Author Interviews, JAMA, Surgical Research / 13.01.2023

MedicalResearch.com Interview with: [caption id="attachment_59920" align="alignleft" width="175"]Casey HribarFourth-year medical student University of North Carolina Casey Hribar[/caption] Casey Hribar Fourth-year medical student University of North Carolina MedicalResearch.com: What is the background for this study? Response: Several great pieces of literature already exist about patient perception of doctors wearing white coats, formal attire, business attire, and the like. But recently, scrubs are garnering favor, especially as a result of the COVID-19 pandemic. While there has been some interest in what is worn over scrubs (jackets, vests, name tags, etc.), to our knowledge, there has not been any investigation into scrub color. Scrubs are a highly variable article of clothing, from fit, to pockets, pattern, and color, and it makes sense that these variations could have their own associated perceptions. Our study served as a way to open up the conversation around scrubs and the potential impact of their color on patients.
Allergies, Author Interviews, BMJ, Immunotherapy, Pediatrics / 13.01.2023

MedicalResearch.com Interview with: A/Prof Luke GrzeskowiakPhD | BPharm(Hons) | GCertClinEpid | AdvPracPharm | FSHP Associate Professor (Practitioner Fellow) Channel 7 Children’s Research Foundation Fellow in Medicines Use and Safety College of Medicine & Public Health Flinders University Affiliate Research Fellow – South Australian Health & Medical Research Institute (SAHMRI) Specialist Pharmacist – Flinders Women & Children, Flinders Medical Centre Adjunct Research Fellow – Faculty of Pharmacy and Pharmaceutical Sciences, Monash University Adjunct Research Fellow – Robinson Research Institute, The University of Adelaide  MedicalResearch.com: What is the background for this study? Response: Peanut allergy affects 1-3% of children in Western countries, making it the most common food-related allergen. Only a small percentage (20%) of children grow out of their peanut allergy, with allergen avoidance and provision of rescue medications for the management of allergic reactions being the recognised mainstay of treatment for many years. However, avoidance of peanuts provides many challenges for children and their caregivers and requires children and caregivers to be hypervigilant regarding peanut ingestion, creating a significant burden. This burden can have a real impact on quality of life for children and their families. In more recent years there has been emerging interest in what is referred to as oral immunotherapy as an active preventive treatment to reduce the risk of accidental peanut exposure. Oral immunotherapy involves exposing children to an extremely small dose of peanut, typically in the form of peanut flour, and then gradually increasing that dose over time to build tolerance. We have been looking at opportunities for making oral immunotherapy safer, which would then make it more suitable for more people. Our previous research showed that boiling peanuts alters its protein structure and allergic properties, meaning they were less likely to cause a severe allergic reaction, but were still able to improve tolerance to peanut allergens.
Author Interviews, Cancer Research, Dermatology, Melanoma, Vitamin C / 10.01.2023

MedicalResearch.com Editors' note:  Please consult your health care provider before initiating any vitamin supplementation, including Vitamin D as potentially serious side effects are possible. MedicalResearch.com Interview with: Prof. Ilkka T Harvima Department of Dermatology University of Eastern Finland and Kuopio University Hospital Kuopio, Finland MedicalResearch.com: What is the background for this study? Response: The North Savo Skin Cancer Program in Eastern Finland was launched in 2017, and it aims at reducing the incidence, morbidity and mortality caused by skin cancers, such as basal cell carcinoma, squamous cell carcinoma and melanoma. A part of this program constituted a follow-up project of patients with an assessed risk of skin cancer. There are also several other parts, such as analysis of skin cancer material reposited in the Biobank of Eastern Finland (see the enclosed BMC Cancer 2021 reference), public information, education of general physicians and medical students etc. In 2021, we published the article in BMC Cancer (enclosed), where we attempted to clarify the reasons for the relatively high melanoma mortality in relation to its incidence in this region (North Savo) of the country. By using the biobank material we also published an article in 2022 showing that melanoma and melanoma in situ associate with keratinocytic premalignant lesions and keratinocyte skin carcinomas (Suhonen V, Siiskonen H, Suni M, Rummukainen J, Mannermaa A, Harvima IT. Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions. Eur J Dermatol 2022 Apr 1;32(2):187-194. doi: 10.1684/ejd.2022.4221.). The follow-up study of about 500 subjects is ongoing (COVID-19 caused pretty much trouble for the recruitment). This is focused on finding risk factors and biomarkers for skin cancers and carcinogenesis. The first study on these follow-up patients was published in 2021 (Komulainen J, Siiskonen H, Harvima IT. Association of elevated serum tryptase with cutaneous photodamage and skin cancers. Int Arch Allergy Immunol 2021;182(11):1135-1142. doi: 10.1159/000517287.). The article on vitamin D just recently published in Melanoma Research on Dec 28, 2022, is the second one. The third work in pipeline deals with the association of atopic disorders with skin cancers, and the manuscript is under revision. So, these provide with some background for the article in Melanoma Research. Actually, we thought that vitamin D use might associate with skin photoaging, actinic keratoses and carcinogenesis, but the only, though very important, finding was its association with melanoma. We have not focused our research just on vitamin D only, but it looks like we need to go further.
Aging, Alzheimer's - Dementia, Author Interviews, Hearing Loss, JAMA, Johns Hopkins / 10.01.2023

This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis or treatment. Contact a qualified medical professional before engaging in any physical activity, or making any changes to your diet, medication or lifestyle,   MedicalResearch.com Interview with: [caption id="attachment_59905" align="alignleft" width="200"]Alison R. Huang, PhD MPH Senior Research Associate Cochlear Center for Hearing & Public Health Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Dr. Huang[/caption] Alison R. Huang, PhD MPH Senior Research Associate Cochlear Center for Hearing & Public Health Department of Epidemiology Johns Hopkins Bloomberg School of Public Health MedicalResearch.com: What is the background for this study? What are the main findings? Response: Hearing loss is a critical public health issue affecting two-thirds of older adults over 70 years old. There is growing understanding of a strong link between hearing loss and dementia, which impacts millions of Americans. Our main findings are that in a nationally representative sample of older adults in the United States from the National Health and Aging Trends Study, every 10 decibel increase in hearing loss was associated with 16% greater prevalence of dementia, such that prevalence of dementia in older adults with moderate or greater hearing loss was 61% higher than prevalence in those with normal hearing. We also found that in older adults with moderate or greater hearing loss, hearing aid use was associated with a 32% lower prevalence of dementia.
Addiction, Author Interviews, Opiods / 29.12.2022

MedicalResearch.com Interview with: Alden MiletoAlden Mileto, BA Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, PA MedicalResearch.com: What is the background for this study? Response: The drug buprenorphine is a partial opioid agonist, originally developed in the 1960s as an alternative to the stronger full opioid mu receptor agonists like morphine. Today, the drug is sometimes used for pain, but is more often used as a treatment for Opioid Use Disorder (OUD). Since the 2002 federal approval for buprenorphine use in treatment of OUD, there has been an increase in buprenorphine prescription across all states. However recent studies have showed a disproportionate increase in buprenorphine prescriptions to rural/ less populated areas in comparison to urban/densely populated areas. The objective of this study [1] was to analyze the trends in buprenorphine distribution, overall and by three-digit zip codes, in Pennsylvania from 2010-2020.
Author Interviews, Cannabis / 27.12.2022

You might have heard good things about CBD oil. You heard that it can assist with numerous conditions and symptoms. However, what you heard might have been simply hearsay and not necessarily proven fact. What you want to know is the science-backed health benefits about CBD oil from actual studies and research, which we provide below.
  1. Alleviate Stress & Anxiety
Stress is something we all experience at some point in time. The worse it gets, the more debilitating it can be and the more it can, in turn, affect our daily lives. A study found that use of CBD oil can not only help one combat excess stress, but it’s also effective for those who struggle with anxiety.
Author Interviews, Biomarkers, Heart Disease, JACC, University of Michigan / 21.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59873" align="alignleft" width="130"]Salim S. Hayek MDAssistant Professor Medical Director of the Frankel Cardiovascular Center Clinics University of Michigan Dr. Hayek[/caption] Salim S. Hayek MD Assistant Professor Medical Director of the Frankel Cardiovascular Center Clinics University of Michigan MedicalResearch.com: What is the background for this study? What are the main findings? Response: Essentially, immune checkpoint myocarditis is a rare but deadly complication of immune checkpoint inhibitors – amazing drugs that are increasingly used for the treatment of various cancers. Most patients present late, and when they do, they’re very ill and have a 50% chance of death. Diagnosing ICI myocarditis is challenging, given there is no one test that can differentiate it from other causes of cardiac injury. It is important to diagnose it fast, early and accurately in order to start immunosuppressive therapy as soon as possible. What we did in this study was look at commonly measured biomarkers in all patients receiving ICI at the University of Michigan. What we found was that patients who developed ICI myocarditis had early signs of muscle destruction (rise in CPK) levels and hepatitis (rise in AST, ALT), and that all patients who had myocarditis with bad outcomes had rises in all of the aforementioned biomarkers. Creatinine phosphokinase was the most sensitive.
Accidents & Violence, Author Interviews, JAMA, Pediatrics / 20.12.2022

MedicalResearch.com Interview with: Rebecca F. Wilson, PhD Division of Violence Prevention National Center for Injury Prevention and Control US Centers for Disease Control and Prevention, Atlanta, Georgia MedicalResearch.com: What is the background for this study? What are the main findings? Response: Our report shows the homicide rate among children aged 0 to 17 years has been increasing annually on average 4.3% since 2013, and rose sharply from 2019 to 2020. The largest 2019 to 2020 rate increases were among children 11-17 years old, boys, and Black children. Overall increases varied by geography and demographics, with some racial and ethnic disparities persisting for more than 20 years. Firearms were the most common weapon used in child homicides. Homicides of younger children (infants to 10 years) were mostly perpetrated by parents and caregivers and precipitated by abuse and/or neglect. Homicides of older children (11-17 years) were mostly perpetrated by someone known to them, like a friend or acquaintance, and precipitated by crime, arguments, and community violence.
Author Interviews, Neurology / 19.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59862" align="alignleft" width="200"]Regina Blye, Chief Program and Policy OfficerDiscusses the  Living with Paralysis & Caregiver National Survey Conducted by the Christopher and Dana Reeve Foundation Regina Blye[/caption] Regina Blye, Chief Program and Policy Officer Discusses the  Living with Paralysis & Caregiver National Survey Conducted by the Christopher and Dana Reeve Foundation MedicalResearch.com: How large is the population of Americans living with paralysis?  Response:  There is a significant population of Americans living with paralysis. To note, a 2013 study by the Christopher & Dana Reeve Foundation found that 1 in 50 people in the US are living with paralysis. This is approximately 5.4 million people. I, myself, have lived with a spinal cord injury (SCI) for over 35 years. While some progress has been made over the past few decades, there is still work to be done. In a new survey conducted by the Christopher & Dana Reeve Foundation called “Living with Paralysis & Caregiver National Survey,” we learned that a majority of Americans (69%) underestimate the prevalence of those living with paralysis in the U.S. - about two out of every 100 individuals. Given the notable size of the population, we must work together to educate and inform families, business leaders, advocates, policymakers and the general public to help improve the quality of life for those living with, or impacted by paralysis. The Christopher & Dana Reeve Foundation is dedicated to curing spinal cord injury by advancing innovative research and improving the quality of life for individuals and families impacted by paralysis. While we’ve been fortunate to make advancements with significant support from the community, we must all unite to accelerate comprehensive information, resources, referral services, and innovative research together.
Author Interviews, Cost of Health Care, JAMA / 19.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59851" align="alignleft" width="125"]MedicalResearch.com Interview with:Anna L Goldman, MD, MPH, MPA Assistant Professor of Medicine Boston Medical Center MedicalResearch.com: What is the background for this study? Response: Experts on the healthcare labor market have long debated the existence and magnitude of a physician shortage. Physician work hours are a major contributor to physician supply issues, but little research is available on recent trends in work hours by physicians. In addition, no available studies have rigorously estimated changes in the physician workforce size during the pandemic. MedicalResearch.com: What are the main findings? Were there gender differences in hours worked? Response: The average hours worked per week by physicians decreased 7.6% in the two decades between 2001 and 2021. On average, physicians worked 52.6 hours per week in 2001-2003 and 48.6 hours per week in 2019-2021. This decrease did not appear to be caused by the COVID-19 pandemic, as the trend continued on the same steady trajectory that was present prior to the pandemic. The observed decreases were driven by reduced work hours among male physicians, full-time physicians, and younger physicians. Male physicians decreased work hours twice as much as female physicians. Physician mothers were the only group to increase weekly work hours, with a 3% increase over 20 years. Physician fathers, by contract, decreased work hours by 12%. The number of part-time physicians remained flat throughout the study period. Broadly decreasing trends in work hours were similarly present among non-physician holders of doctoral degrees, suggesting a broader trend among highly-educated professionals in their approach to work hours. The physician workforce grew by 32.9% over two decades, but then fell by 6.7% during the COVID-19 pandemic, or a drop of 1 in 14 physicians. The physicians who left the workforce during the pandemic were disproportionately white and from rural areas. Work hours generated by the physician workforce, as a whole, grew 7% over the study period, which was about half the rate of population growth in the same period (16.6%). This sluggish growth in physician workforce hours was entirely offset by large increases in the work hours contributed by nurse practitioners and physician assistants. When the clinician workforce was assessed as a whole (combining hours from physicians, nurse practitioners, and physician assistants), growth in total workforce hours was 21.4%, exceeding the population growth rate. MedicalResearch.com: What should readers take away from your report? • Physician weekly work hours fell 8% from 2001-2021, with a particularly large drop for physician fathers (-12%) vs. a small increase for physician mothers (+3%). • Because of this decline in hours, total weekly hours contributed by the physician workforce lagged far behind US population growth, an increase of 7% in work hours vs. 16.6% increase in US population. This gap was entirely offset by a large increase in nurse practitioner and physician assistant hours. • From 2019 to 2021, the physician workforce fell by 7%, which represents 1 in 14 physicians leaving the workforce during the COVID-19 pandemic. MedicalResearch.com: What recommendations do you have for future research as a results of this study? Response: Research on work hours in individual physician specialties is needed to better understand the distribution of work hour changes across the spectrum of physician types. Measurement of these trends can help predict burnout in specialties where hours may be lengthening vs. shortages in fields with rapidly decreasing work hours. MedicalResearch.com: Is there anything else you would like to add? Any disclosures? Response: Our findings may shed light on the high rates of burnout that has been identified among physician-mothers in other research. While increasing work hours among mothers may indicate progress on gender parity in terms of career engagement, this change may not have been sufficiently offset by a reduction in domestic responsibility. Further research should examine the balance of household duties as physician mothers spend an increasing amount of time at work. No disclosures. Citation: Changes in Physician Work Hours and Implications for Workforce Capacity and Work-Life Balance, 2001-2021 The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website. Dr. Goldman[/caption] Anna L. Goldman, M.D., M.P.A., M.P.H Assistant Professor of Medicine General Internal Medicine Boston University Chobanian & Avedisian School of Medicine   MedicalResearch.com: What is the background for this study? Response: Experts on the healthcare labor market have long debated the existence and magnitude of a physician shortage. Physician work hours are a major contributor to physician supply issues, but little research is available on recent trends in work hours by physicians.  In addition, no available studies have rigorously estimated changes in the physician workforce size during the pandemic.
Addiction, Author Interviews / 19.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59854" align="alignleft" width="150"]Lyle Isaacs, Professor       University of Maryland                                                Department of Chemistry and Biochemistry College Park, MD 20742 Prof. Isaacs[/caption] Lyle Isaacs, Professor      University of Maryland                                               Department of Chemistry and BiochemistryCollege Park, MD 20742 MedicalResearch.com: What is the background for this study? Response: The Isaacs laboratory has a long-standing interest in molecular containers compounds and their molecular recognition properties toward chemically and biologically important targets.  Molecular containers include well known pharmaceutical excipients that help dissolve and deliver drugs (e.g. sulfobutyl-beta-cyclodextrin (SBE-b-CD)) and even sequester active pharmaceutical ingredients (e.g. Sugammadex reverses the effects of neuromuscular blockers). Our lab has previously studied a class of molecular containers called cucurbiturils and found that they bind tightly (nanomolar Kd) to hydrophobic cations in aqueous solution.  Recently, we translated our knowledge of tight binding to design and synthesize a novel tight binding molecular container known as Pillar[6]MaxQ and showed that it has superior binding affinity toward hydrophobic cations.[reference = Angewandte Chemie International Edition 2020, 59, 13313]
Accidents & Violence, Aging, Author Interviews, BMJ, Brain Injury, Brigham & Women's - Harvard, Exercise - Fitness / 15.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59841" align="alignleft" width="150"]Rachel Grashow PhDResearch Scientist Department of Environmental Health Football Players Health Study at Harvard University Harvard T.H. Chan School of Public Health Dr. Grashow[/caption] Rachel Grashow PhD Research Scientist Department of Environmental Health Football Players Health Study at Harvard University Harvard T.H. Chan School of Public Health MedicalResearch.com: What is the background for this study? Response: Anecdotally, we heard from former NFL players that they felt older than their chronological age. At the same time, doctors and medical care providers treating former players also observed that players appeared clinically older in some health domains. These observations motivated us to ask:  despite superior fitness and success as young men, are football players experiencing early aging and living with illness and disability for more years than their non-football peers?
Addiction, Author Interviews, JAMA, Mental Health Research, Race/Ethnic Diversity, University of Pennsylvania / 15.12.2022

[caption id="attachment_59828" align="alignleft" width="150"]Rebecca Arden Harris Dr. Harris[/caption] MedicalResearch.com Interview with: Rebecca Arden Harris, MD, MSc Assistant Professor of Family Medicine and Community Health at the Hospital of the University of Pennsylvania Senior Fellow, Leonard Davis Institute of Health Economics Perelman School of Medicine, University of Pennsylvania MedicalResearch.com: What is the background for this study? Response: The impact of the nationwide overdose epidemic on Black women has received little attention from policy-makers, researchers, or the press. MedicalResearch.com: What are the main findings? Response:  Over the 7-year study period, preventable overdose deaths among Black women resulted in nearly 0.75 million years of life lost (YLL). Women aged 25-34 have suffered a rising proportion of this burden.
Author Interviews, Genetic Research, Infections, Neurological Disorders / 14.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59834" align="alignleft" width="150"]Dr. Eli Hatchwell, MA MB BChir (Cantab) DPhil (Oxon) BA (OU)Chief Scientific Officer Population Bio UK, Inc. Begbroke Science Park Begbroke Hill Begbroke, Oxfordshire United Kingdom Dr. Hatchwell[/caption] Dr. Eli Hatchwell, MA MB BChir (Cantab) DPhil (Oxon) BA (OU) Chief Scientific Officer Population Bio UK, Inc. Begbroke Science Park Begbroke Hill Begbroke, Oxfordshire United Kingdom MedicalResearch.com: What is the background for this study? Response: Progressive Multifocal Leukoencephalopathy (PML) is a devastating condition that is associated with a number of clinical situations, including treatment with a variety of drugs. Of these, the best known is natalizumab (Tysabri), which is a very successful drug in the treatment of MS (multiple sclerosis). Only a small proportion of patients treated with natalizumab develop PML and this has always been a mystery. The study was based on a hypothesis that some individuals have an underlying susceptibility to developing PML, based on the presence of variants in genes that are important in the immune system. The study identified several of these variants.
Author Interviews, Dermatology, Lancet / 13.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59823" align="alignleft" width="130"]Dr. Emma Guttman-Yassky, MD, PhDWaldman Professor and System Chair The Kimberly and Eric J. Waldman Department of Dermatology Director, Center of Excellence in Eczema Director, Laboratory of Inflammatory Skin Diseases Icahn School of Medicine at Mount Sinai Dr. Guttman-Yassky[/caption] Dr. Emma Guttman-Yassky, MD, PhD Waldman Professor and System Chair The Kimberly and Eric J. Waldman Department of Dermatology Director, Center of Excellence in Eczema Director, Laboratory of Inflammatory Skin Diseases Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? What are the main findings? Response: The background for this study are studies that show that OX40 is a pathway that is upregulated in patients with atopic dermatitis (or eczema). OX40 is involved in activation of immune molecules associated with allergy and atopy, and also with formation of memory immune cells that are required for disease recurrence. The hypothesis to the study was that giving an OX40 antagonist will not only ameliorate the disease but perhaps have a remittive effect in that the disease will not come back. Indeed all drug doses were significantly effective at week 16, the primary endpoint compared to placebo and continued to improve towards week 36, the secondary endpoint. In addition, the responders to treatment maintained their responses for an additional 20 weeks, which is unusual, suggesting a potential for disease modification.
Author Interviews, CHEST, Pulmonary Disease, Sleep Disorders / 12.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59819" align="alignleft" width="150"]Pamela L. Lutsey, PhD, MPHMinneapolis, Minnesota Professor, Division of Epidemiology and Community Health School of Public Health University of Minnesota Dr. Lutsey[/caption] Pamela L. Lutsey, PhD, MPH Minneapolis, Minnesota Professor, Division of Epidemiology and Community Health School of Public Health University of Minnesota MedicalResearch.com: What is the background for this study? Response: Emerging evidence suggests that patients with OSA may be more susceptible to developing pneumonia. Mechanistically, OSA causes upper airway sensory dysfunction and excessive microaspirations, which can result in significant increases in bacterial organisms in the airway leading to upper airway and laryngeal inflammation. Systemically, healthy sleep is believed to play an important role in the body’s inflammation control and immune system regulation. Despite this evidence, few studies have prospectively evaluated whether individuals with OSA are at elevated risk of being hospitalized with pneumonia, respiratory infection, or any infection
Author Interviews / 12.12.2022

Are you just starting with ELISAs and want to know what to buy? ELISA is a well-known scientific test method used in the lab to detect protein-antibody interactions. It is not only helpful in conducting medical research applications, but it also has excellent industrial uses like tracking down pathogens in food, environmental diagnostics, etc. Use this quick guide to learn exactly how to get the most from your coating buffer.

 Know Your Antigen

ELISA (Enzyme-Linked Immunosorbent Assay) is the gold standard in testing for allergic reactions. They don't just get the job done; they get it right every time! In ELISAs and many other infectious diseases, a single cell or virus may be able to infect another in the same manner and replicate. This is called the passive spread. There are a lot of inactive contacts between people in this community, so your immune system can easily recognize your specific antigen. Since everyone is exposed to this disease at some point in their lives, you should know your particular antigen well enough so that you'll be able to fight it more effectively if it ever re-appears again. 5 Ways to Get the Most out of ELISAs
Author Interviews, Breast Cancer, Mammograms / 07.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59804" align="alignleft" width="150"]Wendie Berg, MD, PhD, FACRProfessor of Radiology University of Pittsburgh Dr. Berg[/caption] Wendie Berg, MD, PhD, FACR Professor of Radiology University of Pittsburgh MedicalResearch.com: What is the background for this study? Response: Mammography misses many cancers in women with a personal history of breast cancer (PHBC). MRI improves early detection of cancer in women with PHBC and the American College of Radiology recommends adding MRI every year for women with PHBC and dense breasts or diagnosis by age 50 but not every woman can tolerate MRI. Contrast-enhanced mammography (CEM) appears to be a good alternative to MRI.  Our study examined performance of CEM after tomosynthesis in women with PHBC.  We first trained our radiologists in CEM (Berg WA et al JBI 2021) and two radiologists interpreted both tomosynthesis and CEM on every participant.
Author Interviews, Cancer Research, Duke, Heart Disease, Pediatrics / 06.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59798" align="alignleft" width="150"]Amy Berkman, MDDepartment of Pediatrics Duke University School of Medicine Dr. Berkman[/caption] Amy Berkman, MD Department of Pediatrics Duke University School of Medicine MedicalResearch.com: What is the background for this study? Response: Cancer incidence in adolescents and young adults (AYAs, aged 15-39 years at diagnosis) is increasing, with approximately 90,000 new diagnoses annually in the US. Improvements in 5-year survival have led to a growing population of survivors of AYA cancer, currently estimated at >600,000 survivors. Survivors are at increased risk of treatment related chronic conditions including cardiovascular disease (CVD). We wanted to determine whether certain sociodemographic and medical history factors further increase the risk of CVD in AYA cancer survivors and also compare risk of CVD between AYA cancer survivors and the general population.
Author Interviews, Heart Disease, JACC, Supplements / 06.12.2022

MedicalResearch.com Interview with: [caption id="attachment_59776" align="alignleft" width="200"]Simin Liu MD MPH ScDProfessor of Epidemiology at the School of Public Health, Professor of Medicine (Endocrinology) and Professor of Surgery at the Alpert School of Medicine Brown University Dr. Simin Liu[/caption] Simin Liu MD MPH ScD Professor of Epidemiology at the School of Public Health, Professor of Medicine (Endocrinology) and Professor of Surgery at the Alpert School of Medicine Brown University MedicalResearch.com: What is the background for this study? Response: Our research team has been researching the roles of environmental and genetic determinants of chronic diseases for nearly three decades, with special emphasis on evaluating micronutrients, minerals, and trace elements in relation to cardiometabolic outcomes, and findings of which have contributed to the design of several large, randomized trials of dietary supplements in the US (Liu JAMA 1999; 2011; Diabetes Care 2005a,b; Diabetes 2006).  Several large intervention trials have consistently shown beneficial effects on clinical cardiometabolic outcomes of a diet pattern rich in micronutrients, although research on micronutrient supplementation has mainly focused on the health effects of a single or a few vitamins and minerals. We decided to take a comprehensive and systematic approach to evaluate all the publicly available/accessible studies reporting all micronutrients including phytochemicals and antioxidant supplements and their effects on cardiovascular risk factors as well as multiple CVDs.
Addiction, Author Interviews, Pain Research / 01.12.2022

  MedicalResearch.com Interview with: [caption id="attachment_59795" align="alignleft" width="172"]Lavinia Harrison Lavinia Harrison[/caption] Lavinia Harrison Geisinger Commonwealth School of Medicine Scranton, PA  18509 MedicalResearch.com: What is the background for this study? Response:   The opioid meperidine (Demerol) was widely prescribed in the United States (US) as an analgesic to treat moderate to severe pain. Meperidine was the most used opioid in the US in 1987 and was considered safer than other opioids during acute pancreatitis. Over the past two decades, meperidine has shifted from being frequently prescribed to being used only when patients are experiencing atypical reactions to opioids (e.g., morphine and hydromorphone); to removal from the World Health Organization's essential medication list and receiving strong warnings against its use from many professional organizations including the American Geriatrics Society. The unfortunate Libby Zion (1965-1984) case increased concerns about serotonin syndrome with meperidine. According to a prior pharmacoepidemiology report, the distribution of meperidine in the United States decreased by 95% between 2001 and 2019 [1]. The aim of the study was to include updated information (2020 and 2021) as well as examine the changes among Medicaid patients [2].
Author Interviews, Cost of Health Care, Rheumatology, University of Pittsburgh / 01.12.2022

MedicalResearch.com Interview with: Raisa Silva, M.D. Resident physician in Internal medicine University of Pittsburgh Medical Center MedicalResearch.com: What is the background for this study? Response: Systemic lupus erythematosus (lupus for short) is a complex disease that significantly affects patients’ lives. Adherence to medications for lupus is known to be suboptimal (it can be as low as 15% in some studies). Multiple social factors may affect treatment adherence. For example, costs of medications (including copayments, deductibles, co-sharing), polypharmacy (patients with lupus often have comorbid diseases that also need medications), and potential side effects are some of the reasons why patients may have difficulty in taking medications for lupus every day. The costs of insurance copayment may represent a major obstacle to adherence. The lack of adherence to lupus medications is associated with poor control of disease, more symptoms, and worse disease outcomes, such as more hospitalizations and more severe disease. In our study, we examined the association between lupus medications copayment and adherence to these medications (some of the most commonly used medications for lupus).
Author Interviews / 30.11.2022

If you find yourself in an emergency situation, then it is important that you have a fully functioning first aid kit to hand. This should be a small kit filled with different supplies that will be helpful for various injuries and ailments.  The Importance of Contents It is incredibly important that the contents of your first aid kit are of high quality and include everything you need – because without them, you will not be able to use the equipment to its fullest extent in an emergency, and you may lack crucial pieces. You can buy complete first aid kits online that are already full of everything you need; however, you will have to keep a list of these supplies so that you can replenish your gear as and when you need to. As such, below, this article will discuss the most crucial components that should make up your first aid kit in more detail.
Accidents & Violence, Author Interviews, Brigham & Women's - Harvard, Emory, JAMA, Race/Ethnic Diversity / 29.11.2022

MedicalResearch.com Interview with: Chris A. Rees, MD, MPH Assistant Professor of Pediatrics and Emergency Medicine Research Director, Pediatric Emergency Medicine Fellowship Emory University School of Medicine Attending Physician, Children's Healthcare of Atlanta Pediatric Research Scientist, CHAMPS, U.S. Program Office  and Eric W. Fleegler, MD, MPH, FAAP Associate in Pediatrics, Division of Emergency Medicine Director Sedation Service Boston Children’s Hospital Assistant Professor of Pediatrics and Emergency Medicine Harvard Medical School MedicalResearch.com: What is the background for this study? Response: Rates of firearm fatalities in the United States have reached a 28-year high. Yet, an understanding of the specific demographic groups who have been most affected, and where in the United States these fatalities have occurred, has not been clearly described in the past.
Author Interviews, Mental Health Research / 28.11.2022

Sound healing is an alternative therapy that uses sound waves to heal the mind and body. This therapy is based on the belief that all matter is vibrating at a certain frequency and that disease or ill health occurs when the body’s natural frequency is out of alignment. Sound healing practitioners use a variety of tools, including singing bowls, gongs, and tuning forks, to restore the body’s natural frequency. There are many benefits of sound healing, including reducing stress, promoting relaxation, improving sleep, and reducing pain. Sound healing can also be used to treat a wide range of conditions, such as anxiety, depression, PTSD, and addiction. If you are looking for a non-invasive way to improve your health and well-being, sound healing may be right for you.
Alzheimer's - Dementia, Author Interviews, Nutrition / 26.11.2022

MedicalResearch.com Interview with: [caption id="attachment_59755" align="alignleft" width="150"]Thomas M Holland, MD, MSAssistant Professor Rush Institute for Health Aging Rush College of Medicine & Rush College of Health Sciences Dr. Holland[/caption] Thomas M Holland, MD, MS Assistant Professor Rush Institute for Health Aging Rush College of Medicine & Rush College of Health Sciences https://www.rushu.rush.edu/faculty/thomas-m-holland-md-ms MedicalResearch.com: What is the background for this study? Response: My late mentor Martha Clare Morris, ScD had published a manuscript investigating leafy green intake, and the nutrients found therein, and cognition. I wanted to take this thought a step further and investigate the potential association bioactives, found in vegetables, like leafy greens, has to cognition. Further, this is a continuation of the research I published in the green journal in 2020 associating flavonols to incident Alzheimer’s dementia. This study extends the understanding that flavonols are not only beneficial for the most detrimental outcome of Alzheimer’s dementia (in decreasing the risk), but also advantageous in mitigating components of the, clinical syndrome i.e. decreasing the rate of cognitive decline.
Aging, Author Interviews, Brigham & Women's - Harvard, Dermatology, Heart Disease, Herpes Viruses, Stroke / 23.11.2022

MedicalResearch.com Interview with:| [caption id="attachment_59757" align="alignleft" width="133"]Sharon G. Curhan, MD, ScM| Dr. Curhan[/caption] Sharon G. Curhan, MD, ScM| Director, CHEARS: The Conservation of Hearing Study Channing Division of Network Medicine Department of Medicine Brigham and Women’s Hospital Harvard Medical School Boston, MA 02114 MedicalResearch.com: What is the background for this study? Response:       Herpes zoster, commonly known as “shingles,” is a viral infection that often causes a painful rash. Shingles can occur anywhere on the head or body. Shingles is caused by the varicella zoster virus (VZV), the same virus that causes chickenpox. After a person has chickenpox, the virus stays in their body for the rest of their life. Years and even decades later, the virus may reactivate as shingles. Almost all individuals age 50 years and older in the US have been infected with the varicella zoster virus and therefore they are at risk for shingles. About 1 in 3 people will develop shingles during their lifetime, and since age is a risk factor for shingles, this number may increase as the population ages. The risk is also higher among individuals of any age who are immunocompromised due to disease or treatment. A number of serious complications can occur when a person develops shingles, such as post-herpetic neuralgia (long-lasting pain), but there was limited information on whether there are other adverse long-term health implications of developing shingles. There is a growing body of evidence that links VZV, the virus that causes shingles, to vascular disease. VZV vasculopathy may cause damage to blood vessels and increase the risk of stroke or coronary heart disease. Although some previous studies showed a higher risk of stroke or heart attack around the time of the shingles infection, it was not known whether this higher risk persisted in the long term. Therefore, the question we aimed to address in this study was to investigate whether shingles is associated with higher long-term risk of stroke or coronary heart disease. To address this question, we conducted a prospective longitudinal study in 3 large US cohorts of >200,000 women and men, the Nurses’ Health Study (>79,000 women), the Nurses’ Health Study II (almost 94,000 women) and the Health Professionals Follow-Up Study (>31,000 men), without a prior history of stroke or coronary heart disease. We collected information on shingles, stroke and coronary heart disease on biennial questionnaires and confirmed the diagnoses with medical record review. We followed the participants for up to 16 years and evaluated whether those who had developed shingles were at higher risk for stroke or coronary heart disease years after the shingles episode. The outcomes we measured were incident stroke, incident coronary heart disease [defined as having a non-fatal or fatal myocardial infarction (heart attack) or a coronary revascularization procedure (CABG, coronary artery bypass graft or percutaneous transluminal coronary angioplasty)]. We also evaluated a combined outcome of cardiovascular disease, which included either stroke or coronary heart disease, whichever came first.
Author Interviews, JAMA, Obstructive Sleep Apnea, Sleep Disorders, USPSTF / 23.11.2022

MedicalResearch.com Interview with: [caption id="attachment_58144" align="alignleft" width="150"]Martha Kubik Dr. Kubik[/caption] Martha Kubik, Ph.D., R.N. Professor, School of Nursing College of Health and Human Services George Mason University Member, U.S. Preventive Services Task Force MedicalResearch.com: What is the background for this study? Response: Obstructive sleep apnea is a health condition in which part or all of a person’s airway gets blocked during sleep, causing their breathing to stop and restart many times. Untreated sleep apnea is associated with heart disease, stroke, and diabetes. However, there is currently very limited evidence on screening people who don’t have signs or symptoms like snoring and excessive daytime sleepiness.