MedicalResearch.com Interview with:
Sarah Windle, MPH
PhD Student in EpidemiologyDepartment of Epidemiology, Biostatistics, and Occupational HealthMcGill University (Montréal, Québec, Canada)
MedicalResearch.com: What is the background for this study? Response: Concerns have been raised about the potential for increases in impaired driving following the legalization of recreational cannabis use in Canada in October 2018. Data from Statistics Canada suggest that cannabis use in the previous three months increased among adults (15 and older) from 14% before legalization in 2018 to 17% in 2019. Among those users with a driver’s license, 13% reported driving within two hours of cannabis use. While this proportion remained the same before and after legalization, this indicates that the absolute number of individuals who reported driving within two hours of use has increased following legalization (due to an increase in the number of users).
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MedicalResearch.com Interview with:
Chien-Wen Tseng, M.D., M.P.H., M.S.E.E.
The Hawaii Medical Service Association Endowed Chair
Health Services and Quality Research
Professor, and Associate Research Director
Department of Family Medicine and Community Health
University of Hawaii John A. Burns School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?Response: Age-related hearing loss cannot be reversed and can be a significant problem for older adults. Four out of 10 adults who are age 70 and older report hearing loss and it can worsen isolation, cognitive decline, and quality of life, as well as interfere with someone’s ability to live independently. There are simple screening tests to detect hearing loss, so the Task Force did an extensive review of whether there are health benefits to screening for hearing loss in people who do not have symptoms before they notice any hearing problems.
The Task Force determined that there is not enough evidence to recommend for or against screening for hearing loss in adults who are age 50 and older and do not have signs or symptoms of hearing loss. This is an I statement. (more…)
MedicalResearch.com Interview with:
Francesco D’Aiuto
Professor/Hon Consultant
Head of Periodontology Unit
UCL Eastman Dental InstituteMedicalResearch.com: What is the background for this study? Response: This study was set out to further our understanding of the link between gum disease and high blood pressure. Recent evidence suggested that individuals with gum disease had a 20-70% increased risk of hypertension and systemic inflammation seemed to be a driver in mediating this association. Further research on the matter was needed. We recruited two relatively large groups of otherwise healthy participants (without a confirmed diagnosis of hypertension) who had gum disease one and healthy gums the other.
We found that diagnosis of periodontitis (gum disease) was consistently linked to higher systolic blood pressure independent of other cardiovascular risk factors.
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MedicalResearch.com Interview with:
David C. Rettew, MD
Child & Adolescent Psychiatrist
Associate Professor of Psychiatry and Pediatrics
University of Vermont Larner College of Medicine
MedicalResearch.com: What is the background for this study? Response: Our group, the Wellness Environment Scientific Team at the University of Vermont, hadn’t planned to look at COVID at the outset of this study and instead were going to look at mental health and engagement in wellness activities in college students across a semester. The pandemic disrupted that plan when students were abruptly sent home but fortunately, they continued to do their daily app-based ratings of their mood, stress levels, and engagement in healthy activities. We then realized we had some interesting pre-COVID to COVID data that was worth exploring.(more…)
MedicalResearch.com Interview with:
Patrick DeMartino MD
Pediatric Hematology and Oncology Fellow
Doernbecher Children's Hospital
Oregon Health & Science University
MedicalResearch.com: What is the background for this study? Response: Dozens of gene therapies are expected to be on the market within a decade or so. Much has been written about the high prices of the therapies currently on the market (exceeding $1 million). However, only a small number of patients are eligible for these existing therapies each year. Gene therapy for sickle cell disease (SCD) appears promising and would potentially apply to a relatively large number of individuals in the U.S. We sought to explore potential affordability challenges associated with a gene therapy for SCD.
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MedicalResearch.com Interview with:
Nathalie Auger
Professeure agrégée de clinique
École de santé publique - Département de médecine sociale et preventive
University of Montreal
MedicalResearch.com: What is the background for this study? Response: COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been a major public health concern. The number of infected pregnant women continues to increase. Pregnant women and infants are particularly susceptible to COVID-19 because the physiologic changes of pregnancy involve cardiovascular, respiratory, and immune changes that may alter the response to SARS-CoV-2 infection. Fetuses may be exposed to SARS-CoV-2 during critical periods of development. The nature of the association between COVID-19 and pregnancy outcomes remains unclear and meta-analyses of pregnant women with COVID-19 are lacking.
(more…)
MedicalResearch.com Interview with:
Sungchul Park, MPH PhDAssistant Professor, Health Management and Policy
Dornsife School of Public Health
Drexel University
Philadelphia, PA 19104
MedicalResearch.com: What is the background for this study? Response: Evidence suggests that a significant share of health care costs in the US is of low value. In some cases, low-value care can be associated with harmful patient outcomes. Thus, decreasing use of low-value care is a major goal for Medicare given the potential to decrease costs and harms. Compared with traditional fee-for-service Medicare (TM), Medicare Advantage (MA) is more strongly financially incentivized to decrease use of low-value care. (more…)
MedicalResearch.com Interview with:
Chao Cao, MPH
PhD student in Movement Science,
Program in Physical Therapy, Washington University School of Medicine.
Senior author:
Lin Yang, PhD
Research Scientist/Epidemiologist
Department of Cancer Epidemiology and Prevention Research
Cancer Care Alberta | Alberta Health Services | Canada
MedicalResearch.com: What is the background for this study? Response: Dizziness and imbalance are common among US adults and increases the risk of serious injuries. However, research related to balance overwhelmingly focuses on functional outcomes among older adults, therefore our understanding on how balance function may affect the long-term health outcomes in adults of different age group is limited.
MedicalResearch.com: What are the main findings?Response: We found that balance disorder affects nearly 2/3 of older Americans (65+ yr) as well as 1/3 of those middle-aged (50-64 yr). Our study, for the first time, found that for middle-aged and older Americans, their overall and sensory-specific balance disorders (visual, proprioceptive, and vestibular) were associated with higher mortality risks driven by cancer and CVD death over 12 years. (more…)
MedicalResearch.com Interview with:
Matt Spick, Post-Graduate Researcher
University of Surrey
Faculty of Engineering and Physical Sciences
Guildford, UK
MedicalResearch.com: What is the background for this study? Are you measuring lipids or the virus?Response: In this study, we aimed to detect what the virus does to us, rather than the virus itself. The gold standard for detecting COVID-19 is the RT-PCR test, but by their nature, PCR tests only provide diagnostic information, and at times during the pandemic the availability of PCR tests has been a bottleneck for the identification of the disease. Our goal was to investigate a novel method for the diagnosis of COVID-19, at the same time as learning more about what the disease does to us through lipidomics.
(more…)
MedicalResearch.com Interview with:
Anne Cust | PhD, Professor of Cancer Epidemiology
The University of Sydney
Faculty of Medicine and Health
Sydney School of Public Health
MedicalResearch.com: What is the background for this study? Are the screeners specially trained, use full body photographs, dermoscopy etc?Response: The Melanoma High-risk Clinic Study was developed to optimise the early detection of new melanomas in people at high risk of developing melanoma. A previous single-centre study observed fewer excisions and healthcare costs, thinner melanomas and better quality of life when surveillance of high risk patients was conducted in a melanoma dermatology clinic with a structured surveillance protocol involving 6-monthly full body examinations aided by total body photography (TBP) and sequential digital dermoscopy imaging (SDDI). The initial pilot study was performed in a single tertiary referral specialist centre using trained dermatologists who routinely used the diagnostic interventions.
Our objective was to examine longer-term sustainability and expansion of the program to multiple practices including a primary care skin cancer clinic setting. The hypothesis was that the outcomes would be similar if using the same protocol and diagnostic tools. The participating doctors were trained to follow the protocol, which included instruction on how to respond and interpret changing lesions, but not in use of dermoscopy or skin examinations, which were routinely and consistently used in all clinics prior to the study commencing. There were 593 participants assessed as very high risk of melanoma who participated in the Melanoma High-risk Clinic Study from 2012-2018. Nearly all of the participants had had a previous melanoma and had additional melanoma risk factors. 57% were male and the median age at study entry was 58 years.
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MedicalResearch.com Interview with:
John B. Wong, M.D.
Chief Scientific Officer,
Vice Chair for Clinical Affairs
Chief of the Division of Clinical Decision Making
Primary Care Clinician
Department of Medicine
Tufts Medical CenterMedicalResearch.com: What is the background for this study? Response: Lung cancer is the leading cause of cancer death for both men and women in the United States. More than 200,000 people are diagnosed with this devastating disease each year. Smoking is the leading cause of lung cancer, resulting in the vast majority of lung cancers in the United States. (more…)
MedicalResearch.com Interview with:
Stephen Salloway, M.D., M.S.
Director of Neurology and the Memory and Aging Program, Butler Hospital
Martin M. Zucker Professor of Psychiatry and Human Behavior
Professor of Neurology, Alpert Medical School of Brown University
Providence, RI 02906MedicalResearch.com: What is the background for this study? Response: This 78 week phase 2 study tested donanemab in patients with early Alzheimer’s disease. Donanemab is a an anti-amyloid monoclonal antibody that targets the N3 pyroglutamate epitope.MedicalResearch.com: What are the main findings?Response: The drug produced a substantial lowering of amyloid plaques and showed a slowing in cognitive decline. Key innovations included using PET scans to ensure all patients were amyloid positive and had a moderate level of tau build-up and switching from drug to placebo once the amyloid level was below the expected cut-off for Alzheimer’s disease.
There were no new safety signals. The main side-effect was amyloid-related imaging abnormalities (ARIA) that have been seen with other anti-amyloid treatments. ARIA is managed with regular safety MRI scans. Donanemab is now being tested in a larger phase 3 trial that could lead to regulatory approval. (more…)
MedicalResearch.com Interview with:
Brandon K Fornwalt, MD, PhD
Associate Professor, Director Department of Imaging Science and Innovation
Geisinger
MedicalResearch.com: What is the background for this study? Response: Atrial fibrillation (AF) is an abnormal heart rhythm that is associated with outcomes such as stroke, heart failure and death. If we know a patient has atrial fibrillation, we can treat them to reduce the risk of stroke by nearly two-thirds. Unfortunately, patients often don’t know they have AF. They present initially with a stroke, and we have no chance to treat them before this happens. If we could predict who is at high risk of either currently having AF or developing it in the near future, we could intervene earlier and hopefully reduce bad outcomes like stroke. Artificial intelligence approaches may be able to help with this task. (more…)
MedicalResearch.com Interview with:
Jesse T. Jacob, MD
School of Medicine
Director, Antibiotic Stewardship Program
Emory University, Atlanta, Georgia
MedicalResearch.com: What is the background for this study? Response: Since coronavirus disease 2019 (COVID-19) was recognized in the United States in January 2020, the risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to exposures in the health care workplace has been studied with conflicting results, and the role of job functions (such as nurse) or specific workplace activities, including care for individuals with known and unknown SARS-CoV-2 positivity, increase the risk of SARS-CoV-2 infection.
We assessed more than 24,000 healthcare providers between April and August 2020 across four large academic medical systems (Emory, Johns Hopkins, Rush University Medical Center, and University of Maryland) which collaborate in the CDC’s Prevention Epicenter Program and conduct innovative infection prevention research. Each site conducted voluntary COVID-19 antibody testing on its health care workers, as well as offered a questionnaire/survey on the employees’ occupational activities and possible exposures to individuals with COVID-19 infection both inside and outside the workplace. We also looked at three-digit residential zip-code prefixes to determine COVID-19 prevalence in communities. (more…)
MedicalResearch.com Interview with:Dr Pirro Hysi
Senior Lecturer in Ophthalmology
Kings College London
MedicalResearch.com: What is the background for this study? Response: - Iris (eye) color is an important human trait. It is one of the main features that makes our faces unique and recognizable. Iris color is similar to other pigmentatio traits, like hair and skin color, in that it is determined by the concentration and relative ratios of the melanin pigment. Pigmentation traits are roughly determined by several of the same genes regulating pigmentation, but many other genes seem to selectively determine pigmentation in any of these tissues.
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MedicalResearch.com Interview with:
Jim Nugent, MD MPH
Pediatric Nephrology FellowYale University School of Medicine
MedicalResearch.com: What is the background for this study? Response: It is now well-established that acute kidney injury is common in patients hospitalized with COVID-19. In addition, patients with COVID-19 tend to have more severe acute kidney injury than patients who have acute kidney injury due to other causes. However, the intermediate and longer-term kidney outcomes after COVID-19-associated acute kidney injury have not yet been described. Our study compares the rate of change in estimated glomerular filtration rate after hospital discharge between patients with and without COVID-19 who experienced in-hospital acute kidney injury. Due to their more severe acute kidney injury in the hospital, we hypothesized that patients with COVID-19-associated acute kidney injury would have greater decline in kidney function after discharge compared to patients with acute kidney injury who tested negative for COVID-19. In order to answer this question, we reviewed the medical records of adult patients at 5 hospitals in Connecticut and Rhode Island admitted between March and August 2020 who had developed acute kidney injury during their hospitalization, survived until discharge, and were discharged off dialysis. For our study, we included patients who had at least one outpatient serum creatinine measurement after discharge. (more…)
MedicalResearch.com Interview with:
Jonathan Silverberg, MD, PHD, MPH
Associate Professor
Director of Clinical Research
Director of Patch Testing
George Washington University School of Medicine and Health Sciences
Washington, DC
MedicalResearch.com: What is the background for this study? Response: The COVID pandemic hit the Orthodox Jewish community in the United States particularly hard, especially in the early days when much was unknown. At that time of great loss, Jewish communities around the United States rallied to help the millions of other people impacted by the pandemic.
A partnership was established of local community organizations across 5 states with premier academic universities across the United States and Canada. Over a 10 day period in May 2020, more than 6500 people came out to participate in the The Multi-Institutional Study Analyzing anti-CoV-2 Antibodies (MITZVA) cohort. Participants completed surveys and donated blood in order to become potential convalescent plasma donors and help learn more about the science of COVID. (more…)
MedicalResearch.com Interview with:
Brian P. Lee, MD, MAS
Assistant Professor Clinical Medicine
University of Southern Californi
Keck School of Medicine
Los Angeles, California
MedicalResearch.com: What is the background for this study? Response: The COVID-19 pandemic has been associated with mental health stressors, including anxiety, loneliness, and social instability. We hypothesized the pandemic may have led to increased alcohol and tobacco use as a coping mechanism for these stressors. National retrospective questionnaires had suggested higher reports of substance use, but these are limited by selection and recall biases, in addition to subjective report – we sought to address this knowledge gap by using a nationally-representative longitudinal cohort (Nielsen National Consumer Panel) tracking real-time purchases of households across the US.(more…)
MedicalResearch.com Interview with:
Giordano Bottà, PhD
CEO and Co-founder
Allelica
The Polygenic Risk Score Company
MedicalResearch.com: What is the background for this study? Response: Previous research identified that polygenic risk score (PRS) has the highest predictive power compared to other risk factors and identifies individuals with the same risk of those with familial hypercholesterolemia, but are invisible to traditional risk assessment. We explored for the first time the interplay between the main causes of atherosclerosis, LDL cholesterol and PRS. We were interested in helping cardiologists understand why some individuals have bad arteries full of plaques while others don't in presence of the same LDL levels and no additional risk factors. Our findings explain why this is the case: LDL does not affect everyone the same. We believe that we are at the forefront of a change of paradigm in cardiovascular risk assessment: LDL levels cannot be accessed without considering the genetics of an individual.
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MedicalResearch.com Interview with:
Dr. Kevin Lu PhD
Clinical Pharmacy and Outcomes Sciences
College of Pharmacy
Medical University of South Carolina
MedicalResearch.com: What is the background for this study? Response: It is documented that the prevalence of autism spectrum disorder (ASD) has been increasing in the past few years. However, no information on potential racial and ethnic disparities in ASD diagnosis can be found in the literature. Most recently, the possible structural racism and health inequities have been a concern for the public and policy makers.
(more…)
MedicalResearch.com Interview with:
Erica M. Wymore, MD MPH
Assistant Professor, Neonatal- Perinatal Medicine
Department of Pediatrics, Section of Neonatology
University of Colorado School of Medicine
Children's Hospital Colorado
Maya Bunik, MD, MPH | Professor, PediatricsMedical Director, Child Health Clinic, Primary Care | Breastfeeding Management Clinic
Adult and Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS)
School of Medicine| University of Colorado Anschutz Medical Campus
Children's Hospital Colorado
MedicalResearch.com: What is the background for this study? Response: Marijuana legalization has been increasing in the United States, with increasing consumption of marijuana products. Currently, the American Academy of Pediatrics (AAP), American College of Obstetricians and Gynecologists (ACOG) and Academy of Breastfeeding Medicine (ABM) do not recommend marijuana use during pregnancy or lactation due to concerning though limited data on the effects of perinatal marijuana exposure.
As there has been increasing prevalence of women using marijuana during pregnancy due to legalization and perceptions of safety, we sought to determine the duration of THC excretion in breast milk among women who had evidence of marijuana use at delivery and abstained post-partum.(more…)
MedicalResearch.com Interview with:
Marie C. Bradley, PhD, MPharm, MScPH
Office of Surveillance and Epidemiology
Center for Drug Evaluation and Research
US Food and Drug Administration
Silver Spring, Maryland
MedicalResearch.com: What is the background for this study? Response: Long-acting insulin analogs, insulin glargine (glargine) and insulin detemir (detemir) are increasingly used in the management of type 2 diabetes mellitus (T2DM). In recent years the price of long-acting insulin analogs has increased substantially2 Higher costs for these insulin analogs may limit patient access.1 Clinical trials showed the risk of severe hypoglycemia did not differ between long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes mellitus (T2DM). An observational study examining severe hypoglycemia in T2DM patients found similar results. However, these previous studies did not focus on patients aged ≥65 years, who are at an increased risk for hypoglycemia, or did not include patients with concomitant prandial insulin use. Therefore, to investigate this further we used Medicare data to assess the risk of severe hypoglycemia among older T2DM patients who initiated a long acting analog ( glargine or detemir) compared to NPH in real-world settings.
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MedicalResearch.com Interview with:
Ninh T. Nguyen, MD
Chief of Gastrointestinal Division, Surgery
UCIMedicalResearch.com: What is the background for this study? What are the main findingsResponse: There are limited national data on hospitalized patients in the US. To our knowledge, the current publication provides data on the largest cohort of COVID-19 patients hospitalized at US academic centers.
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MedicalResearch.com Interview with:
Fernando D Testai, MD, PhD, FAHA
Associate Professor of Neurology and Rehabilitation
Stroke Medical Director
University of Illinois Health
MedicalResearch.com: What is the background for this study? Response: Stroke constitutes a leading cause of disability and mortality in the United States. Large observational studies have shown that up to 90% of the strokes are caused by modifiable vascular risk factors, including hypertension, diabetes mellitus, and several others. In addition, previous history of stroke is one of the most powerful predictors of recurrent stroke. Thus, controlling vascular risk factors in patients with stroke is of paramount importance. To this end, the American Heart Association and the American Stroke Association have developed specific targets for blood pressure, glycemic, and cholesterol levels.
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MedicalResearch.com Interview with:David J. Engel, MD, FACC
Division of Cardiology
Columbia University Irving Medical Center
New York, New York
MedicalResearch.com: What is the background for this study? Response:Early reports and observations in the COVID-19 pandemic found that patients recovering from mild to severe forms of COVID-19 illness had a higher prevalence of cardiac injury in comparison with what historically has been seen and reported with other viruses. This cardiac injury, categorized as inflammatory heart disease, could have serious implications, including a risk for exercise-triggered sudden cardiac death, for athletes and highly active people who have had prior COVID-19 illness and who return to intensive exercise activity with unknowing subclinical cardiac injury.
To address these concerns in COVID positive athletes, the ACC generated return to play cardiac screening recommendations (troponin blood test, ECG, resting echocardiogram) for all competitive athletes after COVID-19 infection prior to resumption of competitive and intensive sport activity. The professional leagues were among the first organizations to return to full-scale sport activity in the setting of the pandemic, and they uniformly adopted and implemented the ACC return to play screening recommendations for all athletes that tested positive for COVID-19. The leagues recognized that there was value in collaborating and formally analyzing their pooled cardiac data, not only for league athlete health and safety purposes, but also to share broadly this information to add to the growing body of knowledge about the virus.
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MedicalResearch.com Interview with:
Dott.ssa Silvia Bloise MD
Prof. Riccardo Lubrano MD PhD
Pediatric and Neonatology Unit
Maternal and Child Department
Sapienza University of Rome
Rome Italy
MedicalResearch.com: What is the background for this study? Response: Pending new evidence, the universal facial masking, with other preventive measures remain the only strategies to limit the spread of SARS-CoV-2 infection. The use of face mask is particularly debated in the children, especially in younger children. Therefore, we wanted to test whether their in children was associated with episodes of desaturation or respiratory distress.
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MedicalResearch.com Interview with:Carlo Giovanni Traverso, MB, BChir, PhD
Associate Physician, Brigham and Women's Hospital
Assistant Professor,
Peter R. Chai, MD, MMS
Emergency Medicine Physician and Medical Toxicologist
Harvard Medical School
Brigham and Women's Hospital
Department of Medicine
MedicalResearch.com: What is the background for this study? What are some of the functions that Dr. Spot can facilitate?Response: During the COVID-19 pandemic, we wanted to consider innovative methods to provide additional social distance for physicians evaluating low acuity individuals who may have COVID-19 disease in the emergency department. While other health systems had instituted processes like evaluating patients from outside of emergency department rooms or calling patients to obtain a history, we considered the use of a mobile robotic system in collaboration with Boston Dynamics to provide telemedicine triage on an agile platform that could be navigated around a busy emergency department. Dr. Spot was built with a camera system to help an operator navigate it through an emergency department into a patient room where an on-board tablet would permit face-to-face triage and assessment of individuals.
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MedicalResearch.com Interview with:
Dr Tapio RäihäCenter for Life Course Health Research
University of Oulu, Oulu, FinlandMedicalResearch.com: What is the background for this study? Response: In ageing societies, understanding risk factors for pre-term disability pensions and poor work ability is an important research priority. We studied whether individual-level chronotype could contribute to these. Previous research has shown that evening chronotypes (E-types) have poorer health compared with morning chronotypes (M-types), and that E-types may have difficulties to function during standard morning working hours. This study was the first population-level study with register linkage to find out whether eveningness would be associated with poor work ability and disability pensions, too.
We surveyed chronotype (with the Morningness–Eveningness Questionnaire) among 5831 non-retired Finns born in 1966 when they were at age 46 years, and compared it with their current perceived work ability. We then followed the emergence of new registered disability pensions during the next 4 years. Multivariate logistic and Cox regression analyses of the associations between chronotype and the outcomes were separately adjusted for sleep, health and behaviours, sociodemographic and economic factors, or working times(more…)
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