, PhD, MPH Professor, Dept. of Health Policy and Management Director, Center for Health Policy Research Milken Institute School of Public Health George Washington University Washington, DC 20052   MedicalResearch.com: What is the background for this study? Response: In this study, we examined how requirements that low-income adults work in order to keep their food assistance benefits (SNAP, formerly called food stamps) affects the number of people receiving benefits.  Briefly, we found, based on analyses of data from 2,410 counties from 2013 to 2017, that soon after work requirements are introduced, more than a third of affected participants lose their food assistance.  This meant that about 600,000 poor adults lost food assistance very quickly. This is important for two reasons: (1) Work requirements create greater hardship, including food insecurity and increased risk of health problems, when poor people lose their nutrition benefits. (2) The Trump Administration is trying to broaden this policy, expanding it further in SNAP, but also applying work requirements to Medicaid (for health insurance) and public housing benefits.  This is a massive effort at social experimentation that will cause tremendous harm. And the sad part is that we already know, from other research, that these work requirement programs do not actually help people get jobs, keep them or to become more self-sufficient.  This is because the work requirements do not address the real needs of low-income unemployed people, to learn how to get better job skills or to have supports, such as child care, transportation or health insurance, that let them keep working.  
Author Interviews, Endocrinology, NIH, Pediatrics / 19.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50940" align="alignleft" width="150"]Kenneth S. Korach, Ph.D. Senior Principal Investigator Chief, Receptor Biology Section Reproductive and Developmental Biology Laboratory NIEHS/NIH Dr. Kenneth Korach[/caption] Kenneth S. Korach, Ph.D. Senior Principal Investigator Chief, Receptor Biology Section Reproductive and Developmental Biology Laboratory NIEHS/NIH MedicalResearch.com: What is the background for this study? Response: Lavender oil is among the most popular essential oils used today. Our society deems essential oils and other homeopathic remedies as safe alternatives for medical treatment, personal hygiene commodities, aromatherapy, and cleaning products; however, there are many natural products that have effects on the human body, similar to potent synthetic drugs.
Author Interviews, Breast Cancer, Brigham & Women's - Harvard, Genetic Research / 19.08.2019

MedicalResearch.com Interview with: Tengteng Wang, PhD, MSPH, MBBS Postdoctoral Research Fellow Department of Epidemiology Harvard T.H. Chan School of Public Health Channing Division of Network Medicine Brigham and Women's Hospital MedicalResearch.com: What is the background for this study? Response: Chronic inflammation is a key player in the development of multiple cancer types, including breast cancer. Aspirin is one of the major non-steroidal anti-inflammatory drugs (NSAIDs) which clearly has anti-inflammatory properties. Given this, substantial evidence from laboratory and population studies suggests that taking aspirin may reduce the risk of developing breast cancer. However, the association of aspirin use with death outcomes following breast cancer diagnosis remains inconclusive and inconsistent across studies. Therefore, we choose to focus on mortality outcomes in this paper and we hypothesized that the inconsistent results for aspirin in relation to mortality could be due to differences in the association by patients’ biological profiles, specifically DNA methylation profiles here. 
Author Interviews, Dental Research, JAMA, Mental Health Research, Mineral Metabolism, Pediatrics / 19.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50911" align="alignleft" width="200"]Rivka Green, MA Doctoral Candidate Clinical Developmental Neuropsychology York University Rivka Green[/caption] Rivka Green, MA Doctoral Candidate Clinical Developmental Neuropsychology York University  MedicalResearch.com: What is the background for this study? What are the main findings? Response: We conducted a study on 512 mother-child pairs from 6 major cities across Canada, about half of whom lived in a region that receives fluoridated water. We found that prenatal fluoride exposure was associated with lower IQ scores in 3-4 year old children.
Author Interviews, Cognitive Issues, End of Life Care, Gender Differences, JAMA / 16.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50851" align="alignleft" width="142"]Dr. Nathan Stall, MD Geriatrician and Research fellow Women’s College Research Institute Dr. Stall[/caption] Dr. Nathan Stall, MD Geriatrician and Research fellow Women’s College Research Institute   [caption id="attachment_50852" align="alignleft" width="133"]Dr. Paula Rochon, MD, MPH, FRCPC Periatrician and Vice-President of Research Women’s College Hospital Dr. Rochon[/caption]     Dr. Paula Rochon, MD, MPH, FRCPC Periatrician and Vice-President of Research Women’s College Hospital     MedicalResearch.com: What is the background for this study? Response: The advanced stages of the dementia are characterized by profound memory impairment, an inability to recognize family, minimal verbal communication, loss of ambulatory abilities, and an inability to perform basic activities of daily living. Nursing homes become a common site of care for people living with advanced dementia, who have a median survival of 1.3 years. In the advanced stages of the disease, the focus of care should generally be on maximizing quality of life. Our study examined the frequency and sex-based differences in burdensome interventions received by nursing home residents with advanced dementia at the very end of life. Burdensome interventions include a variety of treatment and procedures that are often avoidable, may not improve comfort, and are frequently distressing to residents and their families. We found that in the last 30 days of life, nearly one in 10 nursing home residents visited an emergency department, more than one in five were hospitalized, and one in seven died in an acute care setting. In addition, almost one in 10 residents received life-threatening critical care; more than one in four were physically restrained; and more than one in three received antibiotics.
Author Interviews, Gender Differences / 16.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50882" align="alignleft" width="148"]Jack Turban MD MHS Resident physician in Psychiatry The Massachusetts General Hospital and McLean Hospital Harvard Medical School Dr. Turban[/caption] Jack Turban MD MHS Resident Physician in Psychiatry The Massachusetts General Hospital and McLean Hospital Harvard Medical School MedicalResearch.com: What is the background for this study? Response: Gender identity conversion efforts are attempts by a professional (for example a therapist, counselor, or religious advisor) to make a transgender person cisgender. The practice has been labelled unethical and ineffective by major medical organizations, including the American Medical Association. Accordingly, many U.S. states have made this practice illegal. Other states, however, have deferred passing bans on gender identity conversion efforts. Some state legislators have argued that such bans are unnecessary because this practice doesn’t occur in their state.
Author Interviews, Bayer, FDA, Prostate Cancer / 16.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50898" align="alignleft" width="133"]Neal D. Shore, MD, FACS Director, CPI, Carolina Urologic Research Center Atlantic Urology Clinics Myrtle Beach, South Carolina Dr. Shore[/caption] Neal D. Shore, MD, FACS Director, CPI, Carolina Urologic Research Center Atlantic Urology Clinics Myrtle Beach, South Carolina Neal D. Shore, MD, FACS is the Medical Director for the Carolina Urologic Research Center. He practices with Atlantic Urology Clinics in Myrtle Beach, South Carolina. Dr. Shore discusses the recent announcement that the FDA has approved Nubeqa®(darolutamide),  for the treatment of patients with non-metastatic castration-resistant prostate cancer..  MedicalResearch.com: What is the background for this study? How does NUBEQA®(darolutamide) differ from other treatments for nmCRPC?  Response: In 2017, patients did not have an approved therapy for non-metastatic castration-resistant prostate cancer, or nmCRPC. If untreated, patients with this diagnosis will go on to develop metastases, or progression of the cancer throughout the body. NUBEQA® (darolutamide) became the third and most recently approved treatment for nmCRPC, demonstrating a benefit of metastasis-free survival, or MFS. NUBEQA is different due to its adverse event and safety profile reported in the Phase III ARAMIS trial. In that study, there were no significant findings of falls and fractures as well as other adverse events reported from the earlier Phase III trials. 
Author Interviews, Herpes Viruses / 15.08.2019

MedicalResearch.com Interview with: Tejabhiram Yadavalli, Ph.D Department of Ophthalmology and Visual Sciences Chicago, IL MedicalResearch.com: What is the background for this study? What are the main findings?  Response: Charcoal black is a common ingredient used in the cosmetic industry, especially for the eye in products such as eyeliners. Traditionally, black soot obtained from burning clarified butter was used as an eyeliner and is still used today in various cultures across the world. Activated charcoal is highly porous in nature and has a surface area far greater than any other nanoparticle or microparticle known to materials science. Since our lab works on ocular herpes infection we wanted to see whether activated charcoal can influence viral infection potentially by trapping the virus particles and rendering them ineffective. As hypothesized, we found excellent restriction of the virus from infecting the host. The most interesting results came when we applied charcoal in tandem with existing clinical antiviral (Acyclovir). This is where we saw that charcoal can absorb the drug on its surface and slowly release it over a period of time conferring protection for an extended period of time from viral infection. These antiviral drugs have to be taken multiple times a day to show comprehensive protection against the virus. However, we found that the drugs mixed with charcoal were need to be given with much reduced frequency to show excellent antiviral activity. This charcoal platform termed as DECON was effective in controlling both ocular and genital herpes infections.
Author Interviews, Cancer Research, HPV, OBGYNE / 15.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50822" align="alignleft" width="199"]Marc Eloit, D.V.M, Ph.D. Pathogen Discovery Laboratory, Biology of Infection Unit, Institut Pasteur Paris, France Dr. Eloit[/caption] Marc Eloit, D.V.M, Ph.D. Pathogen Discovery Laboratory, Biology of Infection Unit, Institut Pasteur Paris, France MedicalResearch.com: What is the background for this study? Response: Human papillomaviruses (HPV) are responsible for >99% of cervical cancers. Currently, cervical cancer screening either focuses on testing for the presence of HPV or identifying abnormal cervical cells with cytology (Pap test). However, molecular diagnostic tests based on the detection of viral DNA or RNA have low positive predictive values for the identification of cancer or precancerous lesions, and analysis of cervical cells with the Pap test, even when combined with molecular detection of high-risk HPV, results in a significant number of unnecessary colposcopies. We have developed HPV RNA-Seq, a new “two-for-one” molecular diagnostic test that not only detects the type of HPV, but also identifies precancerous markers. This test is therefore designed to diagnose the riskiest forms of HPV infection, provide rapid results at moderate cost, and helps avoiding unnecessary diagnostic procedures. HPV RNA-Seq is based on the dual combination of multiplexed reverse transcription PCR (RT-PCR) and next-generation sequencing (NGS). RT-PCR is a sensitive way to detect small amounts of RNA, the genetic material that reflects the activity of the HPV genes, and NGS finely characterizes the amplified viral sequences. This enables detection of up to 16 high-risk or putative high-risk HPV in a sample as well as the presence of precancerous markers.
Author Interviews, JAMA, Outcomes & Safety, Surgical Research, University of Michigan / 15.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50705" align="alignleft" width="160"]Kyle Sheetz, MD, MSc Research Fellow Center for Healthcare Outcomes and Policy University of Michigan Dr. Sheetz[/caption] Kyle Sheetz, MD, MSc Research Fellow Center for Healthcare Outcomes and Policy University of Michigan MedicalResearch.com: What is the background for this study? What are the main findings? Response: Various patient safety organizations and clinical societies continue to advocate for volume thresholds as a means to improve the short-term safety and overall effectiveness of high risk cancer surgeries in the United States. We asked two questions with this study: 1) What proportion of U.S. hospitals meet discretionary volume standards? 2) Do these standards differentiate hospitals based on short-term safety outcomes (mortality and complications)? We found that a relatively low proportion of hospitals meet even modest volume standards put forth by the Leapfrog Group. These standards did not differentiate hospitals based on outcomes for 3 of 4 high risk cancer operations reported by the Leapfrog Group. However, using higher thresholds, we were able to demonstrate a significant relationship between higher hospital volume and better outcomes, which has been reported numerous times.
Author Interviews, Cancer Research, Cleveland Clinic, Weight Research / 15.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50721" align="alignleft" width="150"]Siran M. Koroukian, PhD Associate Professor Case Western Reserve University Dr. Koroukian[/caption] Siran M. Koroukian, PhD Director, Population Cancer Analytics Shared Resource Case Comprehensive Cancer Center Director, Population Health and Outcomes Research Core Associate Professor Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University Cleveland, OH MedicalResearch.com: What is the background for this study? What are the main findings? Response: Previous studies have shown that obesity-associated cancers (OACs) have been increasing in younger people. Using data from over 6 million cancer cases from 2000-2016, we identified the specific age/sex/race-ethnicity groups that were most affected by increases in OACs. We found a substantial shift of obesity-associated cancers to younger age groups, with the most notable increases occurring to the 50-64 age group. In addition, we observed the greatest percentage increase in the number of OAC cases during the study period in Hispanic men and women, as well as for cancers of the thyroid, gallbladder, liver and intrabiliary duct.
Author Interviews, Cancer Research, FDA, Vaccine Studies / 14.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50871" align="alignleft" width="150"]Dr. Graca Dores (left) and Dr. Perez-Vilar (senior author) Dr. Graca Dores (left) and Dr. Perez-Vilar (senior author)[/caption] Dr. Graca Dores MD MPH US Food and Drug Administration Center for Biologics Evaluation and Research Office of Biostatistics and Epidemiology Division of Epidemiology Silver Spring, Maryland Oklahoma City, OK MedicalResearch.com: What is the background for this study? Would you briefly explain what Sipuleucel-T is used for?  Response: Sipuleucel-T was the first therapeutic vaccine approved by the U.S. Food and Drug Administration (FDA) in 2010.  It is indicated for the treatment of asymptomatic or minimally symptomatic, metastatic, castration-resistant prostate cancer (CRPC; prostate cancer that spreads while an individual is on hormone-blocking therapy).  During the preparation of this product, the patient’s cells are collected (leukapheresis), sent for processing to generate a dose of patient-specific vaccine, and then administered intravenously back to the patient.  This process is repeated approximately every two weeks for a total of three doses. Except for the pre-marketing clinical trials that were reviewed during the sipuleucel-T approval process, post-marketing studies that have evaluated the safety profile of sipuleucel-T are scarce. Therefore, we used the FDA’s Adverse Event Reporting System (FAERS) database to summarize the adverse events reported to FDA by industry, medical professionals, and consumers.  We also assessed whether sipuleucel-T and specific adverse events (product-event pairs) were reported more than expected compared to all other drug/biologic-adverse event pairs in the FAERS database.
Author Interviews, Dermatology, Microbiome, Pediatrics / 14.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50847" align="alignleft" width="150"]Zhe-Xue Quan Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science School of Life Sciences, Fudan University Shanghai, China Dr. Zhe-Xue Quan[/caption] Zhe-Xue Quan, PhD Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science School of Life Sciences, Fudan University Shanghai, China  MedicalResearch.com: What is the background for this study? What are the main findings?  Response: The maturation of skin microbial communities during childhood is important for the skin health of children and development of the immune system into adulthood. This necessitates a better characterization of the environmental and genetic factors influencing these microbiome dynamics. We investigated the skin microbiota of children (158 subjects between 1 and 10 years old) and their mothers using 16S rRNA gene amplicon sequencing. Sample location and age were the primary factors determining a child’s skin bacterial composition. Relative abundances of Streptococcus and Granulicatella were negatively correlated with age, and the alpha diversity at all body sites examined increased during the first 10 years of life, especially on the face. The facial bacterial composition of 10-year-old children was strongly associated with delivery mode at birth. 
Author Interviews, Cancer Research, Dermatology / 14.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50843" align="alignleft" width="160"]Dr Alessia Visconti, PhD Department of Twin Research King's College London, London  Dr. Visconti[/caption] Dr Alessia Visconti, PhD Department of Twin Research King's College London, London MedicalResearch.com: What is the background for this study? Response: We know from previous studies that the body site where melanoma skin cancer develops varies according to sex, with men having melanoma more often on the head, neck, and trunk, and women on the legs. The body site where moles, a major risk factor for melanoma development, are more abundant also varies according to sex, at least in childhood, with boys having more moles on the head, neck, and trunk, and girls on the legs.
Author Interviews, JAMA, Mayo Clinic, Pancreatic, USPSTF / 14.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50834" align="alignleft" width="138"]Dr. Chyke A. Doubeni, M.D., M.P.H. Dr. Doubeni is a family physician and The inaugural director of the Mayo Clinic Center for Health Equity and Community Engagement Research Dr. Doubeni[/caption] Dr. Chyke A. Doubeni, M.D., M.P.H. Dr. Doubeni is a family physician and The inaugural director of the Mayo Clinic Center for Health Equity and Community Engagement Research MedicalResearch.com: What is the background for this study? Response: The U.S. Preventive Services Task Force uses systematic review of existing research to make recommendations on clinical preventive services that are delivered in primary care, with the goal to promote and improve health for all Americans. Although pancreatic cancer is an uncommon condition in the general population, it is often deadly. Pancreatic cancer is now the third most common cause of cancer death in the United States, and could become the second leading cause if current trends continue. The vast majority of people with pancreatic cancer are diagnosed at a late stage and, unfortunately, even when caught early enough when surgery could be most effective, only a little over one-third of patients survive beyond five years.
Author Interviews, Blood Pressure - Hypertension, Duke, Heart Disease, JAMA, Race/Ethnic Diversity / 14.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50729" align="alignleft" width="200"]Yuichiro Yano MD Assistant Professor in Family Medicine and Community Health Duke University  Dr. Yano[/caption] Yuichiro Yano MD Assistant Professor in Family Medicine and Community Health Duke University  MedicalResearch.com: What is the background for this study? What are the main findings?  Response: African Americans are disproportionally affected by hypertension-related cardiovascular disease compared with other racial/ethnic groups in the United States and have higher blood pressure levels inside and outside the clinic than whites and Asians. However, little is known, among African Americans, regarding whether higher mean blood pressure measured outside of the clinic setting on 24-hour ambulatory blood pressure monitoring is associated with an increased risk for cardiovascular disease events, independent of blood pressure measured in the clinic setting.
Author Interviews, Heart Disease, JAMA, Pediatrics / 14.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50819" align="alignleft" width="177"]Dr Juan Pablo Kaski MD(Res) FRCP FESC Director of the GOSH Centre for Inherited Cardiovascular Diseases Great Ormond Street Hospital, University College London Institute of Cardiovascular Science, London, UK Dr. Kaski[/caption] Dr Juan Pablo Kaski MD(Res) FRCP FESC Director of the GOSH Centre for Inherited Cardiovascular Diseases Great Ormond Street Hospital, University College London Institute of Cardiovascular Science, London, UK  MedicalResearch.com: What is the background for this study? Would you briefly explain what is meant by Hypertrophic Cardiomyopathy?  Response: Hypertrophic cardiomyopathy (HCM) is a genetic condition characterised by abnormal thickening of the muscle of the heart and can affect people of all ages. It is associated with an increased risk of sudden cardiac death (SCD) and, in the last few years, a clinical risk tool that estimates the 5-year risk of SCD in adults with HCM has been developed. However, there are no similar risk models in children, where risk stratification has traditionally been based on clinical risk factors extrapolated from the adult population. We have recently shown that this approach does not discriminate risk well in children, and so the aim of this study was to develop a new risk tool to provide an individualised risk of SCD in children with HCM. 
Author Interviews, Cost of Health Care, Medicare / 14.08.2019

MedicalResearch.com Interview with: ABT-AssociatesMatthew Trombley, Ph.D. Associate/Scientist Abt Associates  MedicalResearch.com: What is the background for this study?   Response: CMS developed the Accountable Care Organization (ACO) Investment Model (AIM) as part of the Medicare Shared Savings Program (MSSP) to encourage the growth of ACOs in rural and underserved areas.  The goal of our study was to see if AIM ACOs could successfully decrease Medicare spending in these areas.
Accidents & Violence, Author Interviews, Geriatrics / 13.08.2019

MedicalResearch.com Interview with: XinQi Dong MD, MPH Henry Rutgers Distinguished Professor of Population Health Sciences Director of the Director of Institute for Health, Health Care Policy and Aging Research Rutgers University New Brunswick, NJ 08901XinQi Dong MD, MPH Henry Rutgers Distinguished Professor of Population Health Sciences Director of the Director of Institute for Health, Health Care Policy and Aging Research Rutgers University New Brunswick, NJ 08901  MedicalResearch.com: What is the background for this study? What are the main findings?  Response: This study was done among community-dwelling US Chinese older adults aged 60 and above living in the greater Chicago area. The baseline cohort consisted of 3,157 participants, and we followed up with them from 2011 to 2017. There were heterogeneities in the associations between the strictness of definitions and subtypes of elder mistreatment (EM) and yearly mortality.  
Author Interviews, Environmental Risks, JAMA, NIH, Pulmonary Disease / 13.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50697" align="alignleft" width="150"]Joel Kaufman, MD, MPH, Professor   Environmental & Occupational Health Sciences, Medicine, and Epidemiology University of Washington Prof. Kaufman[/caption] Joel Kaufman, MD, MPH, Professor   Environmental & Occupational Health Sciences, Medicine, and Epidemiology University of Washington  MedicalResearch.com: What is the background for this study? What are the main findings? Response: Increasingly, it is recognized that chronic lung diseases like emphysema occur in nonsmokers and rates of these diseases are continuing to increase.  We really need to understand what’s causing chronic lung disease. Air pollutants are known to make disease worse in people with prior lung disease, but little is known about whether long-term exposure to air pollutants can cause chronic lung disease. We found that higher residential concentrations of air pollutants—especially ozone and traffic-related air pollutants—are associated with changes in the lung—emphysema-like changes in the lung.  The associations were strong and suggest that air pollution may be an important contributor to chronic lung disease. 
Author Interviews, Heart Disease, Nature, Nutrition / 13.08.2019

MedicalResearch.com Interview with: apple-flavenoidsNicola Bondonno PhD National Health and Medical Research Council Early Career Research Fellow School of Medical and Health Sciences Edith Cowan University Joondalup  Perth WA   MedicalResearch.com: What is the background for this study? Response: In an aging society, there could be a huge importance in appropriate evidence-based diets to reduce mortality risk. Therefore, our main question was ‘do diets high in flavonoids reduce the risk of all-cause and cause-specific mortality and is this relationship affected by lifestyle risk factors for early mortality’? In brief, this is the largest study of flavonoid intake and mortality outcomes to date. This population based cohort study was conducted in 56,048 men and women of the Danish Diet, Cancer, and Health Cohort, followed for 23 years, with estimated intakes of 219 individual flavonoid compounds. The results provide a clarity not seen in previous smaller, often underpowered studies. 
Annals Internal Medicine, Author Interviews, Race/Ethnic Diversity, Weight Research / 13.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50610" align="alignleft" width="200"]Dr-Jonathan Emberson Dr. Emberson[/caption] Jonathan Emberson, PhD Associate Professor (Medical Statistics and Epidemiology) Deputy Director of Graduate Studies Medical Research Council Population Health Research Unit Clinical Trial Service Unit & Epidemiological Studies Unit Nuffield Department Population Health University of Oxford    MedicalResearch.com: What is the background for this study? Response: Some previous studies had claimed that being overweight is not strongly associated with mortality in Hispanic populations (the ‘Hispanic paradox’). However, these studies had not accounted for the fact that while obesity makes diabetes and several other chronic diseases more common, these diseases may then result in substantial weight loss, thereby hiding the reason why those diseases arose in the first place. 
Author Interviews, Breast Cancer, JAMA, UCLA / 12.08.2019

MedicalResearch.com Interview with: [caption id="attachment_50709" align="alignleft" width="200"]Joann G. Elmore, MD, MPH Professor of Medicine, Director of the UCLA National Clinician Scholars Program David Geffen School of Medicine at UCLA Dr. Elmore[/caption] Joann G. Elmore, MD, MPH Professor of Medicine, Director of the UCLA National Clinician Scholars Program David Geffen School of Medicine at UCLA  MedicalResearch.com: What is the background for this study? What are the main findings?
  • A pathologist makes the diagnosis of breast cancer versus non-cancer after reviewing the biopsy specimen. Breast biopsies are performed on millions of women each year and It is critical to get a correct diagnosis so that we can guide patients to the most effective treatments.
  • Our prior work (Elmore et al. 2015 JAMA) found significant levels of disagreement among pathologists when they interpreted the same breast biopsy specimen. We also found that pathologists would disagree with their own interpretations of breast biopsies when they where shown the same biopsy specimen a year later.
  • In this study, 240 breast biopsy images were fed into a computer, training it to recognize patterns associated with several types of breast lesions, ranging from benign (noncancerous) to invasive breast cancer. We compared the computer readings to independent diagnoses made by 87 practicing U.S. pathologists and found that while our artificial intelligence program came close to performing as well as human doctors in differentiating cancer from non-cancer, the AI program outperformed doctors when differentiating ductal carcinoma in situ (DCIS) from atypia, which is considered the greatest diagnostic challenge.