Author Interviews, Heart Disease, Science / 31.01.2020
Cancer Drug May Improve Complicated Form of Heart Failure
MedicalResearch.com Interview with:
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Dr. Steven R. Houser[/caption]
Steven R. Houser, PhD, FAHA
Senior Associate Dean, Research
Vera J. Goodfriend Endowed Chair, Cardiovascular Research
Chair and Professor, Physiology
Director, Cardiovascular Research Center (CVRC)
Professor, Medicine
Deborah M Eaton
Doctorate Student / Research Assistant
Temple University
MedicalResearch.com: What is the background for this study?
Response: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of cases of HF and to date clinical trials with HFpEF patients have failed to produce positive outcomes. Part of this is likely due to the lack of HFpEF animal models for preclinical testing. Our lab addressed this gap in knowledge by developing an animal model that mimics critical features of the human HFpEF phenotype. We performed an in-depth cardiopulmonary characterization highlighting that the model has characteristics of human disease. We then tested the effects of a pan-HDAC inhibitor, vorinostat/SAHA, in collaboration with Dr. Timothy McKinsey, who is an expert in HDAC inhibitors and recently published work1 that laid the foundation for this study.
Dr. Steven R. Houser[/caption]
Steven R. Houser, PhD, FAHA
Senior Associate Dean, Research
Vera J. Goodfriend Endowed Chair, Cardiovascular Research
Chair and Professor, Physiology
Director, Cardiovascular Research Center (CVRC)
Professor, Medicine
Deborah M Eaton
Doctorate Student / Research Assistant
Temple University
MedicalResearch.com: What is the background for this study?
Response: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of cases of HF and to date clinical trials with HFpEF patients have failed to produce positive outcomes. Part of this is likely due to the lack of HFpEF animal models for preclinical testing. Our lab addressed this gap in knowledge by developing an animal model that mimics critical features of the human HFpEF phenotype. We performed an in-depth cardiopulmonary characterization highlighting that the model has characteristics of human disease. We then tested the effects of a pan-HDAC inhibitor, vorinostat/SAHA, in collaboration with Dr. Timothy McKinsey, who is an expert in HDAC inhibitors and recently published work1 that laid the foundation for this study.
Dr. Hongying (Daisy) Dai[/caption]
Hongying (Daisy) Dai, PhD
Associate Professor
Department of Biostatistics | College of Public Health
University of Nebraska Medical Center
Omaha, NE
MedicalResearch.com: What is the background for this study?
Response: E-cigarette use increased dramatically from 11.7% to 27.5% for high school students and from 3.3% to 10.5% for middle school students during the periods of 2017 - 2019. In September 2018, the Food and Drug Administration (FDA) warned that youth e-cigarette use is reaching an epidemic proportion.
Exposure to secondhand aerosol (SHA) from e-cigarettes is not harmless as e-cigarettes aerosol contains nicotine and potentially harmful substances, including carbonyl compounds, TSNAs, heavy metals, and glycols. This study analyzed the 2015-2018 National Youth Tobacco Survey (NYTS) and the main findings are:
Prof. Woloshin[/caption]
Steven Woloshin, MD, MS
Professor of Medicine and Community and Family Medicine
Professor, The Dartmouth Institute for Health Policy and Clinical Practice
MedicalResearch.com: What is the background for this study?
Response: Industry spends more on detailing visits and free samples than any other form of prescription drug marketing. There is good evidence that these activities can lead to more use of expensive new drugs over equally effective cheaper options. Given these concerns there have been efforts by some hospitalls and practices to restrict these forms of marketing.
We asked physicians in group practices delivering primary care about how often pharmaceutical reps visit their practice and whether they have a free sample closet.
Dr. Liao[/caption]
Joshua M. Liao, MD, MSc, FACP
Assistant Professor, Department of Medicine
Director, UW Medicine Value and Systems Science Lab
Medical Director of Payment Strategy, UW Medicine
University of Washington
MedicalResearch.com: What is the background for this study?
Response: A prior pilot

Dr. Breyer[/caption]
Benjamin N. Breyer MD, MAS, FACS
Associate Professor
Departments of Urology and Epidemiology and Biostatistics
University of California, San Francisco
Vice-Chair of Urology
Chief of Urology, Zuckerberg San Francisco General Hospital and Trauma Center
Director, UCSF Male Genitourinary Reconstruction and Trauma Surgery Fellowship
MedicalResearch.com: What is the background for this study?
Response: There has been a large increase in upright scooter usage among adults as a mode of transportation. It's convenient for commuters and may encourage greater use of public transit leading to less car traffic in cities.