28 Sep Health Consequences for the Bereaved
Loss of appetite, sleep disturbances, insomnia, feelings of isolation, inability to make decisions, and confusion are all common symptoms while grieving...
Loss of appetite, sleep disturbances, insomnia, feelings of isolation, inability to make decisions, and confusion are all common symptoms while grieving...
MedicalResearch.com Interview with: [caption id="attachment_44776" align="alignleft" width="200"] Dr. McCoy[/caption] Thomas McCoy, M.D. Assistant Professor of Psychiatry Massachusetts General Hospital Psychiatry Massachusetts General Hospital MedicalResearch.com: What is the background for this study? Response: Big data has the potential to transform how we care for patients but comes with risks of big breaches. My co-author and I use health records...
Dr. Okubo[/caption]
Masashi Okubo, MD.
Clinical Instructor of Emergency Medicine
Research Fellow
Department of Emergency Medicine
University of Pittsburgh
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Out-of-hospital cardiac arrest (OHCA) is a major public health problem, annually affecting over 350,000 individuals in the US with low survival rate, 11.4% among those who were treated by emergency medical services (EMS). Prior studies showed a 5-fold difference (3.0% to 16.3%) in survival to hospital discharge between 10 study sites in North America (US and Canada) and 6.5-fold difference (3.4% to 22.0%) between 132 US counties after OHCA.
However, it was unclear how much patient outcome after OHCA differ between EMS agencies which play a critical role in OHCA care. Among 43,656 adults treated for Out-of-hospital cardiac arrest by 112 EMS agencies in North America, we found that survival to hospital discharge differed from 0% to 28.9% between EMS agencies. There was a median difference of 56% in the odds of survival to hospital discharge for patients with similar characteristics between any 2 randomly selected EMS agencies, after adjusting for known measured sources of variability.
Prof. Sanders[/caption]
Professor Prash Sanders
Director, Centre for Heart Rhythm Disorders
NHMRC Practitioner Fellow,
Knapman-NHF Chair of Cardiology Research,
University of Adelaide | SAHMRI
Director, Cardiac Electrophysiology & Pacing,
Royal Adelaide Hospital
MedicalResearch.com: What is the background for this study?
Response: CLINICALLY WE HAVE HAD SOME PATIENTS WHO HAVE SURVIVED SUDDEN DEATH EPISODES AND HAVE NOTED THAT THEY HAD MITRAL VALVE PROLAPSE. THIS STIMULATED US TO UNDERTAKE A REVIEW OF THE LITERATURE.
Dr. Joao Xavier[/caption]
Joao Xavier PhD
Associate Faculty Member | Computational & Systems Biology
Memorial Sloan Kettering Cancer Center
New York, NY 10065
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Our team at Memorial Sloan Kettering has been investigating the intestinal microbiota of patients receiving bone marrow transplantations for more than eight years now. We have found through several studies that these patients lose important healthy bacteria from their microbiota, and that these losses are mostly caused by the antibiotics given as prophylaxis or to treat infections.
We also found that the drastic changes in the microbiota composition, especially the intestinal dominations by bacteria such as Enterococcus, increase the risk of transplant-related complications and lowered patient survival.
We aimed to determine the feasibility of autologous microbiota transplant (auto-FMT) as a way to reconstitute lost bacteria. This randomized study found that indeed auto-FMT could reconstitute important microbial groups to patients.
Dr. Kelkar[/caption]
Dr. Amar Kelkar MD
Clinical Fellow
Division of Hematology & Oncology, Department of Medicine
University of Florida College of Medicine, UF Health Shands Hospital
MedicalResearch.com: What is the background for this study? What are synthetic cannabinoids?
Response: Starting in March 2018, patients began reporting to hospitals and clinics with unexplained and prolonged bleeding symptoms, first in Chicago, Illinois, and then spreading to Peoria, Illinois and elsewhere. This gained a lot of press because the initial identifying factor was that all the patients had reported recent use of synthetic cannabinoids. As the matter was studied further, it was determined that these patients were likely exposed to an anticoagulant poison mixed in with the synthetic cannabinoids.
Synthetic cannabinoids are lab-derived illicit drugs that target the cannabinoid receptors that are also targeted by marijuana. They go by many names including synthetic marijuana, K2, and Spice.
Raghav Tripathi[/caption]
Raghav Tripathi, MPH
Case Western Reserve University
MD Candidate, Class of 2021
MedicalResearch.com: Why did you decide to perform this study?
Response: Differences in the impact of dermatologic conditions on different groups have been of interest to our research group for a long time. Previously, our group had found differences in time to treatment for patients with different skin cancers. Beyond this, we had found differences in mortality and incidence of various skin conditions (controlling for other factors) in different racial groups/ethnicities, socioeconomic groups, demographic groups, and across the rural-urban continuum.
The goal of this study was to investigate socioeconomic and demographic differences in utilization of outpatient dermatologic care across the United States. As demographics throughout the country become more diverse, understanding differences in utilization of dermatologic care is integral to developing policy approaches to increasing access to care across the country.
Robert J Molinari, Ph.D.
President and CEO
Retrotope, Inc.
MedicalResearch.com: What is the background for this study?
How does RT001 differ from other treatments for neurodegenerative diseases?
Response: Lipid peroxidation in critical cell and mitochondrial membranes represents a common pathway of cell death in many neurodegenerative diseases, regardless of the initiating trigger of original damage, e.g. aberrant gene expression, misfolded proteins such as tau and amyloid, environmental insults, etc. This hypothesis was supported by work showing that stabilizing lipids (using virtually indistinguishable isotopic variants of the original dietary molecules) was able to mitigate disease-related cell dysfunction, and reverse disease in a variety of animal models, and more recently, in human patients enrolled in clinical trials.
It has been known for decades that lipid peroxidation detritus of oxidized membrane fats are present in most all diseases of degeneration and aging, including Alzheimer’s disease, Parkinson’s disease, atherosclerosis, ALS, Huntington’s, and fatal inborn genetic errors resulting in neurodegenerative diseases (among others). The hypothesis that controlling such oxidation could provide therapeutic benefit was abandoned when numerous formal trials of classical antioxidants, e.g. Co-enzyme Q, Vitamin E, and others failed to provide meaningful benefit. We believed that the antioxidant mechanism used to attempt control of the membrane oxidation was flawed, but that the target itself was correct. Indeed, by using a new class of oral drugs that are lipids fortified against damage at the key susceptible bonds, we observed reduction in lipid peroxidation damage that halted, and even reversed neurodegenerative disease progression. Dosed in amounts and forms similar to omega 3 and 6 supplements, these drugs exhibited profound disease modification across a broad range of diseases in animal models, placebo controlled- and open label- human trials.
Mark Laughlin, DVM
Veterinary Medical Officer
CDC
MedicalResearch.com: What is the background for this study?
How common are Campylobacter infections? How does a Campylobacter infection typically present?
Response: Campylobacter is one of the most common causes of diarrheal illness in the United States, causing an estimated 1.3 million illnesses each year. Most people with Campylobacter infection usually have diarrhea (often bloody), fever, and abdominal cramps. The diarrhea may be accompanied by nausea and vomiting. These symptoms usually start within 2 to 5 days after exposure and last about a week.
Most illnesses from Campylobacter likely occur due to eating raw or undercooked poultry, or from eating something that touched raw or undercooked poultry. Some illnesses can occur from contact with contaminated water, contact with animals, or from drinking raw (unpasteurized) milk.
Since 2009, 13 outbreaks of human Campylobacter infections linked to contact with dogs have been reported to CDC. These outbreaks account for a reported 47 illnesses and 2 hospitalizations.
Dr. Pandiyan[/caption]
Pushpa Pandiyan, PhD
Assistant Professor, Biological Sciences
School of Dental Medicine
Case Western Reserve University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The objective was to find the role of the resident bacteria in the mouth in controlling oral immunity.
We examined this in a oral fungal infection model. How resident microbiome in the mouth maintains a healthy oral immune system was unknown before.
We found that antibiotics led to destruction of microbiome and some of the good fatty acids the bacteria produced. This created an immune imbalance in the local tissue, thus making the host more susceptible to the fungal infection.
Dr. Solbrig[/caption]
Dr Linda Solbrig PhD
University of Plymouth
MedicalResearch.com: What is the background for this study?
Response: Diets are restrictive; they work in the short-term, but re-gain is common. Individuals trying to manage their weight find that motivation fades over time and that this is the hardest part about maintain a healthy weight. When given choice to self-set goals we are much more likely to stick with them; they are more sustainable and we can succeed long-term. Using multi-sensory mental imagery supports motivation to change in the long run and also the opportunity to test out in our imagination if the actions we decided will lead to personal goal success actually fit with our lives, or whether we need to tweak, or even change them.
Functional Imagery Training (FIT) is based on two decades of research showing that mental imagery is more strongly emotionally charged than other types of thought and that it can directly interfere with unwanted food cravings. It uses multi-sensory mental imagery to strengthen people’s motivation and confidence to achieve their own goals, and teaches people how to do this for themselves, so they can stay motivated even when faced with challenges. It is not about creating a static picture, but encourages the use of all our senses, how a situation may feel, seeing with the mind’s eye and hearing with the mind’s ear and so on, creating a mini movie in our minds where we are the lead actors working on our personal goals, overcoming adversity and succeeding.
Thomas J Moore[/caption]
Thomas J Moore AB
Senior Scientist Institute for Safe Medication Practices
Lecturer, Department of Epidemiology and Biostatistics
The George Washington University
Milken Institute of Public Health
Alexandria, VA 22314
MedicalResearch.com: What is the background for this study? What are the main findings?
Dr. Marcus Smith PhD
Reader in Sport and Exercise Physiology
University of Chichester
Co-founder, Clem Burke Drumming Project
MedicalResearch.com: What is the background for this study?
Response: The research group first started to examine rock drumming from a scientific perspective in 1999 through collaboration with Clem Burke, drummer with the iconic band ‘Blondie’. In 2008 the Clem Burke Drumming Project (CBDP) was formed (visit clemburkedrummingproject.org for further information) where academics from different disciplines came together to not only explore the physiological demands of rock drumming but also the potential use of rock drumming as an intervention in research studies. Rock drumming is attractive to the scientist in that it is a unique activity that requires the coordination of multiple limbs to produce the required drumming pattern. Inherent demands relating to timing, tempo and volume must also be met. Therefore, the ability to manipulate these facets of drumming performance in a research setting is very appealing. In relation to potential research populations drumming has a universal fascination regardless of age, gender, culture, language competency and ethnicity. Anecdotal evidence suggests that drumming is a ‘cool’ activity that has a unique ‘language currency’ in terms of stimulating communication within and between those who can and cannot play the drums.
The impetus for our research study came from parents of autistic children contacting us to express their belief that drumming was having a positive effect on their child’s physical and psychological behaviour. A review of the literature showed a range of anecdotal evidence in support of such statements (Freidman 2000) and an increase in empirical drumming based research being undertaken (Bungay 2010). More recent studies have reported psychosocial benefits such as enhanced communication (Maschi et al. 2010; 2012), emotional processing and tension reduction (Flores et al. 2016; Maschi et al. 2010; 2012), group cohesion and connectedness (Blackett et al. 2005), concentration, psychomotor coordination and posture (Chen et al. 2017). The majority of this work was undertaken with adolescents with very little work focused on younger age groups.
Dr. Mallbris[/caption]
Lotus Mallbris, M.D., Ph.D.,
Vice president, Immunology Development
Lilly Bio-Medicines
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: By exploring creative clinical approaches and patient-centric pathways to more thoroughly address the key aspects of treating these complex conditions, Lilly is bringing innovation forward in hopes of reducing the burden of dermatologic disease for people around the world.
The results of the IXORA-S study suggest that Taltz may provide significantly greater clearance of nail psoriasis than ustekinumab. This is significant because nail lesions are a common feature of psoriasis. It’s often associated with discomfort, which can lead to functional impairment and distress, further supporting the importance of complete clearance.
Dr. Markman[/caption]
John Douglas Markman, M.D.
Director, Translational Pain Research Program
Department of Neurosurgery
Professor
University of Rochester School of Medicine and Dentistry
MedicalResearch.com: What is the background for this study?
Response: Peripheral nerve injury after trauma and surgery is a leading cause of chronic pain and disability. These pain syndromes are often considered to have an underlying neuropathic mechanism because there is altered sensory processing (e.g., numbness, allodynia) at the site of trauma or surgical incision that localizes to the anatomic distribution of a peripheral nerve. A previous eight-week randomized clinical trial demonstrated efficacy for pregabalin in patients with chronic post-traumatic or -surgical pain.(10) The longer duration of treatment of this study was designed to meet the regulatory standard for a chronic pain indication in the US, 12 weeks of treatment at maintenance or fixed dosing.
Dr Dorival Martins
Department of Microbiology and Immunology
Meakins-Christie Laboratories, Research Institute
McGill University Health Centre
Montreal Canada.
MedicalResearch.com: What is the background for this study?
Response: Antibiotic tolerance, together with drug resistance, makes bacteria refractory to antibiotics and can cause treatment failure in subacute and chronic bacterial infections.
Pseudomonas aeruginosa, a major health concern worldwide, can cause severe chronic infections that are refractory to antibiotic treatments due to tolerance. Since the discovery of new antibiotics has been drastically diminished over the last decades, overcoming tolerance could be a strategy to enhance the efficacy of currently available antibiotic treatments. However, very little is known about the mechanism of tolerance, even though this phenomenon has been observed over 60 years ago.
Dr. Kahleova[/caption]
Hana Kahleova, MD, PhD, MBA
Director of Clinical Research
Physicians Committee for Responsible Medicine
Washington, DC 20016
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: The effects of carbohydrates on body weight and insulin sensitivity are controversial.
In this 16-week randomized clinical trial, we tested the role of carbohydrate quantity and quality, as part of a plant-based diet, on body weight, body composition, and insulin resistance. We have demonstrated that carbohydrates and dietary fiber play important roles in the regulation of body weight, body composition, and insulin resistance in overweight individuals.
Increased consumption of total carbohydrate was associated with a decrease in BMI and volume of visceral fat, even after adjustment for energy intake. Increased consumption of total and particularly insoluble fiber was associated with a decrease in BMI, fat mass, and volume of visceral fat.
Dr. Howard[/caption]
Prof. David H. Howard PhD
Department of Health Policy and Management
Emory University
Atlanta, GA 30322
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There is a lot of skepticism that physicians respond to evidence, especially when trials report that widely-used, separately-reimbursed procedures are not effective.
Physicians are reluctant to abandon treatments. This study shows that in the case of knee arthroscopy, evidence has made a difference. The use of knee arthroscopy declined by 23% in Florida between 2002 and 2015. This change occurred despite increases in the prevalence of osteoarthritis.
Andrea Gruneir, PhD
Department of Family Medicine
University of Alberta
Edmonton, AB Canada
MedicalResearch.com: What is the background for this study?
Response: Hospital readmissions – when a patient is discharged from hospital but then returns to hospital in a short period of time – are known to be a problem, both for the patients and for the larger health system. Hospital readmissions have received considerable attention and there have been a number of initiatives to try to reduce them, but with mixed success. Older adults are among the most vulnerable group for hospital readmission. Older adults are also the largest users of continuing care services, such as home care and long-term care homes (also known as nursing homes). Yet, few large studies have really considered how older adults with different pathways through hospital compare on the risk of hospital readmission.
In our study, we take a population-level approach and use health administrative data to create a large cohort of older adults who were hospitalized in Ontario between 2008 and 2015. For each of the 701,527 patients in our study, we identified where they received care before the hospitalization (in the community or in long-term care) and where they received care after discharge (in the community, in the community with home care, or in long-term care).
Site of Ovarian Cancer - Wikipedia Image[/caption]
Fabian Coscia PhD
Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, German and
Ernst Lengyel MD PhD
Department of Obstetrics and Gynecology
Section of Gynecologic Oncology
University of Chicago, Chicago, IL
MedicalResearch.com: What is the background for this study?
Response: Ovarian cancer is a very aggressive disease. Only one in six patients survives more than 10 years after the first diagnosis. This high mortality is primarily because the disease is usually detected late in its course, when the tumor has already spread from the ovaries to the surrounding organs in the abdomen.
In an interdisciplinary collaboration between the Max Planck Institute of Biochemistry in Martinsried, Munich, the University of Chicago and the University of Copenhagen, we performed deep tissue proteomics on archived biobank material to identify drivers of long-term patient survival.
Michael J. Mahan PhD
Professor, Microbiology and Molecular Genetics
Dept of Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara, CA
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Urinary tract infections (UTIs) cause nearly 10 million doctor visits each year in the United States. Women are much more likely to have a UTI than men, and are particularly harmful to pregnant women and can cause miscarriage. Thus, there is a medical need for rapid, low-cost, on-site testing — particularly in resource-limited settings.
We developed a new app that enables a smartphone to identify (ID) bacteria causing UTIs in just one hour — a fraction of the time and cost of clinical diagnostics.
Dr. Persenaire[/caption]
Maarten Persenaire, MD
Co-founder, Chief Medical Officer
TELA Bio
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: OviTex Reinforced BioScaffolds (RBSs) are a novel distinct class of surgical implants that combine biologic and synthetic materials in a unique embroidered construction and design for hernia repair and soft tissue reconstruction. The two recent publications reported clinical results of OviTex RBS performance in inguinal and hiatal hernia repair.
Case series published in the International Journal of Surgery Open evaluated the role of OviTex RBSs in inguinal hernia repair to reduce the incidence of chronic postoperative pain. Thirty-one consecutive patients who had inguinal hernia repaired with OviTex RBSs were followed for an average of 12.6 months, during which time there were no reported recurrences, complications requiring surgical intervention or infections. None of the patients reported postoperative inguinal pain beyond the first days after surgery and none required a narcotic pain medication refill.
The second study published in the Journal of the Society of Laparoendoscopic Surgeons is the first reported series describing the use of OviTex RBSs in hiatal hernia repair. A retrospective chart review of 25 consecutive patients undergoing laparoscopic or open hiatal hernia repairs with mean follow-up of 14.2 months showed no recurrences. The hiatal hernia repairs with OviTex RBSs resulted in good to excellent control and resolution of symptoms, including heartburn, dysphagia, regurgitation, nausea and vomiting, dyspnea, and chest pain or discomfort.
Dr. Haarbauer-Krupa[/caption]
Juliet Haarbauer-Krupa, PhD
Senior Health Scientist
Division of Unintentional Injury Prevention
CDC
MedicalResearch.com: What is the background for this study?
Dr. Johns[/caption]
Michelle M Johns, MPH, PhD
Health Scientist
Division of Adolescent and School Health
CDC
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Gender nonconformity is an under-researched area of adolescent health that is often linked to negative health outcomes. To address this gap, we analyzed Youth Risk Behavior Survey data to describe the associations between gender nonconformity and risk behaviors, including mental distress, and substance use.
Gender nonconformity was associated with feeling sad and hopeless, as well as suicidal thoughts and/or behaviors among female and male students. In addition, gender nonconformity was strongly associated with substance use among male students.
Dr. Hess[/caption]
Erik P. Hess MD MSc
Professor and Vice Chair for Research
Department of Emergency Medicine
UAB Medicine
he University of Alabama at Birmingham
Birmingham Alabama 35249
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: 450,000 children present to U.S emergency departments each year for evaluation of head trauma. Physicians obtain head computed tomography (CT) scans in 37%-50% of these patients, with less than 10% showing evidence of traumatic brain injury and only 0.2% that require neurosurgical treatment.
In order to avoid unnecessary CT scans and to limit radiation exposure, the Pediatric Emergency Care Applied Research Network (PECARN) developed clinical prediction rules that consist of 6 readily available factors that can be assessed from the history and physical examination. If none of these risk factors are present, a CT scan is not indicated.
If either of 2 high risk factors such as signs of a skull fracture are present, CT scanning is indicated.
If 1 or 2 non-high risk factors are present, then either CT scanning or observation are recommended, depending on considerations such as parental preference, clinician experience and/or symptom progression.
In this study we designed a parent decision aid, “Head CT Choice” to educate the parent about the difference between a concussion – which does not show up on a CT scan – and a more serious brain injury causing bleeding in or around the brain. The decision aid also shows parents their child’s risk for a serious brain injury – less than 1% risk in the majority of patients in our trial – what to observe their child at home for should they opt not to obtain a CT scan, and the advantages and disadvantages of CT scanning versus home observation.
In our trial, we did not observe a difference in the rate of head CT scans obtained in the ED but did find that parents who were engaged in shared decision-making using Head CT Choice were more knowledgeable about their child’s risk for serious brain injury, has less difficulty making the decision because they were clearer about the advantages and disadvantages of the diagnostic options, and were more involved in decision-making by their physician. Parents also less frequently sought additional testing for their child within 1 week of the emergency department visit.
Fudi Wang, M.D., Ph.D.
Qiushi Chair Professor
Nutrition Discovery Innovation Center
School of Public Health/School of Medicine
Zhejiang University
Hangzhou China
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Parkinson disease (PD) is the second most common neurodegenerative disease affecting approximately 10 million people around the world. To date, the cause of PD remains poorly understood. It is reported that 90% PD cases have no identifiable genetic cause. What’s worse, few therapeutic advances for the treatment of PD have been made in the past decades. Nevertheless, growing prospective longitudinal studies shed lights on the potential beneficial effect of lifestyle factors on reducing the risk of developing Parkinson disease. In this study, we performed a a dose-response meta-analysis of more than half a million participants.
We found that physical activity, particularly moderate to vigorous physical activity, could significantly reduce PD risk.
Dr. Flom[/caption]
Julie Flom, MD MPH
Clinical Fellow
Division of Allergy & Immunology
Icahn School of Medicine at Mount Sinai
MedicalResearch.com: What is the background for this study?
Response: Women who are minorities and of lower socioeconomic have particularly high rates of exposure to chronic ongoing adversity such as poverty as well as traumatic stressors in their lifetime and are also more likely to have low birthweight infants. Not all women exposed to chronic adversity or trauma transfer this risk to the next generation – it is primarily when the trauma results in changes in her bodies’ ability to handle ongoing stress that the developing child can be impacted.
Our group undertook a study to investigate whether women with increased exposure to traumatic stressors over her lifetime were at higher risk of having low birthweight infants and also whether effects of trauma would only be evident among women who produced higher levels of cortisol, the major stress response hormone, while pregnant.
MedicalResearch.com Interview with: [caption id="attachment_44726" align="alignleft" width="200"] Prof., Hahn[/caption] Juergen Hahn PhD, Professor and Department Head Department of Biomedical Engineerin Department of Chemical & Biological Engineering Center for Biotechnology and Interdisciplinary Studies Rensselaer Polytechnic Institute MedicalResearch.com: What is the background for this study? What are the main findings? Response: Recent estimates indicate that if a mother has...
Dr. Murray[/caption]
Michael F. Murray, MD, FACMG, FACP
Director for Clinical Operations in the Center for Genomic Health
Yale School of Medicine
MedicalResearch.com: What is the background for this study?
Response: Population screening for the cancer risk associated with the BRCA1 and BRCA2 genes has been suggested by some. We screened a cohort of about 50,000 adult patient volunteers at Geisinger Health System in Pennsylvania for this risk.