Author Interviews, Genetic Research, JAMA, Pancreatic, Surgical Research / 25.08.2017
DNA Analysis Identifies Subtype of Pancreatic Cancer With Good Prognosis
MedicalResearch.com Interview with:
Nancy You, MD, MHSc, FACS
Department of Surgical Oncology
The University of Texas MD Anderson Cancer Center
Houston
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This study was motivated by the emerging promise of precision medicine and the emerging evidence that immunotherapy may have phenomenal efficacy in particular molecular subtypes of cancers. This specific molecular subtype shows deficiency in DNA mismatch repair mechanisms and therefore is thought to be more immunogenic. DNA mismatch repair deficiency can arise from germline defects such as in the case of patients with Lynch Syndrome, an inherited cancer syndrome, or from epigenetic inactivation DNA mismatch repair genes.
Overall, pancreas cancer has seen limited success with conventional chemotherapy. In our study, we demonstrated that there is a particular molecular subtype of pancreas cancer that is characterized by defect in DNA mismatch repair genes and by microsatelie instability that has a different prognosis than other pancreas cancers. This subtype of pancreas cancer is suspected to also respond to immunotherapy.
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